The role of stress kinases in metabolic disease

ASK1 inhibition: a therapeutic strategy with multi-system benefits

(2020) Jacqueline M. Ogier et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Regulation of adipose tissue inflammation by interleukin 6

(2020) Myoung Sook Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An updated patent review of p38 MAP kinase inhibitors (2014-2019)

(2020) Vanessa Haller et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma

(2020) Elisa Manieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage p38α promotes nutritional steatohepatitis through M1 polarization

(2019) Xiang Zhang et al.   JOURNAL OF HEPATOLOGY

DUSP12 Regulates Hepatic Lipid Metabolism through Inhibition of Lipogenesis and ASK1 Pathways

(2019) Zhen Huang et al.   HEPATOLOGY

Adiponectin accounts for gender differences in hepatocellular carcinoma incidence

(2019) Elisa Manieri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages

(2019) Guanliang Chen et al.   LABORATORY INVESTIGATION

p38γ is essential for cell cycle progression and liver tumorigenesis

(2019) Antonia Tomás-Loba et al.   NATURE

JNK‐IN‐8, a c‐Jun N‐terminal kinase inhibitor, improves functional recovery through suppressing neuroinflammation in ischemic stroke

(2019) Jianjian Zheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities

(2019) Wei Ying et al.   Nature Reviews Endocrinology

Skeletal Muscle–Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance

(2018) Ahmed Lawan et al.   DIABETES

Obesity as a Disease

(2018) Jagriti Upadhyay et al.   MEDICAL CLINICS OF NORTH AMERICA

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

(2018) Christoph A. Thaiss et al.   SCIENCE

Metabolic benefits of inhibition of p38α in white adipose tissue in obesity

(2018) Shengjie Zhang et al.   PLOS BIOLOGY

p38α blocks brown adipose tissue thermogenesis through p38δ inhibition

(2018) Nuria Matesanz et al.   PLOS BIOLOGY

CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation

(2018) Rubén Cereijo et al.   Cell Metabolism

Dual-specificity Phosphatase 9 Protects Against Non-alcoholic Fatty Liver Disease in Mice via ASK1 Suppression

(2018) Ping Ye et al.   HEPATOLOGY

ASK1 contributes to fibrosis and dysfunction in models of kidney disease

(2018) John T. Liles et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolites as regulators of insulin sensitivity and metabolism

(2018) Qin Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1

(2018) Mar Quiñones et al.   Nature Communications

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

(2018) Ara Koh et al.   CELL

Dual-specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice through TAK1 Suppression

(2018) Ping Ye et al.   HEPATOLOGY

Hypothalamic inflammation in obesity and metabolic disease

(2017) Alexander Jais et al.   JOURNAL OF CLINICAL INVESTIGATION

Apoptosis signal-regulating kinase 1 (ASK1) inhibition reduces liver fibrosis and apoptosis in a NLRP3 mutant model of NASH

(2017) S. Schuster et al.   JOURNAL OF HEPATOLOGY

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

MKK6 controls T3-mediated browning of white adipose tissue

(2017) Nuria Matesanz et al.   Nature Communications

JNK at the crossroad of obesity, insulin resistance, and cell stress response

(2017) Giovanni Solinas et al.   Molecular Metabolism

JNK, p38, ERK, and SGK1 Inhibitors in Cancer

(2017) Jonas Cicenas et al.   Cancers

The etiology of oxidative stress in insulin resistance

(2017) Samantha Hurrle et al.   Biomedical Journal

Obesity and Cancer: The Oil that Feeds the Flame

(2016) Joan Font-Burgada et al.   Cell Metabolism

p38  and p38  reprogram liver metabolism by modulating neutrophil infiltration

(2016) B. Gonzalez-Teran et al.   EMBO JOURNAL

Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury

(2016) Francisco Javier Cubero et al.   GASTROENTEROLOGY

Pathogenesis of Nonalcoholic Steatohepatitis

(2016) Mariana Verdelho Machado et al.   GASTROENTEROLOGY

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src

(2016) Sanda Win et al.   HEPATOLOGY

Activation of the Stress Response Kinase JNK (c-Jun N-terminal Kinase) Attenuates Insulin Action in Retina through a p70S6K1-dependent Mechanism

(2016) William P. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis

(2016) Mei Xiang et al.   JOURNAL OF HEPATOLOGY

Mitochondrial-generated ROS down regulates insulin signaling via activation of the p38MAPK stress response pathway

(2016) Rabab Al-Lahham et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Diet–microbiota interactions as moderators of human metabolism

(2016) Justin L. Sonnenburg et al.   NATURE

Cell Signaling and Stress Responses

(2016) Gökhan S. Hotamisligil et al.   Cold Spring Harbor Perspectives in Biology

p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation

(2016) Bárbara González-Terán et al.   Nature Communications

Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma

(2016) Myoung Sook Han et al.   Cell Reports

Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress

(2016) Santiago Vernia et al.   eLife

An alternative splicing program promotes adipose tissue thermogenesis

(2016) Santiago Vernia et al.   eLife

Dynamics of Protein Kinases: Insights from Nuclear Magnetic Resonance

(2015) Yao Xiao et al.   ACCOUNTS OF CHEMICAL RESEARCH

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Stress kinases in the modulation of metabolism and energy balance

(2015) Elisa Manieri et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo

(2015) Yue Wu et al.   NATURE MEDICINE

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

The case for inhibiting p38 mitogen-activated protein kinase in heart failure

(2015) Pelin Arabacilar et al.   Frontiers in Pharmacology

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

(2014) Yun Sok Lee et al.   CELL

The PPARα-FGF21 Hormone Axis Contributes to Metabolic Regulation by the Hepatic JNK Signaling Pathway

(2014) Santiago Vernia et al.   Cell Metabolism

Recent Progress in the Design, Study, and Development of c-Jun N-Terminal Kinase Inhibitors as Anticancer Agents

(2014) Abdellah Messoussi et al.   CHEMISTRY & BIOLOGY

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

(2014) J. Gautheron et al.   EMBO Molecular Medicine

Nuclear and cytosolic JNK signalling in neurons

(2014) Eleanor T. Coffey   NATURE REVIEWS NEUROSCIENCE

Efficacy and Safety of AM-111 in the Treatment of Acute Sensorineural Hearing Loss

(2014) Markus Suckfuell et al.   OTOLOGY & NEUROTOLOGY

Regulation of the JNK3 Signaling Pathway during Islet Isolation: JNK3 and c-fos as New Markers of Islet Quality for Transplantation

(2014) Saida Abdelli et al.   PLoS One

TNF and MAP kinase signalling pathways

(2014) Guadalupe Sabio et al.   SEMINARS IN IMMUNOLOGY

Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance

(2014) Eva Tsaousidou et al.   Cell Reports

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

(2013) Brendan Egan et al.   Cell Metabolism

Weighing in on Adipocyte Precursors

(2013) Ryan Berry et al.   Cell Metabolism

In Vivo JNK Activation in Pancreatic  -Cells Leads to Glucose Intolerance Caused by Insulin Resistance in Pancreas

(2013) J. Lanuza-Masdeu et al.   DIABETES

Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway

(2013) S. Vernia et al.   GENES & DEVELOPMENT

Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis

(2013) Gang Zhao et al.   GUT

Role of p38, ERK1/2, focal adhesion kinase, RhoA/ROCK and cytoskeleton in the adipogenesis of human mesenchymal stem cells

(2013) Baiyao Xu et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis

(2013) Samar H. Ibrahim et al.   LIVER INTERNATIONAL

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

Modulation of Double-Stranded RNA-Activated Protein Kinase in Insulin Sensitive Tissues of Obese Humans

(2013) Bruno M. Carvalho et al.   Obesity

Alteration of JNK-1 Signaling in Skeletal Muscle Fails to Affect Glucose Homeostasis and Obesity-Associated Insulin Resistance in Mice

(2013) Martin Pal et al.   PLoS One

Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass

(2013) Amandine Girousse et al.   PLOS BIOLOGY

Discovery of Potent and Selective Covalent Inhibitors of JNK

(2012) Tinghu Zhang et al.   CHEMISTRY & BIOLOGY

Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice

(2012) D. C. Henstridge et al.   DIABETOLOGIA

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis

(2012) Bárbara González-Terán et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung

(2012) Arne Ittner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age

(2012) Merly C. Vogt et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

(2011) Jacques Amar et al.   EMBO Molecular Medicine

Association Between Disease-Modifying Antirheumatic Drugs and Diabetes Risk in Patients With Rheumatoid Arthritis and Psoriasis

(2011) Daniel H. Solomon   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

p38 kinase inhibitor approved for idiopathic pulmonary fibrosis

(2011) Nuala Moran   NATURE BIOTECHNOLOGY

p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis

(2011) Jaemin Lee et al.   NATURE MEDICINE

Genetic analysis of specific and redundant roles for p38  and p38  MAPKs during mouse development

(2011) I. del Barco Barrantes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Irs1 Serine 307 Promotes Insulin Sensitivity in Mice

(2010) Kyle D. Copps et al.   Cell Metabolism

MAPK signalling in cellular metabolism: stress or wellness?

(2010) Helmuth Gehart et al.   EMBO REPORTS

Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1

(2010) G. Sabio et al.   GENES & DEVELOPMENT

Inactivation of p38 MAPK during liver regeneration

(2010) Jean S. Campbell et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism

(2010) B. F. Belgardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation: Table 1

(2009) Philip Cohen   BIOCHEMICAL JOURNAL

Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis

(2009) Grzegorz Sumara et al.   CELL

Prevention of Steatosis by Hepatic JNK1

(2009) Guadalupe Sabio et al.   Cell Metabolism

Differential activation of p38MAPK isoforms by MKK6 and MKK3

(2009) Gaëlle Remy et al.   CELLULAR SIGNALLING

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Role of Muscle c-Jun NH2-Terminal Kinase 1 in Obesity-Induced Insulin Resistance

(2009) G. Sabio et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy

(2009) Pedro Geraldes et al.   NATURE MEDICINE

p38γ Mitogen-Activated Protein Kinase Is a Key Regulator in Skeletal Muscle Metabolic Adaptation in Mice

(2009) Andrew R. Pogozelski et al.   PLoS One

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss

(2008) M. F. Gregor et al.   DIABETES

Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals

(2008) G. Boden et al.   DIABETES

Emerging role of adipose tissue hypoxia in obesity and insulin resistance

(2008) J Ye   INTERNATIONAL JOURNAL OF OBESITY

Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle

(2008) Martin J. Gibala et al.   JOURNAL OF APPLIED PHYSIOLOGY

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

(2008) Lijian Hui et al.   JOURNAL OF CLINICAL INVESTIGATION

C-Jun NH2 terminal kinase (JNK) is an essential mediator of Toll-like receptor 2-induced corneal inflammation

(2008) G. Adhikary et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

(2008) J. L. Stebbins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSP72 protects against obesity-induced insulin resistance

(2008) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

(2008) G. Sabio et al.   SCIENCE