Mitochondria-Associated Membranes As Networking Platforms and Regulators of Cancer Cell Fate

The thiol switch C684 in Mitofusin-2 mediates redox-induced alterations of mitochondrial shape and respiration

(2018) Osamah Thaher et al.   NEUROCHEMISTRY INTERNATIONAL

Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling

(2017) Jin Kyung Kim et al.   IMMUNOLOGY AND CELL BIOLOGY

The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling

(2017) Alexander R. van Vliet et al.   MOLECULAR CELL

Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR

(2017) Pan Deng et al.   SEMINARS IN CANCER BIOLOGY

Mitochondrial metabolic regulation by GRP78

(2017) Manoj Prasad et al.   Science Advances

The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics

(2017) Amado Carreras-Sureda et al.   Frontiers in Oncology

Endoplasmic Reticulum–Mitochondrial Ca2+ Fluxes Underlying Cancer Cell Survival

(2017) Hristina Ivanova et al.   Frontiers in Oncology

Evidence for the involvement of lipid rafts localized at the ER-mitochondria associated membranes in autophagosome formation

(2016) Tina Garofalo et al.   Autophagy

When under pressure, get closer: PERKing up membrane contact sites during ER stress

(2016) Alexander R. van Vliet et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca 2+ signaling

(2016) Mart Bittremieux et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Coordination of stress, Ca2+, and immunogenic signaling pathways by PERK at the endoplasmic reticulum

(2016) Alexander R. van Vliet et al.   BIOLOGICAL CHEMISTRY

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

The coming of age of the mitochondria–ER contact: a matter of thickness

(2016) M Giacomello et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

FUNDC1 regulates mitochondrial dynamics at the ER–mitochondrial contact site under hypoxic conditions

(2016) Wenxian Wu et al.   EMBO JOURNAL

ORP5/ORP8 localize to endoplasmic reticulum–mitochondria contacts and are involved in mitochondrial function

(2016) Romain Galmes et al.   EMBO REPORTS

Metabolic signaling functions of ER–mitochondria contact sites: role in metabolic diseases

(2016) Emily Tubbs et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Mitofusins, from Mitochondria to Metabolism

(2016) Emilie Schrepfer et al.   MOLECULAR CELL

Mitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson’s Disease

(2016) M. Rodríguez-Arribas et al.   MOLECULAR NEUROBIOLOGY

Correcting mitochondrial fusion by manipulating mitofusin conformations

(2016) Antonietta Franco et al.   NATURE

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether

(2016) Deborah Naon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

(2016) Samantha C. Lewis et al.   SCIENCE

Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice

(2016) Aleix Sala-Vila et al.   Scientific Reports

PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development

(2016) Sonia Missiroli et al.   Cell Reports

Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria

(2016) César Cárdenas et al.   Cell Reports

Mitochondria-Associated Membranes: Composition, Molecular Mechanisms, and Physiopathological Implications

(2015) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

The BH4 Domain of Anti-apoptotic Bcl-XL, but Not That of the Related Bcl-2, Limits the Voltage-dependent Anion Channel 1 (VDAC1)-mediated Transfer of Pro-apoptotic Ca2+Signals to Mitochondria

(2015) Giovanni Monaco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels

(2015) Arnaud Mourier et al.   JOURNAL OF CELL BIOLOGY

Distinct mechanisms controlling rough and smooth endoplasmic reticulum contacts with mitochondria

(2015) P. T. C. Wang et al.   JOURNAL OF CELL SCIENCE

Immunity, inflammation, and cancer: an eternal fight between good and evil

(2015) Shabnam Shalapour et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Structure and function of ER membrane contact sites with other organelles

(2015) Melissa J. Phillips et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner

(2015) Carlotta Giorgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlling the unfolded protein response-mediated life and death decisions in cancer

(2015) Marion Maurel et al.   SEMINARS IN CANCER BIOLOGY

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

(2015) Abhishek D. Garg et al.   Frontiers in Immunology

New functions of mitochondria associated membranes in cellular signaling

(2014) Alexander R. van Vliet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Mitochondria-associated Endoplasmic Reticulum Membrane (MAM) Regulates Steroidogenic Activity via Steroidogenic Acute Regulatory Protein (StAR)-Voltage-dependent Anion Channel 2 (VDAC2) Interaction

(2014) Manoj Prasad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

(2013) Jean E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Enhanced parkin levels favor ER-mitochondria crosstalk and guarantee Ca2+ transfer to sustain cell bioenergetics

(2013) Tito Calì et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Complex Roles of Inflammasomes in Carcinogenesis

(2013) Stefan K. Drexler et al.   CANCER JOURNAL

TRIAP1/PRELI Complexes Prevent Apoptosis by Mediating Intramitochondrial Transport of Phosphatidic Acid

(2013) Christoph Potting et al.   Cell Metabolism

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Calcium and Endoplasmic Reticulum-Mitochondria Tethering in Neurodegeneration

(2013) Tito Calì et al.   DNA AND CELL BIOLOGY

Mfn2 modulates the UPR and mitochondrial function via repression of PERK

(2013) Juan Pablo Muñoz et al.   EMBO JOURNAL

An Interaction between Bcl-xLand the Voltage-dependent Anion Channel (VDAC) Promotes Mitochondrial Ca2+Uptake

(2013) Huiya Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mechanism and Physiological Function of Macroautophagy

(2013) Daniel J. Klionsky et al.   Journal of Innate Immunity

The coupling of plasma membrane calcium entry to calcium uptake by endoplasmic reticulum and mitochondria

(2013) Javier García-Sancho   JOURNAL OF PHYSIOLOGY-LONDON

Steroid hormone synthesis in mitochondria

(2013) Walter L. Miller   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival

(2013) Tomohisa Mori et al.   PLoS One

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

(2013) C. Betz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial membrane lipid remodeling in pathophysiology: A new target for diet and therapeutic interventions

(2013) João P. Monteiro et al.   PROGRESS IN LIPID RESEARCH

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

(2013) F. Korobova et al.   SCIENCE

Autophagy: shaping the tumor microenvironment and therapeutic response

(2013) Hannelore Maes et al.   TRENDS IN MOLECULAR MEDICINE

Altered Ca2+ signaling in cancer cells: Proto-oncogenes and tumor suppressors targeting IP3 receptors

(2012) Haidar Akl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

The intracellular redox state is a core determinant of mitochondrial fusion

(2012) Timothy Shutt et al.   EMBO REPORTS

Mediation of the Antiapoptotic Activity of Bcl-xL Protein upon Interaction with VDAC1 Protein

(2012) Nir Arbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation

(2012) E. Bobrovnikova-Marjon et al.   MOLECULAR AND CELLULAR BIOLOGY

The functions and regulation of the PTEN tumour suppressor

(2012) Min Sup Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitofusin-2 Independent Juxtaposition of Endoplasmic Reticulum and Mitochondria: An Ultrastructural Study

(2012) Pierre Cosson et al.   PLoS One

Flexibility of the N-Terminal mVDAC1 Segment Controls the Channel’s Gating Behavior

(2012) Barbara Mertins et al.   PLoS One

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Selective modulation of subtype III IP3R by Akt regulates ER Ca2+ release and apoptosis

(2012) S Marchi et al.   Cell Death & Disease

The ER–mitochondria interface: The social network of cell death

(2011) Stefan Grimm   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The multiple roles of autophagy in cancer

(2011) M. T. Rosenfeldt et al.   CARCINOGENESIS

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl

(2011) G Monaco et al.   CELL DEATH AND DIFFERENTIATION

The role of PML in the control of apoptotic cell fate: a new key player at ER–mitochondria sites

(2011) P Pinton et al.   CELL DEATH AND DIFFERENTIATION

Caveolin-1 Deficiency Causes Cholesterol-Dependent Mitochondrial Dysfunction and Apoptotic Susceptibility

(2011) Marta Bosch et al.   CURRENT BIOLOGY

Palmitoylated TMX and calnexin target to the mitochondria-associated membrane

(2011) Emily M Lynes et al.   EMBO JOURNAL

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

(2011) A. Varki   GLYCOBIOLOGY

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

(2011) Kurt J. De Vos et al.   HUMAN MOLECULAR GENETICS

Making heads or tails of phospholipids in mitochondria

(2011) Christof Osman et al.   JOURNAL OF CELL BIOLOGY

Long-chain acyl-CoA synthetase 4 modulates prostaglandin E2release from human arterial smooth muscle cells

(2011) Deidre L. Golej et al.   JOURNAL OF LIPID RESEARCH

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus

(2011) S. M. Horner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

The Ca2+ Pumps of the Endoplasmic Reticulum and Golgi Apparatus

(2011) I. Vandecaetsbeek et al.   Cold Spring Harbor Perspectives in Biology

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

(2010) L Bouman et al.   CELL DEATH AND DIFFERENTIATION

Apoptosis Protection by Mcl-1 and Bcl-2 Modulation of Inositol 1,4,5-Trisphosphate Receptor-dependent Ca2+Signaling

(2010) Emily F. Eckenrode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

The origin of the autophagosomal membrane

(2010) Sharon A. Tooze et al.   NATURE CELL BIOLOGY

PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release

(2010) C. Giorgi et al.   SCIENCE

In Vitro Growth Environment Produces Lipidomic and Electron Transport Chain Abnormalities in Mitochondria from Non-Tumorigenic Astrocytes and Brain Tumours

(2009) Michael A Kiebish et al.   ASN Neuro

Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis

(2009) Zachary T. Schug et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cytochrome c/cardiolipin relations in mitochondria: a kiss of death

(2009) Valerian E. Kagan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Plasma membrane associated membranes (PAM) from Jurkat cells contain STIM1 protein

(2009) Katarzyna Kozieł et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Voltage-dependent Anion Channel 1-based Peptides Interact with Bcl-2 to Prevent Antiapoptotic Activity

(2009) Nir Arbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutively Active Inflammasome in Human Melanoma Cells Mediating Autoinflammation via Caspase-1 Processing and Secretion of Interleukin-1β

(2009) Miyako Okamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins

(2009) S. Abu-Hamad et al.   JOURNAL OF CELL SCIENCE

Sigma-1 Receptors Regulate Bcl-2 Expression by Reactive Oxygen Species-Dependent Transcriptional Regulation of Nuclear Factor  B

(2009) J. Meunier et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

GM1-Ganglioside Accumulation at the Mitochondria-Associated ER Membranes Links ER Stress to Ca2+-Dependent Mitochondrial Apoptosis

(2009) Renata Sano et al.   MOLECULAR CELL

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

(2009) Y.-P. Rong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY

Akt kinase reducing endoplasmic reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuli

(2008) Saverio Marchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation

(2008) Veerle Vanderheyden et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial Cholesterol Contributes to Chemotherapy Resistance in Hepatocellular Carcinoma

(2008) J. Montero et al.   CANCER RESEARCH

Mitochondrial membrane cholesterol, the voltage dependent anion channel (VDAC), and the Warburg effect

(2008) Andrew M. Campbell et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Cardiolipin provides an essential activating platform for caspase-8 on mitochondria

(2008) Francois Gonzalvez et al.   JOURNAL OF CELL BIOLOGY

Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer

(2008) Michael A. Kiebish et al.   JOURNAL OF LIPID RESEARCH

The Subcellular Distribution of Calnexin Is Mediated by PACS-2

(2008) Nathan Myhill et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting Bcl-2-IP3 Receptor Interaction to Reverse Bcl-2's Inhibition of Apoptotic Calcium Signals

(2008) Yi-Ping Rong et al.   MOLECULAR CELL

Role of SERCA1 Truncated Isoform in the Proapoptotic Calcium Transfer from ER to Mitochondria during ER Stress

(2008) Mounia Chami et al.   MOLECULAR CELL

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria: The Hub of Cellular Ca2+ Signaling

(2008) György Szabadkai et al.   PHYSIOLOGY

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis

(2008) T. Szado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

(2008) M. Saotome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA