Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease

Coffee polyphenols prevent cognitive dysfunction and suppress amyloid β plaques in APP/PS2 transgenic mouse

(2019) Keiko Ishida et al.   NEUROSCIENCE RESEARCH

Protective Effect of Caffeic Acid against Alzheimer’s Disease Pathogenesis via Modulating Cerebral Insulin Signaling, β-Amyloid Accumulation, and Synaptic Plasticity in Hyperinsulinemic Rats

(2019) Wenchang Chang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Coffee intake and decreased amyloid pathology in human brain

(2019) Jee Wook Kim et al.   Translational Psychiatry

Effect of Chlorogenic Acid Intake on Cognitive Function in the Elderly: A Pilot Study

(2018) Morimasa Kato et al.   Evidence-based Complementary and Alternative Medicine

Biochemical deficits and cognitive decline in brain aging: Intervention by dietary supplements

(2018) Jit Poddar et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Impact of diet-induced obesity on the mouse brain phosphoproteome

(2018) Valentina Siino et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Southern Brazilian native fruit shows neurochemical, metabolic and behavioral benefits in an animal model of metabolic syndrome

(2018) Pathise Souto Oliveira et al.   METABOLIC BRAIN DISEASE

Flavonoids as Therapeutic Agents in Alzheimer’s and Parkinson’s Diseases: A Systematic Review of Preclinical Evidences

(2018) Roxana Braga de Andrade Teles et al.   Oxidative Medicine and Cellular Longevity

Nutrients and Oxidative Stress: Friend or Foe?

(2018) Bee Ling Tan et al.   Oxidative Medicine and Cellular Longevity

Curcuminoid Binds to Amyloid-β1-42 Oligomer and Fibril

(2018) Daijiro Yanagisawa et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of the Aphanizomenon flos-aquae Extract (Klamin®) on a Neurodegeneration Cellular Model

(2018) D. Nuzzo et al.   Oxidative Medicine and Cellular Longevity

A Natural Dietary Supplement with a Combination of Nutrients Prevents Neurodegeneration Induced by a High Fat Diet in Mice

(2018) Domenico Nuzzo et al.   Nutrients

Effect of Chlorogenic Acids on Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial

(2018) Katsuyoshi Saitou et al.   Nutrients

Japanese, Mediterranean and Argentinean diets and their potential roles in neurodegenerative diseases

(2018) Diana Denise Dohrmann et al.   FOOD RESEARCH INTERNATIONAL

Glucagon-like peptide-2 reduces the obesity-associated inflammation in the brain

(2018) Domenico Nuzzo et al.   NEUROBIOLOGY OF DISEASE

Diabetes mellitus and risk of early-onset Alzheimer's disease: a population-based case-control study

(2017) K. Kadohara et al.   EUROPEAN JOURNAL OF NEUROLOGY

Recent Progress in Alzheimer’s Disease Research, Part 2: Genetics and Epidemiology

(2017) Morgan Robinson et al.   JOURNAL OF ALZHEIMERS DISEASE

Neurotrophic function of phytochemicals for neuroprotection in aging and neurodegenerative disorders: modulation of intracellular signaling and gene expression

(2017) Makoto Naoi et al.   JOURNAL OF NEURAL TRANSMISSION

Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer’s disease

(2017) Oriol Busquets et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Protective Effects of Caffeic Acid and the Alzheimer's Brain: An Update

(2017) Solomon Habtemariam   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Therapeutic Potentials of Microalgae in the Treatment of Alzheimer’s Disease

(2017) Tosin Olasehinde et al.   MOLECULES

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus

(2017) Xiaoyu Song et al.   PHYSIOLOGY & BEHAVIOR

Midlife Coffee and Tea Drinking and the Risk of Late-Life Dementia: A Population-Based CAIDE Study

(2017) Marjo H. Eskelinen et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer’s Disease

(2016) Isaura V.A. Martins et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroprotective Effects of Biochanin A against β-Amyloid-Induced Neurotoxicity in PC12 Cells via a Mitochondrial-Dependent Apoptosis Pathway

(2016) Ji Tan et al.   MOLECULES

Silymarin Extends Lifespan and Reduces Proteotoxicity in C. elegans Alzheimer’s Model

(2015) Jitendra Kumar et al.   CNS & Neurological Disorders-Drug Targets

Insulin Resistance as Common Molecular Denominator Linking Obesity to Alzheimer’s Disease

(2015) Domenico Nuzzo et al.   Current Alzheimer Research

The association between dietary patterns, diabetes and depression

(2015) Joanna F. Dipnall et al.   JOURNAL OF AFFECTIVE DISORDERS

Silibinin inhibits acetylcholinesterase activity and amyloid β peptide aggregation: a dual-target drug for the treatment of Alzheimer’s disease

(2015) Songwei Duan et al.   NEUROBIOLOGY OF AGING

Adult Neurogenesis in Neurodegenerative Diseases: Figure 1.

(2015) Beate Winner et al.   Cold Spring Harbor Perspectives in Biology

Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions

(2015) Ningjian Liang et al.   Nutrients

Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer’s disease

(2015) Fernanda G. De Felice et al.   Frontiers in Aging Neuroscience

Cancer Protective Action of Polysaccharide, Derived from Red MicroalgaPorphyridium Cruentum—A Biological Background

(2014) E. Gardeva et al.   BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT

Nutrition, the brain and cognitive decline: insights from epigenetics

(2014) M J Dauncey   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: A systematic review

(2014) Francesco Panza et al.   Journal of Nutrition Health & Aging

Peripheral alpha-synuclein and Parkinson's disease

(2014) C. Warren Olanow et al.   MOVEMENT DISORDERS

PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s

(2014) Juan Carlos Corona et al.   NEUROCHEMICAL RESEARCH

Working memory and reward association learning impairments in obesity

(2014) Géraldine Coppin et al.   NEUROPSYCHOLOGIA

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Neuroprotective Potential of Silymarin against CNS Disorders: Insight into the Pathways and Molecular Mechanisms of Action

(2013) Anupom Borah et al.   CNS Neuroscience & Therapeutics

Health applications of bioactive compounds from marine microalgae

(2013) Maria Filomena de Jesus Raposo et al.   LIFE SCIENCES

Is obesity a brain disease?

(2013) Gabi Shefer et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells

(2013) Yingjuan Huang et al.   NEUROSCIENCE LETTERS

Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases

(2013) Khushwant S. Bhullar et al.   Oxidative Medicine and Cellular Longevity

Genomic and Epigenomic Insights into Nutrition and Brain Disorders

(2013) Margaret Dauncey   Nutrients

Epidemiology of Dementias and Alzheimer’s Disease

(2012) Ana Luisa Sosa-Ortiz et al.   ARCHIVES OF MEDICAL RESEARCH

Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein

(2012) Yusaku Miyamae et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Improving brain signaling in aging: could berries be the answer?

(2012) Shibu M Poulose et al.   Expert Review of Neurotherapeutics

Obesity increases cerebrocortical reactive oxygen species and impairs brainfunction

(2012) Linnea R. Freeman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Comparative Study on the Inhibitory Effect of Caffeic and Chlorogenic Acids on Key Enzymes Linked to Alzheimer’s Disease and Some Pro-oxidant Induced Oxidative Stress in Rats’ Brain-In Vitro

(2012) Ganiyu Oboh et al.   NEUROCHEMICAL RESEARCH

Protection by silibinin against experimental ischemic stroke: Up-regulated pAkt, pmTOR, HIF-1α and Bcl-2, down-regulated Bax, NF-κB expression

(2012) Chaohui Wang et al.   NEUROSCIENCE LETTERS

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

(2012) John M Ringman et al.   Alzheimers Research & Therapy

Insulin-activated Akt rescues Aβ oxidative stress-induced cell death by orchestrating molecular trafficking

(2011) Pasquale Picone et al.   AGING CELL

Improvement of brain energy metabolism and cholinergic functions contributes to the beneficial effects of silibinin against streptozotocin induced memory impairment

(2011) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

Spectroscopic studies of molybdenum and tungsten enzymes

(2011) M. Jake Pushie et al.   COORDINATION CHEMISTRY REVIEWS

Microalgae: a novel ingredient in nutrition

(2011) Efterpi Christaki et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Protective Effect of Chlorella vulgaris against Lead-Induced Oxidative Stress in Rat Brains

(2011) HyeJun Yun et al.   JOURNAL OF HEALTH SCIENCE

Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: A behavioral, biochemical and immunohistological study in Wistar rats

(2011) Syed Shadab Raza et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction

(2011) Doaa A. Ghareeb et al.   METABOLIC BRAIN DISEASE

Restoring the balance

(2011) Sarah Crunkhorn   NATURE REVIEWS DRUG DISCOVERY

Obesity is associated with previous suicide attempts in bipolar disorder

(2010) Fabiano A. Gomes et al.   ACTA NEUROPSYCHIATRICA

Bioprospecting for hyper-lipid producing microalgal strains for sustainable biofuel production

(2010) T. Mutanda et al.   BIORESOURCE TECHNOLOGY

Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer’s Disease Mouse Model

(2010) Nakaba MURATA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice

(2010) Seung-Hwan Kwon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oxygen Radical Absorbance Capacity of Phycocyanin and Phycocyanobilin from the Food Supplement Aphanizomenon flos-aquae

(2010) Serena Benedetti et al.   JOURNAL OF MEDICINAL FOOD

Neural mechanisms of ageing and cognitive decline

(2010) Nicholas A. Bishop et al.   NATURE

Silibinin: A novel inhibitor of Aβ aggregation

(2010) Fei Yin et al.   NEUROCHEMISTRY INTERNATIONAL

Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease

(2010) T. Ahmed et al.   NEUROSCIENCE

Neuroprotective effect of 3,5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1

(2010) J. Han et al.   NEUROSCIENCE

Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: Involvement of estrogen receptors and oxidative stress

(2010) Tourandokht Baluchnejadmojarad et al.   NEUROSCIENCE LETTERS

Cerebrospinal fluid profile of amyloid β42 (Aβ42), hTau and ubiquitin in North Indian Alzheimer's disease patients

(2010) Ramesh JL. Kandimalla et al.   NEUROSCIENCE LETTERS

Inhibiting NF-κB activation and ROS production are involved in the mechanism of silibinin's protection against D-galactose-induced senescence

(2010) Qiong Wang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices

(2010) Touqeer Ahmed et al.   SYNAPSE

Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps

(2009) Oren A. Levy et al.   APOPTOSIS

Aβ Oligomers and Fibrillar Aggregates Induce Different Apoptotic Pathways in LAN5 Neuroblastoma Cell Cultures

(2009) Pasquale Picone et al.   BIOPHYSICAL JOURNAL

Silibinin prevents amyloid β peptide-induced memory impairment and oxidative stress in mice

(2009) P Lu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT)☆

(2009) Tauheed Ishrat et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Effect of silymarin on biochemical parameters of oxidative stress in aged and young rat brain

(2009) F. Galhardi et al.   FOOD AND CHEMICAL TOXICOLOGY

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

(2009) Larry Baum et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Silibinin Attenuates Amyloid  25-35 Peptide-Induced Memory Impairments: Implication of Inducible Nitric-Oxide Synthase and Tumor Necrosis Factor-  in Mice

(2009) P. Lu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation

(2009) Yoshiari Shimmyo et al.   NEUROREPORT

Consumption of Grape Seed Extract Prevents Amyloid-β Deposition and Attenuates Inflammation in Brain of an Alzheimer’s Disease Mouse

(2009) Yan-Jiang Wang et al.   NEUROTOXICITY RESEARCH

Obesity and Lowered Cognitive Performance in a Canadian First Nations Population

(2009) Jennifer H. Fergenbaum et al.   Obesity

Relationship Between Body Mass Index and Brain Volume in Healthy Adults

(2008) John Gunstad et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Curcumin Stimulates Proliferation of Embryonic Neural Progenitor Cells and Neurogenesis in the Adult Hippocampus

(2008) So Jung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of the Antioxidant Action of Silybin and 2,3-Dehydrosilybin Flavonolignans: A Joint Experimental and Theoretical Study

(2008) Patrick Trouillas et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Attenuation of oxidative neuronal cell death by coffee phenolic phytochemicals

(2008) Eun Sun Cho et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Brain foods: the effects of nutrients on brain function

(2008) Fernando Gómez-Pinilla   NATURE REVIEWS NEUROSCIENCE

Benefits from Dietary Polyphenols for Brain Aging and Alzheimer’s Disease

(2008) L. Rossi et al.   NEUROCHEMICAL RESEARCH