- Home
- Publications
- Publication Search
- Publication Details
Title
Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease
Authors
Keywords
-
Journal
Cells
Volume 10, Issue 5, Pages 1236
Publisher
MDPI AG
Online
2021-05-18
DOI
10.3390/cells10051236
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol
- (2021) Juan Carlos Polanco et al. ACTA NEUROPATHOLOGICA
- Mitochondrial dysfunction, mitophagy, and role of dynamin‐related protein 1 in Alzheimer's disease
- (2021) Vijay Krishna Medala et al. JOURNAL OF NEUROSCIENCE RESEARCH
- An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer
- (2021) Jinyoung Kim et al. Nature Communications
- A guide to understanding endoplasmic reticulum stress in metabolic disorders
- (2021) Imke L. Lemmer et al. Molecular Metabolism
- Human amylin aggregates release within exosomes as a protective mechanism in pancreatic β cells: Pancreatic β-hippocampal cell communication
- (2021) J. Burillo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Combined effect of interventions with pure or enriched mixtures of (poly)phenols and anti-diabetic medication in type 2 diabetes management: a meta-analysis of randomized controlled human trials
- (2020) Ana F. Raimundo et al. EUROPEAN JOURNAL OF NUTRITION
- Liraglutide Suppresses Tau Hyperphosphorylation, Amyloid Beta Accumulation through Regulating Neuronal Insulin Signaling and BACE-1 Activity
- (2020) Salinee Jantrapirom et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer
- (2020) Benjamin D. Hopkins et al. Nature Reviews Endocrinology
- Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s Disease
- (2020) Tina Bilousova et al. ACS Chemical Biology
- Autophagy modulates Aβ accumulation and formation of aggregates in yeast
- (2020) Prashant R. Bharadwaj et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure
- (2020) Décio L. Eizirik et al. Nature Reviews Endocrinology
- Presynaptic failure in Alzheimer's disease
- (2020) Gael Barthet et al. PROGRESS IN NEUROBIOLOGY
- Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure
- (2020) Andrea Ruiz-Velasco et al. eLife
- Advances in Knowledge of Candidate Genes Acting at the Beta-Cell Level in the Pathogenesis of T1DM
- (2020) Haipeng Pang et al. Frontiers in Endocrinology
- Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes
- (2020) Justin Hou Ming Yung et al. Cells
- Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro
- (2020) Andrew T. Templin et al. DIABETOLOGIA
- Insulin receptor endocytosis in the pathophysiology of insulin resistance
- (2020) Catherine Hall et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells
- (2020) Prashant Bharadwaj et al. Scientific Reports
- Pathological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: the Receptor for Advanced Glycation End Products (RAGE)
- (2020) Yanyan Kong et al. Frontiers in Aging Neuroscience
- GABAergic Inhibitory Interneuron Deficits in Alzheimer’s Disease: Implications for Treatment
- (2020) Yilan Xu et al. Frontiers in Neuroscience
- Neuroprotective Effects of Chronic Resveratrol Treatment and Exercise Training in the 3xTg-AD Mouse Model of Alzheimer’s Disease
- (2020) Tom L. Broderick et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases
- (2020) Fang Luo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- JAB1 promotes palmitate-induced insulin resistance via ERK pathway in hepatocytes
- (2020) Yun Zhao et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- The role of stress kinases in metabolic disease
- (2020) Ivana Nikolic et al. Nature Reviews Endocrinology
- Mitochondria-Associated Endoplasmic Reticulum Membranes in the Pathogenesis of Type 2 Diabetes Mellitus
- (2020) Shanshan Yang et al. Frontiers in Cell and Developmental Biology
- Impact of Conventional and Atypical MAPKs on the Development of Metabolic Diseases
- (2020) Toufic Kassouf et al. Biomolecules
- Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease
- (2020) Yuanming Li et al. BIOMEDICINE & PHARMACOTHERAPY
- Unsaturated mannuronate oligosaccharide ameliorates β‐amyloid pathology through autophagy in Alzheimer’s disease cell models
- (2020) Decheng Bi et al. CARBOHYDRATE POLYMERS
- X‐box binding protein 1 (XBP1) function in diseases
- (2020) Wenjing Xu et al. CELL BIOLOGY INTERNATIONAL
- The human islet amyloid polypeptide in protein misfolding disorders: Mechanisms of aggregation and interaction with biomembranes
- (2020) Adam El Saghir et al. CHEMISTRY AND PHYSICS OF LIPIDS
- Comprehensive Review on Alzheimer’s Disease: Causes and Treatment
- (2020) Zeinab Breijyeh et al. MOLECULES
- Beta-Cell Mass in Obesity and Type 2 Diabetes, and Its Relation to Pancreas Fat: A Mini-Review
- (2020) Jun Inaishi et al. Nutrients
- Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease
- (2020) Md. Habibur Rahman et al. Frontiers in Pharmacology
- Nutrition and Metabolic Adaptations in Physiological and Complicated Pregnancy: Focus on Obesity and Gestational Diabetes
- (2020) Sara Parrettini et al. Frontiers in Endocrinology
- Alterations of the Endoplasmic Reticulum (ER) Calcium Signaling Molecular Components in Alzheimer’s Disease
- (2020) Mounia Chami et al. Cells
- Signaling mechanisms underlying inhibition of neuroinflammation by resveratrol in neurodegenerative diseases
- (2020) Juan Huang et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer's disease
- (2020) Vandana Bhatia et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- mTOR: A Cellular Regulator Interface in Health and Disease
- (2019) Fahd Boutouja et al. Cells
- Exposure to environmental chemicals and type 1 diabetes: an update
- (2019) Sarah G Howard JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
- Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes
- (2019) Matthew B. Johnson et al. Current Diabetes Reports
- Bromodomain-containing protein 2 promotes lipolysis via ERK/HSL signalling pathway in white adipose tissue of mice
- (2019) Jiuyu Zong et al. GENERAL AND COMPARATIVE ENDOCRINOLOGY
- Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
- (2019) Eunhee Choi et al. Nature Communications
- Blocking Inflammasome Activation Caused by β-Amyloid Peptide (Aβ) and Islet Amyloid Polypeptide (IAPP) through an IAPP Mimic
- (2019) Maryam Aftabizadeh et al. ACS Chemical Neuroscience
- Higher GABA concentration in the medial prefrontal cortex of Type 2 diabetes patients is associated with episodic memory dysfunction
- (2019) Jan‐Willem Thielen et al. HUMAN BRAIN MAPPING
- Amylin as a potential link between type 2 diabetes and alzheimer disease
- (2019) Ivan Martinez‐Valbuena et al. ANNALS OF NEUROLOGY
- Nicotine induces insulin resistance via downregulation of Nrf2 in cardiomyocyte
- (2019) Zhi Li et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Peptide-Based Molecular Strategies To Interfere with Protein Misfolding, Aggregation, and Cell Degeneration
- (2019) Valentina Armiento et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Endoplasmic reticulum stress: A master regulator of metabolic syndrome
- (2019) Sreelekshmi Mohan et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation
- (2019) Anne-Marie Lundsgaard et al. JOURNAL OF LIPID RESEARCH
- Epigenetic Regulation in Etiology of Type 1 Diabetes Mellitus
- (2019) Marie Cerna INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Extracellular vesicles as an emerging tool for the early detection of Alzheimer’s disease
- (2019) Tao-Ran Li et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Advanced Glycation End Products Modulate Amyloidogenic APP Processing and Tau Phosphorylation: A Mechanistic Link between Glycation and the Development of Alzheimer’s Disease
- (2018) Kedar Batkulwar et al. ACS Chemical Neuroscience
- Diabetes mellitus and Alzheimer’s disease: GSK-3β as a potential link
- (2018) Ying Zhang et al. BEHAVIOURAL BRAIN RESEARCH
- NFATc3 deficiency protects against high fat diet (HFD)-induced hypothalamus inflammation and apoptosis via p38 and JNK suppression
- (2018) Meng-Jun Liao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- P53 modulates hepatic insulin sensitivity through NF-κB and p38/ERK MAPK pathways
- (2018) Shanshan Geng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention
- (2018) Thomas Briston et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells
- (2018) Amin Ardestani et al. Cell Metabolism
- Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease
- (2018) Maria Manczak et al. HUMAN MOLECULAR GENETICS
- Protective effects of a G. lucidum proteoglycan on INS-1 cells against IAPP-induced apoptosis via attenuating endoplasmic reticulum stress and modulating CHOP/JNK pathways
- (2018) Yan-Ming He et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Recent Insight into the Correlation of SREBP-Mediated Lipid Metabolism and Innate Immune Response
- (2018) Hyeon Young Park et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications
- (2018) Geert Jan Biessels et al. Nature Reviews Endocrinology
- Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics
- (2018) Miriam García Hernández et al. Cell Death & Disease
- Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity
- (2018) Soh Yamamoto et al. Cell Reports
- Amylin – Its role in the homeostatic and hedonic control of eating and recent developments of amylin analogs to treat obesity
- (2018) Christina Neuner Boyle et al. Molecular Metabolism
- Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes
- (2018) Shangyu Hong et al. Molecular Metabolism
- Genetic Testing of Maturity-Onset Diabetes of the Young Current Status and Future Perspectives
- (2018) Parveena Firdous et al. Frontiers in Endocrinology
- The PI3K/AKT pathway in obesity and type 2 diabetes
- (2018) Xingjun Huang et al. International Journal of Biological Sciences
- Abnormal Hyperphosphorylation of Tau: Sites, Regulation, and Molecular Mechanism of Neurofibrillary Degeneration
- (2018) Jian-Zhi Wang et al. JOURNAL OF ALZHEIMERS DISEASE
- Amyloid-β and Tau Pathology of Alzheimer's Disease Induced by Diabetes in a Rabbit Animal Model
- (2018) Claudine L. Bitel et al. JOURNAL OF ALZHEIMERS DISEASE
- Mechanisms of Insulin Action and Insulin Resistance
- (2018) Max C. Petersen et al. PHYSIOLOGICAL REVIEWS
- δ-Tocopherol promotes thermogenic gene expression via PGC-1α upregulation in 3T3-L1 cells
- (2018) Rieko Tanaka-Yachi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Resveratrol attenuates hIAPP amyloid formation and restores the insulin secretion ability in hIAPP-INS1 cell line via enhancing autophagy
- (2018) Wu Lv et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2019
- (2018) DIABETES CARE
- Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- (2018) E. Ray Dorsey et al. LANCET NEUROLOGY
- Changes in Cerebrospinal Fluid Tau and β-Amyloid Levels in Diabetic and Prediabetic Patients: A Meta-Analysis
- (2018) Yanhui Lu et al. Frontiers in Aging Neuroscience
- Emerging Roles for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) in Pancreatic Beta Cells and Diabetes
- (2018) Tatiana Danilova et al. Frontiers in Physiology
- mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus
- (2018) Carlos Guillén et al. Frontiers in Endocrinology
- Amyloid-induced β-cell dysfunction and islet inflammation are ameliorated by 4-phenylbutyrate (PBA) treatment
- (2017) Joel Montane et al. FASEB JOURNAL
- Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease
- (2017) Yannis Gerakis et al. FEBS Journal
- Amylin
- (2017) Debbie L. Hay HEADACHE
- Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer’s disease
- (2017) Ramesh Kandimalla et al. HUMAN MOLECULAR GENETICS
- mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function
- (2017) Vivian A. Paschoal et al. IMMUNOBIOLOGY
- Endoplasmic Reticulum (ER) Stress and Endocrine Disorders
- (2017) Daisuke Ariyasu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Amylin Treatment Reduces Neuroinflammation and Ameliorates Abnormal Patterns of Gene Expression in the Cerebral Cortex of an Alzheimer’s Disease Mouse Model
- (2017) Erming Wang et al. JOURNAL OF ALZHEIMERS DISEASE
- The β-cell assassin: IAPP cytotoxicity
- (2017) Daniel Raleigh et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation
- (2017) Wen Fu et al. Journal of Neuroinflammation
- A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease
- (2017) Zhonge Chen et al. Lipids in Health and Disease
- Molecular interaction between type 2 diabetes and Alzheimer’s disease through cross-seeding of protein misfolding
- (2017) I Moreno-Gonzalez et al. MOLECULAR PSYCHIATRY
- Hypothalamic Insulin Resistance in Obesity: Effects on Glucose Homeostasis
- (2017) Weiyi Chen et al. NEUROENDOCRINOLOGY
- Multiple target of hAmylin on rat primary hippocampal neurons
- (2017) Nan Zhang et al. NEUROPHARMACOLOGY
- Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease
- (2017) Haihao Zhu et al. NEUROPHARMACOLOGY
- Islet amyloid polypeptide: Another key molecule in Alzheimer’s pathogenesis?
- (2017) Yun Zhang et al. PROGRESS IN NEUROBIOLOGY
- Insulin resistance in Alzheimer's disease
- (2017) Thomas Diehl et al. Translational Research
- Amylin and Leptin: Co-Regulators of Energy Homeostasis and Neuronal Development
- (2017) Barry E. Levin et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Unraveling the Regulation of Hepatic Metabolism by Insulin
- (2017) Paul M. Titchenell et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
- (2017) Manuel Blandino-Rosano et al. Nature Communications
- Mechanistic target of rapamycin is necessary for changes in dendritic spine morphology associated with long-term potentiation
- (2017) Fredrick E. Henry et al. Molecular Brain
- Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets
- (2017) Queenie Hui et al. Molecular Metabolism
- Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis
- (2017) Lili Guo et al. Molecular Metabolism
- Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells
- (2017) Miriam Cnop et al. Molecular Metabolism
- JNK at the crossroad of obesity, insulin resistance, and cell stress response
- (2017) Giovanni Solinas et al. Molecular Metabolism
- Alterations in Mitochondrial Oxidative Stress and Mitophagy in Subjects with Prediabetes and Type 2 Diabetes Mellitus
- (2017) Shipra Bhansali et al. Frontiers in Endocrinology
- Mitochondria-Associated Membranes As Networking Platforms and Regulators of Cancer Cell Fate
- (2017) Maria Livia Sassano et al. Frontiers in Oncology
- Akt activation: A potential strategy to ameliorate insulin resistance
- (2017) Zhengyi Zhang et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Lysosomal cathepsins and their regulation in aging and neurodegeneration
- (2016) Veronika Stoka et al. AGEING RESEARCH REVIEWS
- Insulin-induced cytokine production in macrophages causes insulin resistance in hepatocytes
- (2016) Julia Manowsky et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Identification of natural products with neuronal and metabolic benefits through autophagy induction
- (2016) Yuying Fan et al. Autophagy
- Dietary and donepezil modulation of mTOR signaling and neuroinflammation in the brain
- (2016) Kalavathi Dasuri et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress
- (2016) W. Rozpedek et al. CURRENT MOLECULAR MEDICINE
- Autophagy is a major regulator of beta cell insulin homeostasis
- (2016) Yael Riahi et al. DIABETOLOGIA
- p38 and p38 reprogram liver metabolism by modulating neutrophil infiltration
- (2016) B. Gonzalez-Teran et al. EMBO JOURNAL
- mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type
- (2016) Daojing Li et al. FASEB JOURNAL
- Endoplasmic Reticulum Stress and Associated ROS
- (2016) Hafiz Zeeshan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
- (2016) Francesca Cinti et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Increased GABA concentrations in type 2 diabetes mellitus are related to lower cognitive functioning
- (2016) Frank C.G. van Bussel et al. MEDICINE
- Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus
- (2016) Matthijs K. C. Hesselink et al. Nature Reviews Endocrinology
- Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
- (2016) Naoto Kubota et al. Nature Communications
- Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin
- (2016) Yu Hu et al. Oncotarget
- Altered Expression of Endoplasmic Reticulum Stress Associated Genes in Hippocampus of Learned Helpless Rats: Relevance to Depression Pathophysiology
- (2016) Matthew A. Timberlake et al. Frontiers in Pharmacology
- Novel roles for JNK1 in metabolism
- (2016) Bengt F. Belgardt et al. Aging-US
- Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1
- (2016) Yannis Gerakis et al. Scientific Reports
- In Vivo Seeding and Cross-Seeding of Localized Amyloidosis
- (2015) Marie E. Oskarsson et al. AMERICAN JOURNAL OF PATHOLOGY
- The Role of Endoplasmic Reticulum Stress in Human Pathology
- (2015) Scott A. Oakes et al. Annual Review of Pathology-Mechanisms of Disease
- The endoplasmic reticulum: structure, function and response to cellular signaling
- (2015) Dianne S. Schwarz et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- PINK1/Parkin-mediated mitophagy in mammalian cells
- (2015) Akinori Eiyama et al. CURRENT OPINION IN CELL BIOLOGY
- Alzheimer-associated A oligomers impact the central nervous system to induce peripheral metabolic deregulation
- (2015) J. R. Clarke et al. EMBO Molecular Medicine
- NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease
- (2015) V. Corsetti et al. HUMAN MOLECULAR GENETICS
- PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease
- (2015) Patricia Martín-Maestro et al. HUMAN MOLECULAR GENETICS
- Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains
- (2015) Xuan Ye et al. HUMAN MOLECULAR GENETICS
- Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption
- (2015) Natalie C. Kegulian et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles
- (2015) Gerhard Multhaup et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo
- (2015) Shannon L. Macauley et al. JOURNAL OF CLINICAL INVESTIGATION
- Endoplasmic Reticulum Stress–Induced IRE1α Activation Mediates Cross-Talk of GSK-3β and XBP-1 To Regulate Inflammatory Cytokine Production
- (2015) Sena Kim et al. JOURNAL OF IMMUNOLOGY
- Stress kinases in the modulation of metabolism and energy balance
- (2015) Elisa Manieri et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD
- (2015) Antonella Tramutola et al. JOURNAL OF NEUROCHEMISTRY
- The roles of c-Jun NH2-terminal kinases (JNKs) in obesity and insulin resistance
- (2015) Martin Pal et al. JOURNAL OF PHYSIOLOGY-LONDON
- Association Between Comorbidity Burden and Rapid Cognitive Decline in Individuals with Mild to Moderate Alzheimer's Disease
- (2015) Lauren Aubert et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- SIL1 Rescued Bip Elevation-Related Tau Hyperphosphorylation in ER Stress
- (2015) Zan-Chao Liu et al. MOLECULAR NEUROBIOLOGY
- Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice
- (2015) Marissa J. Schafer et al. NEUROBIOLOGY OF AGING
- Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity
- (2015) Suneng Fu et al. Science Translational Medicine
- Insulin resistance and impaired adipogenesis
- (2015) Birgit Gustafson et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Type 2 diabetes as a protein misfolding disease
- (2015) Abhisek Mukherjee et al. TRENDS IN MOLECULAR MEDICINE
- The critical role of Akt in cardiovascular function
- (2015) Prasanna Abeyrathna et al. VASCULAR PHARMACOLOGY
- PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
- (2015) P. Liu et al. Cancer Discovery
- Autophagic activity in neuronal cell death
- (2015) Robert W. Button et al. Neuroscience Bulletin
- Mitochondrial dynamics and mitochondrial quality control
- (2015) Hong-Min Ni et al. Redox Biology
- Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies
- (2014) Mark Yarchoan et al. ACTA NEUROPATHOLOGICA
- Genetic Ablation of Tau Mitigates Cognitive Impairment Induced by Type 1 Diabetes
- (2014) Serena Abbondante et al. AMERICAN JOURNAL OF PATHOLOGY
- Targeting type 2 diabetes: lessons from a knockout model of insulin receptor substrate 2
- (2014) Joana Moitinho Oliveira et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions
- (2014) Jimena Baleriola et al. CELL
- Pancreatic -Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment
- (2014) A. Bartolome et al. DIABETES
- Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance
- (2014) E. Tubbs et al. DIABETES
- IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice
- (2014) Clara Y. Westwell-Roper et al. DIABETOLOGIA
- Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice
- (2014) Daniel T. Meier et al. DIABETOLOGIA
- Selenium-enriched Spirulina protects INS-1E pancreatic beta cells from human islet amyloid polypeptide-induced apoptosis through suppression of ROS-mediated mitochondrial dysfunction and PI3/AKT pathway
- (2014) Xiao-Ling Li et al. EUROPEAN JOURNAL OF NUTRITION
- Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review
- (2014) Suzanne M. de la Monte EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Role of Extracellular Signal-regulated Kinase 5 in Adipocyte Signaling
- (2014) Hong Zhu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy
- (2014) Nayumi Shigihara et al. JOURNAL OF CLINICAL INVESTIGATION
- Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity
- (2014) Jacqueline F. Rivera et al. JOURNAL OF CLINICAL INVESTIGATION
- An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ
- (2014) Alexander S. Banks et al. NATURE
- PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease
- (2014) Latha Devi et al. NEUROBIOLOGY OF AGING
- The mTOR signaling pathway and neuronal stem/progenitor cell proliferation in the hippocampus are altered during the development of absence epilepsy in a genetic animal model
- (2014) Emilio Russo et al. NEUROLOGICAL SCIENCES
- Chaperones Ameliorate Beta Cell Dysfunction Associated with Human Islet Amyloid Polypeptide Overexpression
- (2014) Lisa Cadavez et al. PLoS One
- Insulin Receptor Signaling in Normal and Insulin-Resistant States
- (2014) J. Boucher et al. Cold Spring Harbor Perspectives in Biology
- Global Epidemiology of Dementia: Alzheimer’s and Vascular Types
- (2014) Liara Rizzi et al. Biomed Research International
- Importance of Beta Cell Function for the Treatment of Type 2 Diabetes
- (2014) Yoshifumi Saisho Journal of Clinical Medicine
- mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies
- (2013) Antonella Caccamo et al. AGING CELL
- Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease
- (2013) Elena Alberdi et al. AGING CELL
- Amylin deposition in the brain: A second amyloid in Alzheimer disease?
- (2013) Kaleena Jackson et al. ANNALS OF NEUROLOGY
- March separate, strike together — Role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease
- (2013) Anne Eckert et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Mitochondrial permeability transition pore is a potential drug target for neurodegeneration
- (2013) Valasani Koteswara Rao et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner
- (2013) A Bononi et al. CELL DEATH AND DIFFERENTIATION
- TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys
- (2013) Mychael V. Lourenco et al. Cell Metabolism
- The machinery of macroautophagy
- (2013) Yuchen Feng et al. CELL RESEARCH
- Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
- (2013) Takayuki Kondo et al. Cell Stem Cell
- Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction
- (2013) Clara Y. Westwell-Roper et al. DIABETES
- Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease
- (2013) Sven Reinhardt et al. FASEB JOURNAL
- Rapamycin extends murine lifespan but has limited effects on aging
- (2013) Frauke Neff et al. JOURNAL OF CLINICAL INVESTIGATION
- Hepatic ERK activity plays a role in energy metabolism
- (2013) Ping Jiao et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Mutations in DEPDC5 cause familial focal epilepsy with variable foci
- (2013) Leanne M Dibbens et al. NATURE GENETICS
- Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits
- (2013) Tao Ma et al. NATURE NEUROSCIENCE
- Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology
- (2013) Miranda E. Orr et al. NEUROBIOLOGY OF AGING
- Rapamycin decreases tau phosphorylation at Ser214 through regulation of cAMP-dependent kinase
- (2013) Yudong Liu et al. NEUROCHEMISTRY INTERNATIONAL
- Molecular links between Alzheimer’s disease and diabetes mellitus
- (2013) Y. Yang et al. NEUROSCIENCE
- Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice
- (2013) Sefika Ozcelik et al. PLoS One
- Brd2 Inhibits Adipogenesis via the ERK1/2 Signaling Pathway in 3T3-L1 Adipocytes
- (2013) Kun Zang et al. PLoS One
- mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology
- (2013) C. Betz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies
- (2013) Kapil Gudala et al. Journal of Diabetes Investigation
- Aβ Secretion and Plaque Formation Depend on Autophagy
- (2013) Per Nilsson et al. Cell Reports
- Epidemiology of Alzheimer Disease
- (2013) R. Mayeux et al. Cold Spring Harbor Perspectives in Medicine
- Linking Metabolic Abnormalities to Apoptotic Pathways in Beta Cells in Type 2 Diabetes
- (2013) Jibran Wali et al. Cells
- Endoplasmic reticulum stress occurs downstream of GluN2B subunit ofN-methyl-D-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers
- (2012) Rui O. Costa et al. AGING CELL
- The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain
- (2012) Megan M. Varnum et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death
- (2012) Alberto Bartolome et al. Autophagy
- Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies
- (2012) Maria Manczak et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
- (2012) Chutima Talchai et al. CELL
- ERK5: Structure, regulation and function
- (2012) Gopika N. Nithianandarajah-Jones et al. CELLULAR SIGNALLING
- Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease
- (2012) Suzanne M. de la Monte Current Alzheimer Research
- Hrd1 Facilitates Tau Degradation and Promotes Neuron Survival
- (2012) Y.X. Shen et al. CURRENT MOLECULAR MEDICINE
- Central Resistin Overexposure Induces Insulin Resistance Through Toll-Like Receptor 4
- (2012) Yacir Benomar et al. DIABETES
- Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
- (2012) K. D. Copps et al. DIABETOLOGIA
- Insulin Has Multiple Antiamyloidogenic Effects on Human Neuronal Cells
- (2012) Giuseppe Pandini et al. ENDOCRINOLOGY
- Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease
- (2012) M. Manczak et al. HUMAN MOLECULAR GENETICS
- Structure, Function, and Modulation of GABAAReceptors
- (2012) Erwin Sigel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
- (2012) Theresa R. Bomfim et al. JOURNAL OF CLINICAL INVESTIGATION
- Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
- (2012) Konrad Talbot et al. JOURNAL OF CLINICAL INVESTIGATION
- MEK/ERK pathway mediates insulin-promoted degradation of MKP-3 protein in liver cells
- (2012) Bin Feng et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer’s disease
- (2012) YUN-QING MA et al. Molecular Medicine Reports
- NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
- (2012) Michael T. Heneka et al. NATURE
- Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration
- (2012) Zu-Hang Sheng et al. NATURE REVIEWS NEUROSCIENCE
- Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model
- (2012) Helle Mark Sickmann et al. NEUROCHEMISTRY INTERNATIONAL
- Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease
- (2012) Latha Devi et al. PLoS One
- Rapamycin Causes Upregulation of Autophagy and Impairs Islets Function Both In Vitro and In Vivo
- (2011) M. Tanemura et al. AMERICAN JOURNAL OF TRANSPLANTATION
- MEK5/ERK5 pathway: The first fifteen years
- (2011) Barbara A. Drew et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- FoxO1, the transcriptional chief of staff of energy metabolism
- (2011) Stavroula Kousteni BONE
- Effects of streptozotocin-induced diabetes on tau phosphorylation in the rat brain
- (2011) Zhongsen Qu et al. BRAIN RESEARCH
- Activation of mTORC2 by Association with the Ribosome
- (2011) Vittoria Zinzalla et al. CELL
- The insulin receptor substrate (IRS) proteins
- (2011) Leslie M. Shaw CELL CYCLE
- Microautophagy: lesser-known self-eating
- (2011) Wen-wen Li et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Consequences of Aberrant Insulin Regulation in the Brain: Can Treating Diabetes be Effective for Alzheimers Disease
- (2011) L. Arab et al. Current Neuropharmacology
- p38 Mitogen-Activated Protein Kinase-Dependent Transactivation of ErbB Receptor Family: A Novel Common Mechanism for Stress-Induced IRS-1 Serine Phosphorylation and Insulin Resistance
- (2011) R. Hemi et al. DIABETES
- Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo
- (2011) Y. Tan et al. DIABETES
- MODY
- (2011) Stefan S. Fajans et al. DIABETES CARE
- Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimerʼs Disease
- (2011) Suzanne M. de la Monte DRUGS
- Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage
- (2011) Maria Manczak et al. HUMAN MOLECULAR GENETICS
- Cyclin-dependent Kinase-5 Is a Key Molecule in Tumor Necrosis Factor-α-induced Insulin Resistance
- (2011) Atsushi Nohara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction
- (2011) C. Westwell-Roper et al. JOURNAL OF IMMUNOLOGY
- Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function
- (2011) H. S. Bateup et al. JOURNAL OF NEUROSCIENCE
- Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
- (2011) M. Cargnello et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis
- (2011) Jaemin Lee et al. NATURE MEDICINE
- Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation
- (2011) Gary E. Gibson et al. NEUROBIOLOGY OF AGING
- AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation
- (2011) Xiao-Hong Li et al. NEUROBIOLOGY OF AGING
- Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits
- (2011) Smita Majumder et al. PLoS One
- Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
- (2011) Loredana Stoica et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases
- (2011) Oscar Vadas et al. Science Signaling
- Endoplasmic reticulum stress and pancreatic β-cell death
- (2011) Sonya G. Fonseca et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Disease-associated amyloid and misfolded protein aggregates activate the inflammasome
- (2011) Seth L. Masters et al. TRENDS IN MOLECULAR MEDICINE
- PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake
- (2010) Kristy Iskandar et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
- (2010) Gökhan S. Hotamisligil CELL
- Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions
- (2010) J F Rivera et al. CELL DEATH AND DIFFERENTIATION
- Irs1 Serine 307 Promotes Insulin Sensitivity in Mice
- (2010) Kyle D. Copps et al. Cell Metabolism
- Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
- (2010) Ling Yang et al. Cell Metabolism
- Chaperone-mediated autophagy in protein quality control
- (2010) Esperanza Arias et al. CURRENT OPINION IN CELL BIOLOGY
- S6K1 Plays a Critical Role in Early Adipocyte Differentiation
- (2010) Larissa S. Carnevalli et al. DEVELOPMENTAL CELL
- MAPK signalling in cellular metabolism: stress or wellness?
- (2010) Helmuth Gehart et al. EMBO REPORTS
- Disruption of the Dopamine D2 Receptor Impairs Insulin Secretion and Causes Glucose Intolerance
- (2010) Isabel García-Tornadú et al. ENDOCRINOLOGY
- Involvement of mitochondrial dysfunction in human islet amyloid polypeptide-induced apoptosis in INS-1E pancreatic beta cells: An effect attenuated by phycocyanin
- (2010) Xiao-Ling Li et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- A Caspase Cleaved Form of Tau Is Preferentially Degraded through the Autophagy Pathway
- (2010) Philip J. Dolan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau
- (2010) Antonella Caccamo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly
- (2010) Takeshi Kaizuka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
- (2010) Noriyuki Matsuda et al. JOURNAL OF CELL BIOLOGY
- Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid- Generation
- (2010) M. Kaneko et al. JOURNAL OF NEUROSCIENCE
- Autophagy: cellular and molecular mechanisms
- (2010) Danielle Glick et al. JOURNAL OF PATHOLOGY
- SYMPOSIUM REVIEW: The role of the KATPchannel in glucose homeostasis in health and disease: more than meets the islet
- (2010) James S. McTaggart et al. JOURNAL OF PHYSIOLOGY-LONDON
- Requirement of JIP1-Mediated c-Jun N-Terminal Kinase Activation for Obesity-Induced Insulin Resistance
- (2010) C. Morel et al. MOLECULAR AND CELLULAR BIOLOGY
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- Diacylglycerol-mediated insulin resistance
- (2010) Derek M Erion et al. NATURE MEDICINE
- PTEN deletion enhances the regenerative ability of adult corticospinal neurons
- (2010) Kai Liu et al. NATURE NEUROSCIENCE
- Tsc2-Rheb signaling regulates EphA-mediated axon guidance
- (2010) Duyu Nie et al. NATURE NEUROSCIENCE
- The emerging mechanisms of isoform-specific PI3K signalling
- (2010) Bart Vanhaesebroeck et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Alzheimer's Disease
- (2010) Henry W. Querfurth et al. NEW ENGLAND JOURNAL OF MEDICINE
- Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease
- (2010) Tao Ma et al. PLoS One
- The Akt–SREBP nexus: cell signaling meets lipid metabolism
- (2010) James R. Krycer et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus
- (2009) Jeroen J.M. Hoozemans et al. AMERICAN JOURNAL OF PATHOLOGY
- Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation
- (2009) Cinzia Dello Russo et al. BIOCHEMICAL PHARMACOLOGY
- DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
- (2009) Timothy R. Peterson et al. CELL
- Prevention of Steatosis by Hepatic JNK1
- (2009) Guadalupe Sabio et al. Cell Metabolism
- Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease
- (2009) R. Deane et al. CNS & Neurological Disorders-Drug Targets
- The Role of IGF-1 Receptor and Insulin Receptor Signaling for the Pathogenesis of Alzheimers Disease: From Model Organisms to Human Disease
- (2009) S. Freude et al. Current Alzheimer Research
- An Emerging Role of mTOR in Lipid Biosynthesis
- (2009) Mathieu Laplante et al. CURRENT BIOLOGY
- Successful Versus Failed Adaptation to High-Fat Diet-Induced Insulin Resistance: The Role of IAPP-Induced -Cell Endoplasmic Reticulum Stress
- (2009) A. V. Matveyenko et al. DIABETES
- Endoplasmic Reticulum Stress: Another Link Between Obesity and Insulin Resistance/Inflammation?
- (2009) G. Boden DIABETES
- Emerging common themes in regulation of PIKKs and PI3Ks
- (2009) Harri Lempiäinen et al. EMBO JOURNAL
- Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: Role of p38 MAPK
- (2009) Tara L. Archuleta et al. FREE RADICAL BIOLOGY AND MEDICINE
- Inflammation and endoplasmic reticulum stress in obesity and diabetes
- (2009) G S Hotamisligil INTERNATIONAL JOURNAL OF OBESITY
- FoxO1 Controls Insulin-dependent Adipose Triglyceride Lipase (ATGL) Expression and Lipolysis in Adipocytes
- (2009) Partha Chakrabarti et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
- (2009) Ian G. Ganley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glycolytic Flux Signals to mTOR through Glyceraldehyde-3-Phosphate Dehydrogenase-Mediated Regulation of Rheb
- (2009) M. N. Lee et al. MOLECULAR AND CELLULAR BIOLOGY
- The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis
- (2009) Yiguo Wang et al. NATURE
- Molecular mechanisms of mTOR-mediated translational control
- (2009) Xiaoju Max Ma et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions
- (2009) Yaping Chu et al. NEUROBIOLOGY OF DISEASE
- Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus
- (2009) Tony Valente et al. NEUROBIOLOGY OF DISEASE
- RAGE-mediated signaling contributes to intraneuronal transport of amyloid- and neuronal dysfunction
- (2009) K. Takuma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mTOR signaling: At the crossroads of plasticity, memory and disease
- (2009) Charles A. Hoeffer et al. TRENDS IN NEUROSCIENCES
- Phosphorylation of IRS proteins, insulin action, and insulin resistance
- (2008) Sigalit Boura-Halfon et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia
- (2008) Hye Seung Jung et al. Cell Metabolism
- Selective versus Total Insulin Resistance: A Pathogenic Paradox
- (2008) Michael S. Brown et al. Cell Metabolism
- Free fatty acids and skeletal muscle insulin resistance
- (2008) Edward W Kraegen et al. CURRENT OPINION IN LIPIDOLOGY
- The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
- (2008) Fiona Pickford et al. JOURNAL OF CLINICAL INVESTIGATION
- Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
- (2008) Hiraku Ono et al. JOURNAL OF CLINICAL INVESTIGATION
- Forskolin induction of late-LTP and up-regulation of 5 TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells
- (2008) Delphine Gobert et al. JOURNAL OF NEUROCHEMISTRY
- Biphasic Response of Pancreatic -Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice
- (2008) Y. Shigeyama et al. MOLECULAR AND CELLULAR BIOLOGY
- mGluR-Dependent Long-Term Depression Is Associated with Increased Phosphorylation of S6 and Synthesis of Elongation Factor 1A but Remains Expressed in S6K-Deficient Mice
- (2008) M. D. Antion et al. MOLECULAR AND CELLULAR BIOLOGY
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease
- (2008) Melanie Meyer-Luehmann et al. NATURE
- Regulation of TORC1 by Rag GTPases in nutrient response
- (2008) Eunjung Kim et al. NATURE CELL BIOLOGY
- The NALP3 inflammasome is involved in the innate immune response to amyloid-β
- (2008) Annett Halle et al. NATURE IMMUNOLOGY
- Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
- (2008) Tracy O'Connor et al. NEURON
- Disruption of Tsc2 in pancreatic cells induces cell mass expansion and improved glucose tolerance in a TORC1-dependent manner
- (2008) L. Rachdi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The amyloid -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
- (2008) C. A. Hansson Petersen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amyloid beta oligomers induce impairment of neuronal insulin receptors
- (2007) Wei-Qin Zhao et al. FASEB JOURNAL
- Aβ inhibits the proteasome and enhances amyloid and tau accumulation
- (2007) Bertrand P. Tseng et al. NEUROBIOLOGY OF AGING
- Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients
- (2007) Johanna Ojala et al. NEUROBIOLOGY OF AGING
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started