Rapamycin extends murine lifespan but has limited effects on aging

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

(2012) J. Halloran et al.   NEUROSCIENCE

Adult-Onset Fluoxetine Treatment Does Not Improve Behavioral Impairments and May Have Adverse Effects on the Ts65Dn Mouse Model of Down Syndrome

(2012) Markus Heinen et al.   NEURAL PLASTICITY

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

(2011) Smita Majumder et al.   AGING CELL

Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

(2011) N Deblon et al.   BRITISH JOURNAL OF PHARMACOLOGY

mTOR inhibition and erythropoiesis: microcytosis or anaemia?

(2011) F. Diekmann et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice

(2010) Vladimir N. Anisimov et al.   AMERICAN JOURNAL OF PATHOLOGY

Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production

(2010) S. Zhang et al.   BLOOD

Rapamycin increases the yield and effector function of human γδ T cells stimulated in vitro

(2010) Haishan Li et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Loss of Inhibitory Insulin Receptor Substrate-1 Phosphorylation Is an Early Event in Mammalian Target of Rapamycin-Dependent Endometrial Hyperplasia and Carcinoma

(2010) A. S. McCampbell et al.   Cancer Prevention Research

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mouse phenotyping

(2010) Helmut Fuchs et al.   METHODS

Cardiac Aging in Mice and Humans: The Role of Mitochondrial Oxidative Stress

(2010) Dao-Fu Dai et al.   TRENDS IN CARDIOVASCULAR MEDICINE

An Emerging Role of mTOR in Lipid Biosynthesis

(2009) Mathieu Laplante et al.   CURRENT BIOLOGY

Echocardiographic assessment of global left ventricular function in mice

(2009) Jörg Stypmann et al.   LABORATORY ANIMALS

Noninvasive, In Vivo Assessment of Mouse Retinal Structure Using Optical Coherence Tomography

(2009) M. Dominik Fischer et al.   PLoS One

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

Low-dose aspirin prevents age-related endothelial dysfunction in a mouse model of physiological aging

(2008) Hélène Bulckaen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY