Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer
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Title
Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer
Authors
Keywords
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Journal
Cancers
Volume 11, Issue 11, Pages 1775
Publisher
MDPI AG
Online
2019-11-12
DOI
10.3390/cancers11111775
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Note: Only part of the references are listed.- Biological Functions of Autophagy Genes: A Disease Perspective
- (2019) Beth Levine et al. CELL
- Autophagy inhibition to augment mTOR inhibition: A phase I/II trial of everolimus and hydroxychloroquine in patients with previously treated renal cell carcinoma
- (2019) Naomi B. Haas et al. CLINICAL CANCER RESEARCH
- Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers
- (2019) Conan G. Kinsey et al. NATURE MEDICINE
- Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer
- (2019) Kirsten L. Bryant et al. NATURE MEDICINE
- Targeting PI3K in cancer: mechanisms and advances in clinical trials
- (2019) Jing Yang et al. Molecular Cancer
- MicroRNA-137 inhibits autophagy and chemosensitizes pancreatic cancer cells by targeting ATG5
- (2019) Zhi-Chao Wang et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Therapeutic modulation of autophagy: which disease comes first?
- (2019) Maria Chiara Maiuri et al. CELL DEATH AND DIFFERENTIATION
- Protective autophagy decreases osimertinib cytotoxicity through regulation of stem cell-like properties in lung cancer
- (2019) Li Li et al. CANCER LETTERS
- Tumor-associated macrophages modulate resistance to oxaliplatin via inducing autophagy in hepatocellular carcinoma
- (2019) Xiu-Tao Fu et al. Cancer Cell International
- Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells
- (2019) Yihua Wang et al. Autophagy
- Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of β-catenin pathway
- (2019) Satabdi Datta et al. APOPTOSIS
- Autophagy inhibition overcomes sorafenib resistance in S45F‐mutated desmoid tumors
- (2019) Danielle Braggio et al. CANCER
- Zinc chelator TPEN induces pancreatic cancer cell death through causing oxidative stress and inhibiting cell autophagy
- (2019) Zhen Yu et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Anticancer autophagy inhibitors attract ‘resurgent’ interest
- (2019) Elie Dolgin NATURE REVIEWS DRUG DISCOVERY
- Autophagy-induced senescence is regulated by p38α signaling
- (2019) Konstantin Slobodnyuk et al. Cell Death & Disease
- Gefitinib‑mediated apoptosis is enhanced via inhibition of autophagy by chloroquine diphosphate in cutaneous squamous cell carcinoma cells
- (2019) Jianyu Wang et al. Oncology Letters
- Drug resistance: the next target for cancer treatment
- (2019) Nigel Hawkes BMJ-British Medical Journal
- Inhibition LC3B can increase chemosensitivity of ovarian cancer cells
- (2019) Jing Tang et al. Cancer Cell International
- Mechanisms of Innate and Acquired Resistance to Anti-EGFR therapy: A Review of Current Knowledge with a Focus on Rechallenge Therapies
- (2019) Christine M. Parseghian et al. CLINICAL CANCER RESEARCH
- Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux
- (2019) Zhi-peng Wen et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- The dual PI3K/mTOR inhibitor BEZ235 restricts the growth of lung cancer tumors regardless of EGFR status, as a potent accompanist in combined therapeutic regimens
- (2019) Yi-Ying Wu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- The novel autophagy inhibitor ROC-325 augments the antileukemic activity of azacitidine
- (2019) Steffan T. Nawrocki et al. LEUKEMIA
- Cell signaling and cancer: a mechanistic insight into drug resistance
- (2019) Munmun Panda et al. MOLECULAR BIOLOGY REPORTS
- EGCG overcomes gefitinib resistance by inhibiting autophagy and augmenting cell death through targeting ERK phosphorylation in NSCLC
- (2019) Jiao Meng et al. OncoTargets and Therapy
- p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance
- (2019) Karine Flem-Karlsen et al. Scientific Reports
- A novel potent autophagy inhibitor ECDD-S27 targets vacuolar ATPase and inhibits cancer cell survival
- (2019) Jiraporn Paha et al. Scientific Reports
- Xanthium strumarium Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells
- (2019) Hsueh-Wei Chang et al. Toxins
- Relationship of B7-H3 expression in tumor cells and tumor vasculature with FOXP3+ regulatory T cells in renal cell carcinoma
- (2019) Kentaro Inamura et al. Cancer Management and Research
- A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy
- (2019) Rekha Khandia et al. Cells
- Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition
- (2019) Christina G. Towers et al. DEVELOPMENTAL CELL
- A reversible autophagy inhibitor blocks autophagosome–lysosome fusion by preventing Stx17 loading onto autophagosomes
- (2019) Somya Vats et al. MOLECULAR BIOLOGY OF THE CELL
- MCT1 relieves osimertinib-induced CRC suppression by promoting autophagy through the LKB1/AMPK signaling
- (2019) Ping Jin et al. Cell Death & Disease
- Targeting Autophagy in Cancer: Recent Advances and Future Directions
- (2019) Ravi K. Amaravadi et al. Cancer Discovery
- CS-PEI/Beclin-siRNA Downregulate Multidrug Resistance Proteins and Increase Paclitaxel Therapeutic Efficacy against NSCLC
- (2019) Wangta Liu et al. Molecular Therapy-Nucleic Acids
- Hydroxychloroquine potentiates the anti-cancer effect of bevacizumab on glioblastoma via the inhibition of autophagy
- (2019) Lin-qing Liu et al. BIOMEDICINE & PHARMACOTHERAPY
- Colorectal cancer cells respond differentially to autophagy inhibition in vivo
- (2019) Annie Lauzier et al. Scientific Reports
- Enhancing anti-tumor efficiency in hepatocellular carcinoma through the autophagy inhibition by miR-375/sorafenib in lipid-coated calcium carbonate nanoparticles
- (2018) Pengxuan Zhao et al. Acta Biomaterialia
- Mechanisms of acquired resistance to first- and second-generation EGFR tyrosine kinase inhibitors
- (2018) D Westover et al. ANNALS OF ONCOLOGY
- Molecular mechanisms of acquired resistance to third-generation EGFR-TKIs in EGFR T790M-mutant lung cancer
- (2018) C Ricordel et al. ANNALS OF ONCOLOGY
- MTA1 is a novel regulator of autophagy that induces tamoxifen resistance in breast cancer cells
- (2018) Min-Ho Lee et al. Autophagy
- Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
- (2018) Mario Mauthe et al. Autophagy
- Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization
- (2018) Punya Bhat et al. BIOCHEMICAL PHARMACOLOGY
- Autophagy in health and disease: A comprehensive review
- (2018) Sarbari Saha et al. BIOMEDICINE & PHARMACOTHERAPY
- Targeting autophagy in cancer
- (2018) Angelique V. Onorati et al. CANCER
- Pro-survival autophagy and cancer cell resistance to therapy
- (2018) Chandan Kanta Das et al. CANCER AND METASTASIS REVIEWS
- PFN1 Induces drug resistance through Beclin1 Complex mediated autophagy in multiple myeloma
- (2018) Yichen Lu et al. CANCER SCIENCE
- Ambra1 Modulates the Sensitivity of Breast Cancer Cells to Epirubicin by Regulating Autophagy via ATG12
- (2018) Wei-liang Sun et al. CANCER SCIENCE
- Autophagy Facilitates Metadherin-Induced Chemotherapy Resistance Through the AMPK/ATG5 Pathway in Gastric Cancer
- (2018) Guoqing Pei et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- MicroRNA-29c Increases the Chemosensitivity of Pancreatic Cancer Cells by Inhibiting USP22 Mediated Autophagy
- (2018) Limin Huang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- The challenge of drug resistance in cancer treatment: a current overview
- (2018) Michail Nikolaou et al. CLINICAL & EXPERIMENTAL METASTASIS
- Drug Resistance in HER2-Positive Breast Cancer Brain Metastases: Blame the Barrier or the Brain?
- (2018) Sheheryar Kabraji et al. CLINICAL CANCER RESEARCH
- Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover
- (2018) Brent E. Fitzwalter et al. DEVELOPMENTAL CELL
- Autophagy promotes escape from phosphatidylinositol 3-kinase inhibition in estrogen receptor–positive breast cancer
- (2018) Wei Yang et al. FASEB JOURNAL
- Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation
- (2018) Zhe Sha et al. JOURNAL OF CELL BIOLOGY
- Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update
- (2018) Antonio C. Wolff et al. JOURNAL OF CLINICAL ONCOLOGY
- Management of acquired resistance to EGFR TKI–targeted therapy in advanced non-small cell lung cancer
- (2018) Shang-Gin Wu et al. Molecular Cancer
- EGFR-TKIs resistance via EGFR-independent signaling pathways
- (2018) Qian Liu et al. Molecular Cancer
- Inhibition of autophagy promotes cisplatin-induced apoptotic cell death through Atg5 and Beclin 1 in A549 human lung cancer cells
- (2018) Jianhua Chen et al. Molecular Medicine Reports
- CQ sensitizes human pancreatic cancer cells to gemcitabine through the lysosomal apoptotic pathway via reactive oxygen species
- (2018) Zhiping Fu et al. Molecular Oncology
- Autophagy inhibition potentiates SAHA‑mediated apoptosis in glioblastoma cells by accumulation of damaged mitochondria
- (2018) Kovooru Lohitesh et al. ONCOLOGY REPORTS
- Efficacy of PI3K/AKT/mTOR pathway inhibitors for the treatment of advanced solid cancers: A literature-based meta-analysis of 46 randomised control trials
- (2018) Xuan Li et al. PLoS One
- Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors
- (2018) Lucas Robke et al. TETRAHEDRON
- CD24 regulates sorafenib resistance via activating autophagy in hepatocellular carcinoma
- (2018) Shuai Lu et al. Cell Death & Disease
- PIK3CA mutations confer resistance to first-line chemotherapy in colorectal cancer
- (2018) Qiang Wang et al. Cell Death & Disease
- Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence
- (2018) Laura Vera-Ramirez et al. Nature Communications
- Attenuation of everolimus-induced cytotoxicity by a protective autophagic pathway involving ERK activation in renal cell carcinoma cells
- (2018) Yizhou Zeng et al. Drug Design Development and Therapy
- ERK inhibition represses gefitinib resistance in non-small cell lung cancer cells
- (2018) Mengfan Qi et al. Oncotarget
- Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy
- (2018) Pei-Feng Liu et al. Theranostics
- BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells
- (2018) Chandan Kanta Das et al. NEOPLASIA
- High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance
- (2018) In-geun Ryoo et al. Redox Biology
- Tumor B7-H3 (CD276) Expression and Survival in Pancreatic Cancer
- (2018) Kentaro Inamura et al. Journal of Clinical Medicine
- Activation of p62/SQSTM1–Keap1–Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer
- (2018) Yoshinobu Ichimura et al. Frontiers in Oncology
- Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer
- (2018) Lu Zhang et al. Autophagy
- Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo
- (2018) Yuanyuan Fu et al. Autophagy
- USP9X inhibition improves gemcitabine sensitivity in pancreatic cancer by inhibiting autophagy
- (2018) Tao Ma et al. CANCER LETTERS
- Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib
- (2018) Matheus Dyczynski et al. CANCER LETTERS
- Combined inhibition of autophagy and Nrf2 signaling augments bortezomib-induced apoptosis by increasing ROS production and ER stress in pancreatic cancer cells
- (2018) Xu Li et al. International Journal of Biological Sciences
- Human non‑small cell lung cancer cells can be sensitized to camptothecin by modulating autophagy
- (2018) Yi-Han Chiu et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Heme oxygenase-1 induction mediates chemoresistance of breast cancer cells to pharmorubicin by promoting autophagy via PI3K/Akt pathway
- (2018) Lei Pei et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- AZD9291 promotes autophagy and inhibits PI3K/Akt pathway in NSCLC cancer cells
- (2018) Zhirui Zhang et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Inhibition of autophagy by MPT0L145, a novel PIK3C3 inhibitor, to overcome drug resistance in cancer cells.
- (2018) Chun-Han Chen et al. JOURNAL OF CLINICAL ONCOLOGY
- TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis
- (2018) Guo-sheng Zhao et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA
- (2018) Simon Heine et al. Journal of Hematology & Oncology
- Revisiting the clinical and biologic relevance of partial PTEN loss in melanoma
- (2018) Keith M. Giles et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo
- (2018) Lalita Guntuku et al. ONCOGENE
- Autophagy mediates epithelial cancer chemoresistance by reducing p62/SQSTM1 accumulation
- (2018) R. Alessia Battista et al. PLoS One
- Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis
- (2018) Mariachiara Buccarelli et al. Cell Death & Disease
- A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B
- (2018) D. Bosc et al. Scientific Reports
- Autophagy Inhibition Promotes Bevacizumab-induced Apoptosis and Proliferation Inhibition in Colorectal Cancer Cells
- (2018) Zhi Zhao et al. Journal of Cancer
- Inhibition of autophagy by chloroquine makes chemotherapy in nasopharyngeal carcinoma more efficient
- (2018) Tomomi Aga et al. AURIS NASUS LARYNX
- Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma
- (2018) S. Verykiou et al. BRITISH JOURNAL OF DERMATOLOGY
- Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice
- (2018) Kivanc Görgülü et al. GASTROENTEROLOGY
- Combined treatment with modulated electro-hyperthermia and an autophagy inhibitor effectively inhibit ovarian and cervical cancer growth
- (2018) Wookyeom Yang et al. INTERNATIONAL JOURNAL OF HYPERTHERMIA
- Her2-Targeted Therapy Induces Autophagy in Esophageal Adenocarcinoma Cells
- (2018) Félice Janser et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Novel Autophagy Inhibitor Alpha-Hederin Promoted Paclitaxel Cytotoxicity by Increasing Reactive Oxygen Species Accumulation in Non-Small Cell Lung Cancer Cells
- (2018) Yujuan Zhan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- p62/SQSTM1 – steering the cell through health and disease
- (2018) Pablo Sánchez-Martín et al. JOURNAL OF CELL SCIENCE
- The multifaceted role of autophagy in cancer and the microenvironment
- (2018) Hendrik Folkerts et al. MEDICINAL RESEARCH REVIEWS
- The clinical value of using chloroquine or hydroxychloroquine as autophagy inhibitors in the treatment of cancers
- (2018) Ran Xu et al. MEDICINE
- Autophagy Inhibitor (LY294002) and 5-fluorouracil (5-FU) Combination-Based Nanoliposome for Enhanced Efficacy Against Esophageal Squamous Cell Carcinoma
- (2018) Ye Feng et al. Nanoscale Research Letters
- Inhibition of autophagy enhances cinobufagin‑induced apoptosis in gastric cancer
- (2018) Xuanxuan Xiong et al. ONCOLOGY REPORTS
- The autophagy inhibitor spautin-1, either alone or combined with doxorubicin, decreases cell survival and colony formation in canine appendicular osteosarcoma cells
- (2018) Courtney R. Schott et al. PLoS One
- ER translocation of the MAPK pathway drives therapy resistance in BRAF mutant melanoma
- (2018) Rani Ojha et al. Cancer Discovery
- Evolution of Cancer Pharmacological Treatments at the Turn of the Third Millennium
- (2018) Luca Falzone et al. Frontiers in Pharmacology
- Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life
- (2018) Yoomi Chun et al. Cells
- Danthron suppresses autophagy and sensitizes pancreatic cancer cells to doxorubicin
- (2018) Hua Chen et al. TOXICOLOGY IN VITRO
- Concurrent Autophagy Inhibition Overcomes the Resistance of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Human Bladder Cancer Cells
- (2017) Minyong Kang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Inhibition of Autophagy by Deguelin Sensitizes Pancreatic Cancer Cells to Doxorubicin
- (2017) Xiao Xu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Clinical Applications of Autophagy Proteins in Cancer: From Potential Targets to Biomarkers
- (2017) Svetlana Bortnik et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Phase 1 and pharmacokinetic study of LY3007113, a p38 MAPK inhibitor, in patients with advanced cancer
- (2017) Jonathan W. Goldman et al. INVESTIGATIONAL NEW DRUGS
- Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma
- (2017) Lindsay DeVorkin et al. MOLECULAR CANCER RESEARCH
- Resistance Mechanism against Trastuzumab in HER2-Positive Cancer Cells and Its Negation by Src Inhibition
- (2017) Mei Hua Jin et al. MOLECULAR CANCER THERAPEUTICS
- Autophagy Inhibition Improves Sunitinib Efficacy in Pancreatic Neuroendocrine Tumors via a Lysosome-dependent Mechanism
- (2017) Tabea Wiedmer et al. MOLECULAR CANCER THERAPEUTICS
- MicroRNA-410 regulates autophagy-related gene ATG16L1 expression and enhances chemosensitivity via autophagy inhibition in osteosarcoma
- (2017) Ren Chen et al. Molecular Medicine Reports
- Tumour heterogeneity and resistance to cancer therapies
- (2017) Ibiayi Dagogo-Jack et al. Nature Reviews Clinical Oncology
- Autophagy inhibition reduces chemoresistance and tumorigenic potential of human ovarian cancer stem cells
- (2017) Anna Pagotto et al. Cell Death & Disease
- Antitumor effect of sunitinib in human prostate cancer cells functions via autophagy
- (2017) Bangqi Wang et al. Experimental and Therapeutic Medicine
- Chloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy and inducing apoptosis
- (2017) Man‑Li Li et al. Oncology Letters
- Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway
- (2017) He Huang et al. Oncology Letters
- Autophagy inhibition impairs the epithelial-mesenchymal transition and enhances cisplatin sensitivity in nasopharyngeal carcinoma
- (2017) Zhongwu Su et al. Oncology Letters
- Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells
- (2017) Ji-Fan Lin et al. Drug Design Development and Therapy
- HMGB1-mediated autophagy attenuates gemcitabine-induced apoptosis in bladder cancer cells involving JNK and ERK activation
- (2017) Hubin Yin et al. Oncotarget
- Novel strategies to prevent the development of multidrug resistance (MDR) in cancer
- (2017) Jinglu Wang et al. Oncotarget
- Combined targeting of Raf and Mek synergistically inhibits tumorigenesis in triple negative breast cancer model systems
- (2017) Teddy S. Nagaria et al. Oncotarget
- Targeting autophagic cancer stem-cells to reverse chemoresistance in human triple negative breast cancer
- (2017) Guilhem Bousquet et al. Oncotarget
- The molecular mechanisms of chemoresistance in cancers
- (2017) Hua-Chuan Zheng Oncotarget
- How to Use a Chemotherapeutic Agent When Resistance to It Threatens the Patient
- (2017) Elsa Hansen et al. PLOS BIOLOGY
- Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors
- (2017) Jean M Mulcahy Levy et al. eLife
- Blocking autophagy enhances the pro-apoptotic effect of bufalin on human gastric cancer cells through endoplasmic reticulum stress
- (2017) Hongyan Zhao et al. Biology Open
- Tumor cell-intrinsic phenotypic plasticity facilitates adaptive cellular reprogramming driving acquired drug resistance
- (2017) Heinz Hammerlindl et al. Journal of Cell Communication and Signaling
- Autophagy inhibitor facilitates gefitinib sensitivity in vitro and in vivo by activating mitochondrial apoptosis in triple negative breast cancer
- (2017) Zhaoyun Liu et al. PLoS One
- Blocking autophagy improves the anti-tumor activity of afatinib in lung adenocarcinoma with activating EGFR mutations in vitro and in vivo
- (2017) Xiangxiang Hu et al. Scientific Reports
- Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies
- (2016) Giuseppa Pistritto et al. Aging-US
- Enhanced autophagy reveals vulnerability of P-gp mediated epirubicin resistance in triple negative breast cancer cells
- (2016) Li-han Zhang et al. APOPTOSIS
- Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells
- (2016) Xu Li et al. Autophagy
- GFRA1 promotes cisplatin-induced chemoresistance in osteosarcoma by inducing autophagy
- (2016) Mihwa Kim et al. Autophagy
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- (2016) Qi Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inhibition of autophagy sensitizes MDR-phenotype ovarian cancer SKVCR cells to chemotherapy
- (2016) Bing Liang et al. BIOMEDICINE & PHARMACOTHERAPY
- Autophagy is associated with chemoresistance in neuroblastoma
- (2016) Assila Belounis et al. BMC CANCER
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- (2016) V. M. Jansen et al. CLINICAL CANCER RESEARCH
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- (2016) Urmila Santanam et al. GENES & DEVELOPMENT
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- (2016) Ravi Amaravadi et al. GENES & DEVELOPMENT
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- (2016) Luiz R. C. Vasconcellos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2016) Victoria Cohen-Kaplan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2016) Jason J. Kwon et al. Oncotarget
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- (2016) Davide Cervia et al. Oncotarget
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- (2016) Maria Goulielmaki et al. Oncotarget
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- (2016) Debora de Melo Gagliato et al. Oncotarget
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- (2016) Toshinori Sueda et al. Scientific Reports
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- (2016) David L. Chan et al. Therapeutic Advances in Gastroenterology
- DNA Damage Response and Autophagy: A Meaningful Partnership
- (2016) Aristides G. Eliopoulos et al. Frontiers in Genetics
- Therapeutic Targeting of Autophagy
- (2016) Christina G. Towers et al. EBioMedicine
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- (2016) Sofia Halin Bergström et al. PLoS One
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- (2015) Yang Sun et al. Asian Pacific Journal of Cancer Prevention
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- (2015) Hui-Qing Zhang et al. Asian Pacific Journal of Cancer Prevention
- TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer
- (2015) Song-Fa Zhang et al. Autophagy
- Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion
- (2015) Caroline Mauvezin et al. Autophagy
- Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells
- (2015) Kuiqing Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- MiRNA-30a-mediated autophagy inhibition sensitizes renal cell carcinoma cells to sorafenib
- (2015) Bing Zheng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells
- (2015) S. Martin et al. BIOCHEMICAL PHARMACOLOGY
- Endoplasmic reticulum stress and autophagy participate in apoptosis induced by bortezomib in cervical cancer cells
- (2015) Yudi Zhang et al. BIOTECHNOLOGY LETTERS
- Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (−)-Gossypol (AT-101)
- (2015) Jens Mani et al. BMC CANCER
- Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis
- (2015) Jian Wen et al. BREAST CANCER RESEARCH AND TREATMENT
- Antagonistic effects of chloroquine on autophagy occurrence potentiate the anticancer effects of everolimus on renal cancer cells
- (2015) A Grimaldi et al. CANCER BIOLOGY & THERAPY
- The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells
- (2015) Seung Woo Lee et al. CANCER LETTERS
- Dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 synergizes with chloroquine to induce apoptosis in embryonal rhabdomyosarcoma
- (2015) Manuela Hugle et al. CANCER LETTERS
- A First-in-Human Phase I Study of the Oral p38 MAPK Inhibitor, Ralimetinib (LY2228820 Dimesylate), in Patients with Advanced Cancer
- (2015) A. Patnaik et al. CLINICAL CANCER RESEARCH
- Autophagy Inhibition Overcomes the Antagonistic Effect Between Gefitinib and Cisplatin in Epidermal Growth Factor Receptor Mutant Non–Small-Cell Lung Cancer Cells
- (2015) Jia-Tao Liu et al. Clinical Lung Cancer
- Blockage of cisplatin-induced autophagy sensitizes cervical cancer cells to cisplatin
- (2015) W.M. Lin et al. GENETICS AND MOLECULAR RESEARCH
- The anti-malarial chloroquine suppresses proliferation and overcomes cisplatin resistance of endometrial cancer cells via autophagy inhibition
- (2015) Tomohiko Fukuda et al. GYNECOLOGIC ONCOLOGY
- A Nontoxic Concentration of Cisplatin Induces Autophagy in Cervical Cancer
- (2015) Gina Leisching et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Autophagy inhibition enhances sensitivity of endometrial carcinoma cells to paclitaxel
- (2015) SUILING LIU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis
- (2015) Yu Sun et al. JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
- Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates
- (2015) Daniel F. Egan et al. MOLECULAR CELL
- Paxilitaxel induces apoptosis accompanied by protective autophagy in osteosarcoma cells through hypoxia-inducible factor-1α pathway
- (2015) YUANQING GUO et al. Molecular Medicine Reports
- Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors
- (2015) Encouse B. Golden et al. Neurosurgical Focus
- High mobility group box 1-mediated autophagy promotes neuroblastoma cell chemoresistance
- (2015) LI WANG et al. ONCOLOGY REPORTS
- Inhibition of Autophagy Potentiated the Antitumor Effect of Nedaplatin in Cisplatin-Resistant Nasopharyngeal Carcinoma Cells
- (2015) Zhongyu Liu et al. PLoS One
- Autophagy Protects from Trastuzumab-Induced Cytotoxicity in HER2 Overexpressing Breast Tumor Spheroids
- (2015) Cristina E. Rodríguez et al. PLoS One
- EGFR inhibition evokes innate drug resistance in lung cancer cells by preventing Akt activity and thus inactivating Ets-1 function
- (2015) Janyaporn Phuchareon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protective autophagy promotes the resistance of HER2-positive breast cancer cells to lapatinib
- (2015) Suning Chen et al. TUMOR BIOLOGY
- Inhibition of autophagy by bafilomycin A1 promotes chemosensitivity of gastric cancer cells
- (2015) Liang-qing Li et al. TUMOR BIOLOGY
- Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors
- (2015) N Echeverry et al. Cell Death & Disease
- miR-23b-3p regulates the chemoresistance of gastric cancer cells by targeting ATG12 and HMGB2
- (2015) Y An et al. Cell Death & Disease
- Knockdown of autophagy-related gene LC3 enhances the sensitivity of HepG2 cells to epirubicin
- (2015) WANXIN PENG et al. Experimental and Therapeutic Medicine
- The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics
- (2015) A. N. Hata et al. Cancer Discovery
- Inhibition of autophagy potentiates pemetrexed and simvastatin-induced apoptotic cell death in malignant mesothelioma and non-small cell lung cancer cells
- (2015) Ki-Eun Hwang et al. Oncotarget
- KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models
- (2015) Irene Riz et al. Oncotarget
- Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth
- (2015) Ashwani Khurana et al. Oncotarget
- EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanism
- (2015) Alice Modernelli et al. Scientific Reports
- Co-delivery of Gefitinib and chloroquine by chitosan nanoparticles for overcoming the drug acquired resistance
- (2015) Liang Zhao et al. JOURNAL OF NANOBIOTECHNOLOGY
- Chloroquine Enhances Gefitinib Cytotoxicity in Gefitinib-Resistant Nonsmall Cell Lung Cancer Cells
- (2015) Mei-Chuan Tang et al. PLoS One
- Downregulation of Choline Kinase-Alpha Enhances Autophagy in Tamoxifen-Resistant Breast Cancer Cells
- (2015) Hoe Suk Kim et al. PLoS One
- Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment
- (2015) Sílvia Cufí et al. Oncotarget
- PI3K/AKT signaling pathway and cancer: an updated review
- (2014) Miriam Martini et al. ANNALS OF MEDICINE
- Outcome of early clinical trials of the combination of hydroxychloroquine with chemotherapy in cancer
- (2014) Andrew Poklepovic et al. Autophagy
- Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers
- (2014) Sylvain Lefort et al. Autophagy
- A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors
- (2014) Debra Akin et al. Autophagy
- Autophagy inhibition suppresses the tumorigenic potential of cancer stem cell enriched side population in bladder cancer
- (2014) Rani Ojha et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells
- (2014) K. Rothe et al. BLOOD
- The MAPK pathway across different malignancies: A new perspective
- (2014) Mauricio Burotto et al. CANCER
- Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability
- (2014) Rohann J.M. Correa et al. CARCINOGENESIS
- Chloroquine synergizes sunitinib cytotoxicity via modulating autophagic, apoptotic and angiogenic machineries
- (2014) Amal Kamal Abdel-Aziz et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Autophagy Inhibition Augments the Anticancer Effects of Epirubicin Treatment in Anthracycline-Sensitive and -Resistant Triple-Negative Breast Cancer
- (2014) S. Chittaranjan et al. CLINICAL CANCER RESEARCH
- Therapeutic Targeting of Cancers with Loss of PTEN Function
- (2014) Lloye Dillon et al. CURRENT DRUG TARGETS
- LAMP3 is involved in tamoxifen resistance in breast cancer cells through the modulation of autophagy
- (2014) Anika Nagelkerke et al. ENDOCRINE-RELATED CANCER
- The cytoprotective role of gemcitabine-induced autophagy associated with apoptosis inhibition in triple-negative MDA-MB-231 breast cancer cells
- (2014) MING CHEN et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia
- (2014) SHAN SHAO et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system
- (2014) MEIHUI XIA et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Role of Autophagy in Cisplatin Resistance in Ovarian Cancer Cells
- (2014) Juan Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Essential Role of p53-up-regulated Modulator of Apoptosis (Puma) and Its Regulation by FoxO3a Transcription Factor in β-Amyloid-induced Neuron Death
- (2014) Rumana Akhter et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Temsirolimus and chloroquine cooperatively exhibit a potent antitumor effect against colorectal cancer cells
- (2014) Manabu Kaneko et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma
- (2014) Xiao-Hong Ma et al. JOURNAL OF CLINICAL INVESTIGATION
- Chloroquine potentiates temozolomide cytotoxicity by inhibiting mitochondrial autophagy in glioma cells
- (2014) Yusuke S. Hori et al. JOURNAL OF NEURO-ONCOLOGY
- Quinacrine Overcomes Resistance to Erlotinib by Inhibiting FACT, NF- B, and Cell-Cycle Progression in Non-Small Cell Lung Cancer
- (2014) J. K. T. Dermawan et al. MOLECULAR CANCER THERAPEUTICS
- Induction of autophagy contributes to cisplatin resistance in human ovarian cancer cells
- (2014) LINGJIE BAO et al. Molecular Medicine Reports
- Autophagy prevents doxorubicin-induced apoptosis in osteosarcoma
- (2014) DONGXU ZHAO et al. Molecular Medicine Reports
- Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
- (2014) William E. Dowdle et al. NATURE CELL BIOLOGY
- A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy
- (2014) Baptiste Ronan et al. Nature Chemical Biology
- Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy
- (2014) Encouse B. Golden et al. Neurosurgical Focus
- Knockdown of autophagy-related protein 6, Beclin-1, decreases cell growth, invasion, and metastasis and has a positive effect on chemotherapy-induced cytotoxicity in osteosarcoma cells
- (2014) Wei Zhang et al. TUMOR BIOLOGY
- Autophagy promotes paclitaxel resistance of cervical cancer cells: involvement of Warburg effect activated hypoxia-induced factor 1-α-mediated signaling
- (2014) X Peng et al. Cell Death & Disease
- Autophagy Inhibition Improves Chemosensitivity in BRAFV600E Brain Tumors
- (2014) J. M. M. Levy et al. Cancer Discovery
- Autophagy inhibits chemotherapy-induced apoptosis through downregulating Bad and Bim in hepatocellular carcinoma cells
- (2014) Yan Zhou et al. Scientific Reports
- Autophagy inhibition sensitizes hepatocellular carcinoma to the multikinase inhibitor linifanib
- (2014) Hongming Pan et al. Scientific Reports
- Blockade of Autophagy Aggravates Endoplasmic Reticulum Stress and Improves Paclitaxel Cytotoxicity in Human Cervical Cancer Cells
- (2014) Li Xu et al. Cancer Research and Treatment
- Autophagy Controls the Kinetics and Extent of Mitochondrial Apoptosis by Regulating PUMA Levels
- (2014) Jacqueline Thorburn et al. Cell Reports
- Autophagy and Its Effects: Making Sense of Double-Edged Swords
- (2014) Andrew Thorburn PLOS BIOLOGY
- Application and interpretation of current autophagy inhibitors and activators
- (2013) Ya-ping Yang et al. ACTA PHARMACOLOGICA SINICA
- An Overview of Autophagy: Morphology, Mechanism, and Regulation
- (2013) Katherine R. Parzych et al. ANTIOXIDANTS & REDOX SIGNALING
- Autophagy Inhibition Sensitizes Cisplatin Cytotoxicity in Human Gastric Cancer Cell Line Sgc7901
- (2013) Hui-Qing Zhang et al. Asian Pacific Journal of Cancer Prevention
- A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments
- (2013) K. Masui et al. CARCINOGENESIS
- Autophagy and genomic integrity
- (2013) A T Vessoni et al. CELL DEATH AND DIFFERENTIATION
- Autophagy Inhibition Sensitizes Colon Cancer Cells to Antiangiogenic and Cytotoxic Therapy
- (2013) M. Selvakumaran et al. CLINICAL CANCER RESEARCH
- P38 MAPK Contributes to Resistance and Invasiveness of HER2- Overexpressing Breast Cancer
- (2013) S.M. Donnelly et al. CURRENT MEDICINAL CHEMISTRY
- Silencing of Barkor/ATG14 sensitizes osteosarcoma cells to cisplatin-induced apoptosis
- (2013) ZHIFANG ZHAO et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Dual PI3K/mTOR inhibitor NVP-BEZ235-induced apoptosis of hepatocellular carcinoma cell lines is enhanced by inhibitors of autophagy
- (2013) ZHEXING CHANG et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Chloroquine blocks the autophagic process in cisplatin-resistant osteosarcoma cells by regulating the expression of p62/SQSTM1
- (2013) CHENGCHUN SHEN et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Protective role of autophagy in matrine-induced gastric cancer cell death
- (2013) YUMIN LI et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Cytoprotective role of autophagy during paclitaxel-induced apoptosis in Saos-2 osteosarcoma cells
- (2013) HYEON JUN KIM et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Metabolic stress and cancer: is autophagy the common denominator and a feasible target?
- (2013) Charlett M. Giuliani et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- The Autophagy Inhibitor Chloroquine Overcomes the Innate Resistance of Wild-Type EGFR Non-Small-Cell Lung Cancer Cells to Erlotinib
- (2013) Yiyu Zou et al. Journal of Thoracic Oncology
- Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer
- (2013) Yuan-yuan Li et al. LUNG CANCER
- Targeted cancer therapy – Are the days of systemic chemotherapy numbered?
- (2013) Won Duk Joo et al. MATURITAS
- Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling
- (2013) A. Eijkelenboom et al. Molecular Systems Biology
- Autophagy: A critical regulator of cellular metabolism and homeostasis
- (2013) Stefan W. Ryter et al. MOLECULES AND CELLS
- FOXO3A directs a protective autophagy program in haematopoietic stem cells
- (2013) Matthew R. Warr et al. NATURE
- Pharmacological agents with inherent anti-autophagic activity improve the cytotoxicity of imatinib
- (2013) LISA C. CROWLEY et al. ONCOLOGY REPORTS
- miR-101 inhibits autophagy and enhances cisplatin-induced apoptosis in hepatocellular carcinoma cells
- (2013) YONGHUA XU et al. ONCOLOGY REPORTS
- Autophagy Inhibition Promotes 5-Fluorouraci-Induced Apoptosis by Stimulating ROS Formation in Human Non-Small Cell Lung Cancer A549 Cells
- (2013) Xiaohong Pan et al. PLoS One
- Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma
- (2013) Xiaoqi Xie et al. PLoS One
- Induction of Autophagy Is an Early Response to Gefitinib and a Potential Therapeutic Target in Breast Cancer
- (2013) Wieslawa H. Dragowska et al. PLoS One
- A Combination of Pterostilbene With Autophagy Inhibitors Exerts Efficient Apoptotic Characteristics in Both Chemosensitive and Chemoresistant Lung Cancer Cells
- (2013) M.-J. Hsieh et al. TOXICOLOGICAL SCIENCES
- NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells
- (2013) Arya Sobhakumari et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Evading apoptosis in cancer
- (2013) Kaleigh Fernald et al. TRENDS IN CELL BIOLOGY
- The Autophagy Inhibitor Verteporfin Moderately Enhances the Antitumor Activity of Gemcitabine in a Pancreatic Ductal Adenocarcinoma Model
- (2013) Elizabeth Donohue et al. Journal of Cancer
- Mechanisms and insights into drug resistance in cancer
- (2013) Hiba Zahreddine et al. Frontiers in Pharmacology
- Role of the Crosstalk between Autophagy and Apoptosis in Cancer
- (2013) Minfei Su et al. Journal of Oncology
- Blocking the interleukin 2 (IL2)-induced systemic autophagic syndrome promotes profound antitumor effects and limits toxicity
- (2012) Michael T. Lotze et al. Autophagy
- Lys05
- (2012) Ravi K. Amaravadi et al. Autophagy
- microRNA30Apromotes autophagy in response to cancer therapy
- (2012) Yan Yu et al. Autophagy
- Autophagy controls everolimus (RAD001) activity in mantle cell lymphoma
- (2012) Laia Rosich et al. Autophagy
- Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1
- (2012) J. Fang et al. BLOOD
- Inhibiting Systemic Autophagy during Interleukin 2 Immunotherapy Promotes Long-term Tumor Regression
- (2012) X. Liang et al. CANCER RESEARCH
- Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma
- (2012) Y.-L. Hu et al. CANCER RESEARCH
- Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells
- (2012) Hongyan Li et al. CELL BIOCHEMISTRY AND FUNCTION
- Blocked Autophagy Using Lysosomotropic Agents Sensitizes Resistant Prostate Tumor Cells to the Novel Akt Inhibitor AZD5363
- (2012) F. Lamoureux et al. CLINICAL CANCER RESEARCH
- Counteracting Autophagy Overcomes Resistance to Everolimus in Mantle Cell Lymphoma
- (2012) L. Rosich et al. CLINICAL CANCER RESEARCH
- The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosisviamitochondrial-lysosomal cross-talk
- (2012) Christian Seitz et al. INTERNATIONAL JOURNAL OF CANCER
- Inhibition of autophagy enhances anticancer effects of bevacizumab in hepatocarcinoma
- (2012) Xian-ling Guo et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
- (2012) Rafael Rosell et al. LANCET ONCOLOGY
- Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells
- (2012) Y Yu et al. LEUKEMIA
- Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data
- (2012) María S. Degese et al. LUNG CANCER
- Blocking Autophagy Prevents Bortezomib-Induced NF-κB Activation by Reducing I-κBα Degradation in Lymphoma Cells
- (2012) Li Jia et al. PLoS One
- Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion
- (2012) Yeon Ja Choi et al. PLoS One
- Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition
- (2012) Kevin Bray et al. PLoS One
- Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency
- (2012) Q. McAfee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Active autophagy in the tumor microenvironment: A novel mechanism for cancer metastasis
- (2012) YINGHUA XU et al. Oncology Letters
- High expression of heme oxygenase-1 is associated with tumor invasiveness and poor clinical outcome in non-small cell lung cancer patients
- (2012) Jong-Rung Tsai et al. CELLULAR ONCOLOGY
- Heme oxygenase 1 (HO-1) challenges the angiogenic switch in prostate cancer
- (2011) M. Ferrando et al. ANGIOGENESIS
- Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis
- (2011) Ying-Hong Shi et al. Autophagy
- Autophagy inhibition cooperates with erlotinib to induce glioblastoma cell death
- (2011) Sandrine Eimer et al. CANCER BIOLOGY & THERAPY
- Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagy
- (2011) Cheng-Xiong Xu et al. CANCER BIOLOGY & THERAPY
- Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells
- (2011) Guangmin Xi et al. CANCER LETTERS
- PTEN Loss Confers BRAF Inhibitor Resistance to Melanoma Cells through the Suppression of BIM Expression
- (2011) K. H. T. Paraiso et al. CANCER RESEARCH
- Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13
- (2011) Junli Liu et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Autophagy Activation in Hepatocellular Carcinoma Contributes to the Tolerance of Oxaliplatin via Reactive Oxygen Species Modulation
- (2011) Z.-B. Ding et al. CLINICAL CANCER RESEARCH
- Measurements of Tumor Cell Autophagy Predict Invasiveness, Resistance to Chemotherapy, and Survival in Melanoma
- (2011) X.-H. Ma et al. CLINICAL CANCER RESEARCH
- Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
- (2011) M. Cargnello et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance
- (2011) M A de la Cruz-Morcillo et al. ONCOGENE
- EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells
- (2011) Weidong Han et al. PLoS One
- Protective autophagy antagonizes oxaliplatin-induced apoptosis in gastric cancer cells
- (2011) Ling Xu et al. Chinese Journal of Cancer
- Roles of autophagy in cetuximab-mediated cancer therapy against EGFR
- (2010) Xinqun Li et al. Autophagy
- Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells
- (2010) Kazuhito Sasaki et al. BMC CANCER
- Inhibition of MCL-1 enhances Lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy
- (2010) Aditi Pandya Martin et al. CANCER BIOLOGY & THERAPY
- The Epidermal Growth Factor Receptor Antibody Cetuximab Induces Autophagy in Cancer Cells by Downregulating HIF-1 and Bcl-2 and Activating the Beclin 1/hVps34 Complex
- (2010) X. Li et al. CANCER RESEARCH
- Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model
- (2010) Jie Li et al. EUROPEAN JOURNAL OF CANCER
- Inhibition of Autophagosome Formation by the Benzoporphyrin Derivative Verteporfin
- (2010) Elizabeth Donohue et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase
- (2010) You-Tong Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST)
- (2010) A. Gupta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- "Go upstream, young man": lessons learned from the p38 saga
- (2009) D Hammaker et al. ANNALS OF THE RHEUMATIC DISEASES
- RAD001 (Everolimus) induces autophagy in acute lymphoblastic leukemia
- (2009) Roman Crazzolara et al. Autophagy
- The Role of ATF4 Stabilization and Autophagy in Resistance of Breast Cancer Cells Treated with Bortezomib
- (2009) M. Milani et al. CANCER RESEARCH
- Autophagy Facilitates the Development of Breast Cancer Resistance to the Anti-HER2 Monoclonal Antibody Trastuzumab
- (2009) Alejandro Vazquez-Martin et al. PLoS One
- Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization
- (2008) M. A. Qadir et al. BREAST CANCER RESEARCH AND TREATMENT
- Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
- (2008) Michael Degtyarev et al. JOURNAL OF CELL BIOLOGY
- Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
- (2008) Robert J Motzer et al. LANCET
- A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance
- (2008) J. S. Samaddar et al. MOLECULAR CANCER THERAPEUTICS
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