Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease

NRF2 as a Therapeutic Target in Neurodegenerative Diseases

(2020) Mikah S. Brandes et al.   ASN Neuro

PINK1/Parkin Mediated Mitophagy, Ca2+ Signalling, and ER–Mitochondria Contacts in Parkinson’s Disease

(2020) Lucia Barazzuol et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells

(2020) Rodrigo A. Quintanilla et al.   Frontiers in Cellular Neuroscience

Antioxidant and Anti-inflammatory Effect of Nrf2 Inducer Dimethyl Fumarate in Neurodegenerative Diseases

(2020) Sarah A. Scuderi et al.   Antioxidants

ROS networks: designs, aging, Parkinson’s disease and precision therapies

(2020) Alexey N. Kolodkin et al.   npj Systems Biology and Applications

Nrf2: a dark horse in Alzheimer's disease treatment

(2020) Alsiddig Osama et al.   AGEING RESEARCH REVIEWS

Therapeutic Approaches to Alzheimer’s Disease Through Modulation of NRF2

(2019) Gahee Bahn et al.   NEUROMOLECULAR MEDICINE

It’s all about tau

(2019) Cheril Tapia-Rojas et al.   PROGRESS IN NEUROBIOLOGY

Functional role of PGAM5 multimeric assemblies and their polymerization into filaments

(2019) Karen Ruiz et al.   Nature Communications

Mechanisms and roles of mitophagy in neurodegenerative diseases

(2019) Yan Wang et al.   CNS Neuroscience & Therapeutics

CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies

(2019) Sara Castro-Sánchez et al.   Redox Biology

Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways

(2019) Artem P. Gureev et al.   Frontiers in Genetics

Synthesis, characterization and efficacy of mitochondrial targeted delivery of TPP-curcumin in rotenone-induced toxicity

(2019) Whidul Hasan et al.   DARU-Journal of Pharmaceutical Sciences

Effects of curcumin on mitochondria in neurodegenerative diseases

(2019) Hossein Bagheri et al.   BIOFACTORS

Systemic activation of Nrf2 pathway in Parkinson's disease

(2019) Sara Petrillo et al.   MOVEMENT DISORDERS

Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders

(2019) Md. Sahab Uddin et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Neuroprotective mechanisms of S-allyl-L-cysteine in neurological disease (Review)

(2019) Yasuhiro Kosuge   Experimental and Therapeutic Medicine

Microglia and Aging: The Role of the TREM2–DAP12 and CX3CL1-CX3CR1 Axes

(2018) Carmen Mecca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer’s Disease

(2018) D. Allan Butterfield et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease

(2018) Russell H. Swerdlow   JOURNAL OF ALZHEIMERS DISEASE

Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge

(2018) Hallel C. Paraiso et al.   Journal of Neuroinflammation

Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study

(2018) Brian A Gordon et al.   LANCET NEUROLOGY

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease

(2018) Diego Grassi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich’s Ataxia Models

(2018) Rosella Abeti et al.   Frontiers in Cellular Neuroscience

Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control

(2018) Daniela Strobbe et al.   Frontiers in Molecular Neuroscience

Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy

(2018) Antonio Cuadrado et al.   Redox Biology

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy

(2018) Ana I. Rojo et al.   Redox Biology

Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus

(2018) Claudia Jara et al.   Redox Biology

Evaluation of the antioxidant properties of curcumin derivatives by genetic function algorithm

(2018) Ikechukwu Ogadimma Alisi et al.   Journal of Advanced Research

Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease

(2018) Xiongwei Zhu et al.   JOURNAL OF ALZHEIMERS DISEASE

Life, death and autophagy

(2018) Johnna Doherty et al.   NATURE CELL BIOLOGY

Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2/Nrf2 and mitochondria

(2018) In-geun Ryoo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin

(2018) Yuichiro Mita et al.   Scientific Reports

Parkinson’s Disease: Biomarkers, Treatment, and Risk Factors

(2018) Fatemeh N. Emamzadeh et al.   Frontiers in Neuroscience

SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila

(2018) Alessandra Zanon et al.   HUMAN MOLECULAR GENETICS

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) E. Ray Dorsey et al.   LANCET NEUROLOGY

Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson’s disease

(2018) Sandra Franco-Iborra et al.   Cell Death & Disease

NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

(2018) Farzane Sivandzade et al.   Redox Biology

The Oxidative Stress Response inCaenorhabditis elegansRequires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2

(2017) Queenie Hu et al.   GENETICS

Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans

(2017) Genki Hayashi et al.   HUMAN MOLECULAR GENETICS

Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer’s disease

(2017) Caterina Branca et al.   HUMAN MOLECULAR GENETICS

Meta-Analysis of Parkinson’s Disease and Alzheimer’s Disease Revealed Commonly Impaired Pathways and Dysregulation of NRF2-Dependent Genes

(2017) Qian Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

A PGAM5–KEAP1–Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking

(2017) Gary B. O'Mealey et al.   JOURNAL OF CELL SCIENCE

Multiple mechanisms of dimethyl fumarate in amyloid β-induced neurotoxicity in human neuronal cells

(2017) Michela Campolo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Repeated-Dose Oral N-Acetylcysteine in Parkinson's Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress

(2017) Lisa D. Coles et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer’s Disease

(2017) María José Pérez et al.   MOLECULAR NEUROBIOLOGY

Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time

(2017) Yuji Fuse et al.   MOLECULES

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

(2017) Yunjong Lee et al.   Cell Reports

Beneficial Effects of Sulforaphane Treatment in Alzheimer's Disease May Be Mediated through Reduced HDAC1/3 and Increased P75NTR Expression

(2017) Jingzhu Zhang et al.   Frontiers in Aging Neuroscience

The Synucleinopathies: Twenty Years On

(2017) Michel Goedert et al.   Journal of Parkinsons Disease

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease

(2017) Fiona Kerr et al.   PLoS Genetics

Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons

(2017) Prasad Tammineni et al.   eLife

The Oxidative Stress Response inCaenorhabditis elegansRequires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2

(2017) Queenie Hu et al.   GENETICS

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

(2017) Marta Pajares et al.   Redox Biology

Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson’s Disease

(2017) Martin P. Helley et al.   Frontiers in Genetics

Truncation of Tau Protein and its Pathological Significance in Alzheimer's Disease

(2017) Francisco García-Sierra et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduced Posterior Cingulate Mitochondrial Activity in Expired Young Adult Carriers of the APOE ε4 Allele, the Major Late-Onset Alzheimer's Susceptibility Gene

(2017) Jon Valla et al.   JOURNAL OF ALZHEIMERS DISEASE

Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer’s disease

(2017) Isabel Gameiro et al.   Scientific Reports

Late-onset Alzheimer’s disease is associated with inherent changes in bioenergetics profiles

(2017) Kai-C. Sonntag et al.   Scientific Reports

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective Effect of Dimethyl Fumarate on an Oxidative Stress Model Induced by Sodium Nitroprusside in Mice

(2016) Toshiaki Kume et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

(2016) Noemí Esteras et al.   BIOLOGICAL CHEMISTRY

Tau Deletion Prevents Stress-Induced Dendritic Atrophy in Prefrontal Cortex: Role of Synaptic Mitochondria

(2016) Sofia Lopes et al.   CEREBRAL CORTEX

Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease

(2016) M. Ahuja et al.   JOURNAL OF NEUROSCIENCE

GSK-3beta Inhibitor Induces Expression of Nrf2/TrxR2 Signaling Pathway to Protect against Renal Ischemia/Reperfusion Injury in Diabetic Rats

(2016) Bo Hu et al.   KIDNEY & BLOOD PRESSURE RESEARCH

The epidemiology of Parkinson's disease: risk factors and prevention

(2016) Alberto Ascherio et al.   LANCET NEUROLOGY

Inhibition of neuroinflammation in BV2 microglia by the biflavonoid kolaviron is dependent on the Nrf2/ARE antioxidant protective mechanism

(2016) Samuel A. Onasanwo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Inflammatory Response in the CNS: Friend or Foe?

(2016) Marta Sochocka et al.   MOLECULAR NEUROBIOLOGY

Curcumin Ameliorates Memory Decline via Inhibiting BACE1 Expression and β-Amyloid Pathology in 5×FAD Transgenic Mice

(2016) Kunmu Zheng et al.   MOLECULAR NEUROBIOLOGY

Nrf2 mitigates LRRK2- and α-synuclein–induced neurodegeneration by modulating proteostasis

(2016) Gaia Skibinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

The spatiotemporal regulation of the Keap1–Nrf2 pathway and its importance in cellular bioenergetics

(2015) Albena T. Dinkova-Kostova et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

(2015) Stjepana Kovac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

(2015) D Jimenez-Blasco et al.   CELL DEATH AND DIFFERENTIATION

Neuroprotective Effect of Sulforaphane against Methylglyoxal Cytotoxicity

(2015) Cristina Angeloni et al.   CHEMICAL RESEARCH IN TOXICOLOGY

How Mitochondrial Dynamism Orchestrates Mitophagy

(2015) O. S. Shirihai et al.   CIRCULATION RESEARCH

An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders

(2015) Yang Yang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Natural Compounds Modulating Mitochondrial Functions

(2015) Lara Gibellini et al.   Evidence-based Complementary and Alternative Medicine

Mechanisms and functions of Nrf2 signaling in Drosophila

(2015) Andrew Pitoniak et al.   FREE RADICAL BIOLOGY AND MEDICINE

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2—a therapeutic target for the treatment of neurodegenerative diseases

(2015) Delinda A. Johnson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficientmdxMice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-κB Signaling Pathway

(2015) Cheng-Cao Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells

(2015) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway

(2015) Guoguo Shang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Role of Polyphenols and Other Phytochemicals on Molecular Signaling

(2015) Swapna Upadhyay et al.   Oxidative Medicine and Cellular Longevity

Role of the Keap1/Nrf2 pathway in neurodegenerative diseases

(2015) Hiromi Yamazaki et al.   PATHOLOGY INTERNATIONAL

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

(2015) Daniel A. Stevens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview

(2015) Roberto Bomprezzi   Therapeutic Advances in Neurological Disorders

Calcium and ROS: A mutual interplay

(2015) Agnes Görlach et al.   Redox Biology

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions

(2015) Hitoshi Murata et al.   PLoS One

Antioxidative defense mechanisms controlled by Nrf2: state-of-the-art and clinical perspectives in neurodegenerative diseases

(2014) Jamie L. Lim et al.   ARCHIVES OF TOXICOLOGY

Neuroprotective Effects of Sulforaphane on Cholinergic Neurons in Mice with Alzheimer’s Disease-Like Lesions

(2014) Rui Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial reactive oxygen species production and elimination

(2014) Alexander Nickel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance

(2014) P. J. Meakin et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons

(2014) Rodrigo A. Quintanilla et al.   NEUROBIOLOGY OF DISEASE

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52

(2014) Chulman Jo et al.   Nature Communications

Oxidative stress in Alzheimer’s disease

(2014) Zhichun Chen et al.   Neuroscience Bulletin

The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy

(2014) Mónika Lippai et al.   Biomed Research International

Glutathione and mitochondria

(2014) Vicent Ribas et al.   Frontiers in Pharmacology

Phosphorylation of serine 349 of p62 in Alzheimer’s disease brain

(2014) Kunikazu Tanji et al.   Acta Neuropathologica Communications

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

(2013) Marthe H. R. Ludtmann et al.   BIOCHEMICAL JOURNAL

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Glutathione metabolism and Parkinson's disease

(2013) Michelle Smeyne et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

(2013) Susan A. Farr et al.   FREE RADICAL BIOLOGY AND MEDICINE

The impact of reactive oxygen species and genetic mitochondrial mutations in Parkinson's disease

(2013) Li Zuo et al.   GENE

Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice

(2013) Yanyan Zhou et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Peroxisome Proliferator-activated Receptor γ Co-activator 1-α as a Critical Co-activator of the Murine Hepatic Oxidative Stress Response and Mitochondrial Biogenesis inStaphylococcus aureusSepsis

(2013) Anne D. Cherry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective Effect of CNB-001, a Novel Pyrazole Derivative of Curcumin on Biochemical and Apoptotic Markers Against Rotenone-Induced SK-N-SH Cellular Model of Parkinson’s Disease

(2013) Richard L. Jayaraj et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons

(2013) G. Amadoro et al.   NEUROBIOLOGY OF DISEASE

Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases

(2013) Andrea Tarozzi et al.   Oxidative Medicine and Cellular Longevity

Neuroprotective Effects of Puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's Disease Model in Mice

(2013) Guoqi Zhu et al.   PHYTOTHERAPY RESEARCH

Identification of Altered Metabolic Pathways in Plasma and CSF in Mild Cognitive Impairment and Alzheimer’s Disease Using Metabolomics

(2013) Eugenia Trushina et al.   PLoS One

Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

(2013) H. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance

(2012) S. A. Rushworth et al.   BLOOD

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities

(2012) Cristina Carvalho et al.   DIABETES

Mitochondrial fission proteins in peripheral blood lymphocytes are potential biomarkers for Alzheimer’s disease

(2012) S. Wang et al.   EUROPEAN JOURNAL OF NEUROLOGY

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Effects of dimethyl fumarate on neuroprotection and immunomodulation

(2012) Philipp Albrecht et al.   Journal of Neuroinflammation

Keap1 Is Localized in Neuronal and Glial Cytoplasmic Inclusions in Various Neurodegenerative Diseases

(2012) Kunikazu Tanji et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A New Link to Mitochondrial Impairment in Tauopathies

(2012) Kathrin L. Schulz et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity

(2012) Tracy P. Williamson et al.   NEUROTOXICOLOGY

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

(2012) Yosuke Hirotsu et al.   NUCLEIC ACIDS RESEARCH

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

(2012) Eugenia Trushina et al.   PLoS One

Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

(2012) Meijuan Zhang et al.   PROGRESS IN NEUROBIOLOGY

Involvement of the Nrf2-proteasome pathway in the endoplasmic reticulum stress response in pancreatic β-cells

(2012) Sanghwan Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

(2011) Agnieszka Jazwa et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Regulation of Mitochondrial Function

(2011) Diane E. Handy et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease

(2011) R K Dagda et al.   CELL DEATH AND DIFFERENTIATION

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

(2011) Miao Yu et al.   CELLULAR SIGNALLING

Parkin' control: regulation of PGC-1  through PARIS in Parkinson's disease

(2011) J. I. Castillo-Quan   Disease Models & Mechanisms

Sulforaphane inhibits mitochondrial permeability transition and oxidative stress

(2011) Tiffany Greco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

(2011) Arie Neymotin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Trafficking Kinesin Protein (TRAK)-mediated Transport of Mitochondria in Axons of Hippocampal Neurons

(2011) Kieran Brickley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy

(2011) Carlos Enrique Guerrero-Beltrán et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

(2011)   LANCET

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

Interaction between NH2-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration

(2011) Giuseppina Amadoro et al.   NEUROBIOLOGY OF AGING

Truncated tau and Aβ cooperatively impair mitochondria in primary neurons

(2011) Rodrigo A. Quintanilla et al.   NEUROBIOLOGY OF AGING

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Regulation of axonal mitochondrial transport and its impact on synaptic transmission

(2011) Qian Cai et al.   NEUROSCIENCE RESEARCH

Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation

(2011) K.-i. Fujita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beneficial Role of Nrf2 in Regulating NADPH Generation and Consumption

(2011) Kai Connie Wu et al.   TOXICOLOGICAL SCIENCES

The Promise of Neuroprotective Agents in Parkinson?s Disease

(2011) Stacey E. Seidl et al.   Frontiers in Neurology

Mitophagy and Parkinson's disease: The PINK1–parkin link

(2010) Emma Deas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting mitochondrial dysfunction in neurodegenerative disease: Part I

(2010) Victoria S Burchell et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Nuclear Erythroid Factor 2-mediated Proteasome Activation Delays Senescence in Human Fibroblasts

(2010) Suzanne Kapeta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective Roles of CX3CR1-Mediated Signals in Toxin A-Induced Enteritis through the Induction of Heme Oxygenase-1 Expression

(2010) M. Inui et al.   JOURNAL OF IMMUNOLOGY

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

(2010) Dimitrios Kapogiannis et al.   LANCET NEUROLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Review: Autophagy and neurodegeneration: survival at a cost?

(2010) S. J. Cherra III et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

(2010) M. McMahon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Protection against amyloid beta cytotoxicity by sulforaphane: Role of the proteasome

(2009) Hyun-Min Park et al.   ARCHIVES OF PHARMACAL RESEARCH

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Stabilization of transcription factor Nrf2 by tBHQ prevents oxidative stress-induced amyloid β formation in NT2N neurons

(2009) Bahareh Eftekharzadeh et al.   BIOCHIMIE

Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio)

(2009) L. Flinn et al.   BRAIN

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

GSK3: A possible link between beta amyloid peptide and tau protein

(2009) Félix Hernández et al.   EXPERIMENTAL NEUROLOGY

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Parkinson's disease: from monogenic forms to genetic susceptibility factors

(2009) S. Lesage et al.   HUMAN MOLECULAR GENETICS

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

(2009) Javier Alegre-Abarrategui et al.   HUMAN MOLECULAR GENETICS

Brain mitochondrial dysfunction and oxidative damage in Parkinson’s disease

(2009) Ana Navarro et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons

(2009) Rodrigo A. Quintanilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival

(2009) Kuniyasu Niizuma et al.   JOURNAL OF NEUROCHEMISTRY

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease

(2009) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

KIF5B Motor Adaptor Syntabulin Maintains Synaptic Transmission in Sympathetic Neurons

(2009) H. Ma et al.   JOURNAL OF NEUROSCIENCE

Nrf2 activators provide neuroprotection against 6-hydroxydopamine toxicity in rat organotypic nigrostriatal cocultures

(2009) Aubrey Siebert et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

The role of tau in neurodegeneration

(2009) Tania F Gendron et al.   Molecular Neurodegeneration

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease

(2009) Joseph L. Price et al.   NEUROBIOLOGY OF AGING

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

(2009) Pei-Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

(2009) K. Kanninen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE

Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1

(2008) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

(2008) Shih-Ching Lo et al.   EXPERIMENTAL CELL RESEARCH

Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease

(2008) Derek A. Drechsel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

(2008) Helga E. de Vries et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

(2008) C.J. Harvey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells

(2008) Patrick L. Apopa et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

GSK-3β down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress

(2008) Ana I. Rojo et al.   JOURNAL OF NEUROCHEMISTRY

Polymorphism in environment responsive genes and association with Parkinson disease

(2008) Madhu Singh et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A systematic look at an old problem

(2008) Thomas B. L. Kirkwood   NATURE

Mitochondrial fragmentation in neurodegeneration

(2008) Andrew B. Knott et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of Wnt and PI3K Signaling Modulates GSK-3β Activity and Induces Morphological Changes in Cortical Neurons: Role of Tau Phosphorylation

(2008) Octavio Mercado-Gómez et al.   NEUROCHEMICAL RESEARCH

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex I deficiency in Parkinson's disease frontal cortex

(2007) W. Davis Parker et al.   BRAIN RESEARCH