Impaired Redox Signaling in Huntington’s Disease: Therapeutic Implications
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Title
Impaired Redox Signaling in Huntington’s Disease: Therapeutic Implications
Authors
Keywords
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Journal
Frontiers in Molecular Neuroscience
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-03-19
DOI
10.3389/fnmol.2019.00068
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Note: Only part of the references are listed.- Application of quercetin in neurological disorders: from nutrition to nanomedicine
- (2019) Elnaz Amanzadeh et al. REVIEWS IN THE NEUROSCIENCES
- Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities
- (2018) Rachel J Harding et al. ACTA PHARMACOLOGICA SINICA
- Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities
- (2018) Juan I. Sbodio et al. ANTIOXIDANTS & REDOX SIGNALING
- Gasotransmitter hydrogen sulfide signaling in neuronal health and disease
- (2018) Bindu D. Paul et al. BIOCHEMICAL PHARMACOLOGY
- Regulators of the Transsulfuration Pathway
- (2018) Juan I Sbodio et al. BRITISH JOURNAL OF PHARMACOLOGY
- The role of Nrf2 signaling in counteracting neurodegenerative diseases
- (2018) Albena T. Dinkova-Kostova et al. FEBS Journal
- Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications
- (2018) Aitor Almanza et al. FEBS Journal
- Brain mitochondrial iron accumulates in Huntington's disease, mediates mitochondrial dysfunction, and can be removed pharmacologically
- (2018) Sonal Agrawal et al. FREE RADICAL BIOLOGY AND MEDICINE
- Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse
- (2018) Rebecca Kusko et al. Molecular Neurodegeneration
- XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent
- (2018) Aris A. Polyzos et al. PLoS One
- Golgi stress response reprograms cysteine metabolism to confer cytoprotection in Huntington’s disease
- (2018) Juan I. Sbodio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cysteine Metabolism in Neuronal Redox Homeostasis
- (2018) Bindu D. Paul et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Drug Repositioning for Effective Prostate Cancer Treatment
- (2018) Beste Turanli et al. Frontiers in Physiology
- High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration
- (2018) Ismael Al-Ramahi et al. Cell Systems
- Nicotinamide reverses behavioral impairments and provides neuroprotection in 3˗nitropropionic acid induced animal model ofHuntington’s disease: implication of oxidative stress˗ poly(ADP˗ ribose) polymerase pathway
- (2018) Akram Sidhu et al. METABOLIC BRAIN DISEASE
- Autophagy and the cell biology of age-related disease
- (2018) Andrew M. Leidal et al. NATURE CELL BIOLOGY
- Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes
- (2018) Gholamreza Bidkhori et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Safety and efficacy of pridopidine in patients with Huntington's disease (PRIDE-HD): a phase 2, randomised, placebo-controlled, multicentre, dose-ranging study
- (2018) Ralf Reilmann et al. LANCET NEUROLOGY
- Huntington's disease: a clinical review
- (2017) P. McColgan et al. EUROPEAN JOURNAL OF NEUROLOGY
- Physiological/pathological ramifications of transcription factors in the unfolded protein response
- (2017) Jaeseok Han et al. GENES & DEVELOPMENT
- ER stress and the unfolded protein response in neurodegeneration
- (2017) Claudio Hetz et al. Nature Reviews Neurology
- The CREST-E study of creatine for Huntington disease
- (2017) Steven M. Hersch et al. NEUROLOGY
- Mutant Huntingtin Disrupts the Nuclear Pore Complex
- (2017) Jonathan C. Grima et al. NEURON
- Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons
- (2017) Matthew Redmann et al. Redox Biology
- The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code
- (2017) Milica Vučetić et al. Frontiers in Oncology
- The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington’s disease
- (2017) Francesca Farina et al. Scientific Reports
- Creatine for neuroprotection in neurodegenerative disease: end of story?
- (2016) Andreas Bender et al. AMINO ACIDS
- Mammalian Autophagy: How Does It Work?
- (2016) Carla F. Bento et al. Annual Review of Biochemistry
- N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington’s disease
- (2016) Dean J. Wright et al. HUMAN MOLECULAR GENETICS
- Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes
- (2016) Aris Polyzos et al. HUMAN MOLECULAR GENETICS
- Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex
- (2016) Tamara Maiuri et al. HUMAN MOLECULAR GENETICS
- RNA-Seq of Huntington’s disease patient myeloid cells reveals innate transcriptional dysregulation associated with proinflammatory pathway activation
- (2016) James R. C. Miller et al. HUMAN MOLECULAR GENETICS
- Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization
- (2016) Laura F. DiGiovanni et al. HUMAN MOLECULAR GENETICS
- Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease
- (2016) Xiangling Yin et al. HUMAN MOLECULAR GENETICS
- Sulforaphane prevents quinolinic acid-induced mitochondrial dysfunction in rat striatum
- (2016) Erika Rubí Luis-García et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Effect of rutin against a mitochondrial toxin, 3-nitropropionicacid induced biochemical, behavioral and histological alterations-a pilot study on Huntington’s disease model in rats
- (2016) Sarumani Natarajan Suganya et al. METABOLIC BRAIN DISEASE
- Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington’s Disease Models
- (2016) Luana Naia et al. MOLECULAR NEUROBIOLOGY
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- (2016) Andrew McGarry et al. NEUROLOGY
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- (2016) Juan I. Sbodio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Curcumin modulates cell death and is protective in Huntington’s disease model
- (2016) Anjalika Chongtham et al. Scientific Reports
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- (2015) Bindu D. Paul et al. ANTIOXIDANTS & REDOX SIGNALING
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- (2015) Monica Bañez-Coronel et al. NEURON
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- (2015) Bindu D. Paul et al. TRENDS IN BIOCHEMICAL SCIENCES
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- (2015) D J Wright et al. Translational Psychiatry
- Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington's disease
- (2015) Kiersten L. Berggren et al. Redox Biology
- Huntington disease
- (2015) Gillian P. Bates et al. Nature Reviews Disease Primers
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- (2015) Geon Ha Kim et al. Experimental Neurobiology
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- (2014) Yanying Liu et al. JOURNAL OF NEUROCHEMISTRY
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- Huntington disease: natural history, biomarkers and prospects for therapeutics
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- (2014) Natalie M. Frederick et al. NEUROCHEMISTRY INTERNATIONAL
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- (2014) Maria Angeles Fernandez-Estevez et al. PLoS One
- HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response
- (2014) B. Rotblat et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease
- (2014) X.-H. Lu et al. Science Translational Medicine
- Multisource ascertainment of Huntington disease in Canada: Prevalence and population at risk
- (2013) Emily R. Fisher et al. MOVEMENT DISORDERS
- Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
- (2013) Andrey S Tsvetkov et al. Nature Chemical Biology
- Glutathione peroxidase activity is neuroprotective in models of Huntington's disease
- (2013) Robert P Mason et al. NATURE GENETICS
- The ATM protein kinase: regulating the cellular response to genotoxic stress and more
- (2013) Yosef Shiloh et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Impaired Mitochondrial Dynamics and Nrf2 Signaling Contribute to Compromised Responses to Oxidative Stress in Striatal Cells Expressing Full-Length Mutant Huntingtin
- (2013) Youngnam N. Jin et al. PLoS One
- Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine
- (2013) Jianfang Chen et al. PLoS One
- Oxidizing Effects of Exogenous Stressors in Huntington’s Disease Knock-in Striatal Cells—Protective Effect of Cystamine and Creatine
- (2013) Márcio Ribeiro et al. TOXICOLOGICAL SCIENCES
- Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway
- (2013) A Hyrskyluoto et al. Cell Death & Disease
- A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington’s disease in mice
- (2013) Aníbal I. Acuña et al. Nature Communications
- Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease
- (2013) Samantha Giordano et al. Redox Biology
- Quercetin supplementation is effective in improving mitochondrial dysfunctions induced by 3-nitropropionic acid: Implications in Huntington's disease
- (2012) Rajat Sandhir et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cells
- (2012) Márcio Ribeiro et al. FREE RADICAL BIOLOGY AND MEDICINE
- Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington Disease
- (2012) Jiu-Qiang Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its Antiapoptotic Actions
- (2012) Nilkantha Sen et al. MOLECULAR CELL
- Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease
- (2012) Miriam A Hickey et al. Molecular Neurodegeneration
- H2S signalling through protein sulfhydration and beyond
- (2012) Bindu D. Paul et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- N-Acetylcysteine Reverses Mitochondrial Dysfunctions and Behavioral Abnormalities in 3-Nitropropionic Acid-Induced Huntington’s Disease
- (2012) Rajat Sandhir et al. Neurodegenerative Diseases
- Organoselenium Bis Selenide Attenuates 3-Nitropropionic Acid-Induced Neurotoxicity in Rats
- (2012) Cristiani F. Bortolatto et al. NEUROTOXICITY RESEARCH
- Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington’s Disease
- (2012) Zhiyin Xun et al. Cell Reports
- Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease
- (2011) P. Hemachandra Reddy et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth
- (2011) Takatsugu Ishimoto et al. CANCER CELL
- Protein aggregates in Huntington's disease
- (2011) Montserrat Arrasate et al. EXPERIMENTAL NEUROLOGY
- Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage
- (2011) U. Shirendeb et al. HUMAN MOLECULAR GENETICS
- Cysteine Oxidation within N-terminal Mutant Huntingtin Promotes Oligomerization and Delays Clearance of Soluble Protein
- (2011) Jonathan H. Fox et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Melatonin MT1 Receptor Axis Modulates Mutant Huntingtin-Mediated Toxicity
- (2011) X. Wang et al. JOURNAL OF NEUROSCIENCE
- Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity
- (2011) Wenjun Song et al. NATURE MEDICINE
- Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease
- (2011) Gisa Ellrichmann et al. PLoS One
- Oxidative stress caused by mitochondrial calcium overload
- (2010) Tsung-I Peng et al. Annals of the New York Academy of Sciences
- Downregulation of NF-κB signaling by mutant huntingtin proteins induces oxidative stress and cell death
- (2010) Sami Reijonen et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli
- (2010) Veronica Costa et al. EMBO Molecular Medicine
- Cystamine protects from 3-nitropropionic acid lesioning via induction of nf-e2 related factor 2 mediated transcription
- (2010) Marcus J. Calkins et al. EXPERIMENTAL NEUROLOGY
- Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease
- (2010) B. R. Underwood et al. HUMAN MOLECULAR GENETICS
- Aberrant Rab11-Dependent Trafficking of the Neuronal Glutamate Transporter EAAC1 Causes Oxidative Stress and Cell Death in Huntington's Disease
- (2010) X. Li et al. JOURNAL OF NEUROSCIENCE
- S-Nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration
- (2010) Tomohiro Nakamura et al. MITOCHONDRION
- Autophagy and the Integrated Stress Response
- (2010) Guido Kroemer et al. MOLECULAR CELL
- Cystamine and intrabody co-treatment confers additional benefits in a fly model of Huntington's disease
- (2010) S.F. Bortvedt et al. NEUROBIOLOGY OF DISEASE
- Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging
- (2010) Yakup Batlevi et al. NEUROBIOLOGY OF DISEASE
- Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous system
- (2010) Rajat Sandhir et al. NEUROCHEMISTRY INTERNATIONAL
- Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities
- (2009) Georg T. Wondrak ANTIOXIDANTS & REDOX SIGNALING
- Neuroprotective Effects of Calmodulin Peptide 76-121aa: Disruption of Calmodulin Binding to Mutant Huntingtin
- (2009) Nichole L. Dudek et al. BRAIN PATHOLOGY
- A metabolic switch in brain: glucose and lactate metabolism modulation by ascorbic acid
- (2009) Maite A. Castro et al. JOURNAL OF NEUROCHEMISTRY
- Combination therapy with Coenzyme Q10and creatine produces additive neuroprotective effects in models of Parkinson’s and Huntington’s Diseases
- (2009) Lichuan Yang et al. JOURNAL OF NEUROCHEMISTRY
- Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
- (2009) Dunyaporn Trachootham et al. NATURE REVIEWS DRUG DISCOVERY
- H2S Signals Through Protein S-Sulfhydration
- (2009) A. K. Mustafa et al. Science Signaling
- How mitochondria produce reactive oxygen species
- (2008) Michael P. Murphy BIOCHEMICAL JOURNAL
- Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins
- (2008) Sami Reijonen et al. EXPERIMENTAL CELL RESEARCH
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