Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation

The Role of Natural Antioxidants in the Prevention of Dementia—Where Do We Stand and Future Perspectives

(2021) Anamaria Jurcau   Nutrients

Exposure to lutein-loaded nanoparticles attenuates Parkinson's model-induced damage in Drosophila melanogaster: restoration of dopaminergic and cholinergic system and oxidative stress indicators

(2021) Eliana Jardim Fernandes et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Chronic Treatment of Ascorbic Acid Leads to Age-Dependent Neuroprotection against Oxidative Injury in Hippocampal Slice Cultures

(2021) Kyung Hee Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cyto/Biocompatibility of Dopamine Combined with the Antioxidant Grape Seed-Derived Polyphenol Compounds in Solid Lipid Nanoparticles

(2021) Adriana Trapani et al.   MOLECULES

Fucoxanthin Prevents 6-OHDA-Induced Neurotoxicity by Targeting Keap1

(2021) Wei Wu et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease

(2021) Afzal Misrani et al.   Frontiers in Aging Neuroscience

Quercetin-Conjugated Superparamagnetic Iron Oxide Nanoparticles Protect AlCl3-Induced Neurotoxicity in a Rat Model of Alzheimer’s Disease via Antioxidant Genes, APP Gene, and miRNA-101

(2021) Elnaz Amanzadeh Jajin et al.   Frontiers in Neuroscience

Coenzyme Q10 Analogues: Benefits and Challenges for Therapeutics

(2021) Juan M. Suárez-Rivero et al.   Antioxidants

Nanoparticles of resveratrol attenuates oxidative stress and inflammation after ischemic stroke in rats

(2021) Mohammad Ashafaq et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies

(2021) Celia Andrés Juan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer’s Disease

(2021) Ines ELBini-Dhouib et al.   MOLECULES

Nanoemulsion Improves the Neuroprotective Effects of Curcumin in an Experimental Model of Parkinson’s Disease

(2021) Osmar Vieira Ramires Júnior et al.   NEUROTOXICITY RESEARCH

Treating Neurodegenerative Disease with Antioxidants: Efficacy of the Bioactive Phenol Resveratrol and Mitochondrial-Targeted MitoQ and SkQ

(2021) Lindsey J. Shinn et al.   Antioxidants

PLGA-PEG Nanoparticles Facilitate In Vivo Anti-Alzheimer’s Effects of Fucoxanthin, a Marine Carotenoid Derived from Edible Brown Algae

(2021) Mengxiang Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Novel Synthetic Precursor of Styryl Sulfone Neuroprotective Agents Inhibits Neuroinflammatory Responses and Oxidative Stress Damage through the P38 Signaling Pathway in the Cell and Animal Model of Parkinson’s Disease

(2021) Ying Guo et al.   MOLECULES

Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

(2021) Henry Jay Forman et al.   NATURE REVIEWS DRUG DISCOVERY

Resveratrol inhibits inflammation after spinal cord injury via SIRT-1/NF-κB signaling pathway

(2021) Haosen Zhao et al.   NEUROSCIENCE LETTERS

Sirtuins: Potential Therapeutic Targets for Defense against Oxidative Stress in Spinal Cord Injury

(2021) Jialiang Lin et al.   Oxidative Medicine and Cellular Longevity

Cerebral Edema Formation After Stroke: Emphasis on Blood–Brain Barrier and the Lymphatic Drainage System of the Brain

(2021) Sichao Chen et al.   Frontiers in Cellular Neuroscience

Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease

(2021) Francisca Villavicencio Tejo et al.   Antioxidants

Linking Oxidative Stress and Proteinopathy in Alzheimer’s Disease

(2021) Chanchal Sharma et al.   Antioxidants

Anti-inflammatory and antioxidant effects of astaxanthin following spinal cord injury in a rat animal model

(2021) Alireza Masoudi et al.   BRAIN RESEARCH BULLETIN

The neuroprotective potential of carotenoids in vitro and in vivo

(2021) Janani Manochkumar et al.   PHYTOMEDICINE

Inflammatory Response Modulation by Vitamin C in an MPTP Mouse Model of Parkinson’s Disease

(2021) Francesco De Nuccio et al.   Biology-Basel

The role of myeloperoxidase (MPO) in biomolecule modification, chronic inflammation and disease.

(2020) Michael Davies Davies et al.   ANTIOXIDANTS & REDOX SIGNALING

The mitochondria‐targeted anti‐oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance

(2020) Liang Kang et al.   CELL PROLIFERATION

Phenolic Compounds from Nuts: Extraction, Chemical Profiles, and Bioactivity

(2020) Romina Bodoira et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Combination of Omega 3 and Coenzyme Q10 Exerts Neuroprotective Potential Against Hypercholesterolemia-Induced Alzheimer's-Like Disease in Rats

(2020) Ghadha Ibrahim Fouad   NEUROCHEMICAL RESEARCH

Insights into the neuropathology of cerebral ischemia and its mechanisms

(2020) Mohamad Anuar Ahad et al.   REVIEWS IN THE NEUROSCIENCES

Targeting Oxidative Stress and Inflammation to Prevent Ischemia-Reperfusion Injury

(2020) Liquan Wu et al.   Frontiers in Molecular Neuroscience

Synergistic effect of ascorbic acid and taurine in the treatment of a spinal cord injury-induced model in rats

(2020) Chao Chen et al.   3 Biotech

Novel α-Lipoic Acid/3-n-Butylphthalide Conjugate Enhances Protective Effects against Oxidative Stress and 6-OHDA Induced Neuronal Damage

(2020) Kwanchanok Uppakara et al.   ACS Chemical Neuroscience

Edaravone for amyotrophic lateral sclerosis: barriers to access and lifeboat ethics

(2020) Ari Breiner et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Role of oxidative stress in depression

(2020) Shvetank Bhatt et al.   DRUG DISCOVERY TODAY

Quercetin lipid nanoparticles functionalized with transferrin for Alzheimer's disease

(2020) R.G.R Pinheiro et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders

(2020) Luca Pangrazzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons

(2020) Man Yang et al.   Molecular Medicine Reports

Resveratrol regulates Nrf2-mediated expression of antioxidant and xenobiotic metabolizing enzymes in pesticides-induced Parkinsonism

(2020) Mohd Sami-Ur-Rasheed et al.   PROTEIN AND PEPTIDE LETTERS

Nanocurcumin: A Promising Candidate for Therapeutic Applications

(2020) Adhimoolam Karthikeyan et al.   Frontiers in Pharmacology

Modeling Parkinson’s Disease With the Alpha-Synuclein Protein

(2020) Mónica Gómez-Benito et al.   Frontiers in Pharmacology

Intravenously Administered, Retinoid Activating Nanoparticles Increase Lifespan and Reduce Neurodegeneration in the SOD1G93A Mouse Model of ALS

(2020) David X. Medina et al.   Frontiers in Bioengineering and Biotechnology

Post-Treatment of Synthetic Polyphenolic 1,3,4 Oxadiazole Compound A3, Attenuated Ischemic Stroke-Induced Neuroinflammation and Neurodegeneration

(2020) Arooj Mohsin Alvi et al.   Biomolecules

Mitochondria focused neurotherapeutics for spinal cord injury

(2020) Alexander G. Rabchevsky et al.   EXPERIMENTAL NEUROLOGY

Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis

(2020) Chia-Yu Chang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cationic biopolymer functionalized nanoparticles encapsulating lutein to attenuate oxidative stress in effective treatment of Alzheimer’s disease: A non-invasive approach

(2020) Namdev Dhas et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The Antioxidant, Anti-Inflammatory, and Neuroprotective Properties of the Synthetic Chalcone Derivative AN07

(2020) Yih-Fung Chen et al.   MOLECULES

Reperfusion combined with intraarterial administration of resveratrol-loaded nanoparticles improved cerebral ischemia–reperfusion injury in rats

(2020) Xiaowei Lu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Protocatechuic Acid Extends Survival, Improves Motor Function, Diminishes Gliosis, and Sustains Neuromuscular Junctions in the hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

(2020) Lilia A. Koza et al.   Nutrients

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

(2020) Mehdi Sharifi-Rad et al.   Frontiers in Physiology

Mild mitochondrial uncoupling protects from ionizing radiation induced cell death by attenuating oxidative stress and mitochondrial damage

(2020) Yogesh Rai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Resveratrol and Puerarin loaded polymeric nanoparticles to enhance the chemotherapeutic efficacy in spinal cord injury

(2020) Wei Chen et al.   BIOMEDICAL MICRODEVICES

Neuroprotective Effect of Antioxidants in the Brain

(2020) Kyung Hee Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms

(2020) Anam Anjum et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective effect of quercetin nanoparticles: A possible prophylactic and therapeutic role in alzheimer’s disease

(2020) Rehab Ahmed Rifaai et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

(2020) Andy W. C. Man et al.   Oxidative Medicine and Cellular Longevity

ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes

(2020) Yu Sun et al.   Redox Biology

Oxidative Stress, Neuroinflammation and Mitochondria in the Pathophysiology of Amyotrophic Lateral Sclerosis

(2020) Elena Obrador et al.   Antioxidants

Effects of Resistance Training and Bowdichia virgilioides Hydroethanolic Extract on Oxidative Stress Markers in Rats Submitted to Peripheral Nerve Injury

(2020) Luana Santos Costa et al.   Antioxidants

Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status

(2020) Aurelia Magdalena Pisoschi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Modified magnetic core-shell mesoporous silica nano-formulations with encapsulated quercetin exhibit anti-amyloid and antioxidant activity

(2020) Eleftherios Halevas et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Influence of Nanoparticle-Loaded Edaravone on Postoperative Effects in Patients with Cerebral Hemorrhage

(2020) Lianfeng Dang et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral sclerosis

(2020) Miku Kazama et al.   NEUROPATHOLOGY

Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention

(2020) Teresa Cunha-Oliveira et al.   Oxidative Medicine and Cellular Longevity

Pretreatment of Ascorbic Acid Inhibits MPTP-Induced Astrocytic Oxidative Stress through Suppressing NF-κB Signaling

(2020) Xiaokang Zeng et al.   NEURAL PLASTICITY

Novel Therapeutic Delivery of Nanocurcumin in Central Nervous System Related Disorders

(2020) Elisa Panzarini et al.   Nanomaterials

Protective Effects of Alpha-Lipoic Acid on Glutamate-Induced Cytotoxicity in C6 Glioma Cells

(2019) Euteum Park et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Dietary Vitamin E as a Protective Factor for Parkinson's Disease: Clinical and Experimental Evidence

(2019) Tommaso Schirinzi et al.   Frontiers in Neurology

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

(2019) Andrea Rodrigues Vasconcelos et al.   Frontiers in Pharmacology

Impaired Redox Signaling in Huntington’s Disease: Therapeutic Implications

(2019) Bindu D. Paul et al.   Frontiers in Molecular Neuroscience

Effects of Resveratrol on the Mechanisms of Antioxidants and Estrogen in Alzheimer’s Disease

(2019) Danli Kong et al.   Biomed Research International

Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer’s disease

(2019) Sunil S Adav et al.   Molecular Brain

Astaxanthin Ameliorates Lipopolysaccharide-Induced Neuroinflammation, Oxidative Stress and Memory Dysfunction through Inactivation of the Signal Transducer and Activator of Transcription 3 Pathway

(2019) Ji Han et al.   Marine Drugs

Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro

(2019) Young J. Yauger et al.   Journal of Neuroinflammation

Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology

(2019) Geir Bjørklund et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Evaluating accessibility of intravenously administered nanoparticles at the lesion site in rat and pig contusion models of spinal cord injury

(2019) Yue Gao et al.   JOURNAL OF CONTROLLED RELEASE

Edaravone for the treatment of amyotrophic lateral sclerosis

(2019) Hiide Yoshino   Expert Review of Neurotherapeutics

Encapsulation of tissue plasminogen activator in pH-sensitive self-assembled antioxidant nanoparticles for ischemic stroke treatment – Synergistic effect of thrombolysis and antioxidant –

(2019) Ting Mei et al.   BIOMATERIALS

Investigation of protective effects of coenzyme Q10 on impaired synaptic plasticity in a male rat model of Alzheimer’s disease

(2019) Hamidreza Komaki et al.   BRAIN RESEARCH BULLETIN

Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases

(2019) Fabrice Collin   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model

(2019) Amanda Cano et al.   JOURNAL OF CONTROLLED RELEASE

Lycopene protects against t-BHP-induced neuronal oxidative damage and apoptosis via activation of the PI3K/Akt pathway

(2019) Cuiqin Huang et al.   MOLECULAR BIOLOGY REPORTS

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

(2019) Anju Singh et al.   MOLECULES

Vitamin E Loaded Naringenin Nanoemulsion via Intranasal Delivery for the Management of Oxidative Stress in a 6-OHDA Parkinson’s Disease Model

(2019) Bharti Gaba et al.   Biomed Research International

Structural Properties and Interaction Partners of Familial ALS-Associated SOD1 Mutants

(2019) Jisen Huai et al.   Frontiers in Neurology

Safety and efficacy of Edaravone Dexborneol versus edaravone for patients with acute ischaemic stroke: a phase II, multicentre, randomised, double-blind, multiple-dose, active-controlled clinical trial

(2019) Jie Xu et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Prophylactic neuroprotective propensity of Crocin, a carotenoid against rotenone induced neurotoxicity in mice: behavioural and biochemical evidence

(2019) Sriranjini Venkata Rao et al.   METABOLIC BRAIN DISEASE

Aberrations in Oxidative Stress Markers in Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis

(2019) Zihao Wang et al.   Oxidative Medicine and Cellular Longevity

Synthesis and Neuroprotective Properties of N-Substituted C-Dialkoxyphosphorylated Nitrones

(2019) Dorota G. Piotrowska et al.   ACS Omega

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

(2019) Benjamin G. Trist et al.   AGING CELL

Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology

(2019) David K. Simon et al.   CLINICS IN GERIATRIC MEDICINE

The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice

(2019) Melissa L. Young et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Alpha-lipoic acid alleviated 6-OHDA-induced cell damage by inhibiting AMPK/mTOR mediated autophagy

(2019) Lina Zhou et al.   NEUROPHARMACOLOGY

Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats

(2019) Jiancheng Xi et al.   Experimental and Therapeutic Medicine

β-Carotene: A Natural Compound Improves Cognitive Impairment and Oxidative Stress in a Mouse Model of Streptozotocin-Induced Alzheimer’s Disease

(2019) Sundas Hira et al.   Biomolecules

Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases

(2019) William C. Ballance et al.   BIOMATERIALS

Quercetin prevents necroptosis of oligodendrocytes by inhibiting macrophages/microglia polarization to M1 phenotype after spinal cord injury in rats

(2019) Hong Fan et al.   Journal of Neuroinflammation

Antioxidants of Natural Plant Origins: From Sources to Food Industry Applications

(2019) Sofia C. Lourenço et al.   MOLECULES

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases

(2019) Ankita Nandi et al.   Oxidative Medicine and Cellular Longevity

Dietary Supplementation of the Antioxidant Curcumin Halts Systemic LPS-Induced Neuroinflammation-Associated Neurodegeneration and Memory/Synaptic Impairment via the JNK/NF-κB/Akt Signaling Pathway in Adult Rats

(2019) Muhammad Sohail Khan et al.   Oxidative Medicine and Cellular Longevity

Proteomic changes driven by urban pollution suggest particulate matter as a deregulator of energy metabolism, mitochondrial activity, and oxidative pathways in the rat brain

(2019) J.E. Araújo et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Oxidative stress-responsive apoptosis inducing protein (ORAIP) plays a critical role in cerebral ischemia/reperfusion injury

(2019) Masao Kishimoto et al.   Scientific Reports

Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia

(2019) Kushairi et al.   Antioxidants

Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease

(2019) Antonella Amato et al.   Antioxidants

Nanoparticles with antioxidant enzymes protect injured spinal cord from neuronal cell apoptosis by attenuating mitochondrial dysfunction

(2019) Syed Suhail Andrabi et al.   JOURNAL OF CONTROLLED RELEASE

Curcumin-Loaded Nanocapsules Reverses the Depressant-Like Behavior and Oxidative Stress Induced by β-Amyloid in Mice

(2019) Eduarda Monteiro Fidelis et al.   NEUROSCIENCE

FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Protects against Oxidative Stress-Mediated Neuronal Cell Apoptosis and Scopolamine-Induced Cognitive Impairment by Activating Nrf2/HO-1 Signaling

(2019) Ting Wan et al.   Oxidative Medicine and Cellular Longevity

Simultaneous Blood–Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles

(2018) Qunqun Bao et al.   ACS Nano

Alzheimer’s disease paper 1: clinical update on epidemiology, pathophysiology and diagnosis

(2018) Dhamidhu Eratne et al.   Australasian Psychiatry

Neuroprotective effects of coenzyme Q10 on paraquat-induced Parkinson’s disease in experimental animals

(2018) Hanan Naeim Attia et al.   BEHAVIOURAL PHARMACOLOGY

Resveratrol prolongs lifespan and improves 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative damage and behavioural deficits in Drosophila melanogaster

(2018) Amos O. Abolaji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

α-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis

(2018) Tianhang Wang et al.   BRAIN RESEARCH BULLETIN

Resveratrol Treatment in Different Time-Attenuated Neuronal Apoptosis After Oxygen and Glucose Deprivation/Reoxygenation via Enhancing the Activation of Nrf-2 Signaling Pathway In Vitro

(2018) Jun Yang et al.   CELL TRANSPLANTATION

Upregulation of NOX2 and NOX4 Mediated by TGF-β Signaling Pathway Exacerbates Cerebral Ischemia/Reperfusion Oxidative Stress Injury

(2018) Zheng Lou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Oxidative stress: Major threat in traumatic brain injury

(2018) Nidhi Khatri et al.   CNS & Neurological Disorders-Drug Targets

Natural Polyphenols in the Treatment of Alzheimer’s Disease

(2018) Syed-Badrul Syarifah-Noratiqah et al.   CURRENT DRUG TARGETS

CNB-001, a synthetic pyrazole derivative of curcumin, suppresses lipopolysaccharide-induced nitric oxide production through the inhibition of NF-κB and p38 MAPK pathways in microglia

(2018) Tatsuhiro Akaishi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oxidative stress in epilepsy

(2018) Ursula Geronzi et al.   Expert Review of Neurotherapeutics

Protective role of β-carotene against oxidative stress and neuroinflammation in a rat model of spinal cord injury

(2018) Lihui Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

SOD1 in Amyotrophic Lateral Sclerosis: “Ambivalent” Behavior Connected to the Disease

(2018) Orietta Pansarasa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects

(2018) Hang Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Astaxanthin and Docosahexaenoic-Acid-Acylated Astaxanthin on Alzheimer’s Disease in APP/PS1 Double-Transgenic Mice

(2018) Hongxia Che et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of Al(III)-Induced Aβ42 Fibrillation and Reduction of Neurotoxicity by Epigallocatechin-3-Gallate Nanoparticles

(2018) Neha Atulkumar Singh et al.   Journal of Biomedical Nanotechnology

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

(2018) Ying Wang et al.   JOURNAL OF CELL BIOLOGY

Multilayer polyion complex nanoformulations of superoxide dismutase 1 for acute spinal cord injury

(2018) N.V. Nukolova et al.   JOURNAL OF CONTROLLED RELEASE

Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress

(2018) Jia Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Determining the Effect of Catechins on SOD1 Conformation and Aggregation by Ion Mobility Mass Spectrometry Combined with Optical Spectroscopy

(2018) Bing Zhao et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

4-((5-(Tert-butyl)-3-chloro-2-hydroxybenzyl) amino)-2-hydroxybenzoic acid protects against oxygen-glucose deprivation/reperfusion injury

(2018) Yuexinzi Jin et al.   LIFE SCIENCES

Sex-dependent co-occurrence of hypoxia and β-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 × Tg-AD mouse model of Alzheimer's disease

(2018) Javier Frontiñán-Rubio et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Resveratrol improves neurological outcome and neuroinflammation following spinal cord injury through enhancing autophagy involving the AMPK/mTOR pathway

(2018) Hong‑Yu Meng et al.   Molecular Medicine Reports

Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3β Signaling in LPS-Treated Adult Mice

(2018) Muhammad Sohail Khan et al.   MOLECULAR NEUROBIOLOGY

Improved neuroprotective effect of resveratrol nanoparticles as evinced by abrogation of rotenone-induced behavioral deficits and oxidative and mitochondrial dysfunctions in rat model of Parkinson’s disease

(2018) Suresh Palle et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Activation of the Nrf2 signaling pathway and neuroprotection of nigral dopaminergic neurons by a novel synthetic compound KMS99220

(2018) Ji Ae Lee et al.   NEUROCHEMISTRY INTERNATIONAL

Fisetin Exerts Antioxidant and Neuroprotective Effects in Multiple Mutant hSOD1 Models of Amyotrophic Lateral Sclerosis by Activating ERK

(2018) T.H. Wang et al.   NEUROSCIENCE

Safety and Efficacy of Nanocurcumin as Add-On Therapy to Riluzole in Patients With Amyotrophic Lateral Sclerosis: A Pilot Randomized Clinical Trial

(2018) Mona Ahmadi et al.   Neurotherapeutics

KM-34, a Novel Antioxidant Compound, Protects against 6-Hydroxydopamine-Induced Mitochondrial Damage and Neurotoxicity

(2018) Luis Arturo Fonseca-Fonseca et al.   NEUROTOXICITY RESEARCH

Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson’s disease: Relevance to gene and environment interactions in metal neurotoxicity

(2018) Monica R. Langley et al.   NEUROTOXICOLOGY

Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy

(2018) Ming-Shuo Sun et al.   Oxidative Medicine and Cellular Longevity

Redox Regulation of Homeostasis and Proteostasis in Peroxisomes

(2018) Cheryl L. Walker et al.   PHYSIOLOGICAL REVIEWS

Oxidative Stress Biomarkers of Brain Damage

(2018) Svetlana Lorenzano et al.   STROKE

Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer’s disease

(2018) Hui Wang et al.   TOXICOLOGY LETTERS

Inflammatory and oxidative mechanisms potentiate bifenthrin-induced neurological alterations and anxiety-like behavior in adult rats

(2018) Brahim Gargouri et al.   TOXICOLOGY LETTERS

Current Strategies for Brain Drug Delivery

(2018) Xiaowei Dong   Theranostics

Oxidative stress in epilepsy

(2018) Ursula Geronzi et al.   Expert Review of Neurotherapeutics

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Simvastatin Inhibits Activation of NADPH Oxidase/p38 MAPK Pathway and Enhances Expression of Antioxidant Protein in Parkinson Disease Models

(2018) Huichun Tong et al.   Frontiers in Molecular Neuroscience

13 reasons why the brain is susceptible to oxidative stress

(2018) James Nathan Cobley et al.   Redox Biology

Amyotrophic Lateral Sclerosis and Oxidative Stress: a Double-Blind Therapeutic Trial After Curcumin Supplementation

(2018) Lucia Chico et al.   CNS & Neurological Disorders-Drug Targets

Novel synthetic chalcone-coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection

(2018) Shin-Ying Lee et al.   CNS Neuroscience & Therapeutics

Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer’s disease

(2018) Shengnuo Fan et al.   DRUG DELIVERY

Dietary Antioxidants and Dementia in a Population-Based Case-Control Study among Older People in South Germany

(2018) Christine A.F. von Arnim et al.   JOURNAL OF ALZHEIMERS DISEASE

A Randomized Placebo-Controlled Pilot Trial of Omega-3 Fatty Acids and Alpha Lipoic Acid in Alzheimer's Disease

(2018) Lynne Shinto et al.   JOURNAL OF ALZHEIMERS DISEASE

IMM-H004, a Novel Coumarin Derivative Compound, Inhibits H2O2-Induced Neurotoxicity via Antioxidant and Antiapoptosis in PC12 Cells

(2018) Xiu-Yun Song et al.   Journal of Stroke & Cerebrovascular Diseases

Copper Increases Brain Oxidative Stress and Enhances the Ability of 6-Hydroxydopamine to Cause Dopaminergic Degeneration in a Rat Model of Parkinson’s Disease

(2018) Antón Cruces-Sande et al.   MOLECULAR NEUROBIOLOGY

Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease

(2018) Esha Gauba et al.   NEUROBIOLOGY OF DISEASE

Nanoparticles in Medicine: A Focus on Vascular Oxidative Stress

(2018) M. D. Mauricio et al.   Oxidative Medicine and Cellular Longevity

Solar UV damage to cellular DNA: from mechanisms to biological effects

(2018) Leon H. F. Mullenders   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

A novel synthesis of selenium nanoparticles encapsulated PLGA nanospheres with curcumin molecules for the inhibition of amyloid β aggregation in Alzheimer's disease

(2018) Xinlong Huo et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Resveratrol treatment of spinal cord injury in rat model

(2018) Xuehong Liu et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

(2018) Giuseppe Tardiolo et al.   MOLECULES

Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies

(2018) Hasnaa A. Elfawy et al.   LIFE SCIENCES

Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and neurobehavioral disorders in adult rat cerebral cortex#

(2017) Nibedita Naha et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Protective effect of astaxanthin on acute cerebral infarction in rats

(2017) Yu Nai et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer’s disease

(2017) Lina Clara Gayoso e Ibiapina Moreno et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A Combination of Resveratrol and Curcumin is Effective Against Aluminum Chloride-Induced Neuroinflammation in Rats

(2017) Amira Zaky et al.   JOURNAL OF ALZHEIMERS DISEASE

Dietary Lycopene Supplementation Improves Cognitive Performances in Tau Transgenic Mice Expressing P301L Mutation via Inhibiting Oxidative Stress and Tau Hyperphosphorylation

(2017) Lixia Yu et al.   JOURNAL OF ALZHEIMERS DISEASE

Quercetin reduces neural tissue damage and promotes astrocyte activation after spinal cord injury in rats

(2017) Yeyang Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Synergistic effects of negatively charged hydrophobic nanoparticles and (−)-epigallocatechin-3-gallate on inhibiting amyloid β-protein aggregation

(2017) Hongchen Liu et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Probing the inhibitory activity of epigallocatechin-gallate on toxic aggregates of mutant (L84F) SOD1 protein through geometry based sampling and steered molecular dynamics

(2017) E. Srinivasan et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

(2017) Charbel Moussa et al.   Journal of Neuroinflammation

Time-dependent change of in vivo optical imaging of oxidative stress in a mouse stroke model

(2017) Yumiko Nakano et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

(2017) Koji Abe et al.   LANCET NEUROLOGY

Peroxynitrite Activates the NLRP3 Inflammasome Cascade in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis

(2017) Ilaria Bellezza et al.   MOLECULAR NEUROBIOLOGY

Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

(2017) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

Lycopene inhibits regulator of calcineurin 1-mediated apoptosis by reducing oxidative stress and down-regulating Nucling in neuronal cells

(2017) Seiyoung Lim et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s Disease

(2017) Joana Loureiro et al.   MOLECULES

Neuroprotective potential of quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

(2017) Puneet Kumar et al.   Neural Regeneration Research

Vitamin A and retinoic acid combination attenuates neonatal hyperoxia-induced neurobehavioral impairment in adult mice

(2017) Manimaran Ramani et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The effects of omega-3 fatty acids and vitamin E co-supplementation on clinical and metabolic status in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled trial

(2017) Mohsen Taghizadeh et al.   NEUROCHEMISTRY INTERNATIONAL

A green tea polyphenol epigallocatechin-3-gallate enhances neuroregeneration after spinal cord injury by altering levels of inflammatory cytokines

(2017) Lucia Machova Urdzikova et al.   NEUROPHARMACOLOGY

Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1/AMPK signaling pathway

(2017) Haosen Zhao et al.   NEUROSCIENCE

Neuroprotective effects of lycopene in spinal cord injury in rats via antioxidative and anti-apoptotic pathway

(2017) Wei Hu et al.   NEUROSCIENCE LETTERS

Traumatic Spinal Cord Injury—Repair and Regeneration

(2017) Christopher S. Ahuja et al.   NEUROSURGERY

An anthocyanin-enriched extract from strawberries delays disease onset and extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

(2017) Aimee N. Winter et al.   NUTRITIONAL NEUROSCIENCE

Quercitrin and quercetin 3-β-d-glucoside as chemical chaperones for the A4V SOD1 ALS-causing mutant

(2017) Philbert Ip et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Crocin protects against cerebral- ischemia-induced damage in aged rats through maintaining the integrity of blood-brain barrier

(2017) Xuan Zhang et al.   RESTORATIVE NEUROLOGY AND NEUROSCIENCE

Trauma

(2017) Matthew J. Eckert et al.   SURGICAL CLINICS OF NORTH AMERICA

Effects of resveratrol on inflammation and apoptosis after experimental spinal cord injury

(2017) Salim Senturk et al.   Turkish Neurosurgery

A synthetic cell permeable antioxidant protects neurons against acute oxidative stress

(2017) Nicola J. Drummond et al.   Scientific Reports

The effects of Brazilian green propolis that contains flavonols against mutant copper-zinc superoxide dismutase-mediated toxicity

(2017) Tomoyuki Ueda et al.   Scientific Reports

Edaravone-Encapsulated Agonistic Micelles Rescue Ischemic Brain Tissue by Tuning Blood-Brain Barrier Permeability

(2017) Qu Jin et al.   Theranostics

Phase IIb Study of Intranasal Glutathione in Parkinson’s Disease

(2017) Laurie K. Mischley et al.   Journal of Parkinsons Disease

Oxidative stress and cellular pathologies in Parkinson’s disease

(2017) Lesly Puspita et al.   Molecular Brain

Post-hoc analysis of randomised, placebo-controlled, double-blind study (MCI186-19) of edaravone (MCI-186) in amyotrophic lateral sclerosis

(2017) Koji Takei et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Anthocyanins encapsulated by PLGA@PEG nanoparticles potentially improved its free radical scavenging capabilities via p38/JNK pathway against Aβ1–42-induced oxidative stress

(2017) Faiz Ul Amin et al.   JOURNAL OF NANOBIOTECHNOLOGY

Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles

(2017) Liyu Chen et al.   Frontiers in Neuroscience

Ginkgo biloba extract improved cognitive and neurological functions of acute ischaemic stroke: a randomised controlled trial

(2017) Shanshan Li et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical–induced DNA damage

(2017) Shih-Chieh Chiang et al.   Science Advances

Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration

(2017) David A. Patten et al.   JOURNAL OF ALZHEIMERS DISEASE

Delivery of Dual Drug Loaded Lipid Based Nanoparticles across the Blood–Brain Barrier Impart Enhanced Neuroprotection in a Rotenone Induced Mouse Model of Parkinson’s Disease

(2016) Paromita Kundu et al.   ACS Chemical Neuroscience

Tissue plasminogen activator followed by antioxidant-loaded nanoparticle delivery promotes activation/mobilization of progenitor cells in infarcted rat brain

(2016) Marianne Petro et al.   BIOMATERIALS

Effect of Oxidative Damage on the Stability and Dimerization of Superoxide Dismutase 1

(2016) Drazen Petrov et al.   BIOPHYSICAL JOURNAL

Panel of Oxidative Stress and Inflammatory Biomarkers in ALS: A Pilot Study

(2016) Hélène Blasco et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Epigallocatechin Gallate Extends Therapeutic Window of Recombinant Tissue Plasminogen Activator Treatment for Brain Ischemic Stroke

(2016) Xue-Hui Wang et al.   CLINICAL NEUROPHARMACOLOGY

Design of PLGA-functionalized quercetin nanoparticles for potential use in Alzheimer’s disease

(2016) Dongdong Sun et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Neurobehavioral deficits and brain oxidative stress induced by chronic low dose exposure of persistent organic pollutants mixture in adult female rat

(2016) Asma Lahouel et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Oxidative stress in multiple sclerosis: Central and peripheral mode of action

(2016) Kim Ohl et al.   EXPERIMENTAL NEUROLOGY

Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers

(2016) Ralf G Rempe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alpha-Tocopherol Reduces Brain Edema and Protects Blood-Brain Barrier Integrity following Focal Cerebral Ischemia in Rats

(2016) Adel Haghnejad Azar et al.   MEDICAL PRINCIPLES AND PRACTICE

Detection and characterisation of radicals using electron paramagnetic resonance (EPR) spin trapping and related methods

(2016) Michael J. Davies   METHODS

Anthocyanins protect against LPS-induced oxidative stress-mediated neuroinflammation and neurodegeneration in the adult mouse cortex

(2016) Muhammad Sohail Khan et al.   NEUROCHEMISTRY INTERNATIONAL

The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases

(2016) Hor-Yue Tan et al.   Oxidative Medicine and Cellular Longevity

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond

(2016) L. Calderón-Garcidueñas et al.   REVUE NEUROLOGIQUE

Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease

(2016) Simon J. Beck et al.   Nature Communications

The Effect of Chronic Ozone Exposure on the Activation of Endoplasmic Reticulum Stress and Apoptosis in Rat Hippocampus

(2016) Erika Rodríguez-Martínez et al.   Frontiers in Aging Neuroscience

Antioxidant Supplementation in the Treatment of Aging-Associated Diseases

(2016) Valeria Conti et al.   Frontiers in Pharmacology

Resveratrol improves delayed r-tPA treatment outcome by reducing MMPs

(2015) J. Chen et al.   ACTA NEUROLOGICA SCANDINAVICA

Curcumin binds to the pre-fibrillar aggregates of Cu/Zn superoxide dismutase (SOD1) and alters its amyloidogenic pathway resulting in reduced cytotoxicity

(2015) Nidhi K. Bhatia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases

(2015) Xifei Yang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Targeting inflammation to influence mood following spinal cord injury: a randomized clinical trial

(2015) David J. Allison et al.   Journal of Neuroinflammation

A randomized, double-blind phase I/IIa study of intranasal glutathione in Parkinson's disease

(2015) Laurie K. Mischley et al.   MOVEMENT DISORDERS

Potential of the use of an antioxidant compound to promote peripheral nerve regeneration after injury

(2015) SergioA Gerhke et al.   Neural Regeneration Research

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state

(2015) Ergul Belge Kurutas   Nutrition Journal

The Role of Oxidative Damage in the Pathogenesis and Progression of Alzheimer’s Disease and Vascular Dementia

(2015) Maria Luca et al.   Oxidative Medicine and Cellular Longevity

A review on mitochondrial restorative mechanism of antioxidants in Alzheimer’s disease and other neurological conditions

(2015) Anil Kumar et al.   Frontiers in Pharmacology

Does High-Dose Coenzyme Q10 Improve Oxidative Damage and Clinical Outcomes in Parkinson's Disease?

(2014) Raymond Chee-Seong Seet et al.   ANTIOXIDANTS & REDOX SIGNALING

The Role of Reactive Oxygen Species in Microvascular Remodeling

(2014) Marius Staiculescu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease

(2014) Maurice W. Dysken et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

(2014) Katherine HM Cox et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Exposure to As-, Cd-, and Pb-Mixture Induces Aβ, Amyloidogenic APP Processing and Cognitive Impairments via Oxidative Stress-Dependent Neuroinflammation in Young Rats

(2014) Anushruti Ashok et al.   TOXICOLOGICAL SCIENCES

Oxidative Stress, Prooxidants, and Antioxidants: The Interplay

(2014) Anu Rahal et al.   Biomed Research International

A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease

(2014) et al.   JAMA Neurology

Glutathione: new roles in redox signaling for an old antioxidant

(2014) Katia Aquilano et al.   Frontiers in Pharmacology

Effect of Plasma Uric Acid on Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects

(2013) E. Fabbrini et al.   DIABETES

Nitrone-based therapeutics for neurodegenerative diseases: Their use alone or in combination with lanthionines

(2013) Robert A. Floyd et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nerve Physiology

(2013) Ron M.G. Menorca et al.   HAND CLINICS

Application and stability of natural antioxidants in edible oils in order to substitute synthetic additives

(2013) Mostafa Taghvaei et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

ROS and Brain Diseases: The Good, the Bad, and the Ugly

(2013) Aurel Popa-Wagner et al.   Oxidative Medicine and Cellular Longevity

The Effect of SOD1 Mutation on Cellular Bioenergetic Profile and Viability in Response to Oxidative Stress and Influence of Mutation-Type

(2013) Katie Richardson et al.   PLoS One

An Updated Definition of Stroke for the 21st Century

(2013) Ralph L. Sacco et al.   STROKE

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

(2013) Ryan J. Mailloux et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nanoparticle-mediated catalase delivery protects human neurons from oxidative stress

(2013) A Singhal et al.   Cell Death & Disease

Optical imaging to map blood-brain barrier leakage

(2013) Hayder Jaffer et al.   Scientific Reports

Antioxidants for Alzheimer Disease

(2012) Douglas R. Galasko et al.   ARCHIVES OF NEUROLOGY

Oxidative stress in children with attention deficit hyperactivity disorder

(2012) Didem Oztop et al.   CLINICAL BIOCHEMISTRY

Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics

(2012) Frederick A Villamena et al.   Future Medicinal Chemistry

Well-defined cross-linked antioxidant nanozymes for treatment of ischemic brain injury

(2012) Devika S. Manickam et al.   JOURNAL OF CONTROLLED RELEASE

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Dendrimer-Based Postnatal Therapy for Neuroinflammation and Cerebral Palsy in a Rabbit Model

(2012) S. Kannan et al.   Science Translational Medicine

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

(2012) John M Ringman et al.   Alzheimers Research & Therapy

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Effects of Edaravone, a Free Radical Scavenger, on Serum Levels of Inflammatory Biomarkers in Acute Brain Infarction

(2011) Kenji Isahaya et al.   Journal of Stroke & Cerebrovascular Diseases

Alteration in mitochondrial thiol enhances calcium ion dependent membrane permeability transition and dysfunction in vitro: a cross-talk between mtThiol, Ca2+, and ROS

(2011) Brijesh Kumar Singh et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Nanocarriers for vascular delivery of antioxidants

(2011) Elizabeth Hood et al.   Nanomedicine

Cross-linked antioxidant nanozymes for improved delivery to CNS

(2011) Natalia L. Klyachko et al.   Nanomedicine-Nanotechnology Biology and Medicine

Strategies for Reducing or Preventing the Generation of Oxidative Stress

(2011) B. Poljsak   Oxidative Medicine and Cellular Longevity

Reactive Oxygen Species Production by Forward and Reverse Electron Fluxes in the Mitochondrial Respiratory Chain

(2011) Vitaly A. Selivanov et al.   PLoS Computational Biology

Physiologically Based Pharmacokinetic Modeling of Nanoparticles

(2010) Mingguang Li et al.   ACS Nano

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

(2010) Edith Lubos et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuropathic Pain in Children: Special Considerations

(2010) Gary A. Walco et al.   MAYO CLINIC PROCEEDINGS

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

(2010) Kanti Bhooshan Pandey et al.   Oxidative Medicine and Cellular Longevity

Exogenous Antioxidants—Double-Edged Swords in Cellular Redox State: Health Beneficial Effects at Physiologic Doses versus Deleterious Effects at High Doses

(2010) Jaouad Bouayed et al.   Oxidative Medicine and Cellular Longevity

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Amyloid precursor protein transgenic mouse models and Alzheimer's disease: Understanding the paradigms, limitations, and contributions

(2009) Tyler A. Kokjohn et al.   Alzheimers & Dementia

Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III

(2009) Petra Kaufmann et al.   ANNALS OF NEUROLOGY

Edaravone (Radical Scavenger) versus Sodium Ozagrel (Antiplatelet Agent) in Acute Noncardioembolic Ischemic Stroke (EDO Trial)

(2009) Yukito Shinohara et al.   CEREBROVASCULAR DISEASES

Nanoparticle-mediated delivery of superoxide dismutase to the brain: an effective strategy to reduce ischemia-reperfusion injury

(2009) Maram K. Reddy et al.   FASEB JOURNAL

Ginkgo biloba for Preventing Cognitive Decline in Older AdultsA Randomized Trial

(2009) Beth E. Snitz   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

(2009) Larry Baum et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Superoxide Dismutase-Loaded PLGA Nanoparticles Protect Cultured Human Neurons Under Oxidative Stress

(2008) Maram K. Reddy et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

The Novel Antioxidant Edaravone: From Bench to Bedside

(2008) Toshiaki Watanabe et al.   Cardiovascular Therapeutics

Lipid peroxidation up-regulates BACE1 expressionin vivo: a possible early event of amyloidogenesis in Alzheimer’s disease

(2008) Liuji Chen et al.   JOURNAL OF NEUROCHEMISTRY

Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease

(2008) Tanea Reed et al.   NEUROBIOLOGY OF DISEASE

Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons

(2008) W. S. Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA