Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease
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Title
Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease
Authors
Keywords
Melatonin, Alzheimer’s disease, Amyloid beta, Neurotoxicity, Aβ production, ADAM10, BACE1, PIN1, GSK-3, Aβ assembly, Aβ clearance, Glymphatic system, Meningeal lymphatic vessels, Blood-brain barrier, APOE4, Autophagy, TFEB, PrP, Exosome, Tau, Circadian cycle, Clinical trials
Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 132, Issue -, Pages 110887
Publisher
Elsevier BV
Online
2020-11-02
DOI
10.1016/j.biopha.2020.110887
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Note: Only part of the references are listed.- Remodeling of Intracellular Ca2+ Homeostasis in Rat Hippocampal Neurons Aged In Vitro
- (2020) Maria Calvo-Rodriguez et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Melatonin affects the release of exosomes and tau-content in in vitro amyloid-beta toxicity model
- (2020) Mehmet Ozansoy et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Induction of SIRT1 by melatonin improves alcohol‐mediated oxidative liver injury by disrupting the CRBN‐YY1‐CYP2E1 signaling pathway
- (2020) Sung‐Eun Lee et al. JOURNAL OF PINEAL RESEARCH
- Glycogen synthase kinase-3 signaling in Alzheimer's disease
- (2020) Elisabetta Lauretti et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Type 3 Diabetes and Its Role Implications in Alzheimer’s Disease
- (2020) Thuy Trang Nguyen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Melatonin directly binds and inhibits death‐associated protein kinase 1 function in Alzheimer’s disease
- (2020) Dongmei Chen et al. JOURNAL OF PINEAL RESEARCH
- APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
- (2020) Axel Montagne et al. NATURE
- Circadian and sleep dysfunction in Alzheimer’s disease
- (2020) Md. Sahab Uddin et al. AGEING RESEARCH REVIEWS
- Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes
- (2020) Joel W. Blanchard et al. NATURE MEDICINE
- Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface
- (2020) Abril Angélica Escamilla-Ayala et al. eLife
- Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease
- (2020) Neha S. Raghavan et al. JAMA Neurology
- Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular Damages
- (2020) Gabriela Dumitrita Stanciu et al. Journal of Clinical Medicine
- Blood biomarkers indicate that the preclinical stages of Alzheimer's disease present overlapping molecular features
- (2020) Alfonso Di Costanzo et al. Scientific Reports
- Vascular dysfunction—The disregarded partner of Alzheimer's disease
- (2019) Melanie D. Sweeney et al. Alzheimers & Dementia
- Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction
- (2019) Daniel A. Nation et al. NATURE MEDICINE
- Association between circadian rhythms and neurodegenerative diseases
- (2019) Yue Leng et al. LANCET NEUROLOGY
- Melatonin Increases Brown Adipose Tissue Volume and Activity in Melatonin Deficient Patients: a Proof-of-Concept Study
- (2019) Bruno Halpern et al. DIABETES
- A Novel Apolipoprotein E Antagonist Functionally Blocks Apolipoprotein E Interaction With N-terminal Amyloid Precursor Protein, Reduces β-Amyloid-Associated Pathology, and Improves Cognition
- (2019) Darrell Sawmiller et al. BIOLOGICAL PSYCHIATRY
- Effects of melatonin administration on mental health parameters, metabolic and genetic profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial
- (2019) Azade Shabani et al. JOURNAL OF AFFECTIVE DISORDERS
- The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications
- (2019) Amaia M Arranz et al. LANCET NEUROLOGY
- Melatonin in Alzheimer’s Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer’s Neuropathology
- (2019) Md. Farhad Hossain et al. MOLECULAR NEUROBIOLOGY
- Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation
- (2019) Chunyan Li et al. Frontiers in Cell and Developmental Biology
- Is Alzheimer’s disease an inflammasomopathy?
- (2019) Claudia F. Pereira et al. AGEING RESEARCH REVIEWS
- Diabetes as a risk factor for Alzheimer’s disease in the Middle East and its shared pathological mediators
- (2019) Richard L. Jayaraj et al. SAUDI JOURNAL OF BIOLOGICAL SCIENCES
- Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
- (2018) Maitrayee Sardar Sinha et al. ACTA NEUROPATHOLOGICA
- Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics
- (2018) Brendan P. Lucey et al. ANNALS OF NEUROLOGY
- Melatonin protects against Aβ-induced neurotoxicity in primary neurons via miR-132/PTEN/AKT/FOXO3a pathway
- (2018) Yue Zhao et al. BIOFACTORS
- The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM
- (2018) Steffen E. Storck et al. BRAIN BEHAVIOR AND IMMUNITY
- Melatonin Treatment Enhances Aβ Lymphatic Clearance in a Transgenic Mouse Model of Amyloidosis
- (2018) M.A. Pappolla et al. Current Alzheimer Research
- Mitochondrial Dynamics and Proteins Related to Neurodegenerative Diseases
- (2018) Athanasios Alexiou et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Effects of Melatonin and Its Underlying Mechanism on Ethanol-Stimulated Senescence and Osteoclastic Differentiation in Human Periodontal Ligament Cells and Cementoblasts
- (2018) Won-Jung Bae et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade
- (2018) Erika N. Cline et al. JOURNAL OF ALZHEIMERS DISEASE
- Melatonin modulates dysregulated circadian clocks in mice with diethylnitrosamine-induced hepatocellular carcinoma
- (2018) Diana I. Sánchez et al. JOURNAL OF PINEAL RESEARCH
- Melatonin ameliorates Aβ42 -induced alteration of βAPP-processing secretases via the melatonin receptor through the Pin1/GSK3β/NF-κB pathway in SH-SY5Y cells
- (2018) Vorapin Chinchalongporn et al. JOURNAL OF PINEAL RESEARCH
- Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway
- (2018) Mingge Ding et al. JOURNAL OF PINEAL RESEARCH
- APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis
- (2018) Md. Sahab Uddin et al. MOLECULAR NEUROBIOLOGY
- Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
- (2018) Melanie D. Sweeney et al. Nature Reviews Neurology
- TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities
- (2018) Constanza J. Cortes et al. NEUROBIOLOGY OF DISEASE
- Bidirectional relationships between sleep and amyloid-beta in the hippocampus
- (2018) Julien Dufort-Gervais et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Clearance of Amyloid Beta and Tau in Alzheimer’s Disease: from Mechanisms to Therapy
- (2018) Shu-Hui Xin et al. NEUROTOXICITY RESEARCH
- Protective roles of melatonin against the amyloid-dependent development of Alzheimer’s disease: A critical review
- (2018) Bruno Vincent PHARMACOLOGICAL RESEARCH
- Melatonin Mitigates Kainic Acid-Induced Neuronal Tau Hyperphosphorylation and Memory Deficits through Alleviating ER Stress
- (2018) Cai Shi et al. Frontiers in Molecular Neuroscience
- Sleep Disorders Associated With Alzheimer's Disease: A Perspective
- (2018) Anna Brzecka et al. Frontiers in Neuroscience
- Current progress on peroxisome proliferator-activated receptor gamma agonist as an emerging therapeutic approach for the treatment of Alzheimer's disease: An update
- (2018) Mahmood Ahmad Khan et al. Current Neuropharmacology
- Association between Stroke and Alzheimer's Disease: Systematic Review and Meta-Analysis
- (2018) Jing Zhou et al. JOURNAL OF ALZHEIMERS DISEASE
- Exosomes and microRNAs: New potential therapeutic candidates in Alzheimer disease therapy
- (2018) Elmira Iranifar et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease
- (2018) Sandro Da Mesquita et al. NATURE
- Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults
- (2018) Gene L. Bowman et al. Alzheimers & Dementia
- Melatonin Modulates lipid Metabolism in HepG2 Cells Cultured in High Concentrations of Oleic Acid: AMPK Pathway Activation may Play an Important Role
- (2018) Yan Mi et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- Melatonin protects mesenchymal stem cells from autophagy-mediated death under ischaemic ER-stress conditions by increasing prion protein expression
- (2018) Jun Hee Lee et al. CELL PROLIFERATION
- Autophagic dysfunction in Alzheimer’s disease: Cellular and molecular mechanistic approaches to halt Alzheimer’s pathogenesis
- (2018) Md. Sahab Uddin et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Is There Sufficient Evidence that the Melatonin Binding Site MT3 Is Quinone Reductase 2?
- (2018) Jean A. Boutin et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Melatonin protects chronic kidney disease mesenchymal stem cells against senescence via PrPC -dependent enhancement of the mitochondrial function
- (2018) Yong-Seok Han et al. JOURNAL OF PINEAL RESEARCH
- Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease
- (2018) Rodrigo Martins dos Santos et al. LIFE SCIENCES
- Microglia in Alzheimer's Disease: Risk Factors and Inflammation
- (2018) Atsuko Katsumoto et al. Frontiers in Neurology
- Alzheimer's disease
- (2017) C. A. Lane et al. EUROPEAN JOURNAL OF NEUROLOGY
- Melatonin-mediated upregulation of GLUT1 blocks exit from pluripotency by increasing the uptake of oxidized vitamin C in mouse embryonic stem cells
- (2017) Haibo Wu et al. FASEB JOURNAL
- The Gut Microbiota and Alzheimer’s Disease
- (2017) Chunmei Jiang et al. JOURNAL OF ALZHEIMERS DISEASE
- Cellular cholesterol homeostasis and Alzheimer’s disease
- (2017) Ta-Yuan Chang et al. JOURNAL OF LIPID RESEARCH
- Melatonin impedes Tet1-dependent mGluR5 promoter demethylation to relieve pain
- (2017) Ming-Chun Hsieh et al. JOURNAL OF PINEAL RESEARCH
- Melatonin ameliorates alcohol-induced bile acid synthesis by enhancing miR-497 expression
- (2017) Yong Deuk Kim et al. JOURNAL OF PINEAL RESEARCH
- Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis
- (2017) Ibtissem Rahim et al. JOURNAL OF PINEAL RESEARCH
- Melatonin suppresses platelet activation and function against cardiac ischemia/reperfusion injury via PPARγ/FUNDC1/mitophagy pathways
- (2017) Hao Zhou et al. JOURNAL OF PINEAL RESEARCH
- Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
- (2017) Fiona M. Menzies et al. NEURON
- The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
- (2017) Costantino Iadecola NEURON
- The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation
- (2017) Fatou Amar et al. Science Signaling
- Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/ NF-κB signaling pathway after LPS treatment in neonatal rats
- (2017) Yingying Hu et al. Oncotarget
- Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer’s Mouse Phenotypes
- (2017) Laura T. Haas et al. Cell Reports
- The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation
- (2017) Fatou Amar et al. Science Signaling
- Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease
- (2017) Xin Wang et al. Frontiers in Molecular Neuroscience
- Statins and the Squalene Synthase Inhibitor Zaragozic Acid Stimulate the Non-Amyloidogenic Pathway of Amyloid-β Protein Precursor Processing by Suppression of Cholesterol Synthesis
- (2017) Elzbieta Kojro et al. JOURNAL OF ALZHEIMERS DISEASE
- Effects of melatonin supplementation on blood lipid concentrations: A systematic review and meta-analysis of randomized controlled trials
- (2017) Mohsen Mohammadi-Sartang et al. CLINICAL NUTRITION
- 2016 Alzheimer's disease facts and figures
- (2016) Alzheimers & Dementia
- MT1and MT2Melatonin Receptors: A Therapeutic Perspective
- (2016) Jiabei Liu et al. Annual Review of Pharmacology and Toxicology
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease
- (2016) Laura Vella et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Oligomers of Amyloid β Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer Disease
- (2016) Laura T. Haas et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glymphatic clearance controls state-dependent changes in brain lactate concentration
- (2016) Iben Lundgaard et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium-dependent translocation of Drp1 to the mitochondria
- (2016) Shangcheng Xu et al. JOURNAL OF PINEAL RESEARCH
- Melatonin antagonizes cadmium-induced neurotoxicity by activating the transcription factor EB-dependent autophagy-lysosome machinery in mouse neuroblastoma cells
- (2016) Min Li et al. JOURNAL OF PINEAL RESEARCH
- Melatonin suppresses TPA-induced metastasis by downregulating matrix metalloproteinase-9 expression through JNK/SP-1 signaling in nasopharyngeal carcinoma
- (2016) Hsin-Yu Ho et al. JOURNAL OF PINEAL RESEARCH
- Melatonin as an antioxidant: under promises but over delivers
- (2016) Russel J. Reiter et al. JOURNAL OF PINEAL RESEARCH
- Modulation of Diabetes-Induced Oxidative Stress, Apoptosis, and Ca2+ Entry Through TRPM2 and TRPV1 Channels in Dorsal Root Ganglion and Hippocampus of Diabetic Rats by Melatonin and Selenium
- (2016) Mehmet Cemal Kahya et al. MOLECULAR NEUROBIOLOGY
- Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease
- (2016) Harm J. van de Haar et al. RADIOLOGY
- Mechanisms linking circadian clocks, sleep, and neurodegeneration
- (2016) Erik S. Musiek et al. SCIENCE
- Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease?
- (2016) Bryce A. Mander et al. TRENDS IN NEUROSCIENCES
- Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency
- (2016) Kavya Reddy et al. Cell Reports
- Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia
- (2016) Jintao Bao et al. Protein & Cell
- Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition
- (2016) Himakarnika Alluri et al. PLoS One
- Fyn inhibition rescues established memory and synapse loss in Alzheimer mice
- (2015) Adam C. Kaufman et al. ANNALS OF NEUROLOGY
- Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer’s disease
- (2015) Laura T. Haas et al. BRAIN
- Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease
- (2015) Matthew R Halliday et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier
- (2015) Steffen E. Storck et al. JOURNAL OF CLINICAL INVESTIGATION
- Pharmacokinetics of high-dose intravenous melatonin in humans
- (2015) Lars P. H. Andersen et al. JOURNAL OF CLINICAL PHARMACOLOGY
- A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
- (2015) Aleksanteri Aspelund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to -Amyloid Oligomer-Related Neurotoxicity and Memory Impairment
- (2015) V. G. Ostapchenko et al. JOURNAL OF NEUROSCIENCE
- Anatomical and cellular localization of melatonin MT1and MT2receptors in the adult rat brain
- (2015) Baptiste Lacoste et al. JOURNAL OF PINEAL RESEARCH
- Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling
- (2015) Lei Zhao et al. JOURNAL OF PINEAL RESEARCH
- Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer
- (2015) David Hevia et al. JOURNAL OF PINEAL RESEARCH
- Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus
- (2015) Tahir Ali et al. JOURNAL OF PINEAL RESEARCH
- Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia
- (2015) Cheng-Shi Xu et al. Journal of Translational Medicine
- Structural and functional features of central nervous system lymphatic vessels
- (2015) Antoine Louveau et al. NATURE
- GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration
- (2015) Ethan A Winkler et al. NATURE NEUROSCIENCE
- Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
- (2015) Zhen Zhao et al. NATURE NEUROSCIENCE
- Clearance systems in the brain—implications for Alzheimer disease
- (2015) Jenna M. Tarasoff-Conway et al. Nature Reviews Neurology
- Blood-Brain Barrier Breakdown in the Aging Human Hippocampus
- (2015) Axel Montagne et al. NEURON
- Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP
- (2015) Grant T. Corbett et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Melatonin attenuates carbon tetrachloride–induced liver fibrosis via inhibition of necroptosis
- (2015) Hyo-Sun Choi et al. Translational Research
- Hypoxia-controlled matrix metalloproteinase-9 hyperexpression promotes behavioral recovery after ischemia
- (2015) Hongxia Cai et al. Neuroscience Bulletin
- Impairment of paravascular clearance pathways in the aging brain
- (2014) Benjamin T. Kress et al. ANNALS OF NEUROLOGY
- Melatonin Treatment Protects Against Acute Spinal Cord Injury-Induced Disruption of Blood Spinal Cord Barrier in Mice
- (2014) Qingbin Wu et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Enhancing Astrocytic Lysosome Biogenesis Facilitates A Clearance and Attenuates Amyloid Plaque Pathogenesis
- (2014) Q. Xiao et al. JOURNAL OF NEUROSCIENCE
- Cognitive Enhancing Treatment with a PPARγ Agonist Normalizes Dentate Granule Cell Presynaptic Function in Tg2576 APP Mice
- (2014) Miroslav N. Nenov et al. JOURNAL OF NEUROSCIENCE
- Cilostazol suppresses β-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor-β
- (2014) Hye Rin Lee et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Melatonin stimulates the nonamyloidogenic processing ofβAPP through the positive transcriptional regulation of ADAM10 and ADAM17
- (2014) Mayuri Shukla et al. JOURNAL OF PINEAL RESEARCH
- Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-KB/JNK signaling pathway in aging mouse model
- (2014) Tahir Ali et al. JOURNAL OF PINEAL RESEARCH
- Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling
- (2014) In-Sik Shin et al. JOURNAL OF PINEAL RESEARCH
- Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia
- (2014) Pallab Bhattacharya et al. LIFE SCIENCES
- Reduction in traumatic brain injury-induced oxidative stress, apoptosis, and calcium entry in rat hippocampus by melatonin: Possible involvement of TRPM2 channels
- (2014) Vehbi Yürüker et al. METABOLIC BRAIN DISEASE
- Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk
- (2014) Leon M Tai et al. Molecular Neurodegeneration
- 'The clocks that time us'—circadian rhythms in neurodegenerative disorders
- (2014) Aleksandar Videnovic et al. Nature Reviews Neurology
- Correction: Melatonin Promotes Oligodendroglial Maturation of Injured White Matter in Neonatal Rats
- (2014) Paul Olivier et al. PLoS One
- Drowning stars: reassessing the role of astrocytes in brain edema
- (2014) Alexander S. Thrane et al. TRENDS IN NEUROSCIENCES
- Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain β-amyloid through PPARγ activation
- (2013) Li-ping Liu et al. ACTA PHARMACOLOGICA SINICA
- Effect of melatonin and cholesterol on the structure of DOPC and DPPC membranes
- (2013) E. Drolle et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre
- (2013) Jon B. Toledo et al. BRAIN
- Melatonin in Alzheimer’s Disease
- (2013) Li Lin et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Levels of Soluble Apolipoprotein E/Amyloid-β (Aβ) Complex Are Reduced and Oligomeric Aβ Increased withAPOE4and Alzheimer Disease in a Transgenic Mouse Model and Human Samples
- (2013) Leon M. Tai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
- (2013) Joanna M Wardlaw et al. LANCET NEUROLOGY
- Alzheimer disease therapy—moving from amyloid-β to tau
- (2013) Ezio Giacobini et al. Nature Reviews Neurology
- Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
- (2013) Chia-Chen Liu et al. Nature Reviews Neurology
- Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein
- (2013) Ji Won Um et al. NEURON
- Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats
- (2013) Yao-Wu Liu et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Sleep Drives Metabolite Clearance from the Adult Brain
- (2013) L. Xie et al. SCIENCE
- Increased in Vivo Amyloid- 42 Production, Exchange, and Loss in Presenilin Mutation Carriers
- (2013) R. Potter et al. Science Translational Medicine
- Melatonin directly interacts with cholesterol and alleviates cholesterol effects in dipalmitoylphosphatidylcholine monolayers
- (2013) Youngjik Choi et al. Soft Matter
- Amyloid-β–Associated Clinical Decline Occurs Only in the Presence of Elevated P-tau
- (2012) Rahul S. Desikan et al. ARCHIVES OF NEUROLOGY
- MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
- (2012) Jose A. Martina et al. Autophagy
- Two-Step Mechanism of Membrane Disruption by Aβ through Membrane Fragmentation and Pore Formation
- (2012) Michele F.M. Sciacca et al. BIOPHYSICAL JOURNAL
- Drugs for insomnia
- (2012) Nava Zisapel EXPERT OPINION ON EMERGING DRUGS
- Activation of AMP-activated protein kinase alleviates High-glucose-induced dysfunction of brain microvascular endothelial cell tight-junction dynamics
- (2012) Chao Liu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Spreading of Neurodegenerative Pathology via Neuron-to-Neuron Transmission of -Amyloid
- (2012) S. Nath et al. JOURNAL OF NEUROSCIENCE
- Melatonin inhibits type 1 interferon signaling of toll-like receptor 4 via heme oxygenase-1 induction in hepatic ischemia/reperfusion
- (2012) Jung-Woo Kang et al. JOURNAL OF PINEAL RESEARCH
- Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study
- (2012) Eric M Reiman et al. LANCET NEUROLOGY
- Aquaporin-4 mediates astrocyte response to β-amyloid
- (2012) Wei Yang et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Exosomal cell-to-cell transmission of alpha synuclein oligomers
- (2012) Karin M Danzer et al. Molecular Neurodegeneration
- Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
- (2012) Robert D. Bell et al. NATURE
- A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid
- (2012) J. J. Iliff et al. Science Translational Medicine
- Apolipoprotein E, amyloid-ß clearance and therapeutic opportunities in Alzheimer's disease
- (2012) Adam Kline Alzheimers Research & Therapy
- Peptidyl-prolyl cis–trans isomerase Pin1 in ageing, cancer and Alzheimer disease
- (2011) Tae Ho Lee et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Prolyl Isomerase Pin1 Promotes Amyloid Precursor Protein (APP) Turnover by Inhibiting Glycogen Synthase Kinase-3β (GSK3β) Activity
- (2011) Suk Ling Ma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of β-site APP-cleaving enzyme 1 gene expression and its role in Alzheimer’s Disease
- (2011) Xiulian Sun et al. JOURNAL OF NEUROCHEMISTRY
- Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo
- (2011) Tomohiro Umeda et al. JOURNAL OF NEUROSCIENCE RESEARCH
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- (2011) Rosa Cristòfol et al. JOURNAL OF PINEAL RESEARCH
- Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin
- (2011) Sergio A. Rosales-Corral et al. JOURNAL OF PINEAL RESEARCH
- GREATER RISK OF ALZHEIMER'S DISEASE IN OLDER ADULTS WITH INSOMNIA
- (2011) Ricardo S. Osorio et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- GSK-3α/β kinases and amyloid production in vivo
- (2011) Tomasz Jaworski et al. NATURE
- Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
- (2011) Berislav V. Zlokovic NATURE REVIEWS NEUROSCIENCE
- Mechanism of neuroprotection of melatonin against beta-amyloid neurotoxicity
- (2011) M. Ionov et al. NEUROSCIENCE
- Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet
- (2011) N. N. Haj-Yasein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Melatonin reduces hippocampal β-amyloid generation in rats exposed to chronic intermittent hypoxia
- (2010) Kwong-Man Ng et al. BRAIN RESEARCH
- The RAGE Axis
- (2010) Shi Fang Yan et al. CIRCULATION RESEARCH
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- (2010) Joshua B. Owen et al. FREE RADICAL BIOLOGY AND MEDICINE
- Melatonin Protects CD4+ T Cells from Activation-Induced Cell Death by Blocking NFAT-Mediated CD95 Ligand Upregulation
- (2010) A. M. d. C. Pedrosa et al. JOURNAL OF IMMUNOLOGY
- Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A
- (2010) Xifei Yang et al. JOURNAL OF PSYCHOPHARMACOLOGY
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- (2010) Pil-Jae Kong et al. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
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- (2010) M. L. Dubocovich et al. PHARMACOLOGICAL REVIEWS
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- (2009) Hyun Jin Cho et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2009) Emilie Cerf et al. BIOCHEMICAL JOURNAL
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- (2009) Jun Wang et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
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- (2009) Benjamin Harris et al. BRAIN RESEARCH
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- (2009) Russel J. Reiter et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Up-regulation of the α-secretase ADAM10 by retinoic acid receptors and acitretin
- (2009) Frank Tippmann et al. FASEB JOURNAL
- The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide
- (2009) Diego Albani et al. JOURNAL OF NEUROCHEMISTRY
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- (2009) Hung-Ming Chang et al. JOURNAL OF PINEAL RESEARCH
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- (2009) Jong-Wook Park et al. JOURNAL OF PINEAL RESEARCH
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- (2009) N. Joan Abbott et al. NEUROBIOLOGY OF DISEASE
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- (2009) Dong-Hyung Cho et al. SCIENCE
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- (2008) Hyun Jin Cho et al. AGING CELL
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- (2008) Ana I. Duarte et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
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- (2008) S. Otmani et al. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
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- (2008) Rixt F. Riemersma-van der Lek JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
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- (2008) Carl Julien et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
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- (2008) Glenna A. Dowling et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
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- (2008) R. Resende et al. NEUROSCIENCE
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- (2008) S PANDIPERUMAL et al. PROGRESS IN NEUROBIOLOGY
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- (2008) Jessica Pruessmeyer et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
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