Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral sclerosis

Glial Cells—The Strategic Targets in Amyotrophic Lateral Sclerosis Treatment

(2020) Tereza Filipi et al.   Journal of Clinical Medicine

DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

(2020) Byung Woo Kim et al.   Acta Neuropathologica Communications

Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases

(2020) Adam Armada-Moreira et al.   Frontiers in Cellular Neuroscience

Tat-HSP70 protects neurons from oxidative damage in the NSC34 cells and ischemic damage in the ventral horn of rabbit spinal cord

(2019) Woosuk Kim et al.   NEUROCHEMISTRY INTERNATIONAL

Biochemical basis and metabolic interplay of redox regulation

(2019) Lixiao Zhang et al.   Redox Biology

Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis

(2019) Motoko Niida‐Kawaguchi et al.   NEUROPATHOLOGY

Main path and byways: non-vesicular glutamate release by system xc−as an important modifier of glutamatergic neurotransmission

(2015) Ann Massie et al.   JOURNAL OF NEUROCHEMISTRY

Glutamate transporters in brain ischemia: to modulate or not?

(2014) Weronika Krzyżanowska et al.   ACTA PHARMACOLOGICA SINICA

System xC− is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice

(2014) Pinar Mesci et al.   BRAIN

Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage

(2014) Federico N. Soria et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of system xc− in the SOD1-G93A mouse model of ALS

(2013) Rebecca Albano et al.   EXPERIMENTAL NEUROLOGY

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Non-Cell Autonomous Influence of the Astrocyte System xc− on Hypoglycaemic Neuronal Cell Death

(2012) Nicole A Jackman et al.   ASN Neuro

Nitric Oxide-Mediated Oxidative Damage and the Progressive Demise of Motor Neurons in ALS

(2012) Derek A. Drechsel et al.   NEUROTOXICITY RESEARCH

Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS

(2011) Victòria Ayala et al.   ACTA NEUROPATHOLOGICA

MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11

(2011) Xiao-Xiao Liu et al.   FEBS LETTERS

Functional upregulation of system xc− by fibroblast growth factor-2

(2011) XiaoQian Liu et al.   NEUROPHARMACOLOGY

Erythropoietin-induced neuroprotection requires cystine glutamate exchanger activity

(2010) Brian Sims et al.   BRAIN RESEARCH

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

(2010) Moonhee Lee et al.   FASEB JOURNAL

Regulation of System xc−Activity and Expression in Astrocytes by Interleukin-1β

(2010) Nicole A. Jackman et al.   GLIA

β-N-methylamino-l-alanine induces oxidative stress and glutamate release through action on system Xc−

(2009) XiaoQian Liu et al.   EXPERIMENTAL NEUROLOGY

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxonein vitro

(2009) Jan Lewerenz et al.   JOURNAL OF NEUROCHEMISTRY

Amyotrophic lateral sclerosis

(2009) Lokesh C Wijesekera et al.   Orphanet Journal of Rare Diseases

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

(2008) C.J. Harvey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Basal Levels of eIF2α Phosphorylation Determine Cellular Antioxidant Status by Regulating ATF4 and xCT Expression

(2008) Jan Lewerenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY