Peptide-Based Molecular Strategies To Interfere with Protein Misfolding, Aggregation, and Cell Degeneration

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer’s disease

(2019) Dylan Shea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

(2019) Tom Scheidt et al.   Science Advances

Designed Macrocyclic Peptides as Nanomolar Amyloid Inhibitors Based on Minimal Recognition Elements

(2018) Anna Spanopoulou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improving oral bioavailability of cyclic peptides by N -methylation

(2018) Andreas F.B. Räder et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Peptide chemistry toolbox – Transforming natural peptides into peptide therapeutics

(2018) Miloš Erak et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of tau-derived hexapeptide aggregation and toxicity by a self-assembled cyclic d,l-α-peptide conformational inhibitor

(2018) A. Belostozky et al.   CHEMICAL COMMUNICATIONS

In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer’s Disease

(2018) Elena Schartmann et al.   JOURNAL OF ALZHEIMERS DISEASE

BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells

(2018) Marie E. Oskarsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploiting the therapeutic potential of ready-to-use drugs: Repurposing antibiotics against amyloid aggregation in neurodegenerative diseases

(2018) Sergio B. Socias et al.   PROGRESS IN NEUROBIOLOGY

The Physiological Roles of Amyloid-β Peptide Hint at New Ways to Treat Alzheimer's Disease

(2018) Holly M. Brothers et al.   Frontiers in Aging Neuroscience

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

Impact of nanoparticles on amyloid peptide and protein aggregation: a review with a focus on gold nanoparticles

(2018) Torsten John et al.   Nanoscale

The amyloid hypothesis on trial

(2018) Simon Makin   NATURE

Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors

(2017) Pascal Krotee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Key aromatic/hydrophobic amino acids controlling a cross-amyloid peptide interaction versus amyloid self-assembly

(2017) Maria Bakou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Current State of Peptide Drug Discovery: Back to the Future?

(2017) Antoine Henninot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Backbone Engineering within a Latent β-Hairpin Structure to Design Inhibitors of Polyglutamine Amyloid Formation

(2017) Karunakar Kar et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure-based inhibitors of tau aggregation

(2017) P. M. Seidler et al.   Nature Chemistry

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates

(2017) Sean Chia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer’s Disease

(2017) Deepti Goyal et al.   ACS Combinatorial Science

Noncerebral Amyloidoses: Aspects on Seeding, Cross-Seeding, and Transmission

(2017) Gunilla T. Westermark et al.   Cold Spring Harbor Perspectives in Medicine

Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity

(2017) Benedetta Mannini et al.   Frontiers in Molecular Neuroscience

Targeting Apolipoprotein E/Amyloid β Binding by Peptoid CPO_Aβ17-21 P Ameliorates Alzheimer’s Disease Related Pathology and Cognitive Decline

(2017) Shan Liu et al.   Scientific Reports

TANGO-Inspired Design of Anti-Amyloid Cyclic Peptides

(2016) Xiaomeng Lu et al.   ACS Chemical Neuroscience

Alpha-crystallin-derived peptides as therapeutic chaperones

(2016) Murugesan Raju et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Functional sequences in human alphaB crystallin

(2016) John I. Clark   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structure and function of α-crystallins: Traversing from in vitro to in vivo

(2016) Martin Haslbeck et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Self-Assembled Cyclic d,l -α-Peptides as Generic Conformational Inhibitors of the α-Synuclein Aggregation and Toxicity: In Vitro and Mechanistic Studies

(2016) Marina Chemerovski-Glikman et al.   CHEMISTRY-A EUROPEAN JOURNAL

Peptide Inhibitors of the amyloidogenesis of IAPP: verification of the hairpin-binding geometry hypothesis

(2016) Kalkena Sivanesam et al.   FEBS LETTERS

Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis

(2016) Jinghui Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptides Composed of Alternating L- and D-Amino Acids Inhibit Amyloidogenesis in Three Distinct Amyloid Systems Independent of Sequence

(2016) Jackson Kellock et al.   JOURNAL OF MOLECULAR BIOLOGY

Switchable photooxygenation catalysts that sense higher-order amyloid structures

(2016) Atsuhiko Taniguchi et al.   Nature Chemistry

Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson’s disease

(2016) Istvan Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Cyclic Peptide Mimic of the β-Amyloid Binding Domain on Transthyretin

(2015) Patricia Y. Cho et al.   ACS Chemical Neuroscience

In Vivo Seeding and Cross-Seeding of Localized Amyloidosis

(2015) Marie E. Oskarsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Contact between the β1 and β2 Segments of α-Synuclein that Inhibits Amyloid Formation

(2015) Hamed Shaykhalishahi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Hot-Segment-Based Approach for the Design of Cross-Amyloid Interaction Surface Mimics as Inhibitors of Amyloid Self-Assembly

(2015) Erika Andreetto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Uncovering the Mechanism of Aggregation of Human Transthyretin

(2015) Lorena Saelices et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting protein aggregation for the treatment of degenerative diseases

(2015) Yvonne S. Eisele et al.   NATURE REVIEWS DRUG DISCOVERY

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The role of type 2 diabetes in neurodegeneration

(2015) Giuseppe Verdile et al.   NEUROBIOLOGY OF DISEASE

Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins

(2015) Pietro Sormanni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transthyretin-Derived Peptides as β-Amyloid Inhibitors

(2014) Patricia Y. Cho et al.   ACS Chemical Neuroscience

Rational Design and Identification of a Non-Peptidic Aggregation Inhibitor of Amyloid-β Based on a Pharmacophore Motif Obtained fromcyclo[-Lys-Leu-Val-Phe-Phe-]

(2014) Tadamasa Arai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A β-Hairpin-Binding Protein for Three Different Disease-Related Amyloidogenic Proteins

(2014) Hamed Shaykhalishahi et al.   CHEMBIOCHEM

The structured core domain of  B-crystallin can prevent amyloid fibrillation and associated toxicity

(2014) G. K. A. Hochberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers

(2014) Gene Hopping et al.   eLife

Attenuation of the Aggregation and Neurotoxicity of Amyloid-β Peptides by Catalytic Photooxygenation

(2013) Atsuhiko Taniguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selectively N-Methylated Soluble IAPP Mimics as Potent IAPP Receptor Agonists and Nanomolar Inhibitors of Cytotoxic Self-Assembly of Both IAPP and Aβ40

(2013) Li-Mei Yan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multifaceted Roles of Disulfide Bonds. Peptides as Therapeutics

(2013) Miriam Góngora-Benítez et al.   CHEMICAL REVIEWS

Inhibiting and Reversing Amyloid-β Peptide (1-40) Fibril Formation with Gramicidin S and Engineered Analogues

(2013) Jinghui Luo et al.   CHEMISTRY-A EUROPEAN JOURNAL

In Vitro and Mechanistic Studies of an Antiamyloidogenic Self-Assembled Cyclic d,l-α-Peptide Architecture

(2013) Michal Richman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Novel Retro-Inverso Peptide Inhibitor Reduces Amyloid Deposition, Oxidation and Inflammation and Stimulates Neurogenesis in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease

(2013) Vadivel Parthsarathy et al.   PLoS One

Designed Trpzip-3 β-Hairpin Inhibits Amyloid Formation in Two Different Amyloid Systems

(2013) Gene Hopping et al.   ACS Medicinal Chemistry Letters

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

A Two-Step Strategy for Structure-Activity Relationship Studies of N-Methylated Aβ42 C-Terminal Fragments as Aβ42 Toxicity Inhibitors

(2012) Huiyuan Li et al.   ChemMedChem

Peptides for Therapy and Diagnosis of Alzheimer's Disease

(2012) Susanne Aileen Funke et al.   CURRENT PHARMACEUTICAL DESIGN

Inhibition of Amyloid Formation

(2012) Torleif Härd et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity

(2012) Pin-Nan Cheng et al.   Nature Chemistry

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Rational design of potent domain antibody inhibitors of amyloid fibril assembly

(2012) A. R. A. Ladiwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The generic amyloid formation inhibition effect of a designed small aromatic β-breaking peptide

(2011) Anat Frydman-Marom et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Designed Hairpin Peptides Interfere with Amyloidogenesis Pathways: Fibril Formation and Cytotoxicity Inhibition, Interception of the Preamyloid State

(2011) Kelly N. L. Huggins et al.   BIOCHEMISTRY

Macrocyclic β-Sheet Peptides That Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide

(2011) Jing Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

(2011) Stuart A. Sievers et al.   NATURE

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Structure-based design of conformation- and sequence-specific antibodies against amyloid  

(2011) J. M. Perchiacca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Hot Regions of the Aβ-IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association

(2010) Erika Andreetto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of a Proteolytically Stable Retro-Inverso Peptide Inhibitor of β-Amyloid Oligomerization as a Potential Novel Treatment for Alzheimer’s Disease

(2010) Mark Taylor et al.   BIOCHEMISTRY

Retro-Enantio N-Methylated Peptides as β-Amyloid Aggregation Inhibitors

(2009) Dolors Grillo-Bosch et al.   ChemMedChem

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process

(2009) Jed J. W. Wiltzius et al.   PROTEIN SCIENCE

N-Methylation of Peptides: A New Perspective in Medicinal Chemistry

(2008) Jayanta Chatterjee et al.   ACCOUNTS OF CHEMICAL RESEARCH

Exploiting Cross-Amyloid Interactions To Inhibit Protein Aggregation but not Function: Nanomolar Affinity Inhibition of Insulin Aggregation by an IAPP Mimic

(2008) Aleksandra Velkova et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cognitive-Performance Recovery of Alzheimer's Disease Model Mice by Modulation of Early Soluble Amyloidal Assemblies

(2008) Anat Frydman-Marom et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reduction of Alzheimer’s Disease Amyloid Plaque Load in Transgenic Mice by D3, a D-Enantiomeric Peptide Identified by Mirror Image Phage Display

(2008) Thomas van Groen et al.   ChemMedChem

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of A  toxicity

(2008) J. N. Buxbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA