mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus

mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells

(2018) Amin Ardestani et al.   Cell Metabolism

Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics

(2018) Miriam García Hernández et al.   Cell Death & Disease

MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling

(2017) Alberto Bartolomé et al.   MOLECULAR AND CELLULAR BIOLOGY

The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond

(2017) Peter L. Lee et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Unraveling the Regulation of Hepatic Metabolism by Insulin

(2017) Paul M. Titchenell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

mTORC1 signaling in hepatic lipid metabolism

(2017) Jinbo Han et al.   Protein & Cell

DAF-16/FOXO Transcription Factor in Aging and Longevity

(2017) Xiaojuan Sun et al.   Frontiers in Pharmacology

Alterations in Mitochondrial Oxidative Stress and Mitophagy in Subjects with Prediabetes and Type 2 Diabetes Mellitus

(2017) Shipra Bhansali et al.   Frontiers in Endocrinology

Functional Mitochondria in Health and Disease

(2017) Patries M. Herst et al.   Frontiers in Endocrinology

TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy

(2016) Ana García-Aguilar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pancreatic β-cell identity in diabetes

(2016) M. S. Remedi et al.   DIABETES OBESITY & METABOLISM

Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes

(2016) Ting Yuan et al.   DIABETOLOGIA

Insights into Lysine Deacetylation of Natively Folded Substrate Proteins by Sirtuins

(2016) Philipp Knyphausen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus

(2016) Lucie Caillon et al.   Journal of Diabetes Research

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology

(2016) Rehana Akter et al.   Journal of Diabetes Research

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity

(2015) Suneng Fu et al.   Science Translational Medicine

Type 2 diabetes as a protein misfolding disease

(2015) Abhisek Mukherjee et al.   TRENDS IN MOLECULAR MEDICINE

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Pancreatic  -Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment

(2014) A. Bartolome et al.   DIABETES

Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy

(2014) Nayumi Shigihara et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity

(2014) Jacqueline F. Rivera et al.   JOURNAL OF CLINICAL INVESTIGATION

Nutrient control of Drosophila longevity

(2014) Marc Tatar et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Resveratrol vs. calorie restriction: Data from rodents to humans

(2013) Yan Y. Lam et al.   EXPERIMENTAL GERONTOLOGY

Rapamycin Extends Life and Health in C57BL/6 Mice

(2013) Yiqiang Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Deficiency of the BiP cochaperone ERdj4 causes constitutive endoplasmic reticulum stress and metabolic defects

(2013) Jill M. Fritz et al.   MOLECULAR BIOLOGY OF THE CELL

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death

(2012) Alberto Bartolome et al.   Autophagy

Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy

(2012) Shu-Yong Lin et al.   Autophagy

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

(2012) S.-Y. Lin et al.   SCIENCE

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer

(2011) D. Grahame Hardie   BIOCHEMICAL SOCIETY TRANSACTIONS

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Globalization of Diabetes: The role of diet, lifestyle, and genes

(2011) F. B. Hu   DIABETES CARE

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

(2011) Cathrin Meissner et al.   JOURNAL OF NEUROCHEMISTRY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Quality Control of Mitochondrial Proteostasis

(2011) M. J. Baker et al.   Cold Spring Harbor Perspectives in Biology

At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways

(2010) Gian Paolo Fadini et al.   AGING CELL

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Autophagy inhibition induces atrophy and myopathy in adult skeletal muscles

(2010) Eva Masiero et al.   Autophagy

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Protein misfolding disorders and macroautophagy

(2010) Fiona M Menzies et al.   CURRENT OPINION IN CELL BIOLOGY

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

(2010) S. Zraika et al.   DIABETOLOGIA

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

The regulation of autophagy - unanswered questions

(2010) Y. Chen et al.   JOURNAL OF CELL SCIENCE

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways inC. elegans

(2009) Eric L. Greer et al.   AGING CELL

Critical roles for the TSC-mTOR pathway in β-cell function

(2009) Hiroyuki Mori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The tuberous sclerosis complex

(2009) Ksenia A. Orlova et al.   Annals of the New York Academy of Sciences

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

(2009) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic  -Cells Leads to Increased  -Cell Mass and Prevention of Hyperglycemia

(2009) S. Hamada et al.   DIABETES

Autophagy in human type 2 diabetes pancreatic beta cells

(2009) M. Masini et al.   DIABETOLOGIA

Emerging common themes in regulation of PIKKs and PI3Ks

(2009) Harri Lempiäinen et al.   EMBO JOURNAL

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Macroautophagy and its role in nutrient homeostasis

(2009) Martha H Stipanuk   NUTRITION REVIEWS

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

Biphasic Response of Pancreatic  -Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice

(2008) Y. Shigeyama et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Disruption of Tsc2 in pancreatic   cells induces   cell mass expansion and improved glucose tolerance in a TORC1-dependent manner

(2008) L. Rachdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE