Mitochondria-Associated Endoplasmic Reticulum Membranes in the Pathogenesis of Type 2 Diabetes Mellitus

Emerging roles of β-cell mitochondria in type-2-diabetes

(2020) Guy Las et al.   MOLECULAR ASPECTS OF MEDICINE

mPTP opening caused by Cdk5 loss is due to increased mitochondrial Ca2+ uptake

(2020) Saranya NavaneethaKrishnan et al.   ONCOGENE

Sphingolipids distribution at mitochondria-associated membranes (MAM) upon induction of apoptosis.

(2020) Vincent Mignard et al.   JOURNAL OF LIPID RESEARCH

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

(2020) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria and diabetes

(2020) Gerasimos Siasos et al.   Annals of Translational Medicine

Mitochondrial Dysfunction in Type 2 Diabetes Mellitus: An Organ-Based Analysis

(2019) Mark V Pinti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Unraveling the Regulation of Hepatic Gluconeogenesis

(2019) Xueping Zhang et al.   Frontiers in Endocrinology

Deficiency of Mitophagy Receptor FUNDC1 Impairs Mitochondrial Quality and Aggravates Dietary-Induced Obesity and Metabolic Syndrome

(2019) Hao Wu et al.   Autophagy

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

(2019) Amado Carreras-Sureda et al.   NATURE CELL BIOLOGY

Inhibition of Mitofusin-2 Promotes Cardiac Fibroblast Activation via the PERK/ATF4 Pathway and Reactive Oxygen Species

(2019) Yanguo Xin et al.   Oxidative Medicine and Cellular Longevity

Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output

(2019) Hristina Ivanova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MITOL prevents ER stress‐induced apoptosis by IRE1α ubiquitylation at ER–mitochondria contact sites

(2019) Keisuke Takeda et al.   EMBO JOURNAL

VDAC1 and the TSPO: Expression, Interactions, and Associated Functions in Health and Disease States

(2019) Varda Shoshan-Barmatz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATG2 regulation of phagophore expansion at mitochondria-associated ER membranes

(2019) Zhenyuan Tang et al.   Autophagy

The roles of mitochondria-associated membranes in mitochondrial quality control under endoplasmic reticulum stress

(2019) Beiwu Lan et al.   LIFE SCIENCES

Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes

(2019) Rajarshi Ghosh et al.   Molecular Metabolism

Mechanistic Connections between Endoplasmic Reticulum (ER) Redox Control and Mitochondrial Metabolism

(2019) Yuxiang Fan et al.   Cells

DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1

(2019) Yi Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Mitochondria-Associated Membranes (MAMs) by NO/sGC/PKG Participates in the Control of Hepatic Insulin Response

(2019) Arthur Bassot et al.   Cells

Deficiency in the short-chain acyl-CoA dehydrogenase protects mice against diet-induced obesity and insulin resistance

(2019) Yulong Chen et al.   FASEB JOURNAL

Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane

(2019) Stefano Bestetti et al.   Redox Biology

Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca 2+ -calcineurin-Akt axis

(2018) Mario Navarro-Marquez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Endoplasmic reticulum chaperones tweak the mitochondrial calcium rheostat to control metabolism and cell death

(2018) Tomas Gutiérrez et al.   CELL CALCIUM

Endoplasmic reticulum-resident selenoproteins as regulators of calcium signaling and homeostasis

(2018) Matthew W. Pitts et al.   CELL CALCIUM

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca 2+ Transfer

(2018) Riccardo Filadi et al.   CURRENT BIOLOGY

Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans

(2018) Emily Tubbs et al.   DIABETES

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

(2018) N.H. Cho et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

FGF21 gene therapy as treatment for obesity and insulin resistance

(2018) Veronica Jimenez et al.   EMBO Molecular Medicine

Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites

(2018) Thomas Di Mattia et al.   EMBO REPORTS

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

(2018) Gian-Luca McLelland et al.   eLife

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells

(2018) Enming Zhang et al.   Cell Metabolism

PDK4 Augments ER-Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity

(2018) Themis Thoudam et al.   DIABETES

An Insulin-Responsive Sensor in the SIRT1 Disordered Region Binds DBC1 and PACS-2 to Control Enzyme Activity

(2018) Troy C. Krzysiak et al.   MOLECULAR CELL

An Inconvenient Truth: Calcium Sensors Are Calcium Buffers

(2018) Shane M. McMahon et al.   TRENDS IN NEUROSCIENCES

Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75

(2018) Manuela D’Eletto et al.   Cell Reports

Retinoic acid receptor-related orphan receptor α stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress

(2017) Yin Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Calcium Homeostasis by ER Redox: A Close-Up of the ER/Mitochondria Connection

(2017) Alexander L. Chernorudskiy et al.   JOURNAL OF MOLECULAR BIOLOGY

ER-mitochondria tethering by PDZD8 regulates Ca2+dynamics in mammalian neurons

(2017) Yusuke Hirabayashi et al.   SCIENCE

A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling

(2017) Jemma Gatliff et al.   Cell Death & Disease

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling

(2017) Mee-Sup Yoon   Nutrients

ROS Control Mitochondrial Motility through p38 and the Motor Adaptor Miro/Trak

(2017) Valentina Debattisti et al.   Cell Reports

Mitochondrial metabolic regulation by GRP78

(2017) Manoj Prasad et al.   Science Advances

Modeling analysis of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ mobilization under the control of glucagon-like peptide-1 in mouse pancreatic β-cells

(2016) Yukari Takeda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

Coordination of stress, Ca2+, and immunogenic signaling pathways by PERK at the endoplasmic reticulum

(2016) Alexander R. van Vliet et al.   BIOLOGICAL CHEMISTRY

Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells

(2016) Jing Wang et al.   CELLULAR SIGNALLING

FUNDC1 regulates mitochondrial dynamics at the ER–mitochondrial contact site under hypoxic conditions

(2016) Wenxian Wu et al.   EMBO JOURNAL

ORP5/ORP8 localize to endoplasmic reticulum–mitochondria contacts and are involved in mitochondrial function

(2016) Romain Galmes et al.   EMBO REPORTS

Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface

(2016) David M. Booth et al.   MOLECULAR CELL

Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether

(2016) Deborah Naon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

(2016) Samantha C. Lewis et al.   SCIENCE

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver

(2016) Pierre Theurey et al.   Journal of Molecular Cell Biology

Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice

(2016) Aleix Sala-Vila et al.   Scientific Reports

Mitochondria-Associated Membranes: Composition, Molecular Mechanisms, and Physiopathological Implications

(2015) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of Mitofusin-2 in mitochondrial localization and calcium uptake in skeletal muscle

(2015) Alina Ainbinder et al.   CELL CALCIUM

A Role for the Ancient SNARE Syntaxin 17 in Regulating Mitochondrial Division

(2015) Kohei Arasaki et al.   DEVELOPMENTAL CELL

Contribution of mitochondria and endoplasmic reticulum dysfunction in insulin resistance: Distinct or interrelated roles?

(2015) J. Rieusset   DIABETES & METABOLISM

Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance

(2015) Jennifer Rieusset et al.   DIABETOLOGIA

Mitochondria-Associated Membrane Formation in Hormone-Stimulated Leydig Cell Steroidogenesis: Role of ATAD3

(2015) Leeyah Issop et al.   ENDOCRINOLOGY

p66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosis

(2015) Sahar S Bhat et al.   Molecular Cancer

Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein

(2015) Y Teng et al.   ONCOGENE

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alteration in mitochondrial Ca 2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes

(2014) Tomás Gutiérrez et al.   Cell Communication and Signaling

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

(2014) E. Tubbs et al.   DIABETES

SEPN1, an endoplasmic reticulum-localized selenoprotein linked to skeletal muscle pathology, counteracts hyperoxidation by means of redox-regulating SERCA2 pump activity

(2014) Marianna Marino et al.   HUMAN MOLECULAR GENETICS

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reversible Blockade of Complex I or Inhibition of PKCβ Reduces Activation and Mitochondria Translocation of p66Shc to Preserve Cardiac Function after Ischemia

(2014) Meiying Yang et al.   PLoS One

A Mitofusin-2–dependent inactivating cleavage of Opa1 links changes in mitochondriacristaeand ER contacts in the postprandial liver

(2014) Aditi Sood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner

(2013) A Bononi et al.   CELL DEATH AND DIFFERENTIATION

Mfn2 modulates the UPR and mitochondrial function via repression of PERK

(2013) Juan Pablo Muñoz et al.   EMBO JOURNAL

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum

(2013) A. M. Benham et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Osbpl8 Deficiency in Mouse Causes an Elevation of High-Density Lipoproteins and Gender-Specific Alterations of Lipid Metabolism

(2013) Olivier Béaslas et al.   PLoS One

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

(2013) C. Betz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

(2013) F. Korobova et al.   SCIENCE

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ero1α Regulates Ca2+ Fluxes at the Endoplasmic Reticulum–Mitochondria Interface (MAM)

(2011) Tiziana Anelli et al.   ANTIOXIDANTS & REDOX SIGNALING

VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria

(2011) D De Stefani et al.   CELL DEATH AND DIFFERENTIATION

Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in Aging

(2011) Daniel C. Andersson et al.   Cell Metabolism

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

(2011) Kurt J. De Vos et al.   HUMAN MOLECULAR GENETICS

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

(2011) R. Bravo et al.   JOURNAL OF CELL SCIENCE

The Soluble Form of Bax Regulates Mitochondrial Fusion via MFN2 Homotypic Complexes

(2011) Suzanne Hoppins et al.   MOLECULAR CELL

Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4

(2011) Q.-A. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction

(2010) Ryota Iwasawa et al.   EMBO JOURNAL

Trichoplein/mitostatin regulates endoplasmic reticulum–mitochondria juxtaposition

(2010) Cristina Cerqua et al.   EMBO REPORTS

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

(2010) György Csordás et al.   MOLECULAR CELL

PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release

(2010) C. Giorgi et al.   SCIENCE

Mitochondrial Reactive Oxygen Species Production in Excitable Cells: Modulators of Mitochondrial and Cell Function

(2009) David F. Stowe et al.   ANTIOXIDANTS & REDOX SIGNALING

Potential Therapeutic Benefits of Strategies Directed to Mitochondria

(2009) Amadou K.S. Camara et al.   ANTIOXIDANTS & REDOX SIGNALING

SR/ER–mitochondrial local communication: Calcium and ROS

(2009) György Csordás et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Crosstalk signaling between mitochondrial Ca2+ and ROS

(2009) Robert et al.   Frontiers in Bioscience-Landmark

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Mitofusin-2 regulates mitochondrial and endoplasmic reticulum morphology and tethering: The role of Ras

(2009) Olga Martins de Brito et al.   MITOCHONDRION

Akt and 14-3-3 Control a PACS-2 Homeostatic Switch that Integrates Membrane Traffic with TRAIL-Induced Apoptosis

(2009) Joseph E. Aslan et al.   MOLECULAR CELL

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

PTPIP51, a novel 14–3–3 binding protein, regulates cell morphology and motility via Raf–ERK pathway

(2008) Chuanfei Yu et al.   CELLULAR SIGNALLING

The Endoplasmic Reticulum Enzyme DGAT2 Is Found in Mitochondria-associated Membranes and Has a Mitochondrial Targeting Signal That Promotes Its Association with Mitochondria

(2008) Scot J. Stone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Steroidogenic Activity of StAR Requires Contact with Mitochondrial VDAC1 and Phosphate Carrier Protein

(2008) Mahuya Bose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology

(2008) Xiao-Jian Han et al.   JOURNAL OF CELL BIOLOGY

The Subcellular Distribution of Calnexin Is Mediated by PACS-2

(2008) Nathan Myhill et al.   MOLECULAR BIOLOGY OF THE CELL

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA