Endoplasmic Reticulum (ER) Stress and Endocrine Disorders

The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases?

(2016) Paula Garcia-Huerta et al.   BRAIN RESEARCH

Wolfram Syndrome: Diagnosis, Management, and Treatment

(2016) Fumihiko Urano   Current Diabetes Reports

Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum

(2016) Leena Haataja et al.   DIABETES

Rescue of Isolated GH Deficiency Type II (IGHD II) via Pharmacologic Modulation ofGH-1Splicing

(2016) Maria Consolata Miletta et al.   ENDOCRINOLOGY

Pathogenic Mechanism of Diabetes Development Due to Dysfunction of Unfolded Protein Response

(2016) Yuichi Tsuchiya et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation of ATF2 in mouse adipose

(2016) Zhenjiang Liu et al.   Cell Death & Disease

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

(2016) Ciara M Gallagher et al.   eLife

Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress

(2016) Ciara M Gallagher et al.   eLife

Novel mechanism of enhancing IRE1α-XBP1 signalling via the PERK-ATF4 pathway

(2016) Akio Tsuru et al.   Scientific Reports

Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2α-dependent translational attenuation and insulin biosynthesis in pancreatic β cells

(2015) Ryoko Akai et al.   GENES TO CELLS

Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy

(2015) Xuejing Wang et al.   International Journal of Biological Sciences

Endoplasmic Reticulum (ER) Localization Is Critical for DsbA-L Protein to Suppress ER Stress and Adiponectin Down-regulation in Adipocytes

(2015) Meilian Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin demand regulates β cell number via the unfolded protein response

(2015) Rohit B. Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

Deletion ofAtf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice

(2015) Akifumi Yoshikawa et al.   JOURNAL OF NEUROCHEMISTRY

Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes☆

(2015) Jinhong Sun et al.   MOLECULAR ASPECTS OF MEDICINE

Proteostasis control by the unfolded protein response

(2015) Claudio Hetz et al.   NATURE CELL BIOLOGY

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

(2015) I. Das et al.   SCIENCE

IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions

(2015) Kohsuke Kanekura et al.   Science Signaling

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity

(2015) Suneng Fu et al.   Science Translational Medicine

Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate

(2015) Z Liu et al.   Cell Death & Disease

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling

(2015) Marta Carrara et al.   eLife

IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions

(2015) Kohsuke Kanekura et al.   Science Signaling

Activating Transcription Factor 6α Is Required for the Vasopressin Neuron System to Maintain Water Balance Under Dehydration in Male Mice

(2014) Yoshinori Azuma et al.   ENDOCRINOLOGY

Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation of the Endoplasmic Reticulum Stress Transducer BBF2H7/CREB3L2 in Chondrocytes

(2014) Kenta Hino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription Factor CREB3L1 Regulates Vasopressin Gene Expression in the Rat Hypothalamus

(2014) M. Greenwood et al.   JOURNAL OF NEUROSCIENCE

VEGF Signals through ATF6 and PERK to Promote Endothelial Cell Survival and Angiogenesis in the Absence of ER Stress

(2014) Evdoxia Karali et al.   MOLECULAR CELL

Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy

(2014) Norihiko Yokoi et al.   NATURE MEDICINE

Adiponectin Protects Rat Myocardium against Chronic Intermittent Hypoxia-Induced Injury via Inhibition of Endoplasmic Reticulum Stress

(2014) Wenxiao Ding et al.   PLoS One

Getting RIDD of RNA: IRE1 in cell fate regulation

(2014) M. Maurel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Involvement of p38 in signal switching from autophagy to apoptosis via the PERK/eIF2α/ATF4 axis in selenite-treated NB4 cells

(2014) Q Jiang et al.   Cell Death & Disease

Arginine vasopressin neuronal loss results from autophagy-associated cell death in a mouse model for familial neurohypophysial diabetes insipidus

(2014) D Hagiwara et al.   Cell Death & Disease

ERp29 deficiency affects sensitivity to apoptosis via impairment of the ATF6–CHOP pathway of stress response

(2013) Irina Hirsch et al.   APOPTOSIS

Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

(2013) Marc Schneeberger et al.   CELL

UBC9 Regulates the Stability of XBP1, a Key Transcription Factor Controlling the ER Stress Response

(2013) Aya Uemura et al.   CELL STRUCTURE AND FUNCTION

 -Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome

(2013) L. Shang et al.   DIABETES

Endoplasmic Reticulum Stress and Apoptosis Contribute to the Pathogenesis of Dominantly Inherited Isolated GH Deficiency Due toGH1Gene Splice Site Mutations

(2013) Daisuke Ariyasu et al.   ENDOCRINOLOGY

Endoplasmic reticulum stress in vasopressin neurons of familial diabetes insipidus model mice: aggregate formation and mRNA poly(A) tail shortening

(2013) Hiroshi Arima et al.   EXPERIMENTAL PHYSIOLOGY

ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish

(2013) Tokiro Ishikawa et al.   MOLECULAR BIOLOGY OF THE CELL

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Deficiency for the ER-stress transducer OASIS causes severe recessive osteogenesis imperfecta in humans

(2013) Sofie Symoens et al.   Orphanet Journal of Rare Diseases

Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response

(2013) B. M. Gardner et al.   Cold Spring Harbor Perspectives in Biology

Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression

(2013) H. Matsumoto et al.   Biology Open

Activation of OASIS family, ER stress transducers, is dependent on its stabilization

(2012) S Kondo et al.   CELL DEATH AND DIFFERENTIATION

Brown Rice and Its Component,  -Oryzanol, Attenuate the Preference for High-Fat Diet by Decreasing Hypothalamic Endoplasmic Reticulum Stress in Mice

(2012) C. Kozuka et al.   DIABETES

The Endoplasmic Reticulum Stress Transducer OASIS Is involved in the Terminal Differentiation of Goblet Cells in the Large Intestine

(2012) Rie Asada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance

(2012) Masahiro Usui et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B

(2012) Connie W. Woo et al.   NATURE CELL BIOLOGY

Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract

(2012) Makoto Minamiyama et al.   NATURE MEDICINE

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

An Orchestrated Program Regulating Secretory Pathway Genes and Cargos by the Transmembrane Transcription Factor CREB-H

(2012) Sónia Barbosa et al.   TRAFFIC

Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue

(2012) Noritaka Kawasaki et al.   Scientific Reports

The structure of the PERK kinase domain suggests the mechanism for its activation

(2011) Wenjun Cui et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Vertebrate Unfolded Protein Response: Mammalian Signaling Pathways Are Conserved in Medaka Fish

(2011) Tokiro Ishikawa et al.   CELL STRUCTURE AND FUNCTION

Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol

(2011) Gurdeep Marwarha et al.   CELLULAR SIGNALLING

Poly(A) Tail Length of Neurohypophysial Hormones Is Shortened Under Endoplasmic Reticulum Stress

(2011) Yoshiaki Morishita et al.   ENDOCRINOLOGY

Physiological unfolded protein response regulated by OASIS family members, transmembrane bZIP transcription factors

(2011) Shinichi Kondo et al.   IUBMB LIFE

The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology

(2011) R. Asada et al.   JOURNAL OF BIOCHEMISTRY

New perspectives on osteogenesis imperfecta

(2011) Antonella Forlino et al.   Nature Reviews Endocrinology

Dual and opposing roles of the unfolded protein response regulated by IRE1  and XBP1 in proinsulin processing and insulin secretion

(2011) A.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational Pausing Ensures Membrane Targeting and Cytoplasmic Splicing of XBP1u mRNA

(2011) K. Yanagitani et al.   SCIENCE

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

Calpain and caspase processing of caspase-12 contribute to the ER stress-induced cell death pathway in differentiated PC12 cells

(2010) Juan A. Martinez et al.   APOPTOSIS

Autophagy

(2010) Lijun Zhou et al.   Autophagy

ATF3 negatively regulates adiponectin receptor 1 expression

(2010) Hyun Jin Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Luminal Domain of ATF6 Alone Is Sufficient for Sensing Endoplasmic Reticulum Stress and Subsequent Transport to the Golgi Apparatus

(2010) Yoshimi Sato et al.   CELL STRUCTURE AND FUNCTION

Cranio-lenticulo-sutural dysplasia associated with defects in collagen secretion

(2010) SA Boyadjiev et al.   CLINICAL GENETICS

DsbA-L Alleviates Endoplasmic Reticulum Stress-Induced Adiponectin Downregulation

(2010) L. Zhou et al.   DIABETES

Isolated GH Deficiency Type II: Knockdown of the Harmful Δ3GH Recoverswt-GH Secretion in Rat Tumor Pituitary Cells

(2010) Didier Lochmatter et al.   ENDOCRINOLOGY

AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells

(2010) In-uk Koh et al.   FEBS Journal

Regulated increase in folding capacity prevents unfolded protein stress in the ER

(2010) C. Christis et al.   JOURNAL OF CELL SCIENCE

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

(2010) Sonya G. Fonseca et al.   JOURNAL OF CLINICAL INVESTIGATION

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice

(2010) Yasuhisa Oida et al.   NEUROSCIENCE LETTERS

Identification of a consensus element recognized and cleaved by IRE1α

(2010) Daisuke Oikawa et al.   NUCLEIC ACIDS RESEARCH

FFA-Induced Adipocyte Inflammation and Insulin Resistance: Involvement of ER Stress and IKKβ Pathways

(2010) Ping Jiao et al.   Obesity

Progressive polyuria without vasopressin neuron loss in a mouse model for familial neurohypophysial diabetes insipidus

(2009) Masayuki Hayashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Evidence that endoplasmic reticulum (ER) stress and caspase-4 activation occur in human neutrophils

(2009) François Binet et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Roles for Endoplasmic Reticulum–Associated Degradation and the Novel Endoplasmic Reticulum Stress Response Gene Derlin-3 in the Ischemic Heart

(2009) Peter J. Belmont et al.   CIRCULATION RESEARCH

XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

(2009) Chih-Chi Andrew Hu et al.   EMBO JOURNAL

Signalling Pathways in the Unfolded Protein Response: Development from Yeast to Mammals

(2009) K. Mori   JOURNAL OF BIOCHEMISTRY

Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis

(2009) Shin-ichiro Hino et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

ATF6  induces XBP1-independent expansion of the endoplasmic reticulum

(2009) H. Bommiasamy et al.   JOURNAL OF CELL SCIENCE

Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through the GRP78 chaperone in mice

(2009) Tomokazu Matsuda et al.   JOURNAL OF CLINICAL INVESTIGATION

The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response

(2009) Sana Basseri et al.   JOURNAL OF LIPID RESEARCH

Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid inOASIS-deficient mice

(2009) Kazuyasu Chihara et al.   JOURNAL OF NEUROCHEMISTRY

Cotranslational Targeting of XBP1 Protein to the Membrane Promotes Cytoplasmic Splicing of Its Own mRNA

(2009) Kota Yanagitani et al.   MOLECULAR CELL

Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis

(2009) Atsushi Saito et al.   NATURE CELL BIOLOGY

Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation

(2009) Tomohiko Murakami et al.   NATURE CELL BIOLOGY

In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles

(2009) A. J. Schindler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil

(2008) Y. Oida et al.   BRAIN RESEARCH

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals

(2008) G. Boden et al.   DIABETES

Cross-sectional multicenter study of patients with urea cycle disorders in the United States

(2008) Mendel Tuchman et al.   MOLECULAR GENETICS AND METABOLISM

The Role of IRE1α in the Degradation of Insulin mRNA in Pancreatic β-Cells

(2008) Kathryn L. Lipson et al.   PLoS One

A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization

(2008) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A kinase inhibitor activates the IRE1α RNase to confer cytoprotection against ER stress

(2007) Dan Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS