Simvastatin Inhibits Activation of NADPH Oxidase/p38 MAPK Pathway and Enhances Expression of Antioxidant Protein in Parkinson Disease Models

Complement receptor 3 mediates NADPH oxidase activation and dopaminergic neurodegeneration through a Src-Erk-dependent pathway

(2018) Liyan Hou et al.   Redox Biology

Amyloid-beta peptide decreases expression and function of glutamate transporters in nervous system cells

(2017) Huichun Tong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Simvastatin Protects Human Melanocytes from H 2 O 2 -Induced Oxidative Stress by Activating Nrf2

(2017) Yuqian Chang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Parkinsonian features in aging GFAP.HMOX1 transgenic mice overexpressing human HO-1 in the astroglial compartment

(2017) Wei Song et al.   NEUROBIOLOGY OF AGING

Paraquat and maneb co-exposure induces noradrenergic locus coeruleus neurodegeneration through NADPH oxidase-mediated microglial activation

(2017) Liyan Hou et al.   TOXICOLOGY

NOX Activation by Subunit Interaction and Underlying Mechanisms in Disease

(2017) Radhika Rastogi et al.   Frontiers in Cellular Neuroscience

Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson’s disease

(2017) Yunlong Zhang et al.   Cell Death & Disease

A synthetic cell permeable antioxidant protects neurons against acute oxidative stress

(2017) Nicola J. Drummond et al.   Scientific Reports

Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin: possible role in modulating NADPH oxidase/ROS-mediated NFκB redox signaling cascade

(2017) Lohanathan Bharathi Priya et al.   Scientific Reports

In vitro gastrointestinal digestion promotes the protective effect of blackberry extract against acrylamide-induced oxidative stress

(2017) Wei Chen et al.   Scientific Reports

Neuroprotective effect of sulfated polysaccharide isolated from sea cucumber Stichopus japonicus on 6-OHDA-induced death in SH-SY5Y through inhibition of MAPK and NF-κB and activation of PI3K/Akt signaling pathways

(2016) Chao Cui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Superoxide Dismutase (SOD)-mimetic M40403 Is Protective in Cell and Fly Models of Paraquat Toxicity

(2016) Roberta Filograna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversal effect of simvastatin on the decrease in cannabinoid receptor 1 density in 6-hydroxydopamine lesioned rat brains

(2016) Nikolce Mackovski et al.   LIFE SCIENCES

Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson’s Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions

(2016) Haidy E. Michel et al.   MOLECULAR NEUROBIOLOGY

Palmitoyl Serotonin Inhibits L-dopa-induced Abnormal Involuntary Movements in the Mouse Parkinson Model

(2016) Hye-Yeon Park et al.   Experimental Neurobiology

Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson’s disease models

(2015) Qingshan Wang et al.   BRAIN

A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis

(2015) Lulu Jiang et al.   GLIA

Long-term administration of simvastatin reduces ventilator-induced lung injury and upregulates heme oxygenase 1 expression in a rat model

(2015) Wenjing Zhao et al.   JOURNAL OF SURGICAL RESEARCH

Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson’s Disease via Protein Semisynthesis and Mutagenesis

(2015) Ritwik Burai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transcranial Direct Current Stimulation Ameliorates Behavioral Deficits and Reduces Oxidative Stress in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Mouse Model of Parkinson's Disease

(2015) Chengbiao Lu et al.   NEUROMODULATION

Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson’s disease by enhancing Nrf2 activity

(2015) X. Jing et al.   NEUROSCIENCE

Inhibition of Adenylyl Cyclase Type 5 Prevents L-DOPA-Induced Dyskinesia in an Animal Model of Parkinson's Disease

(2014) H.-Y. Park et al.   JOURNAL OF NEUROSCIENCE

Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase

(2014) Q. Wang et al.   JOURNAL OF NEUROSCIENCE

Simvastatin prevents neuroinflammation by inhibiting N-methyl-D-aspartic acid receptor 1 in 6-hydroxydopamine-treated PC12 cells

(2014) Junqiang Yan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Sleep Fragmentation in Mice Induces Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2-Dependent Mobilization, Proliferation, and Differentiation of Adipocyte Progenitors in Visceral White Adipose Tissue

(2014) Abdelnaby Khalyfa et al.   SLEEP

PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage

(2013) G Arena et al.   CELL DEATH AND DIFFERENTIATION

NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration

(2013) Liya Qin et al.   GLIA

Discontinuation of statin therapy associates with Parkinson disease: A population-based study

(2013) Y.-C. Lee et al.   NEUROLOGY

Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway

(2013) Haiyan Lou et al.   NEUROPHARMACOLOGY

Ameliorative effect of Sida cordifolia in rotenone induced oxidative stress model of Parkinson's disease

(2013) Navneet Khurana et al.   NEUROTOXICOLOGY

Methamphetamine and Parkinson's Disease

(2013) Noelia Granado et al.   Parkinsons Disease

Role of Oxidative Stress in Parkinson's Disease

(2013) Onyou Hwang   Experimental Neurobiology

Prospective Study of Statin Use and Risk of Parkinson Disease

(2012) Xiang Gao   ARCHIVES OF NEUROLOGY

Simvastatin Induces Neuroprotection in 6-OHDA-Lesioned PC12 via the PI3K/AKT/Caspase 3 Pathway and Anti-Inflammatory Responses

(2012) Yun-Qi Xu et al.   CNS Neuroscience & Therapeutics

Statin use and risk of Parkinson’s disease: a meta-analysis of observational studies

(2012) Krishna Undela et al.   JOURNAL OF NEUROLOGY

Meta-Analysis of Statin Effects in Women Versus Men

(2012) William J. Kostis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Reactive Oxygen Species and Inhibitors of Inflammatory Enzymes, NADPH Oxidase, and iNOS in Experimental Models of Parkinson’s Disease

(2012) Sushruta Koppula et al.   MEDIATORS OF INFLAMMATION

Oxidative Stress and Microglial Cells in Parkinson's Disease

(2012) Lynda J. Peterson et al.   MEDIATORS OF INFLAMMATION

RETRACTED: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors

(2012) Julio C. Tobón-Velasco et al.   TOXICOLOGY

NADPH Oxidase 1-Mediated Oxidative Stress Leads to Dopamine Neuron Death in Parkinson's Disease

(2011) Dong-Hee Choi et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH-oxidase activation and cognition in Alzheimer disease progression

(2011) Mubeen A. Ansari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox

(2011) Hui Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parkinson disease: Insights in clinical, genetic and pathological features of monogenic disease subtypes

(2011) David Crosiers et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Activation of NOX2 by the Stimulation of Ionotropic and Metabotropic Glutamate Receptors Contributes to Glutamate Neurotoxicity In Vivo Through the Production of Reactive Oxygen Species and Calpain Activation

(2011) Alicia Guemez-Gamboa et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Evaluation of Markers of Oxidative Stress, Antioxidant Function and Astrocytic Proliferation in the Striatum and Frontal Cortex of Parkinson’s Disease Brains

(2011) Rajeswara Babu Mythri et al.   NEUROCHEMICAL RESEARCH

Can Parkinson's disease pathology be propagated from one neuron to another?

(2011) Christopher J.R. Dunning et al.   PROGRESS IN NEUROBIOLOGY

Involvement of the p38 pathway in the differential induction of heme oxygenase-1 by statins in Neuro-2A cells exposed to lipopolysaccharide

(2010) Ching-Hua Hsieh et al.   DRUG AND CHEMICAL TOXICOLOGY

The Genetics of Parkinson Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Missing pieces in the Parkinson's disease puzzle

(2010) Jose A Obeso et al.   NATURE MEDICINE

Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models

(2009) Li-Fang Hu et al.   AGING CELL

Simvastatin Inhibits the Activation of p21ras and Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson's Disease

(2009) A. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease

(2009) Cristine Alves da Costa et al.   NATURE CELL BIOLOGY

Oxidative and Inflammatory Pathways in Parkinson’s Disease

(2008) Rebecca L. Miller et al.   NEUROCHEMICAL RESEARCH

Total cholesterol and the risk of Parkinson disease

(2008) G. Hu et al.   NEUROLOGY