The mitochondria‐targeted anti‐oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

(2019) Davide D’Amico et al.   MOLECULAR CELL

Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure

(2019) You Wu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Sigma-1 receptor ablation impairs autophagosome clearance

(2019) Huan Yang et al.   Autophagy

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

(2019) Man J. Livingston et al.   Autophagy

Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc

(2019) Xinghuo Wu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Isolevuglandin scavenger attenuates pressure overload-induced cardiac oxidative stress, cardiac hypertrophy, heart failure and lung remodeling

(2019) Linlin Shang et al.   FREE RADICAL BIOLOGY AND MEDICINE

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

(2019) Qisheng Lin et al.   Redox Biology

Critical contribution of RIPK1 mediated mitochondrial dysfunction and oxidative stress to compression-induced rat nucleus pulposus cells necroptosis and apoptosis

(2018) Songfeng Chen et al.   APOPTOSIS

MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α

(2018) Ye Xi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Nrf2 inhibits oxaliplatin-induced peripheral neuropathy via protection of mitochondrial function

(2018) Yang Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

PINK1 Protects Auditory Hair Cells and Spiral Ganglion Neurons from Cisplatin-induced Ototoxicity via Inducing Autophagy and Inhibiting JNK Signaling Pathway

(2018) Qianqian Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway

(2018) Pan Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission

(2018) Xudong Yao et al.   PHARMACOLOGICAL RESEARCH

Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration

(2018) Zengjie Zhang et al.   Cell Death & Disease

Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration

(2018) Yu Song et al.   Redox Biology

Sirtuin 6 prevents matrix degradation through inhibition of the NF-κB pathway in intervertebral disc degeneration

(2017) Liang Kang et al.   EXPERIMENTAL CELL RESEARCH

Mdivi-1 Protects Adult Rat Hippocampal Neural Stem Cells against Palmitate-Induced Oxidative Stress and Apoptosis

(2017) Sehee Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Theo Vos et al.   LANCET

Edaravone ameliorates compression-induced damage in rat nucleus pulposus cells

(2017) Hui Lin et al.   LIFE SCIENCES

Nutrient deprivation induces apoptosis of nucleus pulposus cells via activation of the BNIP3/AIF signalling pathway

(2017) Jie Liu et al.   Molecular Medicine Reports

ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration

(2017) Chencheng Feng et al.   Oxidative Medicine and Cellular Longevity

Hydrogen sulfide protects against endoplasmic reticulum stress and mitochondrial injury in nucleus pulposus cells and ameliorates intervertebral disc degeneration

(2017) Daoliang Xu et al.   PHARMACOLOGICAL RESEARCH

Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover

(2017) Konstantinos Palikaras et al.   PHARMACOLOGY & THERAPEUTICS

Parkin Knockout Inhibits Neuronal Development via Regulation of Proteasomal Degradation of p21

(2017) Mi Hee Park et al.   Theranostics

Mesenchymal Stem Cells Protect Nucleus Pulposus Cells from Compression-Induced Apoptosis by Inhibiting the Mitochondrial Pathway

(2017) Sheng Chen et al.   Stem Cells International

Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications

(2017) Susana Rovira-Llopis et al.   Redox Biology

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Anti-inflammatory Chitosan/Poly-γ-glutamic acid nanoparticles control inflammation while remodeling extracellular matrix in degenerated intervertebral disc

(2016) Graciosa Q. Teixeira et al.   Acta Biomaterialia

MicroRNA-23a-3p promotes the development of osteoarthritis by directly targeting SMAD3 in chondrocytes

(2016) Liang Kang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial fission and fusion

(2016) H. Lee et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Peroxiredoxin 5 prevents amyloid-beta oligomer-induced neuronal cell death by inhibiting ERK–Drp1-mediated mitochondrial fragmentation

(2016) Bokyung Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial dynamics, mitophagy and cardiovascular disease

(2016) César Vásquez-Trincado et al.   JOURNAL OF PHYSIOLOGY-LONDON

Melatonin antagonizes cadmium-induced neurotoxicity by activating the transcription factor EB-dependent autophagy-lysosome machinery in mouse neuroblastoma cells

(2016) Min Li et al.   JOURNAL OF PINEAL RESEARCH

The Effect of Substance P on an Intervertebral Disc Rat Organ Culture Model

(2016) John D. Koerner et al.   SPINE

A Degenerative/Proinflammatory Intervertebral Disc Organ Culture: AnEx VivoModel for Anti-inflammatory Drug and Cell Therapy

(2016) Graciosa Q. Teixeira et al.   TISSUE ENGINEERING PART C-METHODS

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Adipose-Derived Stromal Cells Protect Intervertebral Disc Cells in Compression: Implications for Stem Cell Regenerative Disc Therapy

(2015) Zhen Sun et al.   International Journal of Biological Sciences

Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria

(2015) Ken Itoh et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration

(2015) Satoshi Suzuki et al.   ARTHRITIS RESEARCH & THERAPY

Mitochondrial dynamics and mitochondrial quality control

(2015) Hong-Min Ni et al.   Redox Biology

Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines

(2013) Amarjargal Dashdorj et al.   BMC Medicine

Age-Related Carbonylation of Fibrocartilage Structural Proteins Drives Tissue Degenerative Modification

(2013) Brian Scharf et al.   CHEMISTRY & BIOLOGY

Reactive oxygen species-mediated mitochondrial dysfunction plays a critical role in high glucose-induced nucleus pulposus cell injury

(2013) Lianjun Yang et al.   INTERNATIONAL ORTHOPAEDICS

The molecular basis of intervertebral disc degeneration

(2013) Christopher K. Kepler et al.   Spine Journal

Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells

(2012) Fan Ding et al.   APOPTOSIS

Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants

(2012) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

(2012) Ralf Gold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis

(2011) Balu K. Chacko et al.   HEPATOLOGY

An organ culture system to model early degenerative changes of the intervertebral disc

(2011) Ravi K Ponnappan et al.   ARTHRITIS RESEARCH & THERAPY

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

(2010) Edward J. Gane et al.   LIVER INTERNATIONAL

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

(2010) Barry J. Snow et al.   MOVEMENT DISORDERS

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice

(2009) Sergio Rodriguez-Cuenca et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

(2009) Delyth Graham et al.   HYPERTENSION

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide–peptidoglycan model of sepsis

(2008) Damon A. Lowes et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Simple Disc Degeneration Model Induced by Percutaneous Needle Puncture in the Rat Tail

(2008) Bin Han et al.   SPINE

Factors associated with lumbar intervertebral disc degeneration in the elderly

(2007) Mika Hangai et al.   Spine Journal