Oxidative Stress, Neuroinflammation and Mitochondria in the Pathophysiology of Amyotrophic Lateral Sclerosis

Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study

(2019) JosÉ E. de la Rubia et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

(2019) Zhiqiang Deng et al.   Autophagy

Increased Interleukin-6 Levels in the Astrocyte-Derived Exosomes of Sporadic Amyotrophic Lateral Sclerosis Patients

(2019) Yong Chen et al.   Frontiers in Neuroscience

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

(2019) Vandana Deora et al.   GLIA

Could Conservative Iron Chelation Lead to Neuroprotection in Amyotrophic Lateral Sclerosis?

(2018) Caroline Moreau et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuroinflammation in Amyotrophic Lateral Sclerosis: Role of Redox (dys)Regulation

(2018) Nadia D'Ambrosi et al.   ANTIOXIDANTS & REDOX SIGNALING

Acute Effects of Riluzole and Retigabine on Axonal Excitability in Patients With Amyotrophic Lateral Sclerosis: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

(2018) Maria O. Kovalchuk et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Infectious agents and amyotrophic lateral sclerosis: another piece of the puzzle of motor neuron degeneration

(2018) David Castanedo-Vazquez et al.   JOURNAL OF NEUROLOGY

Autophagy and mitophagy in ALS

(2018) Chantell S. Evans et al.   NEUROBIOLOGY OF DISEASE

TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics

(2018) Stephani A. Davis et al.   NEUROSCIENCE LETTERS

The multi-dimensional roles of astrocytes in ALS

(2018) Koji Yamanaka et al.   NEUROSCIENCE RESEARCH

Analysis of endocannabinoid receptors and enzymes in the post-mortem motor cortex and spinal cord of amyotrophic lateral sclerosis patients

(2018) Francisco Espejo-Porras et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients

(2018) Daisy Sproviero et al.   Frontiers in Neuroscience

Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase

(2018) Patrick Oeckl et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis

(2018) Xi Chen et al.   Frontiers in Immunology

SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis

(2018) Adrianna Z. Herskovits et al.   AGING CELL

Amyotrophic Lateral Sclerosis and Occupational Exposures: A Systematic Literature Review and Meta-Analyses

(2018) Lars-Gunnar Gunnarsson et al.   International Journal of Environmental Research and Public Health

Metals and neurodegenerative diseases. A systematic review

(2017) Calogero Edoardo Cicero et al.   ENVIRONMENTAL RESEARCH

Clinical efficacy of edaravone for the treatment of amyotrophic lateral sclerosis

(2017) Hideyuki Sawada   EXPERT OPINION ON PHARMACOTHERAPY

Targeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 and Their Relevance for Treatment of Spinal Cord Injury

(2017) Kathleen Keefe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Drug therapy: On the treatment trail for ALS

(2017) Andrew Scott   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

SIRT3 and mitochondrial metabolism in neurodegenerative diseases

(2017) Illari Salvatori et al.   NEUROCHEMISTRY INTERNATIONAL

Possible concurrence of TDP-43, tau and other proteins in amyotrophic lateral sclerosis/frontotemporal lobar degeneration

(2017) Takahiro Takeda   NEUROPATHOLOGY

The role of mitochondria in amyotrophic lateral sclerosis

(2017) Emma F. Smith et al.   NEUROSCIENCE LETTERS

ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?

(2017) Dmitry Petrov et al.   Frontiers in Aging Neuroscience

Exploring the diagnosis delay and ALS functional impairment at diagnosis as relevant criteria for clinical trial enrolment*

(2017) Bello Hamidou et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications

(2017) Jia Liu et al.   Frontiers in Immunology

SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury

(2016) Yedong Cheng et al.   APOPTOSIS

Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning

(2016) Fen Xue et al.   BEHAVIOURAL BRAIN RESEARCH

SIRT1-mediated deacetylation of PGC1α attributes to the protection of curcumin against glutamate excitotoxicity in cortical neurons

(2016) Ning Jia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuroprotective effects of pterostilbene against oxidative stress injury: Involvement of nuclear factor erythroid 2-related factor 2 pathway

(2016) Bodong Wang et al.   BRAIN RESEARCH

Enhancing NAD+Salvage Pathway Reverts the Toxicity of Primary Astrocytes Expressing Amyotrophic Lateral Sclerosis-linked Mutant Superoxide Dismutase 1 (SOD1)

(2016) Benjamin A. Harlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

(2016) Emiliano Trias et al.   Journal of Neuroinflammation

Pterostilbene Attenuates Early Brain Injury Following Subarachnoid Hemorrhage via Inhibition of the NLRP3 Inflammasome and Nox2-Related Oxidative Stress

(2016) Haixiao Liu et al.   MOLECULAR NEUROBIOLOGY

Sirt1 and the Mitochondria

(2016)   MOLECULES AND CELLS

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Gene discovery in amyotrophic lateral sclerosis: implications for clinical management

(2016) Ammar Al-Chalabi et al.   Nature Reviews Neurology

Physical activity, and physical activity related to sports, leisure and occupational activity as risk factors for ALS: A systematic review

(2016) Eleonora Lacorte et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model

(2016) Siqi Xu et al.   Oxidative Medicine and Cellular Longevity

Epidemiology of amyotrophic lateral sclerosis: A review of literature

(2016) P. Couratier et al.   REVUE NEUROLOGIQUE

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

(2016) Samuel A. J. Trammell et al.   Nature Communications

Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment

(2015) Minghai Zhou et al.   BRAIN

Interactions of innate and adaptive immunity in brain development and function

(2015) Anthony J. Filiano et al.   BRAIN RESEARCH

Aspirin Use Associated With Amyotrophic Lateral Sclerosis: a Total Population-Based Case-Control Study

(2015) Ching-Piao Tsai et al.   JOURNAL OF EPIDEMIOLOGY

Epidemiology of mild traumatic brain injury and neurodegenerative disease

(2015) Raquel C. Gardner et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The dual roles of immunity in ALS: Injury overrides protection

(2015) Benjamin J. Murdock et al.   NEUROBIOLOGY OF DISEASE

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

(2015) Kristopher G. Hooten et al.   Neurotherapeutics

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia

(2015) Rowan A. Radford et al.   Frontiers in Cellular Neuroscience

High yield extraction of pure spinal motor neurons, astrocytes and microglia from single embryo and adult mouse spinal cord

(2015) Marie-Josée Beaudet et al.   Scientific Reports

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Over-expression of the Sirt3 sirtuin Protects neuronally differentiated PC12 Cells from degeneration induced by oxidative stress and trophic withdrawal

(2014) Natalya Shulyakova et al.   BRAIN RESEARCH

Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis

(2014) Urte Neniskyte et al.   FEBS LETTERS

Sirt3 Protects Cortical Neurons against Oxidative Stress via Regulating Mitochondrial Ca2+ and Mitochondrial Biogenesis

(2014) Shu-Hui Dai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects

(2014) Haiyan Qiu et al.   JOURNAL OF CLINICAL INVESTIGATION

Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

(2014) Diane B. Re et al.   NEURON

Motor cortex glutathione deficit in ALS measured in vivo with the J-editing technique

(2014) N. Weiduschat et al.   NEUROSCIENCE LETTERS

Glucocorticoid Receptor Knockdown Decreases the Antioxidant Protection of B16 Melanoma Cells: An Endocrine System-Related Mechanism that Compromises Metastatic Cell Resistance to Vascular Endothelium-Induced Tumor Cytotoxicity

(2014) Elena Obrador et al.   PLoS One

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis

(2014) Eveliina Pollari et al.   Frontiers in Cellular Neuroscience

Resveratrol Ameliorates Motor Neuron Degeneration and Improves Survival in SOD1G93AMouse Model of Amyotrophic Lateral Sclerosis

(2014) Lin Song et al.   Biomed Research International

CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis

(2014) Matthew C Evans et al.   Acta Neuropathologica Communications

Retroviruses and amyotrophic lateral sclerosis

(2013) Tariq Alfahad et al.   ANTIVIRAL RESEARCH

Sirtuins as therapeutic targets of ALS

(2013) Giulio Maria Pasinetti et al.   CELL RESEARCH

Pterostilbene: Biomedical applications

(2013) José M. Estrela et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Aberrant Assembly of RNA Recognition Motif 1 Links to Pathogenic Conversion of TAR DNA-binding Protein of 43 kDa (TDP-43)

(2013) Akemi Shodai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyotrophic Lateral Sclerosis: An update for 2013 Clinical Features, Pathophysiology, Management and Therapeutic Trials

(2013) Paul Gordon et al.   Aging and Disease

Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice

(2012) Soyoung Han et al.   BRAIN RESEARCH

Impaired antioxydative Keap1/Nrf2 system and the downstream stress protein responses in the motor neuron of ALS model mice

(2012) Takafumi Mimoto et al.   BRAIN RESEARCH

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival

(2012) Jenny S. Henkel et al.   EMBO Molecular Medicine

SIRT3 regulation of mitochondrial oxidative stress

(2012) Alexandra S. Bause et al.   EXPERIMENTAL GERONTOLOGY

Decreased mRNA Expression of PGC-1α and PGC-1α-Regulated Factors in the SOD1G93AALS Mouse Model and in Human Sporadic ALS

(2012) Nadine Thau et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms

(2012) Weihua Zhao et al.   NEUROBIOLOGY OF DISEASE

Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: Neuroprotection by SIRT3 and PGC-1α

(2012) Wenjun Song et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial complex I deficiency and ATP/ADP ratio in lymphocytes of amyotrophic lateral sclerosis patients

(2012) Parisa Ghiasi et al.   NEUROLOGICAL RESEARCH

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway

(2011) Pei Wang et al.   ANNALS OF NEUROLOGY

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

(2011) Todd J Cohen et al.   EMBO JOURNAL

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

(2011) Arie Neymotin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial pathobiology in ALS

(2011) Lee J. Martin   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS

(2010) Adrian Israelson et al.   NEURON

Mutant TAR DNA-binding protein-43 induces oxidative injury in motor neuron-like cell

(2010) W. Duan et al.   NEUROSCIENCE

Astrogliosis in amyotrophic lateral sclerosis: Role and therapeutic potential of astrocytes

(2010) Marcelo R. Vargas et al.   Neurotherapeutics

Intercellular Glutamate Signaling in the Nervous System and Beyond

(2009) David E. Featherstone   ACS Chemical Neuroscience

Diet and Amyotrophic Lateral Sclerosis

(2009) Natalia Morozova et al.   EPIDEMIOLOGY

The mitochondrial permeability transition pore in motor neurons: Involvement in the pathobiology of ALS mice

(2009) Lee J. Martin et al.   EXPERIMENTAL NEUROLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Glutathione and apoptosis

(2008) Magdalena L. Circu et al.   FREE RADICAL RESEARCH

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

(2008) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA