Hypothalamic Insulin Resistance in Obesity: Effects on Glucose Homeostasis

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue

(2016) Sophie M. Steculorum et al.   CELL

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

(2016) Cristina García-Cáceres et al.   CELL

Asprosin, a Fasting-Induced Glucogenic Protein Hormone

(2016) Chase Romere et al.   CELL

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

(2016) Paul M. Titchenell et al.   Cell Metabolism

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance

(2016) Reema P. Vazirani et al.   DIABETES

Insulin receptor activation in the nucleus accumbens reflects nutritive value of a recently ingested meal

(2016) C.A. Woods et al.   PHYSIOLOGY & BEHAVIOR

Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor

(2016) Kumi Kimura et al.   Cell Reports

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Immune Regulation of Metabolic Homeostasis in Health and Disease

(2015) Jonathan R. Brestoff et al.   CELL

Glucoregulatory Relevance of Small Intestinal Nutrient Sensing in Physiology, Bariatric Surgery, and Pharmacology

(2015) Frank A. Duca et al.   Cell Metabolism

Effects of Intranasal Insulin on Hepatic Fat Accumulation and Energy Metabolism in Humans

(2015) Sofiya Gancheva et al.   DIABETES

New insights in leptin resistance mechanisms in mice

(2015) Eglantine Balland et al.   FRONTIERS IN NEUROENDOCRINOLOGY

The cell biology of fat expansion

(2015) Joseph M. Rutkowski et al.   JOURNAL OF CELL BIOLOGY

Impaired insulin action in the human brain: causes and metabolic consequences

(2015) Martin Heni et al.   Nature Reviews Endocrinology

Regulation of metabolism by the innate immune system

(2015) Denise E. Lackey et al.   Nature Reviews Endocrinology

S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction

(2015) L. Yang et al.   SCIENCE

Insulin resistance and impaired adipogenesis

(2015) Birgit Gustafson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo

(2015) Paul M. Titchenell et al.   Nature Communications

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis

(2015) Rachel J. Perry et al.   Nature Communications

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain

(2014) Eglantine Balland et al.   Cell Metabolism

Central Insulin Administration Improves Whole-Body Insulin Sensitivity via Hypothalamus and Parasympathetic Outputs in Men

(2014) M. Heni et al.   DIABETES

Intranasal Insulin Suppresses Endogenous Glucose Production in Humans Compared With Placebo in the Presence of Similar Venous Insulin Concentrations

(2014) Satya Dash et al.   DIABETES

Macrophages, Immunity, and Metabolic Disease

(2014) Joanne C. McNelis et al.   IMMUNITY

Adipose tissue-resident regulatory T cells: phenotypic specialization, functions and therapeutic potential

(2014) Daniela Cipolletta   IMMUNOLOGY

Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

(2014) Rachel J Perry et al.   NATURE MEDICINE

Targeting inflammation in the treatment of type 2 diabetes: time to start

(2014) Marc Y. Donath   NATURE REVIEWS DRUG DISCOVERY

Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss

(2014) Xiong Su et al.   Obesity

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

(2014) Julia Szendroedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors

(2014) Rebecca A. Haeusler et al.   Nature Communications

Immunological Goings-on in Visceral Adipose Tissue

(2013) Diane Mathis   Cell Metabolism

PET imaging reveals distinctive roles for different regional adipose tissue depots in systemic glucose metabolism in nonobese humans

(2012) Jason M. Ng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hyperinsulinemia Does Not Change Atherosclerosis Development in Apolipoprotein E Null Mice

(2012) Christian Rask-Madsen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Evidence against a Physiologic Role for Acute Changes in CNS Insulin Action in the Rapid Regulation of Hepatic Glucose Production

(2012) Christopher J. Ramnanan et al.   Cell Metabolism

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Interaction Between the Central and Peripheral Effects of Insulin in Controlling Hepatic Glucose Metabolism in the Conscious Dog

(2012) Christopher J. Ramnanan et al.   DIABETES

Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects

(2012) Faidon Magkos et al.   GASTROENTEROLOGY

Dysfunctional Adiposity and the Risk of Prediabetes and Type 2 Diabetes in Obese Adults

(2012) Ian J. Neeland et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

(2012) Mark A. Herman et al.   NATURE

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

(2012) Mingjian Lu et al.   NATURE MEDICINE

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Adaptive immunity in obesity and insulin resistance

(2012) Henrike Sell et al.   Nature Reviews Endocrinology

Leptin Therapy Reverses Hyperglycemia in Mice With Streptozotocin-Induced Diabetes, Independent of Hepatic Leptin Signaling

(2011) H. C. Denroche et al.   DIABETES

Banting Lecture 2011: Hyperinsulinemia: Cause or Consequence?

(2011) B. E. Corkey   DIABETES

Type 2 Diabetes Can Be Prevented With Early Pharmacological Intervention

(2011) R. A. DeFronzo et al.   DIABETES CARE

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice

(2011) K. Raddatz et al.   DIABETOLOGIA

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin-sensitive obesity

(2010) Nora Klöting et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The role of the autonomic nervous liver innervation in the control of energy metabolism

(2010) Chun-Xia Yi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

(2010) Jennifer W. Hill et al.   Cell Metabolism

Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men

(2010) C. Benedict et al.   DIABETES

Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic β-Cell Leptin Signaling

(2010) Sarah L. Gray et al.   ENDOCRINOLOGY

Regulation of fat specific protein 27 by isoproterenol and TNF-α to control lipolysis in murine adipocytes

(2010) Srijana Ranjit et al.   JOURNAL OF LIPID RESEARCH

Leptin therapy in insulin-deficient type I diabetes

(2010) M.-y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice

(2010) T. Fujikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and impaired adipogenesis in hypertrophic obesity in man

(2009) Birgit Gustafson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology

(2009) E. Arner et al.   DIABETES

Circulating Palmitoleate Strongly and Independently Predicts Insulin Sensitivity in Humans

(2009) N. Stefan et al.   DIABETES CARE

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis

(2009) Jennifer W. Hill et al.   ENDOCRINOLOGY

Chronic TNFα and cAMP pre-treatment of human adipocytes alter HSL, ATGL and perilipin to regulate basal and stimulated lipolysis

(2009) Véronic Bézaire et al.   FEBS LETTERS

STAT3 Targets the Regulatory Regions of Gluconeogenic Genesin Vivo

(2009) Preeti Ramadoss et al.   MOLECULAR ENDOCRINOLOGY

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

(2008) Haiming Cao et al.   CELL

Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation

(2008) Xiaocheng C. Dong et al.   Cell Metabolism

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity

(2008) Leonie Heilbronn et al.   CURRENT PHARMACEUTICAL DESIGN

Elevated Levels of the Anti-Inflammatory Interleukin-1 Receptor Antagonist Precede the Onset of Type 2 Diabetes: The Whitehall II Study

(2008) C. Herder et al.   DIABETES CARE

Regulation of hepatic glucose production and the role of gluconeogenesis in humans: is the rate of gluconeogenesis constant?

(2008) Frank Q. Nuttall et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Starvation and Triglycerides Reverse the Obesity-Induced Impairment of Insulin Transport at the Blood-Brain Barrier

(2008) Akihiko Urayama et al.   ENDOCRINOLOGY

Central insulin action regulates peripheral glucose and fat metabolism in mice

(2008) Linda Koch et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY