The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases

Membrane-Tethered MUC1 Mucin Counter-Regulates the Phagocytic Activity of Macrophages

(2016) Kosuke Kato et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Functions of omega-3 fatty acids and FFA4 (GPR120) in macrophages

(2016) Dong-Soon Im   EUROPEAN JOURNAL OF PHARMACOLOGY

Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity

(2016) Stephanie Hucke et al.   JOURNAL OF AUTOIMMUNITY

Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPARγ

(2015) Chathyan Pararasa et al.   AGING CELL

Lipid signaling in adipose tissue: Connecting inflammation & metabolism

(2015) Mojgan Masoodi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Curcumin Modulates Macrophage Polarization Through the Inhibition of the Toll-Like Receptor 4 Expression and its Signaling Pathways

(2015) Yaoyao Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Reshaping of Human Macrophage Polarization through Modulation of Glucose Catabolic Pathways

(2015) Elena Izquierdo et al.   JOURNAL OF IMMUNOLOGY

Transcription Factors STAT6 and KLF4 Implement Macrophage Polarization via the Dual Catalytic Powers of MCPIP

(2015) Nidhi Kapoor et al.   JOURNAL OF IMMUNOLOGY

Pyruvate Dehydrogenase Kinase 1 Participates in Macrophage Polarization via Regulating Glucose Metabolism

(2015) Zheng Tan et al.   JOURNAL OF IMMUNOLOGY

Pivotal Roles of GM-CSF in Autoimmunity and Inflammation

(2015) Aoi Shiomi et al.   MEDIATORS OF INFLAMMATION

Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin

(2015) H-Y Tan et al.   Cell Death & Disease

Defective mitochondrial fission augments NLRP3 inflammasome activation

(2015) Sangjun Park et al.   Scientific Reports

Phagocytic Entry of Legionella pneumophila into Macrophages through Phosphatidylinositol 3,4,5-Trisphosphate-Independent Pathway

(2015) Toshihiko Harada et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

NRF2 Signaling Negatively Regulates Phorbol-12-Myristate-13-Acetate (PMA)-Induced Differentiation of Human Monocytic U937 Cells into Pro-Inflammatory Macrophages

(2015) Min-gu Song et al.   PLoS One

PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment

(2015) Wing Lam et al.   Scientific Reports

SYNCRIP-Dependent Nox2 mRNA Destabilization Impairs ROS Formation in M2-Polarized Macrophages

(2014) Laura Kuchler et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages

(2014) Ae Sin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic ‘eat-me’ signals: cleavage and inhibition of phagocytosis by Lp-PLA2

(2014) V A Tyurin et al.   CELL DEATH AND DIFFERENTIATION

Sphingosine 1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4

(2014) Soo-Jin Park et al.   CELLULAR SIGNALLING

Stem cells and the impact of ROS signaling

(2014) C. L. Bigarella et al.   DEVELOPMENT

Loss of NADPH Oxidase–Derived Superoxide Skews Macrophage Phenotypes to Delay Type 1 Diabetes

(2014) Lindsey E. Padgett et al.   DIABETES

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

(2014) R. Allam et al.   EMBO REPORTS

NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair?

(2014) Evan A. Bordt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Macrophage polarisation by fatty acids is PPARgamma-dependent

(2014) Chatyan Pararasa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Macrophage phenotypes in atherosclerosis

(2014) Sophie Colin et al.   IMMUNOLOGICAL REVIEWS

CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke

(2014) Zhiwei Tang et al.   Journal of Neuroinflammation

Contrasting phagosome pH regulation and maturation in human M1 and M2 macrophages

(2014) Johnathan Canton et al.   MOLECULAR BIOLOGY OF THE CELL

Metabolism of stromal and immune cells in health and disease

(2014) Bart Ghesquière et al.   NATURE

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

Macrophage subsets in atherosclerosis

(2014) Giulia Chinetti-Gbaguidi et al.   Nature Reviews Cardiology

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

Caspase-1/ASC Inflammasome-Mediated Activation of IL-1β–ROS–NF-κB Pathway for Control of Trypanosoma cruzi Replication and Survival Is Dispensable in NLRP3−/− Macrophages

(2014) Nilay Dey et al.   PLoS One

Macrophage Polarization in Obesity and Type 2 Diabetes: Weighing Down Our Understanding of Macrophage Function?

(2014) Michael James Kraakman et al.   Frontiers in Immunology

Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis

(2013) Ha-Na Lee et al.   BIOCHEMICAL PHARMACOLOGY

The effect of Lycium barbarum on spinal cord injury, particularly its relationship with M1 and M2 macrophage in rats

(2013) Yu-Kai Zhang et al.   BMC Complementary and Alternative Medicine

Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-Lineage Cells by Regulating β-Oxidation-Dependent Mitochondrial ROS Production

(2013) Christopher J. Hall et al.   Cell Metabolism

ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

(2013) Yan Zhang et al.   CELL RESEARCH

Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways

(2013) Dexi Zhou et al.   CELLULAR SIGNALLING

Accelerated Development of Pulmonary Fibrosis via Cu,Zn-superoxide Dismutase-induced Alternative Activation of Macrophages

(2013) Chao He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The carotenoid lutein enhances matrix metalloproteinase-9 production and phagocytosis through intracellular ROS generation and ERK1/2, p38 MAPK, and RARβ activation in murine macrophages

(2013) Huey-Ming Lo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

(2013) Dominic De Nardo et al.   NATURE IMMUNOLOGY

Regulation of Monocyte Adhesion and Migration by Nox4

(2013) Chi Fung Lee et al.   PLoS One

The Connection of Monocytes and Reactive Oxygen Species in Pain

(2013) Dagmar Hackel et al.   PLoS One

Postprandial lipoproteins and the molecular regulation of vascular homeostasis

(2013) Kathleen M. Botham et al.   PROGRESS IN LIPID RESEARCH

Mycobacterial HBHA induces endoplasmic reticulum stress-mediated apoptosis through the generation of reactive oxygen species and cytosolic Ca2+ in murine macrophage RAW 264.7 cells

(2013) J-A Choi et al.   Cell Death & Disease

p47phox Directs Murine Macrophage Cell Fate Decisions

(2012) Liang Yi et al.   AMERICAN JOURNAL OF PATHOLOGY

Reactive Oxygen Species and Thiol Redox Signaling in the Macrophage Biology of Atherosclerosis

(2012) Sina Tavakoli et al.   ANTIOXIDANTS & REDOX SIGNALING

Mycobacterium kansasii-induced death of murine macrophages involves endoplasmic reticulum stress responses mediated by reactive oxygen species generation or calpain activation

(2012) Yun-Ji Lim et al.   APOPTOSIS

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production

(2012) G. B. Fortes et al.   BLOOD

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Orchestration of Metabolism by Macrophages

(2012) Subhra K. Biswas et al.   Cell Metabolism

Candida albicans Induces Arginine Biosynthetic Genes in Response to Host-Derived Reactive Oxygen Species

(2012) Claudia Jiménez-López et al.   EUKARYOTIC CELL

TPA induces the expression of EC-SOD in human monocytic THP-1 cells: Involvement of PKC, MEK/ERK and NOX-derived ROS

(2012) Junya Makino et al.   FREE RADICAL RESEARCH

Anti-tumour strategies aiming to target tumour-associated macrophages

(2012) Xiaoqiang Tang et al.   IMMUNOLOGY

Palmitate and Lipopolysaccharide Trigger Synergistic Ceramide Production in Primary Macrophages

(2012) Joel D. Schilling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidatively modified high density lipoprotein promotes inflammatory response in human monocytes–macrophages by enhanced production of ROS, TNF-α, MMP-9, and MMP-2

(2012) V. S. Soumyarani et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cellular Adaptation to Anthrax Lethal Toxin-Induced Mitochondrial Cholesterol Enrichment, Hyperpolarization, and Reactive Oxygen Species Generation through Downregulating MLN64 in Macrophages

(2012) S.-D. Ha et al.   MOLECULAR AND CELLULAR BIOLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

High-Resolution Transcriptome of Human Macrophages

(2012) Marc Beyer et al.   PLoS One

Methemoglobin exposure produces toxicological effects in macrophages due to multiple ROS spike induced apoptosis

(2012) Rohitas Deshmukh et al.   TOXICOLOGY IN VITRO

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

NADPH Oxidase 4 Mediates Monocyte Priming and Accelerated Chemotaxis Induced by Metabolic Stress

(2011) Sarah Ullevig et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The mitochondrial citrate carrier: a new player in inflammation

(2011) Vittoria Infantino et al.   BIOCHEMICAL JOURNAL

Alternative activation of macrophages by IL-4 enhances the proteolytic capacity of their phagosomes through synergistic mechanisms

(2011) D. R. Balce et al.   BLOOD

Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice

(2011) Xavier Prieur et al.   DIABETES

Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels

(2011) David J. Rowlands et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation

(2011) Sang-Ho Choi et al.   JOURNAL OF NEUROCHEMISTRY

Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer

(2011) Hanseul Yang et al.   Molecular Cancer

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Endoplasmic Reticulum Stress Pathway-Mediated Apoptosis in Macrophages Contributes to the Survival of Mycobacterium tuberculosis

(2011) Yun-Ji Lim et al.   PLoS One

Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress

(2011) M. Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay between redox status and inflammasome activation

(2011) Anna Rubartelli et al.   TRENDS IN IMMUNOLOGY

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency

(2010) Shigeki Hoshino et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal redox environment of phagosomes

(2010) J. M. Rybicka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of a functional NADPH oxidase in neutrophils and macrophages during programmed cell clearance: implications for chronic granulomatous disease

(2009) Duangmanee Sanmun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hyperhomocysteinemia Promotes Inflammatory Monocyte Generation and Accelerates Atherosclerosis in Transgenic Cystathionine β-Synthase–Deficient Mice

(2009) Daqing Zhang et al.   CIRCULATION

Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosphates

(2009) Pablo Pelegrin et al.   EMBO JOURNAL

Differential regulation of iron homeostasis during human macrophage polarized activation

(2009) Stefania Recalcati et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Role of sestrin2 in peroxide signaling in macrophages

(2009) Silke Essler et al.   FEBS LETTERS

Purification, Cloning, and Functional Characterization of a Novel Immunomodulatory Protein from Antrodia camphorata (Bitter Mushroom) That Exhibits TLR2-Dependent NF-κB Activation and M1 Polarization within Murine Macrophages

(2009) Fuu Sheu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Tumor-Specific Bacteriophages Induce Tumor Destruction through Activation of Tumor-Associated Macrophages

(2009) F. Eriksson et al.   JOURNAL OF IMMUNOLOGY

NADPH Oxidase NOX2 Mediates Rapid Cellular Oxidation following ATP Stimulation of Endotoxin-Primed Macrophages

(2009) S. F. Moore et al.   JOURNAL OF IMMUNOLOGY

Divergent Effects on Phagocytosis by Macrophage-Derived Oxygen Radicals

(2009) Kelly L. Brown et al.   Journal of Innate Immunity

Oxidative modifications of S100 proteins: functional regulation by redox

(2009) Su Yin Lim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

5-Lipoxygenase inhibitors potentiate 1α,25-dihydroxyvitamin D3-induced monocytic differentiation by activating p38 MAPK pathway

(2009) Lenka Stixová et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

LPS Induces Hypoxia-Inducible Factor 1 Activation in Macrophage-Differentiated Cells in a Reactive Oxygen Species–Dependent Manner

(2008) Kenichiro Nishi et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of catalase in monocytic differentiation of U937 cells by TPA: hydrogen peroxide as a second messenger

(2008) T Yamamoto et al.   LEUKEMIA

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

(2008) Felix Meissner et al.   NATURE IMMUNOLOGY

The Recently Identified P2Y-Like Receptor GPR17 Is a Sensor of Brain Damage and a New Target for Brain Repair

(2008) Davide Lecca et al.   PLoS One

Baicalin inhibits macrophage activation by lipopolysaccharide and protects mice from endotoxin shock

(2007) Lin-lin Liu et al.   BIOCHEMICAL PHARMACOLOGY