Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
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Title
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
Authors
Keywords
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Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 20, Issue 9, Pages 689-709
Publisher
Springer Science and Business Media LLC
Online
2021-06-30
DOI
10.1038/s41573-021-00233-1
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Note: Only part of the references are listed.- Antioxidants Promote Intestinal Tumor Progression in Mice
- (2021) Zhiyuan V. Zou et al. Antioxidants
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- (2020) Rhian M. Touyz et al. CANADIAN JOURNAL OF CARDIOLOGY
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- ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease
- (2020) Dominic S. A. Simpson et al. Antioxidants
- A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania
- (2020) Ann L Sharpley et al. PSYCHOPHARMACOLOGY
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- (2020) Thị Hằng Giang Phan et al. CELLULAR AND MOLECULAR LIFE SCIENCES
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- (2019) Antonio Cuadrado et al. NATURE REVIEWS DRUG DISCOVERY
- Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
- (2019) D. Allan Butterfield et al. NATURE REVIEWS NEUROSCIENCE
- Nrf2 in cancers: A double‐edged sword
- (2019) Shijia Wu et al. Cancer Medicine
- Aconitases: Non-redox Iron–Sulfur Proteins Sensitive to Reactive Species
- (2019) Laura Castro et al. ACCOUNTS OF CHEMICAL RESEARCH
- BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis
- (2019) Clotilde Wiel et al. CELL
- Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development
- (2019) Natalia Robledinos-Antón et al. Oxidative Medicine and Cellular Longevity
- An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals
- (2019) Dominique Detaille et al. PLoS One
- Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells
- (2019) Hongqiao Zhang et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis
- (2019) Kazuya Tsubouchi et al. JOURNAL OF IMMUNOLOGY
- Pharmacological characterization of the seven human NOX isoforms and their inhibitors
- (2019) Fiona Augsburger et al. Redox Biology
- Radiation-Induced Lung Injury (RILI)
- (2019) Lorena Giuranno et al. Frontiers in Oncology
- Broccoli or Sulforaphane: Is It the Source or Dose That Matters?
- (2019) Yoko Yagishita et al. MOLECULES
- Oncogenic pathways and the electron transport chain: a dangeROS liaison
- (2019) Vittoria Raimondi et al. BRITISH JOURNAL OF CANCER
- Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights
- (2018) Diego de Sá Coutinho et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Phase 1b/2a Trial of the Superoxide Dismutase Mimetic GC4419 to Reduce Chemoradiotherapy-Induced Oral Mucositis in Patients With Oral Cavity or Oropharyngeal Carcinoma
- (2018) Carryn M. Anderson et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Increased DNA damage and increased apoptosis and necrosis in patients with severe sepsis and septic shock
- (2018) Ilhan Bahar et al. JOURNAL OF CRITICAL CARE
- C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape
- (2018) Sharadha Dayalan Naidu et al. Scientific Reports
- Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts
- (2018) Michael Schuliga et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia
- (2018) David R. Lynch et al. Annals of Clinical and Translational Neurology
- 4-hydroxynonenal-mediated signaling and aging
- (2017) Hongqiao Zhang et al. FREE RADICAL BIOLOGY AND MEDICINE
- The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer
- (2017) Shasha Tao et al. MOLECULAR CARCINOGENESIS
- Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies
- (2017) Xinyu Yang et al. Frontiers in Physiology
- Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis
- (2017) Jong-Lyel Roh et al. Redox Biology
- Controversy about pharmacological modulation of Nrf2 for cancer therapy
- (2017) Lidija Milkovic et al. Redox Biology
- Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress
- (2017) Helmut Sies Redox Biology
- Therapeutic potential of NADPH oxidase 1/4 inhibitors
- (2016) G Teixeira et al. BRITISH JOURNAL OF PHARMACOLOGY
- Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels
- (2016) Sarah J. Chapple et al. FREE RADICAL BIOLOGY AND MEDICINE
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- (2016) Zheng-Yu Jiang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Adaptive homeostasis
- (2016) Kelvin J.A. Davies MOLECULAR ASPECTS OF MEDICINE
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- (2016) Jinhui Li et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Impact of Superoxide Dismutase Mimetic AEOL 10150 on the Endothelin System of Fischer 344 Rats
- (2016) Devi Ganesh et al. PLoS One
- Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing
- (2016) Charles Masaki et al. PSYCHOPHARMACOLOGY
- Redox homeostasis: The Golden Mean of healthy living
- (2016) Fulvio Ursini et al. Redox Biology
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- (2015) Rumen V. Kostov et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2015) M. Cifuentes-Pagano et al. CURRENT PHARMACEUTICAL DESIGN
- Oxidative stress response and Nrf2 signaling in aging
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- (2014) Anne Cleasby et al. PLoS One
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- (2014) K. Singh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2014) V. I. Sayin et al. Science Translational Medicine
- Physiological and pathological functions of NADPH oxidases during myocardial ischemia–reperfusion
- (2014) Shouji Matsushima et al. TRENDS IN CARDIOVASCULAR MEDICINE
- Vitamin E Inadequacy in Humans: Causes and Consequences
- (2014) Maret G. Traber Advances in Nutrition
- Sulforaphane Accelerates Acetaldehyde Metabolism by Inducing Aldehyde Dehydrogenases: Relevance to Ethanol Intolerance
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- Role of Nrf2 in Oxidative Stress and Toxicity
- (2013) Qiang Ma Annual Review of Pharmacology and Toxicology
- Reactive Oxygen Species, Vascular Noxs, and Hypertension: Focus on Translational and Clinical Research
- (2013) Augusto C. Montezano et al. ANTIOXIDANTS & REDOX SIGNALING
- Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin
- (2013) Scott A. Reisman et al. ARCHIVES OF DERMATOLOGICAL RESEARCH
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- (2013) M. Rawal et al. CANCER RESEARCH
- Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis
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- (2013) Gordon F. Rushworth et al. PHARMACOLOGY & THERAPEUTICS
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- (2013) C. Massart et al. FEBS Open Bio
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- (2012) Jin-Sook Kwon et al. ATHEROSCLEROSIS
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- (2012) Andrew M. Pickering et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2012) Robert J. Fox et al. NEW ENGLAND JOURNAL OF MEDICINE
- Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis
- (2012) Ralf Gold et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2012) S Chowdhry et al. ONCOGENE
- Oxidative DNA damage and obesity in type 2 diabetes mellitus
- (2011) Hayder A Al-Aubaidy et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Iron-mediated lipid peroxidation and lipid raft disruption in low-dose silica-induced macrophage cytokine production
- (2011) Gayatri Premasekharan et al. FREE RADICAL BIOLOGY AND MEDICINE
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- (2011) Hans-Jörg Warnatz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) Thambi Dorai et al. JOURNAL OF UROLOGY
- Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes
- (2011) Pablo E. Pergola et al. NEW ENGLAND JOURNAL OF MEDICINE
- Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3
- (2011) P. M. Rappold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Plasma Biomarkers of Oxidant Stress and Development of Organ Failure in Severe Sepsis
- (2011) Lorraine B. Ware et al. SHOCK
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- (2011) Raymond C.S. Seet et al. STROKE
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- Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities
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- Mitochondria-Targeted Antioxidants in the Treatment of Disease
- (2010) Robin A.J. Smith et al. Annals of the New York Academy of Sciences
- Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential
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- (2010) Henry Jay Forman et al. BIOCHEMISTRY
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- (2010) Kelly A. Graham et al. CANCER BIOLOGY & THERAPY
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- (2010) T. Jiang et al. CANCER RESEARCH
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- (2010) Corrine R. Kliment et al. FREE RADICAL BIOLOGY AND MEDICINE
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- (2010) Mubeen A. Ansari et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
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- (2010) Z. Peng et al. MOLECULAR PHARMACOLOGY
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- (2010) Masaaki Komatsu et al. NATURE CELL BIOLOGY
- Protein oxidation biomarkers in plasma of type 2 diabetic patients
- (2009) Kanti Bhooshan Pandey et al. CLINICAL BIOCHEMISTRY
- Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer
- (2009) S. Homma et al. CLINICAL CANCER RESEARCH
- Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP5+, via suppression of oxidative stress in a mouse model of breast tumor
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- (2009) Emilia Kansanen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) Hiang Ping Chan et al. Journal of Thoracic Oncology
- Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response
- (2009) Weimin Chen et al. MOLECULAR CELL
- Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis
- (2009) Marzia Perluigi et al. Proteomics Clinical Applications
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- (2008) Kosuke Okada et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
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- (2008) Brian J. Day BIOCHEMICAL PHARMACOLOGY
- Targeting lipophilic cations to mitochondria
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- (2008) Tatsuhiro Shibata et al. GASTROENTEROLOGY
- Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection
- (2007) Benjamin Gauter-Fleckenstein et al. FREE RADICAL BIOLOGY AND MEDICINE
- Oxidized to non-oxidized lipoprotein ratios are associated with arteriosclerosis and the metabolic syndrome in diabetic patients
- (2007) Josefa Girona et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
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