Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

N-Acetylcysteine for the Treatment of Psychiatric Disorders: A Review of Current Evidence

(2018) Soo Liang Ooi et al.   Biomed Research International

Repeated-Dose Oral N-Acetylcysteine in Parkinson's Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress

(2017) Lisa D. Coles et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Neuropathic pain

(2017) Luana Colloca et al.   Nature Reviews Disease Primers

Inflammatory Aspects of Alzheimer Disease and Other Neurodegenerative Disorders

(2017) Claudia Schwab et al.   JOURNAL OF ALZHEIMERS DISEASE

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

The effect of ethyl pyruvate and N-acetylcysteine on ischemia-reperfusion injury in an experimental model of ischemic stroke

(2016) Suha Turkmen et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

N-acetylcysteine in the treatment of psychiatric disorders: current status and future prospects

(2016) Alessandro Minarini et al.   Expert Opinion on Drug Metabolism & Toxicology

The protection conferred against ischemia-reperfusion injury in the diabetic brain by N-acetylcysteine is associated with decreased dicarbonyl stress

(2016) Bin Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Maintenance of Cognitive Performance and Mood for Individuals with Alzheimer’s Disease Following Consumption of a Nutraceutical Formulation: A One-Year, Open-Label Study

(2016) Ruth Remington et al.   JOURNAL OF ALZHEIMERS DISEASE

What Future Role Might N-Acetyl-Cysteine Have in the Treatment of Obsessive Compulsive and Grooming Disorders?

(2016) Louise Smith et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Normobaric Hyperoxia Extends Neuro- and Vaso-Protection of N-Acetylcysteine in Transient Focal Ischemia

(2016) Yushan Liu et al.   MOLECULAR NEUROBIOLOGY

N-acetyl-cysteine attenuates neuropathic pain by suppressing matrix metalloproteinases

(2016) Jiajie Li et al.   PAIN

N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data

(2016) Daniel A. Monti et al.   PLoS One

Sulfasalazine attenuates ACL transection and medial menisectomy-induced cartilage destruction by inhibition of cystine/glutamate antiporter

(2015) Wei-Yuan Tsai et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Diabetes enhances oxidative stress-induced TRPM2 channel activity and its control by N-acetylcysteine in rat dorsal root ganglion and brain

(2015) Ercan Sözbir et al.   METABOLIC BRAIN DISEASE

Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review

(2015) Deepmala et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Effect of N-acetylcysteine on the spinal-cord glutathione system and nitric-oxide metabolites in rats with neuropathic pain

(2014) Andréa Horst et al.   NEUROSCIENCE LETTERS

N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities

(2014) Reza Bavarsad Shahripour et al.   Brain and Behavior

The chemistry and biological activities of N-acetylcysteine

(2013) Yuval Samuni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

N-acetylcysteine Boosts Brain and Blood Glutathione in Gaucher and Parkinson Diseases

(2013) Mary J. Holmay et al.   CLINICAL NEUROPHARMACOLOGY

Hypoxia-inducible factor 1 contributes to N-acetylcysteine’s protection in stroke

(2013) Ziyan Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels

(2013) N. Nishio et al.   NEUROSCIENCE

The promise of N-acetylcysteine in neuropsychiatry

(2013) Michael Berk et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

N-Acetyl-Cysteine Causes Analgesia by Reinforcing the Endogenous Activation of Type-2 Metabotropic Glutamate Receptors

(2012) Matteo Bernabucci et al.   Molecular Pain

Limb Remote Postconditioning Alleviates Cerebral Reperfusion Injury Through Reactive Oxygen Species-Mediated Inhibition of Delta Protein Kinase C in Rats

(2011) Qiang Wang et al.   ANESTHESIA AND ANALGESIA

System xc- cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

(2011) Richard J Bridges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nutritional Approaches to Modulate Oxidative Stress in Alzheimers Disease

(2011) C. B. Pocernich et al.   Current Alzheimer Research

Molecular basis of NMDA receptor functional diversity

(2011) Pierre Paoletti   EUROPEAN JOURNAL OF NEUROSCIENCE

From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment

(2011) Bita Moghaddam et al.   NEUROPSYCHOPHARMACOLOGY

Glutamatergic medications for the treatment of drug and behavioral addictions

(2011) M. Foster Olive et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Stroke intervention pathways: NMDA receptors and beyond

(2011) Ted Weita Lai et al.   TRENDS IN MOLECULAR MEDICINE

Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease☆

(2010) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: The final common pathway on the road to schizophrenia?

(2010) Joshua T. Kantrowitz et al.   BRAIN RESEARCH BULLETIN

Antioxidant approaches for the treatment of Alzheimer’s disease

(2010) Hyun Pil Lee et al.   Expert Review of Neurotherapeutics

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

(2010) Moonhee Lee et al.   FASEB JOURNAL

Potential in vivo amelioration by N-acetyl-L-cysteine of oxidative stress in brain in human double mutant APP/PS-1 knock-in mice: Toward therapeutic modulation of mild cognitive impairment

(2010) Quanzhen Huang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Recommendations for the Pharmacological Management of Neuropathic Pain: An Overview and Literature Update

(2010) Robert H. Dworkin et al.   MAYO CLINIC PROCEEDINGS

The functional neurophysiology of the amyloid precursor protein (APP) processing pathway

(2010) A.D. Randall et al.   NEUROPHARMACOLOGY

EFFECT OF ORAL N-ACETYLCYSTEINE TREATMENT ON PLASMA INFLAMMATORY AND OXIDATIVE STRESS MARKERS IN PERITONEAL DIALYSIS PATIENTS: A PLACEBO-CONTROLLED STUDY

(2010) M. M. Nascimento et al.   PERITONEAL DIALYSIS INTERNATIONAL

Oral N-Acetyl-Cysteine Attenuates Loss of Dopaminergic Terminals in α-Synuclein Overexpressing Mice

(2010) Joanne Clark et al.   PLoS One

Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain

(2010) Santina Chiechio et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF- B signaling

(2009) D. Sha et al.   HUMAN MOLECULAR GENETICS

Activated astroglia during chronic inflammation in Alzheimer's disease—Do they neglect their neurosupportive roles?

(2009) Stacey Fuller et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The glutamate homeostasis hypothesis of addiction

(2009) Peter W. Kalivas   NATURE REVIEWS NEUROSCIENCE

Metabotropic receptors for glutamate and GABA in pain

(2008) Cyril Goudet et al.   BRAIN RESEARCH REVIEWS

Acetylcholine esterase activity in mild cognitive impairment and Alzheimer’s disease

(2008) Karl Herholz   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine)-induced apoptosis in nigral neurons of mice

(2008) Eriko Aoki et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Quinone and oxyradical scavenging properties of N-acetylcysteine prevent dopamine mediated inhibition of Na+, K+-ATPase and mitochondrial electron transport chain activity in rat brain: Implications in the neuroprotective therapy of Parkinson's disease

(2008) Maria B. Bagh et al.   FREE RADICAL RESEARCH

N-acetylcysteine prevents β-amyloid toxicity by a stimulatory effect on p35/cyclin-dependent kinase 5 activity in cultured cortical neurons

(2008) Ya-Hsin Hsiao et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Different protection of K252a and N-acetyl-L-cysteine against amyloid-β peptide-induced cortical neuron apoptosis involving inhibition of MLK3-MKK7-JNK3 signal cascades

(2008) Yan Xu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Molecular mechanisms of L-DOPA-induced dyskinesia

(2008) Peter Jenner   NATURE REVIEWS NEUROSCIENCE

Lipopolysaccharide-induced peroxisomal dysfunction exacerbates cerebral white matter injury: Attenuation by N-acetyl cysteine

(2007) Manjeet K. Paintlia et al.   EXPERIMENTAL NEUROLOGY