Fucoxanthin Prevents 6-OHDA-Induced Neurotoxicity by Targeting Keap1

Floridoside Exhibits Antioxidant Properties by Activating HO-1 Expression via p38/ERK MAPK Pathway

(2020) Tingting Niu et al.   Marine Drugs

Effect of Quercetin on PC12 Alzheimer’s Disease Cell Model Induced by Aβ25-35 and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway

(2020) Xinjun Yu et al.   Biomed Research International

In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ1-42) toxicity and aggregation

(2019) Mousa Alghazwi et al.   NEUROCHEMISTRY INTERNATIONAL

Investigation of Molecular Details of Keap1-Nrf2 Inhibitors Using Molecular Dynamics and Umbrella Sampling Techniques

(2019) Ashwini Machhindra Londhe et al.   MOLECULES

Interaction Energetics and Druggability of the Protein–Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2)

(2019) Mengqi Zhong et al.   BIOCHEMISTRY

Protective effects of cichoric acid on H 2 O 2 -induced oxidative injury in hepatocytes and larval zebrafish models

(2018) Ji Ma et al.   BIOMEDICINE & PHARMACOTHERAPY

Antioxidant Properties of Crocus Sativus L. and its Constituents and Relevance to Neurodegenerative Diseases; Focus on Alzheimer’s And Parkinson’s disease

(2018) Kyriaki Hatziagapiou et al.   Current Neuropharmacology

Acteoside protects against 6-OHDA-induced dopaminergic neuron damage via Nrf2-ARE signaling pathway

(2018) Maiquan Li et al.   FOOD AND CHEMICAL TOXICOLOGY

The delayed effects of antibiotics in type 2 diabetes, friend or foe?

(2018) Lihong Fu et al.   JOURNAL OF ENDOCRINOLOGY

Gallic Acid Protects 6-OHDA Induced Neurotoxicity by Attenuating Oxidative Stress in Human Dopaminergic Cell Line

(2018) Y. Chandrasekhar et al.   NEUROCHEMICAL RESEARCH

Neuroprotective role of fucoxanthin against cerebral ischemic/reperfusion injury through activation of Nrf2/HO-1 signaling

(2018) Lixun Hu et al.   BIOMEDICINE & PHARMACOTHERAPY

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) E. Ray Dorsey et al.   LANCET NEUROLOGY

The effects of omega-3 fatty acids and vitamin E co-supplementation on clinical and metabolic status in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled trial

(2017) Mohsen Taghizadeh et al.   NEUROCHEMISTRY INTERNATIONAL

Fucoxanthin, a Marine Carotenoid, Attenuates β-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells

(2017) Jiajia Lin et al.   Oxidative Medicine and Cellular Longevity

Comment on “A Preclinical Systematic Review of Ginsenoside-Rg1 in Experimental Parkinson’s Disease”

(2017) Yi-bo He et al.   Oxidative Medicine and Cellular Longevity

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways

(2017) Chao Zhang et al.   Redox Biology

Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways

(2017) Li Zhang et al.   Scientific Reports

Neuroprotection of inositol hexaphosphate and changes of mitochondrion mediated apoptotic pathway and α-synuclein aggregation in 6-OHDA induced parkinson׳s disease cell model

(2016) Zheng Zhang et al.   BRAIN RESEARCH

Novel walnut peptide–selenium hybrids with enhanced anticancer synergism: facile synthesis and mechanistic investigation of anticancer activity

(2016) Jiaoyan Ren et al.   International Journal of Nanomedicine

The efficacy and safety of coenzyme Q10 in Parkinson’s disease: a meta-analysis of randomized controlled trials

(2016) Zhen-Guo Zhu et al.   NEUROLOGICAL SCIENCES

Neuroprotective effects of pyrroloquinoline quinone against rotenone injury in primary cultured midbrain neurons and in a rat model of Parkinson's disease

(2016) Qi Zhang et al.   NEUROPHARMACOLOGY

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

(2016) Reem Arafa et al.   Drug Design Development and Therapy

Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson’s disease: Involvement of antioxidative enzymes induction

(2015) Chi-Rei Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways

(2015) Lun Qing Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protection from neurodegeneration in the 6-hydroxydopamine (6-OHDA) model of Parkinson's with novel 1-hydroxypyridin-2-one metal chelators

(2015) David G. Workman et al.   Metallomics

Activation of α7 nicotinic acetylcholine receptors protects astrocytes against oxidative stress-induced apoptosis: Implications for Parkinson's disease

(2015) Yuan Liu et al.   NEUROPHARMACOLOGY

Selective toxicity of L-DOPA to dopamine transporter-expressing neurons and locomotor behavior in zebrafish larvae

(2015) Sarah J. Stednitz et al.   NEUROTOXICOLOGY AND TERATOLOGY

Nrf2 Amplifies Oxidative Stress via Induction of Klf9

(2014) Shoshanna N. Zucker et al.   MOLECULAR CELL

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

(2014) Min-Cheol Kang et al.   Journal of Functional Foods

Glutathione metabolism and Parkinson's disease

(2013) Michelle Smeyne et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus

(2013) A. Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

The KCTD family of proteins: structure, function, disease relevance

(2013) Zhepeng Liu et al.   Cell and Bioscience

Effect of a phytopharmaceutical medicine, Ginko biloba extract 761, in an animal model of Parkinson's disease: Therapeutic perspectives

(2012) Patricia Rojas et al.   NUTRITION

Ethanolic Extract of Fructus Alpinia oxyphylla Protects Against 6-Hydroxydopamine-Induced Damage of PC12 Cells In Vitro and Dopaminergic Neurons in Zebrafish

(2011) Zai-Jun Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vitro and in vivo evaluation of mutagenicity of fucoxanthin (FX) and its metabolite fucoxanthinol (FXOH)

(2009) Fumiaki Beppu et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

(2008) Marcus J. Calkins et al.   ANTIOXIDANTS & REDOX SIGNALING