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Title
Mechanisms of Insulin Action and Insulin Resistance
Authors
Keywords
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Journal
PHYSIOLOGICAL REVIEWS
Volume 98, Issue 4, Pages 2133-2223
Publisher
American Physiological Society
Online
2018-08-01
DOI
10.1152/physrev.00063.2017
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- Ceramides and Glucosylceramides Are Independent Antagonists of Insulin Signaling
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- Cooperation between brain and islet in glucose homeostasis and diabetes
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- Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans
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- Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
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- An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
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- Alteration of JNK-1 Signaling in Skeletal Muscle Fails to Affect Glucose Homeostasis and Obesity-Associated Insulin Resistance in Mice
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- Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo
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- CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
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- A proteolytic pathway that controls glucose uptake in fat and muscle
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- The Insulin Receptor: Both a Prototypical and Atypical Receptor Tyrosine Kinase
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- Insulin stimulation regulates AS160 and TBC1D1 phosphorylation sites in human skeletal muscle
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- Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass
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- Insulin resistance/hyperinsulinemia and cancer mortality: the Cremona study at the 15th year of follow-up
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- Mechanisms for Insulin Resistance: Common Threads and Missing Links
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- Evidence against a Physiologic Role for Acute Changes in CNS Insulin Action in the Rapid Regulation of Hepatic Glucose Production
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- The Problem of Establishing Relationships between Hepatic Steatosis and Hepatic Insulin Resistance
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- Acetylation Negatively Regulates Glycogen Phosphorylase by Recruiting Protein Phosphatase 1
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- The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals
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- Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance
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- 31P-Magnetization Transfer Magnetic Resonance Spectroscopy Measurements of In Vivo Metabolism
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- Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet-Fed Mice
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- Interaction Between the Central and Peripheral Effects of Insulin in Controlling Hepatic Glucose Metabolism in the Conscious Dog
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- Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults
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- Adiponectin: mechanistic insights and clinical implications
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- Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
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- Hepatic ATGL knockdown uncouples glucose intolerance from liver TAG accumulation
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- Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects
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- Cyclic Nucleotide Phosphodiesterase 3 Signaling Complexes
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- Endoproteolytic Cleavage of TUG Protein Regulates GLUT4 Glucose Transporter Translocation
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- The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans
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- Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover
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- Increased Bioactive Lipids Content in Human Subcutaneous and Epicardial Fat Tissue Correlates with Insulin Resistance
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- Retinol-Binding Protein 4 Inhibits Insulin Signaling in Adipocytes by Inducing Proinflammatory Cytokines in Macrophages through a c-Jun N-Terminal Kinase- and Toll-Like Receptor 4-Dependent and Retinol-Independent Mechanism
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- A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
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- A unifying model for mTORC1-mediated regulation of mRNA translation
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- Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
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- Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
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- Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
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- Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
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- Leptin revisited: its mechanism of action and potential for treating diabetes
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- Regulation of glucose transport by insulin: traffic control of GLUT4
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- Revisiting the diacylglycerol-induced insulin resistance hypothesis
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- Paradoxical Lower Serum Triglyceride Levels and Higher Type 2 Diabetes Mellitus Susceptibility in Obese Individuals with the PNPLA3 148M Variant
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- Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor
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- Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum
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- Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
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- Nuclear receptor PPAR -regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis
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- The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase
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- JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation
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- TBC1D13 is a RAB35 Specific GAP that Plays an Important Role in GLUT4 Trafficking in Adipocytes
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- Linking mitochondrial bioenergetics to insulin resistance via redox biology
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- New insights into ER stress-induced insulin resistance
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- Dissociating fatty liver and diabetes
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- Quantifying the Contribution of the Liver to Glucose Homeostasis: A Detailed Kinetic Model of Human Hepatic Glucose Metabolism
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- Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
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- FoxO transcription factors; Regulation by AKT and 14-3-3 proteins
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- C2 Domain-Containing Phosphoprotein CDP138 Regulates GLUT4 Insertion into the Plasma Membrane
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- Hormonal Regulation of Hepatic Glucose Production in Health and Disease
- (2011) Hua V. Lin et al. Cell Metabolism
- Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis
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- Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype
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- Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking
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- Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle
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- Endoplasmic Reticulum Stress Promotes LIPIN2-Dependent Hepatic Insulin Resistance
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- Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation
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- Progressive Erosion of -Cell Function Precedes the Onset of Hyperglycemia in the NOD Mouse Model of Type 1 Diabetes
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- Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice
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- Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice
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- Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance
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- Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis
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- Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance
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- Hepatic FoxOs Regulate Lipid Metabolism via Modulation of Expression of the Nicotinamide Phosphoribosyltransferase Gene
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- Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice
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- Phospholipid Synthesis Participates in the Regulation of Diacylglycerol Required for Membrane Trafficking at the Golgi Complex
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- Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis
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- Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice
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- Ceramides as modulators of cellular and whole-body metabolism
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- Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs
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- Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling
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- PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans
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- The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population
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- Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
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- Metabolite profiles and the risk of developing diabetes
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- Skeletal Muscle Fatty Acid Handling in Insulin Resistant Men
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- Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism
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- Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
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- Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2
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- Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
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- The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
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- FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
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- Long-term effects of high-fat or high-carbohydrate diets on glucose tolerance in mice with heterozygous carnitine palmitoyltransferase-1a deficiency
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- Macrophages, Inflammation, and Insulin Resistance
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- Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
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- Acute or Chronic Upregulation of Mitochondrial Fatty Acid Oxidation Has No Net Effect on Whole-Body Energy Expenditure or Adiposity
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- Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance
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- Irs1 Serine 307 Promotes Insulin Sensitivity in Mice
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- Total Skeletal Muscle PGC-1 Deficiency Uncouples Mitochondrial Derangements from Fiber Type Determination and Insulin Sensitivity
- (2010) Christoph Zechner et al. Cell Metabolism
- Allosteric Regulation of Glycogen Synthase Controls Glycogen Synthesis in Muscle
- (2010) Michale Bouskila et al. Cell Metabolism
- Specific Roles of the p110α Isoform of Phosphatidylinsositol 3-Kinase in Hepatic Insulin Signaling and Metabolic Regulation
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- Insulin Reciprocally Regulates Glucagon Secretion in Humans
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- Downregulation of Adipose Tissue Fatty Acid Trafficking in Obesity: A Driver for Ectopic Fat Deposition?
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- Influence of Insulin in the Ventromedial Hypothalamus on Pancreatic Glucagon Secretion In Vivo
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- Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
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- Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice
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- Epidemiology of Non-Alcoholic Fatty Liver Disease
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- Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
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- Saturated- and n-6 Polyunsaturated-Fat Diets Each Induce Ceramide Accumulation in Mouse Skeletal Muscle: Reversal and Improvement of Glucose Tolerance by Lipid Metabolism Inhibitors
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- The unfolded protein response in human skeletal muscle is not involved in the onset of glucose tolerance impairment induced by a fat-rich diet
- (2010) Louise Deldicque et al. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
- Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma
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- Surgical Removal of Omental Fat Does Not Improve Insulin Sensitivity and Cardiovascular Risk Factors in Obese Adults
- (2010) Elisa Fabbrini et al. GASTROENTEROLOGY
- Hepatic Overexpression of a Constitutively Active Form of Liver Glycogen Synthase Improves Glucose Homeostasis
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- FoxOs Function Synergistically to Promote Glucose Production
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- Adipose Tissue Branched Chain Amino Acid (BCAA) Metabolism Modulates Circulating BCAA Levels
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- TNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome
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- Skeletal Muscle Mitochondria in Insulin Resistance: Differences in IntermyofibrillarVersusSubsarcolemmal Subpopulations and Relationship to Metabolic Flexibility
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- Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas
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- Regulation of fat specific protein 27 by isoproterenol and TNF-α to control lipolysis in murine adipocytes
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- CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance
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- Lipid-induced insulin resistance: unravelling the mechanism
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- Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways
- (2010) Y. C. Long et al. MOLECULAR AND CELLULAR BIOLOGY
- Insulin Regulates Adipocyte Lipolysis via an Akt-Independent Signaling Pathway
- (2010) S. M. Choi et al. MOLECULAR AND CELLULAR BIOLOGY
- A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action
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- Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
- (2010) Shomit Sengupta et al. MOLECULAR CELL
- Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
- (2010) William L Holland et al. NATURE MEDICINE
- Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease
- (2010) Kitt Falk Petersen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Increased Levels of Plasma Acylcarnitines in Obesity and Type 2 Diabetes and Identification of a Marker of Glucolipotoxicity
- (2010) Stephanie J. Mihalik et al. Obesity
- Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
- (2010) Shijie Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake
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- mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis: Fig. 1.
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- Paracrinology of islets and the paracrinopathy of diabetes
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- Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity
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- Leptin therapy in insulin-deficient type I diabetes
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- Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice
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- cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance
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- In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis
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- The Akt–SREBP nexus: cell signaling meets lipid metabolism
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- Fructose induced lipogenesis: from sugar to fat to insulin resistance
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- Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter
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- Insulin modulation of glucagon secretion: The role of insulin and other factors in the regulation of glucagon secretion
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- Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults
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- NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse
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- Asymmetrical dimethylarginine triggers lipolysis and inflammatory response via induction of endoplasmic reticulum stress in cultured adipocytes
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- Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome
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- Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance
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- TORC2 Regulates Hepatic Insulin Signaling via a Mammalian Phosphatidic Acid Phosphatase, LIPIN1
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- Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo
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- A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
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- Plasma Membrane Subdomain Compartmentalization Contributes to Distinct Mechanisms of Ceramide Action on Insulin Signaling
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- Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator-Activated Receptor- Coactivator-1 Expression
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- Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance
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- Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes
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- Muscle-Specific IRS-1 Ser->Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle
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- Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals
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- Skeletal Muscle-Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues
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- Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans
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- Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights fromin VivoManipulation of Sphingolipid Metabolism
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- Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways: Fig. 1.
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- Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice
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- Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding
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- Interplay and Effects of Temporal Changes in the Phosphorylation State of Serine-302, -307, and -318 of Insulin Receptor Substrate-1 on Insulin Action in Skeletal Muscle Cells
- (2008) Cora Weigert et al. MOLECULAR ENDOCRINOLOGY
- A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
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- Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production
- (2008) Penny Y. T. Wang et al. NATURE
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
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- Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
- (2008) Adilson Guilherme et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2
- (2008) Jinhua Wu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Sources of hepatic triglyceride accumulation during high-fat feeding in the healthy rat
- (2008) T. C. Delgado et al. NMR IN BIOMEDICINE
- Chromium Alleviates Glucose Intolerance, Insulin Resistance, and Hepatic ER Stress in Obese Mice
- (2008) Nair Sreejayan et al. Obesity
- Structural Basis of Protein Kinase C Isoform Function
- (2008) Susan F. Steinberg PHYSIOLOGICAL REVIEWS
- Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome
- (2008) M.-Y. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Paradoxical effects of increased expression of PGC-1 on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
- (2008) C. S. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1
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- A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance
- (2008) G. Sabio et al. SCIENCE
- The insulin receptor: a prototype for dimeric, allosteric membrane receptors?
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- Chronic Antidiabetic Sulfonylureas In Vivo: Reversible Effects on Mouse Pancreatic β-Cells
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- (2007) Michale Bouskila et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Mechanisms of Leptin Action and Leptin Resistance
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