Therapeutic modulation of autophagy: which disease comes first?

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Nucleophagy: from homeostasis to disease

(2019) Margarita-Elena Papandreou et al.   CELL DEATH AND DIFFERENTIATION

The good, the bad and the autophagosome: exploring unanswered questions of autophagy-dependent cell death

(2019) Jurgen Kriel et al.   CELL DEATH AND DIFFERENTIATION

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

(2019) Didac Carmona-Gutierrez et al.   Nature Communications

Autophagy and cardiac aging

(2019) Shigeki Miyamoto   CELL DEATH AND DIFFERENTIATION

Autophagy in endothelial cells and tumor angiogenesis

(2019) Marco B. Schaaf et al.   CELL DEATH AND DIFFERENTIATION

Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications

(2019) Francesca Nazio et al.   CELL DEATH AND DIFFERENTIATION

High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding

(2018) Wei-Chung Chiang et al.   ACS Chemical Biology

Higher spermidine intake is linked to lower mortality: a prospective population-based study

(2018) Stefan Kiechl et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The Role of Autophagy in the Heart

(2018) Sebastiano Sciarretta et al.   Annual Review of Physiology

Ambroxol induces autophagy and potentiates Rifampin antimycobacterial activity

(2018) Seong Won Choi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aspirin—another caloric-restriction mimetic

(2018) Federico Pietrocola et al.   Autophagy

Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade

(2018) Sachet A. Shukla et al.   CELL

Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction

(2018) Sebastiano Sciarretta et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Targeting autophagy in obesity: from pathophysiology to management

(2018) Yingmei Zhang et al.   Nature Reviews Endocrinology

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Evaluation of autophagy inducers in epithelial cells carrying the ΔF508 mutation of the cystic fibrosis transmembrane conductance regulator CFTR

(2018) Shaoyi Zhang et al.   Cell Death & Disease

A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes

(2018) Hyejin Lim et al.   Nature Communications

Aspirin Recapitulates Features of Caloric Restriction

(2018) Federico Pietrocola et al.   Cell Reports

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

(2018) Sung Min Son et al.   Cell Metabolism

Autophagy in Cardiovascular Aging

(2018) Mahmoud Abdellatif et al.   CIRCULATION RESEARCH

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

(2018) Álvaro F. Fernández et al.   NATURE

Life, death and autophagy

(2018) Johnna Doherty et al.   NATURE CELL BIOLOGY

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

(2018) Barry Boland et al.   NATURE REVIEWS DRUG DISCOVERY

The hallmarks of successful anticancer immunotherapy

(2018) Lorenzo Galluzzi et al.   Science Translational Medicine

Spermidine reduces cancer-related mortality in humans

(2018) Federico Pietrocola et al.   Autophagy

Autophagy-dependent cell death

(2018) Donna Denton et al.   CELL DEATH AND DIFFERENTIATION

Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation

(2018) Sandra M. Hill et al.   CELL DEATH AND DIFFERENTIATION

A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease

(2018) Valeria R Villella et al.   EMBO JOURNAL

The clinical value of using chloroquine or hydroxychloroquine as autophagy inhibitors in the treatment of cancers

(2018) Ran Xu et al.   MEDICINE

Autophagy maintains tumour growth through circulating arginine

(2018) Laura Poillet-Perez et al.   NATURE

Autophagy and the cell biology of age-related disease

(2018) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington’s disease

(2017) Benjamin R. Underwood et al.   JOURNAL OF NEUROLOGY

Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis

(2017) Luigina Romani et al.   NATURE MEDICINE

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens

(2017) Álvaro F Fernández et al.   Cell Death & Disease

Cysteamine re-establishes the clearance of Pseudomonas aeruginosa by macrophages bearing the cystic fibrosis-relevant F508del-CFTR mutation

(2017) Eleonora Ferrari et al.   Cell Death & Disease

Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

(2017) Chensu Wang et al.   Nature Communications

Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury

(2016) Cuicui Xie et al.   Autophagy

The presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer

(2016) Sylvain Ladoire et al.   Autophagy

Revisiting autophagy addiction of tumor cells

(2016) Beat Nyfeler et al.   Autophagy

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR

(2016) A Tosco et al.   CELL DEATH AND DIFFERENTIATION

Methanobactin reverses acute liver failure in a rat model of Wilson disease

(2016) Josef Lichtmannegger et al.   JOURNAL OF CLINICAL INVESTIGATION

U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3′ End Formation

(2016) Sung Mi Park et al.   MOLECULAR CELL

Defective Autophagy Initiates Malignant Transformation

(2016) Lorenzo Galluzzi et al.   MOLECULAR CELL

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy

(2016) Lorenzo Galluzzi et al.   Nature Reviews Clinical Oncology

Autophagy in acute brain injury

(2016) Lorenzo Galluzzi et al.   NATURE REVIEWS NEUROSCIENCE

Combined evaluation of LC3B puncta and HMGB1 expression predicts residual risk of relapse after adjuvant chemotherapy in breast cancer

(2015) Sylvain Ladoire et al.   Autophagy

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Autophagy in cellular metabolism and cancer

(2015) Xuejun Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy: a druggable process that is deregulated in aging and human disease

(2015) Guido Kroemer   JOURNAL OF CLINICAL INVESTIGATION

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic targeting of autophagy in neurodegenerative and infectious diseases

(2015) David C. Rubinsztein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis

(2014) Melissa Nassif et al.   Autophagy

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation

(2014) Daniela De Stefano et al.   Autophagy

Spermidine induces autophagy by inhibiting the acetyltransferase EP300

(2014) F Pietrocola et al.   CELL DEATH AND DIFFERENTIATION

Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

(2014) M. Schiebler et al.   EMBO Molecular Medicine

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

Caloric restriction mimetics: towards a molecular definition

(2014) Frank Madeo et al.   NATURE REVIEWS DRUG DISCOVERY

Cystic fibrosis genetics: from molecular understanding to clinical application

(2014) Garry R. Cutting   NATURE REVIEWS GENETICS

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes

(2014) Yu-Mi Lim et al.   Nature Communications

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator

(2013) V R Villella et al.   CELL DEATH AND DIFFERENTIATION

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Autophagy and Cellular Immune Responses

(2013) Yuting Ma et al.   IMMUNITY

Autophagy and Viruses: Adversaries or Allies?

(2013) Xiaonan Dong et al.   Journal of Innate Immunity

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ΔF508 cystic fibrosis transmembrane conductance regulator

(2012) Alessandro Luciani et al.   Autophagy

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production

(2012) Claudia Capparelli et al.   CELL CYCLE

The secret ally: immunostimulation by anticancer drugs

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Liver mitochondrial membrane crosslinking and destruction in a rat model of Wilson disease

(2011) Hans Zischka et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Autophagy in aging, disease and death: the true identity of a cell death impostor

(2008) B Levine et al.   CELL DEATH AND DIFFERENTIATION

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE