Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

Oxidative Modification of Brain Proteins in Alzheimer's Disease: Perspective on Future Studies Based on Results of Redox Proteomics Studies

(2018) Rukhsana Sultana et al.   JOURNAL OF ALZHEIMERS DISEASE

Ferulic Acid Improves Cognitive Skills Through the Activation of the Heme Oxygenase System in the Rat

(2017) Emanuela Mhillaj et al.   MOLECULAR NEUROBIOLOGY

Reduction in Post-Synaptic Scaffolding PSD-95 and SAP-102 Protein Levels in the Alzheimer Inferior Temporal Cortex is Correlated with Disease Pathology

(2017) Dustin T. Proctor et al.   JOURNAL OF ALZHEIMERS DISEASE

Nrf2 Weaves an Elaborate Network of Neuroprotection Against Stroke

(2016) Shuai Jiang et al.   MOLECULAR NEUROBIOLOGY

Anthocyanin-Loaded PEG-Gold Nanoparticles Enhanced the Neuroprotection of Anthocyanins in an Aβ1–42 Mouse Model of Alzheimer’s Disease

(2016) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

Anthocyanins control neuroinflammation and consequent memory dysfunction in mice exposed to lipopolysaccharide

(2016) Fabiano B. Carvalho et al.   MOLECULAR NEUROBIOLOGY

Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats

(2016) Abhishek Kumar Singh et al.   MOLECULAR NEUROBIOLOGY

Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and Aβ Aggregates in Hippocampal Neurons: the Role of Mitochondria

(2016) Juan A. Godoy et al.   MOLECULAR NEUROBIOLOGY

Anthocyanins Reversed D-Galactose-Induced Oxidative Stress and Neuroinflammation Mediated Cognitive Impairment in Adult Rats

(2016) Shafiq Ur Rehman et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice

(2016) Ashfaq Ahmad et al.   MOLECULAR NEUROBIOLOGY

Nrf2—a Promising Therapeutic Target for Defensing Against Oxidative Stress in Stroke

(2016) Rongrong Zhang et al.   MOLECULAR NEUROBIOLOGY

Co-Treatment with Anthocyanins and Vitamin C Ameliorates Ethanol- Induced Neurodegeneration via Modulation of GABAB Receptor Signaling in the Adult Rat Brain

(2015) Haroon Badshah et al.   CNS & Neurological Disorders-Drug Targets

Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus

(2015) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Sulforaphane Ameliorates Okadaic Acid-Induced Memory Impairment in Rats by Activating the Nrf2/HO-1 Antioxidant Pathway

(2015) Subhash Dwivedi et al.   MOLECULAR NEUROBIOLOGY

Long-Term Dietary Alpha-Linolenic Acid Supplement Alleviates Cognitive Impairment Correlate with Activating Hippocampal CREB Signaling in Natural Aging Rats

(2015) Hui Gao et al.   MOLECULAR NEUROBIOLOGY

Anti-amyloid Aggregation Activity of Natural Compounds: Implications for Alzheimer’s Drug Discovery

(2015) Xian-Le Bu et al.   MOLECULAR NEUROBIOLOGY

The Natural Flavonoid Pinocembrin: Molecular Targets and Potential Therapeutic Applications

(2015) Xi Lan et al.   MOLECULAR NEUROBIOLOGY

Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice

(2015) Andiara E. Freitas et al.   MOLECULAR NEUROBIOLOGY

Oxidative Stress in Neurodegenerative Diseases

(2015) Ewa Niedzielska et al.   MOLECULAR NEUROBIOLOGY

Protective effects of Anthocyanins against Amyloid beta-induced neurotoxicity in vivo and in vitro

(2015) Haroon Badshah et al.   NEUROCHEMISTRY INTERNATIONAL

Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus

(2015) Tahir Ali et al.   Scientific Reports

Luteolin provides neuroprotection in models of traumatic brain injury via the Nrf2–ARE pathway

(2014) Jianguo Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Salvianolic acid A protects RPE cells against oxidative stress through activation of Nrf2/HO-1 signaling

(2014) Hui Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-KB/JNK signaling pathway in aging mouse model

(2014) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Maged1 Co-interacting with CREB Through a Hexapeptide Repeat Domain Regulates Learning and Memory in Mice

(2014) JianJun Yang et al.   MOLECULAR NEUROBIOLOGY

Protection of the Developing Brain with Anthocyanins Against Ethanol-Induced Oxidative Stress and Neurodegeneration

(2014) Shahid Ali Shah et al.   MOLECULAR NEUROBIOLOGY

Polyphenols as Therapeutic Molecules in Alzheimer’s Disease Through Modulating Amyloid Pathways

(2014) Johant Lakey-Beitia et al.   MOLECULAR NEUROBIOLOGY

Agmatine Induces Nrf2 and Protects Against Corticosterone Effects in Hippocampal Neuronal Cell Line

(2014) Andiara E. Freitas et al.   MOLECULAR NEUROBIOLOGY

Posttreatment with 11-Keto-β-Boswellic Acid Ameliorates Cerebral Ischemia–Reperfusion Injury: Nrf2/HO-1 Pathway as a Potential Mechanism

(2014) Yi Ding et al.   MOLECULAR NEUROBIOLOGY

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease

(2014) Yasuko Kitagishi et al.   Alzheimers Research & Therapy

Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice

(2013) Yanyan Zhou et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Anthocyanins Protect Against Ethanol-Induced Neuronal Apoptosis via GABAB1 Receptors Intracellular Signaling in Prenatal Rat Hippocampal Neurons

(2013) Shahid ali Shah et al.   MOLECULAR NEUROBIOLOGY

Amyloid Precursor Protein Mutation Disrupts Reproductive Experience-Enhanced Normal Cognitive Development in a Mouse Model of Alzheimer's Disease

(2013) Jie Cui et al.   MOLECULAR NEUROBIOLOGY

Food, Nutrigenomics, and Neurodegeneration—Neuroprotection by What You Eat!

(2013) Ashraf Virmani et al.   MOLECULAR NEUROBIOLOGY

(−)-Epigallocatechin-3-Gallate Ameliorates Learning and Memory Deficits by Adjusting the Balance of TrkA/p75NTR Signaling in APP/PS1 Transgenic Mice

(2013) Mingyan Liu et al.   MOLECULAR NEUROBIOLOGY

Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway

(2013) Haiyan Lou et al.   NEUROPHARMACOLOGY

Dietary Levels of Pure Flavonoids Improve Spatial Memory Performance and Increase Hippocampal Brain-Derived Neurotrophic Factor

(2013) Catarina Rendeiro et al.   PLoS One

The effect of ageing on neurogenesis and oxidative stress in the APPswe/PS1deltaE9 mouse model of Alzheimer's disease

(2012) Alison Hamilton et al.   BRAIN RESEARCH

Glycogen synthase kinase-3β regulates anti-inflammatory property of fluoxetine

(2012) Hui-Chen Su et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis

(2012) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Effects of Polyphenols on Brain Ageing and Alzheimer’s Disease: Focus on Mitochondria

(2012) Sebastian Schaffer et al.   MOLECULAR NEUROBIOLOGY

Targeting Synaptic Dysfunction in Alzheimer’s Disease Therapy

(2012) Robert Nisticò et al.   MOLECULAR NEUROBIOLOGY

Protective Effects of Decursin and Decursinol Angelate against Amyloid β-Protein-Induced Oxidative Stress in the PC12 Cell Line: The Role of Nrf2 and Antioxidant Enzymes

(2011) Li LI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

(2011) Janel E. Le Belle et al.   Cell Stem Cell

4-Ketopinoresinol, a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling

(2011) Huang-Hui Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders

(2011) Giovanni Scapagnini et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective effect of naringin, a dietary flavonoid against 3-Nitropropionic acid-induced neuronal apoptosis

(2011) Kulasekaran Gopinath et al.   NEUROCHEMISTRY INTERNATIONAL

β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease

(2010) Li Wan et al.   FREE RADICAL BIOLOGY AND MEDICINE

4-O-Methylhonokiol attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway

(2010) Young Jung Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-, PKA- and PI3K/Akt-dependent pathways and requires GLP-1 receptor

(2010) Ö. Erdogdu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Effect of Purple Sweet Potato Anthocyanins on β-Amyloid-Mediated PC-12 Cells Death by Inhibition of Oxidative Stress

(2009) Junli Ye et al.   NEUROCHEMICAL RESEARCH

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

(2009) K. Kanninen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis

(2009) Marzia Perluigi et al.   Proteomics Clinical Applications

Viral-mediated expression of a constitutively active form of CREB in hippocampal neurons increases memory

(2008) Leonardo Restivo et al.   HIPPOCAMPUS

Amyloid β-Protein Assembly and Alzheimer Disease

(2008) Robin Roychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GSK-3β down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress

(2008) Ana I. Rojo et al.   JOURNAL OF NEUROCHEMISTRY

Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal celldeath

(2008) Ana I. Rojo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

(2008) Katja Kanninen et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

(2008) Young-Joon Surh et al.   PLANTA MEDICA