Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical–induced DNA damage

Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin

(2017) Reham Atteya et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial dysfunction in fibroblasts derived from patients with Niemann-Pick type C disease

(2016) Marcin Woś et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Immunodetection of human topoisomerase I-DNA covalent complexes

(2016) Anand G. Patel et al.   NUCLEIC ACIDS RESEARCH

Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1

(2016) Waheba Elsayed et al.   Scientific Reports

Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration

(2015) Salim Khiati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors

(2014) Sarah Walker et al.   ANALYTICAL BIOCHEMISTRY

Mitochondrial Topoisomerase I (Top1mt) Is a Novel Limiting Factor of Doxorubicin Cardiotoxicity

(2014) S. Khiati et al.   CLINICAL CANCER RESEARCH

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2)

(2014) Yves Pommier et al.   DNA REPAIR

Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing

(2014) Jean Carroll et al.   HUMAN MOLECULAR GENETICS

Mapping Topoisomerase Sites in Mitochondrial DNA with a Poisonous Mitochondrial Topoisomerase I (Top1mt)

(2014) Ilaria Dalla Rosa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical and Cellular Roles for TDP1 and TOP1 in Modulating Colorectal Cancer Response to Irinotecan

(2014) C. Meisenberg et al.   MOLECULAR CANCER THERAPEUTICS

PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage

(2014) Benu Brata Das et al.   NUCLEIC ACIDS RESEARCH

ATM Deficiency Results in Accumulation of DNA-Topoisomerase I Covalent Intermediates in Neural Cells

(2014) Meryem Alagoz et al.   PLoS One

Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency

(2014) L Carlessi et al.   Cell Death & Disease

Expression profile and mitochondrial colocalization of Tdp1 in peripheral human tissues

(2013) Hok Khim Fam et al.   JOURNAL OF MOLECULAR HISTOLOGY

Tracking the processing of damaged DNA double-strand break ends by ligation-mediated PCR: increased persistence of 3′-phosphoglycolate termini in SCAN1 cells

(2013) Konstantin Akopiants et al.   NUCLEIC ACIDS RESEARCH

Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I

(2013) Stefan Sobek et al.   NUCLEIC ACIDS RESEARCH

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy

(2013) M. Alagoz et al.   NUCLEIC ACIDS RESEARCH

Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites

(2012) Natalia A. Lebedeva et al.   BIOCHIMIE

DNA Repair and Resistance to Topoisomerase I Inhibitors: Mechanisms, Biomarkers and Therapeutic Targets

(2012) M. Alagoz et al.   CURRENT MEDICINAL CHEMISTRY

Measuring sunscreen protection against solar-simulated radiation-induced structural radical damage to skin using ESR/spin trapping: Development of anex vivotest method

(2012) Rachel Haywood et al.   FREE RADICAL RESEARCH

Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells

(2012) Junko Murai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1

(2012) Zhihong Zeng et al.   NUCLEIC ACIDS RESEARCH

Two-dimensional intact mitochondrial DNA agarose electrophoresis reveals the structural complexity of the mammalian mitochondrial genome

(2012) Jill E. Kolesar et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism

(2012) Céline Douarre et al.   PLoS One

A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity

(2012) Y. Seol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets

(2011) D C Gilbert et al.   BRITISH JOURNAL OF CANCER

To live or to die: a matter of processing damaged DNA termini in neurons

(2011) Sherif F. El-Khamisy   EMBO Molecular Medicine

Chronically elevated glucose compromises myocardial mitochondrial DNA integrity by alteration of mitochondrial topoisomerase function

(2010) S. Medikayala et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inhibition of mitochondrial respiration mediates apoptosis induced by the anti-tumoral alkaloid lamellarin D

(2010) Caroline Ballot et al.   APOPTOSIS

Distinguishing the Roles of Topoisomerases I and II in Relief of Transcription-Induced Torsional Stress in Yeast rRNA Genes

(2010) S. L. French et al.   MOLECULAR AND CELLULAR BIOLOGY

Intensity-dependent Direct Solar Radiation- and UVA-induced Radical Damage to Human Skin and DNA, Lipids and Proteins

(2010) Rachel Haywood et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria

(2010) B. B. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis

(2009) Jianxin Lu et al.   CELL RESEARCH

Tyrosyl-DNA phosphodiesterase and the repair of 3′-phosphoglycolate-terminated DNA double-strand breaks

(2009) Tong Zhou et al.   DNA REPAIR

Mitochondrial Topoisomerase I Sites in the Regulatory D-Loop Region of Mitochondrial DNA†

(2008) Hongliang Zhang et al.   BIOCHEMISTRY

Single-strand break repair and genetic disease

(2008) Keith W. Caldecott   NATURE REVIEWS GENETICS

Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation

(2008) Xuan Fu et al.   PLoS One

Protein, lipid, and DNA radicals to measure skin UVA damage and modulation by melanin

(2007) Rachel Haywood et al.   FREE RADICAL BIOLOGY AND MEDICINE