Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention
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Title
Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention
Authors
Keywords
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Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume -, Issue -, Pages BST20180025
Publisher
Portland Press Ltd.
Online
2018-07-09
DOI
10.1042/bst20180025
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Note: Only part of the references are listed.- Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs
- (2018) Diego Mastroeni et al. Alzheimers & Dementia
- Synthesis and evaluation of 2-(3-arylureido)pyridines and 2-(3-arylureido)pyrazines as potential modulators of Aβ-induced mitochondrial dysfunction in Alzheimer's disease
- (2018) Ahmed Elkamhawy et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton
- (2018) Dalila G. Ordonez et al. NEURON
- TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics
- (2018) Stephani A. Davis et al. NEUROSCIENCE LETTERS
- Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein
- (2018) Tammy Ryan et al. Nature Communications
- Decreased Proteolytic Activity of the Mitochondrial Amyloid-β Degrading Enzyme, PreP Peptidasome, in Alzheimer's Disease Brain Mitochondria
- (2018) Nyosha Alikhani et al. JOURNAL OF ALZHEIMERS DISEASE
- Amyloid-β Peptides are Generated in Mitochondria-Associated Endoplasmic Reticulum Membranes
- (2018) Bernadette Schreiner et al. JOURNAL OF ALZHEIMERS DISEASE
- Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity
- (2017) Jung-eun Park et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Interactions between Tau and Different Conformations of Tubulin: Implications for Tau Function and Mechanism
- (2017) Aranda R. Duan et al. JOURNAL OF MOLECULAR BIOLOGY
- Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage
- (2017) Veronica Lindström et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- PINK1 suppresses alpha-synuclein-induced neuronal injury: a novel mechanism in protein phosphatase 2A activation
- (2017) Weiwei Yang et al. Oncotarget
- αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease
- (2017) Victorio Martin Pozo Devoto et al. Scientific Reports
- Antioxidants in Central Nervous System Diseases: Preclinical Promise and Translational Challenges
- (2017) Chandrashekhar D. Kamat et al. JOURNAL OF ALZHEIMERS DISEASE
- Neuronal Calcium Signaling, Mitochondrial Dysfunction, and Alzheimer's Disease
- (2017) Charlene Supnet et al. JOURNAL OF ALZHEIMERS DISEASE
- A NH2 Tau Fragment Targets Neuronal Mitochondria at AD Synapses: Possible Implications for Neurodegeneration
- (2017) Giuseppina Amadoro et al. JOURNAL OF ALZHEIMERS DISEASE
- Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability
- (2017) Thomas Briston et al. Scientific Reports
- Quantification of active mitochondrial permeability transition pores using GNX-4975 inhibitor titrations provides insights into molecular identity
- (2016) A. P. Richardson et al. BIOCHEMICAL JOURNAL
- Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease
- (2016) Chung-Han Hsieh et al. Cell Stem Cell
- Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers
- (2016) Cathryn L. Ugalde et al. JOURNAL OF NEUROCHEMISTRY
- Mitochondrial dysfunction in Parkinson's disease
- (2016) Anindita Bose et al. JOURNAL OF NEUROCHEMISTRY
- Amyloid β-peptides interfere with mitochondrial preprotein import competence by a coaggregation process
- (2016) Giovanna Cenini et al. MOLECULAR BIOLOGY OF THE CELL
- Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease
- (2016) Zoi Alexopoulou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease
- (2016) Roberto Di Maio et al. Science Translational Medicine
- Identification of a Small Molecule Cyclophilin D Inhibitor for Rescuing Aβ-Mediated Mitochondrial Dysfunction
- (2016) Koteswara Rao Valasani et al. ACS Medicinal Chemistry Letters
- Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease
- (2016) Simon J. Beck et al. Nature Communications
- Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin
- (2016) Yu Hu et al. Oncotarget
- Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins
- (2016) Xia-Chun Li et al. Scientific Reports
- Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria
- (2016) Thomas Briston et al. Scientific Reports
- Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation
- (2016) Sun Young Chung et al. Stem Cell Reports
- Deubiquitinating enzymes regulate PARK2-mediated mitophagy
- (2015) Yuqing Wang et al. Autophagy
- N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore
- (2015) Sudeshna Roy et al. ChemMedChem
- Defective PITRM1 mitochondrial peptidase is associated with A amyloidotic neurodegeneration
- (2015) D. Brunetti et al. EMBO Molecular Medicine
- Proteinopathies, a core concept for understanding and ultimately treating degenerative disorders?
- (2015) Thomas A. Bayer EUROPEAN NEUROPSYCHOPHARMACOLOGY
- NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease
- (2015) V. Corsetti et al. HUMAN MOLECULAR GENETICS
- F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy
- (2015) Zhi Dong Zhou et al. HUMAN MOLECULAR GENETICS
- Mitochondria: A Therapeutic Target for Parkinson’s Disease?
- (2015) Yu Luo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α-synuclein in oligodendroglial cells
- (2015) Katharina Pukaß et al. JOURNAL OF NEUROCHEMISTRY
- A53T Human -Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration
- (2015) L. Chen et al. JOURNAL OF NEUROSCIENCE
- USP30: A new promising target for Parkinson's disease?
- (2015) S. Thobois MOVEMENT DISORDERS
- USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
- (2015) Christian N. Cunningham et al. NATURE CELL BIOLOGY
- The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
- (2015) Alicia M. Pickrell et al. NEURON
- α-Synuclein amino terminus regulates mitochondrial membrane permeability
- (2014) Jiamei Shen et al. BRAIN RESEARCH
- A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30
- (2014) Wen Yue et al. CELL RESEARCH
- Loss of the m-AAA protease subunit AFG3L2 causes mitochondrial transport defects and tau hyperphosphorylation
- (2014) A. K. Kondadi et al. EMBO JOURNAL
- USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin
- (2014) T. M. Durcan et al. EMBO JOURNAL
- The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease
- (2014) Li Fang Ng et al. FREE RADICAL BIOLOGY AND MEDICINE
- Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis
- (2014) Ernesto Miquel et al. FREE RADICAL BIOLOGY AND MEDICINE
- Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression
- (2014) Suzana Gispert et al. HUMAN MOLECULAR GENETICS
- Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice
- (2014) Chen Wenqiang et al. HUMAN MOLECULAR GENETICS
- The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy
- (2014) Tom Cornelissen et al. HUMAN MOLECULAR GENETICS
- Cinnamic Anilides as New Mitochondrial Permeability Transition Pore Inhibitors Endowed with Ischemia-Reperfusion Injury Protective Effect in Vivo
- (2014) Daniele Fancelli et al. JOURNAL OF MEDICINAL CHEMISTRY
- -Synuclein Is Localized to Mitochondria-Associated ER Membranes
- (2014) C. Guardia-Laguarta et al. JOURNAL OF NEUROSCIENCE
- The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
- (2014) Baris Bingol et al. NATURE
- GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis
- (2014) Lee J. Martin et al. Frontiers in Cellular Neuroscience
- Mitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?
- (2013) H Muyderman et al. BRITISH JOURNAL OF PHARMACOLOGY
- Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease
- (2013) Laura D. Osellame et al. Cell Metabolism
- Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance
- (2013) Irina Lonskaya et al. EMBO Molecular Medicine
- The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons
- (2013) Wenzhang Wang et al. HUMAN MOLECULAR GENETICS
- Parkin overexpression ameliorates hippocampal long-term potentiation and -amyloid load in an Alzheimer's disease mouse model
- (2013) X. Hong et al. HUMAN MOLECULAR GENETICS
- Down-regulation of Mortalin Exacerbates Aβ-mediated Mitochondrial Fragmentation and Dysfunction
- (2013) So Jung Park et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance
- (2013) Irina Lonskaya et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy
- (2013) Victoria S Burchell et al. NATURE NEUROSCIENCE
- AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons
- (2013) G. Amadoro et al. NEUROBIOLOGY OF DISEASE
- Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons
- (2013) Lan Guo et al. PLoS One
- Dimers of mitochondrial ATP synthase form the permeability transition pore
- (2013) V. Giorgio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin
- (2012) Michael Lazarou et al. DEVELOPMENTAL CELL
- Synthesis and evaluation of oxime derivatives as modulators for amyloid beta-induced mitochondrial dysfunction
- (2012) Young Seub Kim et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Mitochondria-targeted catalase reduces abnormal APP processing, amyloid production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension
- (2012) P. Mao et al. HUMAN MOLECULAR GENETICS
- Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease
- (2012) M. Manczak et al. HUMAN MOLECULAR GENETICS
- Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo
- (2012) Brian DuBoff et al. NEURON
- Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1
- (2012) Kanae Iijima-Ando et al. PLoS Genetics
- Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration
- (2012) Carsten Merkwirth et al. PLoS Genetics
- Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain
- (2011) Katherine J. Kopeikina et al. AMERICAN JOURNAL OF PATHOLOGY
- Mitochondria: The Common Upstream Driver of Amyloid-β and Tau Pathology in Alzheimers Disease
- (2011) D. F.F. Silva et al. Current Alzheimer Research
- FTD and ALS: A Tale of Two Diseases
- (2011) R. Ferrari et al. Current Alzheimer Research
- Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A in AD models
- (2011) P. J. Khandelwal et al. HUMAN MOLECULAR GENETICS
- α-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator
- (2011) Yuangang Zhu et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
- (2011) Ken Nakamura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease
- (2011) M. J. McManus et al. JOURNAL OF NEUROSCIENCE
- Interaction between NH2-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration
- (2011) Giuseppina Amadoro et al. NEUROBIOLOGY OF AGING
- -Synuclein fate is determined by USP9X-regulated monoubiquitination
- (2011) R. Rott et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FUS Transgenic Rats Develop the Phenotypes of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration
- (2011) Cao Huang et al. PLoS Genetics
- Extensive FUS-Immunoreactive Pathology in Juvenile Amyotrophic Lateral Sclerosis with Basophilic Inclusions
- (2010) Eric J. Huang et al. BRAIN PATHOLOGY
- Mortalin overexpression attenuates beta-amyloid-induced neurotoxicity in SH-SY5Y cells
- (2010) Mingyue Qu et al. BRAIN RESEARCH
- The dysregulation of intracellular calcium in Alzheimer disease
- (2010) Charlene Supnet et al. CELL CALCIUM
- Calcium-dependent mitochondrial function and dysfunction in neurons
- (2010) Natalia B. Pivovarova et al. FEBS Journal
- Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice
- (2010) Y.-F. Xu et al. JOURNAL OF NEUROSCIENCE
- TRO40303, a New Cardioprotective Compound, Inhibits Mitochondrial Permeability Transition
- (2010) S. Schaller et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
- (2010) Shankar J. Chinta et al. NEUROSCIENCE LETTERS
- Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
- (2010) H. S. Ko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice
- (2010) X. Shan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects inCol6a1−/−myopathic mice
- (2009) T Tiepolo et al. BRITISH JOURNAL OF PHARMACOLOGY
- Amyloid-beta Leads to Impaired Cellular Respiration, Energy Production and Mitochondrial Electron Chain Complex Activities in Human Neuroblastoma Cells
- (2009) V. Rhein et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Parkin promotes intracellular A 1-42 clearance
- (2009) M. P. Burns et al. HUMAN MOLECULAR GENETICS
- Cyclophilin D Modulates Mitochondrial F0F1-ATP Synthase by Interacting with the Lateral Stalk of the Complex
- (2009) Valentina Giorgio et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport
- (2009) Will Stoothoff et al. JOURNAL OF NEUROCHEMISTRY
- Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
- (2009) Martin Schwickart et al. NATURE
- Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model
- (2009) Heng Du et al. NEUROBIOLOGY OF AGING
- Amyloid- and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
- (2009) V. Rhein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain
- (2008) Latha Devi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
- (2008) Derek Narendra et al. JOURNAL OF CELL BIOLOGY
- Regulation of Mitochondrial Morphology by USP30, a Deubiquitinating Enzyme Present in the Mitochondrial Outer Membrane
- (2008) Nobuhiro Nakamura et al. MOLECULAR BIOLOGY OF THE CELL
- Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
- (2008) Heng Du et al. NATURE MEDICINE
- Study of subcellular localization and proteolysis of ataxin-3
- (2008) Chiara Pozzi et al. NEUROBIOLOGY OF DISEASE
- The amyloid -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
- (2008) C. A. Hansson Petersen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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