Alterations of the Endoplasmic Reticulum (ER) Calcium Signaling Molecular Components in Alzheimer’s Disease

Targeting Post-Translational Remodeling of Ryanodine Receptor: a New Track for Alzheimer's Disease Therapy?

(2020) Mounia Chami et al.   Current Alzheimer Research

Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase

(2020) Noemi Esteras et al.   FEBS Journal

Identification of Structural Calcium Binding Sites in Membrane-Bound Presenilin 1 and 2

(2020) Rukmankesh Mehra et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium

(2020) Rebekah Mahoney et al.   Cell Reports

Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology

(2020) Noemi Esteras et al.   Cells

Transient Receptor Potential Canonical (TRPC) Channels: Then and Now

(2020) Xingjuan Chen et al.   Cells

Potential Drug Candidates to Treat TRPC6 Channel Deficiencies in the Pathophysiology of Alzheimer’s Disease and Brain Ischemia

(2020) Veronika Prikhodko et al.   Cells

Amyloid-β pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo

(2019) Cristina Vergara et al.   ACTA NEUROPATHOLOGICA

Dynamic compartmentalization of calcium channel signalling in neurons

(2019) Martin Heine et al.   NEUROPHARMACOLOGY

Familial Alzheimer’s disease-linked presenilin mutants and intracellular Ca2+ handling: A single-organelle, FRET-based analysis

(2019) Elisa Greotti et al.   CELL CALCIUM

Calcium Ions Stimulate the Hyperphosphorylation of Tau by Activating Microsomal Prostaglandin E Synthase 1

(2019) Long-Long Cao et al.   Frontiers in Aging Neuroscience

Antagonist of neuronal store-operated calcium entry exerts beneficial effects in neurons expressing PSEN1ΔE9 mutant linked to familial Alzheimer disease

(2019) Daria Chernyuk et al.   NEUROSCIENCE

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

(2019) Pooja Jadiya et al.   Nature Communications

Upregulation of the Sarco-Endoplasmic Reticulum Calcium ATPase 1 Truncated Isoform Plays a Pathogenic Role in Alzheimer’s Disease

(2019) Bussiere et al.   Cells

Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death

(2019) Elena Britti et al.   CELL CALCIUM

Xestospongin C, a Reversible IP3 Receptor Antagonist, Alleviates the Cognitive and Pathological Impairments in APP/PS1 Mice of Alzheimer’s Disease

(2019) Zhao-Jun Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Polymorphisms Within RYR3 Gene Are Associated With Risk and Age at Onset of Hypertension, Diabetes, and Alzheimer’s Disease

(2018) Shaoqing Gong et al.   AMERICAN JOURNAL OF HYPERTENSION

Ryanodine receptor dysfunction in human disorders

(2018) Alexander Kushnir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A new target for Alzheimer’s disease: A small molecule SERCA activator is neuroprotective in vitro and improves memory and cognition in APP/PS1 mice

(2018) Katherine Krajnak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neuronal calcium signaling via store-operated channels in health and disease

(2018) Tomasz Wegierski et al.   CELL CALCIUM

Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders

(2018) Polina A. Egorova et al.   FEBS Journal

Ryanodine receptor Ca 2+ release channel post-translational modification: Central player in cardiac and skeletal muscle disease

(2018) Amanda Denniss et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Role of Amyloid-β and Tau Proteins in Alzheimer’s Disease: Confuting the Amyloid Cascade

(2018) Walter Gulisano et al.   JOURNAL OF ALZHEIMERS DISEASE

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease

(2018) Estela Area-Gomez et al.   Cell Death & Disease

On the Role of Store-Operated Calcium Entry in Acute and Chronic Neurodegenerative Diseases

(2018) Agnese Secondo et al.   Frontiers in Molecular Neuroscience

Calcium signaling in Alzheimer's disease & therapies

(2018) Benjamin Chun-Kit Tong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hidden Risk Genes with High-Order Intragenic Epistasis in Alzheimer's Disease

(2018) Jiya Sun et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease

(2018) María José Pérez et al.   Redox Biology

Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy

(2017) Mikiko Oka et al.   JOURNAL OF BIOCHEMISTRY

Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor

(2017) Renaud Bussiere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of ryanodine receptor ion channel function

(2017) Gerhard Meissner   JOURNAL OF GENERAL PHYSIOLOGY

Presenilin-1 Delta E9 Mutant Induces STIM1-Driven Store-Operated Calcium Channel Hyperactivation in Hippocampal Neurons

(2017) Maria Ryazantseva et al.   MOLECULAR NEUROBIOLOGY

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Familial Alzheimer's Disease Mutations in Presenilins: Effects on Endoplasmic Reticulum Calcium Homeostasis and Correlation with Clinical Phenotypes

(2017) Omar Nelson et al.   JOURNAL OF ALZHEIMERS DISEASE

Presenilin-1 Holoprotein is an Interacting Partner of Sarco Endoplasmic Reticulum Calcium-ATPase and Confers Resistance to Endoplasmic Reticulum Stress

(2017) Haifeng Jin et al.   JOURNAL OF ALZHEIMERS DISEASE

Knockdown of amyloid precursor protein increases calcium levels in the endoplasmic reticulum

(2017) Kinga Gazda et al.   Scientific Reports

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

(2016) Inger Lauritzen et al.   ACTA NEUROPATHOLOGICA

The gain-of-function enhancement of IP3-receptor channel gating by familial Alzheimer's disease-linked presenilin mutants increases the open probability of mitochondrial permeability transition pore

(2016) Patrick Toglia et al.   CELL CALCIUM

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes

(2016) Dolores Del Prete et al.   JOURNAL OF ALZHEIMERS DISEASE

Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment

(2016) Hua Zhang et al.   JOURNAL OF NEUROSCIENCE

The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model

(2016) M Cissé et al.   MOLECULAR PSYCHIATRY

Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2

(2016) Wei Peng et al.   SCIENCE

Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry

(2016) Benjamin Chun-Kit Tong et al.   Science Signaling

Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry

(2016) Benjamin Chun-Kit Tong et al.   Science Signaling

Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1

(2016) Yannis Gerakis et al.   Scientific Reports

Mitochondria-Associated Membranes: Composition, Molecular Mechanisms, and Physiopathological Implications

(2015) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer’s disease

(2015) Kévin Baranger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

STIM and ORAI proteins in the nervous system

(2015) Robert Kraft   Channels

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease

(2015) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity

(2015) Elena Popugaeva et al.   Molecular Neurodegeneration

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

(2015) Michael Willem et al.   NATURE

An atomic structure of human γ-secretase

(2015) Xiao-chen Bai et al.   NATURE

Stim and Orai proteins in neuronal Ca2+ signaling and excitability

(2015) Francesco Moccia et al.   Frontiers in Cellular Neuroscience

TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production

(2015) Junfeng Wang et al.   Nature Communications

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer’s Disease-Causing Mutants in Presenilins

(2015) Don-On Daniel Mak et al.   PLoS Computational Biology

The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

(2014) Hoang S. Nhan et al.   ACTA NEUROPATHOLOGICA

Differential deregulation of astrocytic calcium signalling by amyloid-β, TNFα, IL-1β and LPS

(2014) Virginia Ronco et al.   CELL CALCIUM

The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease

(2014) Jie Liu et al.   Channels

Suppression of InsP3 Receptor-Mediated Ca2+ Signaling Alleviates Mutant Presenilin-Linked Familial Alzheimer's Disease Pathogenesis

(2014) D. Shilling et al.   JOURNAL OF NEUROSCIENCE

Ryanodine receptors: physiological function and deregulation in Alzheimer disease

(2014) Dolores Del Prete et al.   Molecular Neurodegeneration

Three-dimensional structure of human γ-secretase

(2014) Peilong Lu et al.   NATURE

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

(2014) Zhen Yan et al.   NATURE

PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease

(2014) Latha Devi et al.   NEUROBIOLOGY OF AGING

Administration of a selective β2 adrenergic receptor antagonist exacerbates neuropathology and cognitive deficits in a mouse model of Alzheimer's disease

(2014) Caterina Branca et al.   NEUROBIOLOGY OF AGING

Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice

(2014) Suya Sun et al.   NEURON

Formoterol, a Long-Acting β2 Adrenergic Agonist, Improves Cognitive Function and Promotes Dendritic Complexity in a Mouse Model of Down Syndrome

(2013) Van Dang et al.   BIOLOGICAL PSYCHIATRY

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

(2013) Devin M. Wolfe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

FK506 binding proteins: Cellular regulators of intracellular Ca2+ signalling

(2013) Debbi MacMillan   EUROPEAN JOURNAL OF PHARMACOLOGY

Calcium channelopathies and Alzheimer's disease: Insight into therapeutic success and failures

(2013) Shreaya Chakroborty et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography

(2013) Mary Ellen I. Koran et al.   HUMAN GENETICS

Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice

(2013) Marta Dobarro et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Ca2+Influx through Store-operated Ca2+Channels Reduces Alzheimer Disease β-Amyloid Peptide Secretion

(2013) William Zeiger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 1 Inositol Trisphosphate Receptor Regulates Cerebellar Circuits by Maintaining the Spine Morphology of Purkinje Cells in Adult Mice

(2013) T. Sugawara et al.   JOURNAL OF NEUROSCIENCE

Can the Calcium Hypothesis Explain Synaptic Loss in Alzheimer's Disease?

(2013) Elena Popugaeva et al.   Neurodegenerative Diseases

The role of intracellular calcium stores in synaptic plasticity and memory consolidation

(2013) Kathryn D. Baker et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Deconstructing Mitochondrial Dysfunction in Alzheimer Disease

(2013) Vega García-Escudero et al.   Oxidative Medicine and Cellular Longevity

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons

(2013) B. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β-peptide oligomers, ryanodine receptor-mediated Ca2+ release, and Wnt-5a/Ca2+ signaling: opposing roles in neuronal mitochondrial dynamics?

(2013) Andrea C. Paula-Lima et al.   Frontiers in Cellular Neuroscience

Amyloid-β and Alzheimer’s disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions

(2013) A A Grolla et al.   Cell Death & Disease

RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer’s brain synaptosomes

(2013) J P Palavicini et al.   Cell Death & Disease

Alzheimer's disease-associated peptide Aβ42 mobilizes ER Ca2+ via InsP3R-dependent and -independent mechanisms

(2013) Laura E. Jensen et al.   Frontiers in Molecular Neuroscience

Ca2+dysregulation in neurons from transgenic mice expressing mutant presenilin 2

(2012) Maulilio J. Kipanyula et al.   AGING CELL

Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease

(2012) Olivier Thibault et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of Leaky Neuronal Ryanodine Receptors in Stress- Induced Cognitive Dysfunction

(2012) Xiaoping Liu et al.   CELL

Response to Shillinget al.(10.1074/jbc.M111.300491)

(2012) Ilya Bezprozvanny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca2+Leak Channels

(2012) Dustin Shilling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Luminal Ca2+controls activation of the cardiac ryanodine receptor by ATP

(2012) Barbora Tencerová et al.   JOURNAL OF GENERAL PHYSIOLOGY

Early Presynaptic and Postsynaptic Calcium Signaling Abnormalities Mask Underlying Synaptic Depression in Presymptomatic Alzheimer's Disease Mice

(2012) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

Ryanodine Receptor Blockade Reduces Amyloid-  Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

(2012) B. Oules et al.   JOURNAL OF NEUROSCIENCE

The  -Secretase-Derived C-Terminal Fragment of  APP, C99, But Not A , Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

(2012) I. Lauritzen et al.   JOURNAL OF NEUROSCIENCE

BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease

(2012) Linda Chami et al.   Molecular Neurodegeneration

Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice

(2012) Jun Peng et al.   NEUROSCIENCE LETTERS

Stabilizing ER Ca2+ Channel Function as an Early Preventative Strategy for Alzheimer’s Disease

(2012) Shreaya Chakroborty et al.   PLoS One

Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability

(2012) Z. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of Ca2+ signaling in astrocytes from mice lacking amyloid precursor protein

(2011) Cristina I. Linde et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

(2011) Rommy von Bernhardi et al.   ANTIOXIDANTS & REDOX SIGNALING

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in Aging

(2011) Daniel C. Andersson et al.   Cell Metabolism

The ER stress factor XBP1s prevents amyloid-β neurotoxicity

(2011) Sergio Casas-Tinto et al.   HUMAN MOLECULAR GENETICS

Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore

(2011) Omar Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion

(2011) Jérémy Fauconnier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early calcium dysregulation in Alzheimer’s disease: setting the stage for synaptic dysfunction

(2011) Shreaya Chakroborty et al.   Science China-Life Sciences

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Redox Control of Brain Calcium in Health and Disease

(2010) Cecilia Hidalgo et al.   ANTIOXIDANTS & REDOX SIGNALING

Amyloid β-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF

(2010) Andrea C. Paula-Lima et al.   ANTIOXIDANTS & REDOX SIGNALING

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

The dysregulation of intracellular calcium in Alzheimer disease

(2010) Charlene Supnet et al.   CELL CALCIUM

Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors

(2010) Elena Alberdi et al.   CELL CALCIUM

Ryanodine receptor studies using genetically engineered mice

(2010) Alexander Kushnir et al.   FEBS LETTERS

Cardiac ryanodine receptor phosphorylation by CaM Kinase II: keeping the balance right

(2010) Susan Currie   Frontiers in Bioscience-Landmark

Activation and regulation of store-operated calcium entry

(2010) Jeremy T. Smyth et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

NMDA-Mediated Ca2+ Influx Drives Aberrant Ryanodine Receptor Activation in Dendrites of Young Alzheimer's Disease Mice

(2010) I. Goussakov et al.   JOURNAL OF NEUROSCIENCE

Calcium Signalling and Alzheimer’s Disease

(2010) Michael J. Berridge   NEUROCHEMICAL RESEARCH

ER Calcium and Alzheimer's Disease: In a State of Flux

(2010) M. P. Mattson   Science Signaling

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

(2010) J. T. Lanner et al.   Cold Spring Harbor Perspectives in Biology

The E693Δ Mutation in Amyloid Precursor Protein Increases Intracellular Accumulation of Amyloid β Oligomers and Causes Endoplasmic Reticulum Stress-Induced Apoptosis in Cultured Cells

(2009) Kazuchika Nishitsuji et al.   AMERICAN JOURNAL OF PATHOLOGY

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

(2009) Jeroen J.M. Hoozemans et al.   AMERICAN JOURNAL OF PATHOLOGY

Calcium enhances the proteolytic activity of BACE1: An in vitro biophysical and biochemical characterization of the BACE1–calcium interaction

(2009) Michael Hayley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake

(2009) Lucia Brunello et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

(2009) Antero Salminen et al.   Journal of Neuroinflammation

Expression of Human Amyloid Precursor Protein in Rat Cortical Neurons Inhibits Calcium Oscillations

(2009) S. F. Santos et al.   JOURNAL OF NEUROSCIENCE

Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice

(2009) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

Presenilins are essential for regulating neurotransmitter release

(2009) Chen Zhang et al.   NATURE

STIMulating store-operated Ca2+ entry

(2009) Michael D. Cahalan   NATURE CELL BIOLOGY

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

(2009) Andrew M Bellinger et al.   NATURE MEDICINE

Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapses

(2009) N. Holbro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive behavioral phenotyping of ryanodine receptor type3 (RyR3) knockout mice: Decreased social contact duration in two social interaction tests

(2009) Naoki Matsuo   Frontiers in Behavioral Neuroscience

Regulation of the Cardiac Muscle Ryanodine Receptor by O2Tension andS-Nitrosoglutathione†

(2008) Junhui Sun et al.   BIOCHEMISTRY

Effect of amyloid β on capacitive calcium entry in neural 2a cells

(2008) Ying Niu et al.   BRAIN RESEARCH BULLETIN

The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct protein–protein interaction

(2008) Volodya Hayrapetyan et al.   CELL CALCIUM

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

(2008) Kim N. Green et al.   JOURNAL OF CELL BIOLOGY

Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice

(2008) Stephan E. Lehnart et al.   JOURNAL OF CLINICAL INVESTIGATION

Luminal Mg2+, A Key Factor Controlling RYR2-mediated Ca2+Release: Cytoplasmic and Luminal Regulation Modeled in a Tetrameric Channel

(2008) Derek R. Laver et al.   JOURNAL OF GENERAL PHYSIOLOGY

Increased intraneuronal resting [Ca2+] in adult Alzheimer’s disease mice

(2008) José R. Lopez et al.   JOURNAL OF NEUROCHEMISTRY

Role of SERCA1 Truncated Isoform in the Proapoptotic Calcium Transfer from ER to Mitochondria during ER Stress

(2008) Mounia Chami et al.   MOLECULAR CELL

Amyloid-β protein impairs Ca2+ release and contractility in skeletal muscle

(2008) Alexander Shtifman et al.   NEUROBIOLOGY OF AGING

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON

Remodeling of ryanodine receptor complex causes "leaky" channels: A molecular mechanism for decreased exercise capacity

(2008) A. M. Bellinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES

Effect of the knockdown of amyloid precursor protein on intracellular calcium increases in a neuronal cell line derived from the cerebral cortex of a trisomy 16 mouse

(2007) Guillermo Rojas et al.   EXPERIMENTAL NEUROLOGY

The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity

(2007) Volodymyr Rybalchenko et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Calcium dysregulation in Alzheimer's disease

(2007) Lukasz Bojarski et al.   NEUROCHEMISTRY INTERNATIONAL