Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption

Islet Amyloid-Induced Cell Death and Bilayer Integrity Loss Share a Molecular Origin Targetable with Oligopyridylamide-Based α-Helical Mimetics

(2015) Sunil Kumar et al.   CHEMISTRY & BIOLOGY

The pathogenic mechanism of diabetes varies with the degree of overexpression and oligomerization of human amylin in the pancreatic islet β cells

(2014) Shaoping Zhang et al.   FASEB JOURNAL

α-Synuclein oligomers distinctively permeabilize complex model membranes

(2014) Anja N. D. Stefanovic et al.   FEBS Journal

Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation

(2014) M. R. Ambroso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies

(2014) Yaron Bram et al.   Scientific Reports

Probing the interplay between amyloidogenic proteins and membranes using lipid monolayers and bilayers

(2013) Annalisa Relini et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Evaluation of membrane models and their composition for islet amyloid polypeptide-membrane aggregation

(2013) Lucie Caillon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Huntingtin disrupts lipid bilayers in a polyQ-length dependent manner

(2013) Kathleen A. Burke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Understanding the Role of Amphipathic Helices in N-BAR Domain Driven Membrane Remodeling

(2013) Haosheng Cui et al.   BIOPHYSICAL JOURNAL

α-Synuclein Oligomers with Broken Helical Conformation Form Lipoprotein Nanoparticles

(2013) Jobin Varkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling

(2013) Myriam M. Ouberai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping the Subcellular Distribution of  -Synuclein in Neurons using Genetically Encoded Probes for Correlated Light and Electron Microscopy: Implications for Parkinson's Disease Pathogenesis

(2013) D. Boassa et al.   JOURNAL OF NEUROSCIENCE

Membrane-Mediated Neuroprotection by Curcumin from Amyloid-β-Peptide-Induced Toxicity

(2013) Arjun Thapa et al.   LANGMUIR

Membrane disordering is not sufficient for membrane permeabilization by islet amyloid polypeptide: studies of IAPP(20–29) fragments

(2013) Jeffrey R. Brender et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Islet amyloid polypeptide toxicity and membrane interactions

(2013) P. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common mechanism unites membrane poration by amyloid and antimicrobial peptides

(2013) N. B. Last et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipids of mitochondria

(2013) Susanne E. Horvath et al.   PROGRESS IN LIPID RESEARCH

α-Helical Structures Drive Early Stages of Self-Assembly of Amyloidogenic Amyloid Polypeptide Aggregate Formation in Membranes

(2013) Martina Pannuzzo et al.   Scientific Reports

Mitofilin complexes: conserved organizers of mitochondrial membrane architecture

(2012) Ralf M. Zerbes et al.   BIOLOGICAL CHEMISTRY

Remodeling of Lipid Vesicles into Cylindrical Micelles by α-Synuclein in an Extended α-Helical Conformation

(2012) Naoko Mizuno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Peptide-Induced Pore Formation in Lipid Bilayers Investigated by Oriented 31P Solid-State NMR Spectroscopy

(2012) Kresten Bertelsen et al.   PLoS One

Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

(2011) Ravi Prakash Reddy Nanga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Biphasic Effects of Insulin on Islet Amyloid Polypeptide Membrane Disruption

(2011) Jeffrey R. Brender et al.   BIOPHYSICAL JOURNAL

Mechanism of Membrane Curvature Sensing by Amphipathic Helix Containing Proteins

(2011) Haosheng Cui et al.   BIOPHYSICAL JOURNAL

Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptide

(2011) Mazin Magzoub et al.   FASEB JOURNAL

α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding

(2011) Iwona M. Pranke et al.   JOURNAL OF CELL BIOLOGY

α-Synuclein-Induced Tubule Formation in Lipid Bilayers

(2011) Anjan P. Pandey et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Effects of cholesterol on pore formation in lipid bilayers induced by human islet amyloid polypeptide fragments: A coarse-grained molecular dynamics study

(2011) Weixin Xu et al.   PHYSICAL REVIEW E

Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity

(2011) N. B. Last et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BAR domains, amphipathic helices and membrane-anchored proteins use the same mechanism to sense membrane curvature

(2010) K.L. Madsen et al.   FEBS LETTERS

Liposome Damage and Modeling of Fragments of Human Islet Amyloid Polypeptide (IAPP) Support a Two-Step Model of Membrane Destruction

(2010) Deborah L. Heyl et al.   International Journal of Peptide Research and Therapeutics

Roles of Amphipathic Helices and the Bin/Amphiphysin/Rvs (BAR) Domain of Endophilin in Membrane Curvature Generation

(2010) Christine C. Jao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

(2010) Jobin Varkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for Proteotoxicity in β Cells in Type 2 Diabetes

(2009) Tatyana Gurlo et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanisms of Antimicrobial, Cytolytic, and Cell-Penetrating Peptides: From Kinetics to Thermodynamics

(2009) Paulo F. Almeida et al.   BIOCHEMISTRY

Amphipathic motifs in BAR domains are essential for membrane curvature sensing

(2009) Vikram K Bhatia et al.   EMBO JOURNAL

Dynamic α-Helix Structure of Micelle-bound Human Amylin

(2009) Sharadrao M. Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Negative Curvature as a Mechanism of Cell Toxicity by Amyloidogenic Peptides: The Case of Islet Amyloid Polypeptide

(2009) Pieter E. S. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Single Mutation in the Nonamyloidogenic Region of Islet Amyloid Polypeptide Greatly Reduces Toxicity†

(2008) Jeffrey R. Brender et al.   BIOCHEMISTRY

Characterization of antimicrobial peptide activity by electrochemical impedance spectroscopy

(2008) William K. Chang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Toroidal pores formed by antimicrobial peptides show significant disorder

(2008) Durba Sengupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structure and Dynamics of Helix-0 of the N-BAR Domain in Lipid Micelles and Bilayers

(2008) Christian Löw et al.   BIOPHYSICAL JOURNAL

The Hydrophobic Insertion Mechanism of Membrane Curvature Generation by Proteins

(2008) Felix Campelo et al.   BIOPHYSICAL JOURNAL

Structure of α-Helical Membrane-bound Human Islet Amyloid Polypeptide and Its Implications for Membrane-mediated Misfolding

(2008) Melania Apostolidou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Fiber Formation and Membrane Disruption are Separate Processes Localized in Two Distinct Regions of IAPP, the Type-2-Diabetes-Related Peptide

(2008) Jeffrey R. Brender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On the Nature of Antimicrobial Activity:  A Model for Protegrin-1 Pores

(2008) Allison A. Langham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

(2008) M. F. M. Engel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of membrane-bound  -synuclein from site-directed spin labeling and computational refinement

(2008) C. C. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA