Comprehensive Review on Alzheimer’s Disease: Causes and Treatment

A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles

(2020) Jian-Guo Li et al.   Molecular Neurodegeneration

A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice

(2020) Júlia Companys-Alemany et al.   Pharmaceutics

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

(2020) Gill Livingston et al.   LANCET

Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval

(2020) Martin Tolar et al.   Alzheimers Research & Therapy

Targeting Amyloidogenic Processing of APP in Alzheimer’s Disease

(2020) Jing Zhao et al.   Frontiers in Molecular Neuroscience

Metal Toxicity Links to Alzheimer’s Disease and Neuroinflammation

(2019) Tee Jong Huat et al.   JOURNAL OF MOLECULAR BIOLOGY

Changes in synaptic proteins precede neurodegeneration markers in preclinical Alzheimer’s disease cerebrospinal fluid

(2019) Alberto Lleó et al.   MOLECULAR & CELLULAR PROTEOMICS

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies

(2019) Evangeline M. Foster et al.   Frontiers in Neuroscience

The Role of NMDA Receptors in Alzheimer’s Disease

(2019) Jinping Liu et al.   Frontiers in Neuroscience

Full recovery of the Alzheimer’s disease phenotype by gain of function of vacuolar protein sorting 35

(2019) Jian-Guo Li et al.   MOLECULAR PSYCHIATRY

Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model

(2019) Robert J. Andrew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding the Amyloid Hypothesis in Alzheimer’s Disease

(2019) Giulia Paroni et al.   JOURNAL OF ALZHEIMERS DISEASE

Natural Compounds for Alzheimer’s Disease Therapy: A Systematic Review of Preclinical and Clinical Studies

(2019) Stephanie Andrade et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cholinesterase inhibitors as Alzheimer's therapeutics (Review)

(2019) Kamlesh Sharma   Molecular Medicine Reports

VPS35 regulates tau phosphorylation and neuropathology in tauopathy

(2019) Alana N. Vagnozzi et al.   MOLECULAR PSYCHIATRY

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Common bacterial infections and risk of incident cognitive decline or dementia: a systematic review protocol

(2019) Rutendo Muzambi et al.   BMJ Open

Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases

(2019) Anastasiia Bohush et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In Vivo Validation of a Small Molecule Inhibitor of Tau Self-Association in htau Mice

(2019) Eliot J. Davidowitz et al.   JOURNAL OF ALZHEIMERS DISEASE

Therapeutic Effects of Natural Drugs on Alzheimer’s Disease

(2019) Yuan Ma et al.   Frontiers in Pharmacology

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

An Overview on the Clinical Development of Tau-Based Therapeutics

(2018) Miguel Medina   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Memantine for the Treatment of Dementia: A Review on its Current and Future Applications

(2018) Jaume Folch et al.   JOURNAL OF ALZHEIMERS DISEASE

Ozone Atmospheric Pollution and Alzheimer’s Disease: From Epidemiological Facts to Molecular Mechanisms

(2018) Marine L. Croze et al.   JOURNAL OF ALZHEIMERS DISEASE

The genes associated with early-onset Alzheimer’s disease

(2018) Meng-Hui Dai et al.   Oncotarget

Engineered Hsp70 chaperones prevent Aβ42-induced memory impairments in a Drosophila model of Alzheimer’s disease

(2018) Alfonso Martín-Peña et al.   Scientific Reports

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

Suboptimal Baseline Serum Vitamin B12 Is Associated With Cognitive Decline in People With Alzheimer’s Disease Undergoing Cholinesterase Inhibitor Treatment

(2018) Hsiao Shan Cho et al.   Frontiers in Neurology

The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease

(2018) Ulf Neumann et al.   EMBO Molecular Medicine

Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting

(2018) Claudia Campanella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Study of Estrogen Receptor-α and Receptor-β Gene Polymorphisms on Alzheimer's Disease

(2018) Louisa Goumidi et al.   JOURNAL OF ALZHEIMERS DISEASE

Bridging Integrator 1 (BIN1) Protein Expression Increases in the Alzheimer's Disease Brain and Correlates with Neurofibrillary Tangle Pathology

(2018) Christopher J. Holler et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Microbes in the Development of Alzheimer’s Disease: State of the Art – An International Symposium Presented at the 2017 IAGG Congress in San Francisco

(2018) Tamàs Fülöp et al.   Frontiers in Genetics

The Epigenetics of Alzheimer’s Disease: Factors and Therapeutic Implications

(2018) Xiaolei Liu et al.   Frontiers in Genetics

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Obesity as a risk factor for Alzheimer's disease: weighing the evidence

(2017) S. Alford et al.   Obesity Reviews

Nutrition and AGE-ing: Focusing on Alzheimer’s Disease

(2017) Giulia Abate et al.   Oxidative Medicine and Cellular Longevity

Presenilin-1 mutations and Alzheimer’s disease

(2017) Raymond J. Kelleher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer’s disease prevention: from risk factors to early intervention

(2017) Marta Crous-Bou et al.   Alzheimers Research & Therapy

APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases

(2017) Hélène-Marie Lanoiselée et al.   PLOS MEDICINE

Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1

(2017) Stuart K. Calderwood et al.   Frontiers in Neuroscience

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

(2016) Bruno Dubois et al.   Alzheimers & Dementia

Drug treatments in Alzheimers disease

(2016) R. Briggs et al.   CLINICAL MEDICINE

Alzheimer's disease: Targeting the Cholinergic System

(2016) Talita H. Ferreira-Vieira et al.   Current Neuropharmacology

Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70)

(2016) Xiaokai Li et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Age, APOE and sex: Triad of risk of Alzheimer’s disease

(2016) Brandalyn C. Riedel et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Ceria-containing uncoated and coated hydroxyapatite-based galantamine nanocomposites for formidable treatment of Alzheimer's disease in ovariectomized albino-rat model

(2016) Sanaa M.R. Wahba et al.   Materials Science & Engineering C-Materials for Biological Applications

A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer’s mouse model via an HSF1-mediated mechanism

(2016) B Wang et al.   MOLECULAR PSYCHIATRY

Neurofibrillary tangles in Alzheimer′s disease: elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics

(2016) StefanJ Kempf et al.   Neural Regeneration Research

Overview of Alzheimer’s Disease and Some Therapeutic Approaches Targeting Aβby Using Several Synthetic and Herbal Compounds

(2016) Sandeep Kumar Singh et al.   Oxidative Medicine and Cellular Longevity

Mild versus moderate stages of Alzheimer's disease: three-year outcomes in a routine clinical setting of cholinesterase inhibitor therapy

(2016) Carina Wattmo et al.   Alzheimers Research & Therapy

Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease

(2016) Julia TCW et al.   Cold Spring Harbor Perspectives in Medicine

Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease

(2016) Rawan Tarawneh et al.   JAMA Neurology

Malnutrition in Alzheimer’s Disease, Dementia with Lewy Bodies, and Frontotemporal Lobar Degeneration: Comparison Using Serum Albumin, Total Protein, and Hemoglobin Level

(2016) Asuka Koyama et al.   PLoS One

Estrogen receptor β in Alzheimer’s disease: From mechanisms to therapeutics

(2015) Liqin Zhao et al.   AGEING RESEARCH REVIEWS

Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease

(2015) Liv Tybjærg Nordestgaard et al.   Alzheimers & Dementia

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-κBs in Toll-like receptor 4 signaling

(2015) Sae Mi Wi et al.   MOLECULAR BIOLOGY OF THE CELL

Screening strategies to identify HSP70 modulators to treat Alzheimer’s disease

(2015) Jayanthi Repalli et al.   Drug Design Development and Therapy

The age factor in Alzheimer’s disease

(2015) Rita Guerreiro et al.   Genome Medicine

Mutations in presenilin 2 and its implications in Alzheimer’s disease and other dementia-associated disorders

(2015) Seong Soo An et al.   Clinical Interventions in Aging

Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease

(2014) Cassia R. Overk et al.   BIOCHEMICAL PHARMACOLOGY

Cardiovascular risk factors and future risk of Alzheimer’s disease

(2014) Renée FAG de Bruijn et al.   BMC Medicine

Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APPE693Q mice through reduction of ganglioside-bound Aβ

(2014) E M Knight et al.   MOLECULAR PSYCHIATRY

Pharmacological chaperones stabilize retromer to limit APP processing

(2014) Vincent J Mecozzi et al.   Nature Chemical Biology

ATP-binding cassette transporter A1: From metabolism to neurodegeneration

(2014) Radosveta Koldamova et al.   NEUROBIOLOGY OF DISEASE

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

The therapeutic potential of chemical chaperones in protein folding diseases

(2014) Leonardo Cortez et al.   Prion

Environmental factors in the development and progression of late-onset Alzheimer’s disease

(2014) Moses N. Wainaina et al.   Neuroscience Bulletin

Heat Shock Protein 90 in Alzheimer’s Disease

(2014) Jiang-Rong Ou et al.   Biomed Research International

A review on cholinesterase inhibitors for Alzheimer’s disease

(2013) Preet Anand et al.   ARCHIVES OF PHARMACAL RESEARCH

Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau

(2013) Jose Abisambra et al.   BIOLOGICAL PSYCHIATRY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Disease-modifying drugs in Alzheimer's disease

(2013) Elio Scarpini et al.   Drug Design Development and Therapy

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Epidemiology of Alzheimer Disease

(2013) R. Mayeux et al.   Cold Spring Harbor Perspectives in Medicine

Nutrition and the Risk of Alzheimer's Disease

(2013) Nan Hu et al.   Biomed Research International

Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction

(2012) Montserrat Soler-López et al.   BIOESSAYS

NMDA Neurotransmission Dysfunction in Behavioral and Psychological Symptoms of Alzheimer's Disease

(2012) Yu-Jhen Huang et al.   Current Neuropharmacology

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Alzheimer's Disease: Diagnosis and Treatment Across the Spectrum of Disease Severity

(2011) Judith Neugroschl et al.   MOUNT SINAI JOURNAL OF MEDICINE

Disease-modifying treatments for Alzheimer’s disease

(2011) Daniela Galimberti et al.   Therapeutic Advances in Neurological Disorders

Galantamine for Alzheimer's disease

(2010) David Prvulovic et al.   Expert Opinion on Drug Metabolism & Toxicology

Interactome mapping suggests new mechanistic details underlying Alzheimer's disease

(2010) M. Soler-Lopez et al.   GENOME RESEARCH

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

A review of estrogen receptor α gene (ESR1) polymorphisms, mood, and cognition

(2010) Erin E. Sundermann et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Neuropathology of Alzheimer's Disease

(2010) Daniel P. Perl   MOUNT SINAI JOURNAL OF MEDICINE

Alzheimer and his disease: a brief history

(2010) Gabriele Cipriani et al.   NEUROLOGICAL SCIENCES

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Estrogen receptor genotype and risk of cognitive impairment in elders: Findings from the Health ABC study

(2007) Kristine Yaffe et al.   NEUROBIOLOGY OF AGING