Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

Cell Cycle Control by the CDC25 Phosphatases

(2012) Bernadette Aressy et al.   Anti-Cancer Agents in Medicinal Chemistry

Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival

(2012) Tina M. Thornton et al.   International Journal of Biological Sciences

Casein Kinase 2 interacts with human mitogen- and stress-activated protein kinase MSK1 and phosphorylates it at Multiple sites

(2011) Yan Shi et al.   BMB Reports

C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis

(2010) Pierre-Luc Tanguay et al.   BIOCHEMICAL JOURNAL

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Characterization of a novel MK3 splice variant from murine ventricular myocardium

(2010) Nadège Moïse et al.   CELLULAR SIGNALLING

Characterization of the expression and regulation of MK5 in the murine ventricular myocardium

(2010) Dharmendra Dingar et al.   CELLULAR SIGNALLING

A Two-Step Inactivation Mechanism of Myt1 Ensures CDK1/Cyclin B Activation and Meiosis I Entry

(2010) E. Josué Ruiz et al.   CURRENT BIOLOGY

HP1: Heterochromatin binding proteins working the genome

(2010) Weihua Zeng et al.   Epigenetics

Phenotypic annotation of the mouse X chromosome

(2010) B. J. Cox et al.   GENOME RESEARCH

MAPKAP Kinase 2 Blocks Tristetraprolin-directed mRNA Decay by Inhibiting CAF1 Deadenylase Recruitment

(2010) Francesco P. Marchese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From basic research to clinical development of MEK1/2 inhibitors for cancer therapy

(2010) Christophe Frémin et al.   Journal of Hematology & Oncology

A Benzothiophene Inhibitor of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Inhibits Tumor Necrosis Factor   Production and Has Oral Anti-Inflammatory Efficacy in Acute and Chronic Models of Inflammation

(2010) R. J. Mourey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Promoter chromatin remodeling of immediate-early genes is mediated through H3 phosphorylation at either serine 28 or 10 by the MSK1 multi-protein complex

(2010) Bojan Drobic et al.   NUCLEIC ACIDS RESEARCH

c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges

(2009) Marie A. Bogoyevitch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

MK2 regulates the early stages of skin tumor promotion

(2009) Claus Johansen et al.   CARCINOGENESIS

Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology

(2009) Sergiy Kostenko et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5

(2009) Sergiy Kostenko et al.   CELLULAR SIGNALLING

Regulation of Replicative and Stress-Induced Senescence by RSK4, which is Down-regulated in Human Tumors

(2009) L. Lopez-Vicente et al.   CLINICAL CANCER RESEARCH

MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells

(2009) Jessica Schwermann et al.   EMBO JOURNAL

Multilayered control of gene expression by stress-activated protein kinases

(2009) Eulàlia de Nadal et al.   EMBO JOURNAL

mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor α serine 167 phosphorylation

(2009) Rachel L. Yamnik et al.   FEBS LETTERS

Differential Regulation of Mitogen- and Stress-activated Protein Kinase-1 and -2 (MSK1 and MSK2) by CK2 following UV Radiation

(2009) Kellie A. Jacks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif

(2009) Espen Åberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The subcellular localization of MEK and ERK—A novel nuclear translocation signal (NTS) paves a way to the nucleus

(2009) Eldar Zehorai et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

RSK Is a Principal Effector of the RAS-ERK Pathway for Eliciting a Coordinate Promotile/Invasive Gene Program and Phenotype in Epithelial Cells

(2009) Ulrik Doehn et al.   MOLECULAR CELL

Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation

(2009) Bin Zheng et al.   MOLECULAR CELL

RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility

(2009) M. D. Larrea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality

(2009) S. Klinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MSK2 Inhibits p53 Activity in the Absence of Stress

(2009) S. Llanos et al.   Science Signaling

The versatile role of MSKs in transcriptional regulation

(2009) Linda Vermeulen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Fluorescence-based quantitative scratch wound healing assay demonstrating the role of MAPKAPK-2/3 in fibroblast migration

(2009) Manoj B. Menon et al.   CELL MOTILITY AND THE CYTOSKELETON

The Ser186phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5

(2008) Maria Perander et al.   BIOCHEMICAL JOURNAL

Mitogen- and Stress-Activated Kinase 1-Mediated Histone H3 Phosphorylation Is Crucial for Cell Transformation

(2008) H.-G. Kim et al.   CANCER RESEARCH

Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells

(2008) Andrea Bianchini et al.   CARCINOGENESIS

Anti-invasive and Antimetastatic Activities of Ribosomal Protein S6 Kinase 4 in Breast Cancer Cells

(2008) A. Thakur et al.   CLINICAL CANCER RESEARCH

Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation

(2008) Audrey Carrière et al.   CURRENT BIOLOGY

The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)

(2008) Maria Buxade   Frontiers in Bioscience-Landmark

Specificity of signaling from MAPKs to MAPKAPKs: Kinases' Tango Nuevo

(2008) Matthias Gaestel   Frontiers in Bioscience-Landmark

Does MK5 reconcile classical and atypical MAP kinases?

(2008) Maria Perander   Frontiers in Bioscience-Landmark

MK2 and MK3 - a pair of isoenzymes?

(2008) Natalia Ronkina   Frontiers in Bioscience-Landmark

The RSK factors of activating the Ras/MAPK signaling cascade

(2008) Audrey Carriere   Frontiers in Bioscience-Landmark

MSK activation and physiological roles

(2008) J. Simon et al.   Frontiers in Bioscience-Landmark

Substrate Discrimination among Mitogen-activated Protein Kinases through Distinct Docking Sequence Motifs

(2008) Douglas L. Sheridan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5

(2008) Paul Déléris et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of Polysome Assembly Enhances Imatinib Activity against Chronic Myelogenous Leukemia and Overcomes Imatinib Resistance

(2008) M. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Ran-Binding Protein 3 Phosphorylation Links the Ras and PI3-Kinase Pathways to Nucleocytoplasmic Transport

(2008) Sang-Oh Yoon et al.   MOLECULAR CELL

Codependent Functions of RSK2 and the Apoptosis-Promoting Factor TIA-1 in Stress Granule Assembly and Cell Survival

(2008) T.S. Karin Eisinger-Mathason et al.   MOLECULAR CELL

The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

(2008) Chun Kim et al.   NATURE IMMUNOLOGY

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

(2008) Olga Ananieva et al.   NATURE IMMUNOLOGY

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1

(2008) J. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2

(2008) S. Maitra et al.   RNA

The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

(2008) Deborah K. Morrison   TRENDS IN CELL BIOLOGY

Critical role for Rsk2 in T-lymphocyte activation

(2007) J.-X. Lin et al.   BLOOD