Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer's disease

Amyloid-β-Induced Mitochondrial Dysfunction Impairs the Autophagic Lysosomal Pathway in a Tubulin Dependent Pathway

(2018) Diana F.F. Silva et al.   JOURNAL OF ALZHEIMERS DISEASE

Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease

(2018) Xiongwei Zhu et al.   JOURNAL OF ALZHEIMERS DISEASE

An Integrative View of the Role of Oxidative Stress, Mitochondria and Insulin in Alzheimer's Disease

(2017) Paula I. Moreira et al.   JOURNAL OF ALZHEIMERS DISEASE

A New Function of Human HtrA2 as an Amyloid-β Oligomerization Inhibitor

(2017) Joel Kooistra et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

(2016) Md. Torequl Islam   NEUROLOGICAL RESEARCH

The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease

(2015) Zhenzhen Liu et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival

(2014) Juliana Navarro-Yepes et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

Oxidative Stress and Metabolic Syndrome: Cause or Consequence of Alzheimer's Disease?

(2014) Diana Luque-Contreras et al.   Oxidative Medicine and Cellular Longevity

Visual-Statistical Interpretation of 18F-FDG-PET Images for Characteristic Alzheimer Patterns in a Multicenter Study: Inter-Rater Concordance and Relationship to Automated Quantitative Evaluation

(2013) T. Yamane et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

(2013) Valasani Koteswara Rao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Physiologic Functions of Cyclophilin D and the Mitochondrial Permeability Transition Pore

(2013) John W. Elrod et al.   CIRCULATION JOURNAL

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

SOD2 in mitochondrial dysfunction and neurodegeneration

(2013) James M. Flynn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acetylcholinesterase Inhibitors: Structure Based Design, Synthesis, Pharmacophore Modeling, and Virtual Screening

(2013) Koteswara Rao Valasani et al.   Journal of Chemical Information and Modeling

Longitudinal Progression of Cognitive Decline Correlates with Changes in the Spatial Pattern of Brain 18F-FDG PET

(2013) S. Shokouhi et al.   JOURNAL OF NUCLEAR MEDICINE

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Rapamycin decreases tau phosphorylation at Ser214 through regulation of cAMP-dependent kinase

(2013) Yudong Liu et al.   NEUROCHEMISTRY INTERNATIONAL

Deconstructing Mitochondrial Dysfunction in Alzheimer Disease

(2013) Vega García-Escudero et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

(2013) Sefika Ozcelik et al.   PLoS One

Antioxidants for Alzheimer Disease

(2012) Douglas R. Galasko et al.   ARCHIVES OF NEUROLOGY

UCP2 inhibition triggers ROS-dependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells

(2012) Ilaria Dando et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Transitory phases of autophagic death and programmed necrosis during superoxide-induced neuronal cell death

(2012) Gavin C. Higgins et al.   FREE RADICAL BIOLOGY AND MEDICINE

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

(2012) Keiichi Inoue et al.   Molecular Neurodegeneration

PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins

(2012) Amandine Magnaudeix et al.   NEUROBIOLOGY OF AGING

Elevated Oxidative Stress and Decreased Antioxidant Function in the Human Hippocampus and Frontal Cortex with Increasing Age: Implications for Neurodegeneration in Alzheimer’s Disease

(2012) C. Venkateshappa et al.   NEUROCHEMICAL RESEARCH

Effects of Ginkgolide A on Okadaic Acid-induced Tau Hyperphosphorylation and the PI3K-Akt Signaling Pathway in N2a Cells

(2012) Yan Chen et al.   PLANTA MEDICA

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration

(2011) Björn Oettinghaus et al.   ACTA NEUROPATHOLOGICA

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice

(2011) Magali Dumont et al.   FASEB JOURNAL

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Manganese Superoxide Dismutase: Guardian of the Powerhouse

(2011) Aaron K. Holley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of Amyloid-  (A ) Peptide-Binding Alcohol Dehydrogenase-A  Interaction Reduces A  Accumulation and Improves Mitochondrial Function in a Mouse Model of Alzheimer's Disease

(2011) J. Yao et al.   JOURNAL OF NEUROSCIENCE

Suppression of Autophagy and Activation of Glycogen Synthase Kinase 3beta Facilitate the Aggregate Formation of Tau

(2011) Song-In Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation

(2011) Gary E. Gibson et al.   NEUROBIOLOGY OF AGING

The Role of Oxidative Stress in the Aging Process

(2011) Barbara F. Oliveira et al.   TheScientificWorldJOURNAL

Atg8: an autophagy-related ubiquitin-like protein family

(2011) Tomer Shpilka et al.   GENOME BIOLOGY

Convergence of Amyloid-β and Tau Pathologies on Mitochondria In Vivo

(2010) Anne Eckert et al.   MOLECULAR NEUROBIOLOGY

Cell “Self-Eating” (Autophagy) Mechanism in Alzheimer's Disease

(2010) Sarah F. Funderburk et al.   MOUNT SINAI JOURNAL OF MEDICINE

Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex

(2010) Philipp A. Jaeger et al.   PLoS One

Oxidative stress in Alzheimer disease

(2010) Alejandro Gella et al.   Cell Adhesion & Migration

Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease

(2009) S.M. Cardoso et al.   EXPERIMENTAL NEUROLOGY

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

(2009) Sandra L. Siedlak et al.   FREE RADICAL RESEARCH

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

(2009) Heng Du et al.   NEUROBIOLOGY OF AGING

Targeting Mitochondria

(2008) Adam T. Hoye et al.   ACCOUNTS OF CHEMICAL RESEARCH

Dynamin-Like Protein 1 Reduction Underlies Mitochondrial Morphology and Distribution Abnormalities in Fibroblasts from Sporadic Alzheimer's Disease Patients

(2008) Xinglong Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Oxidative Stress Signaling in Alzheimers Disease

(2008) B. Su et al.   Current Alzheimer Research

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

(2008) Tadanori Hamano et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease

(2008) J. Greilberger et al.   FREE RADICAL RESEARCH

Proteomic identification of nitrated brain proteins in early Alzheimer’s disease inferior parietal lobule

(2008) Tanea T. Reed et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Okadaic acid increases autophagosomes in rat neurons: Implications for Alzheimer's disease

(2008) Seung Yong Yoon et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE