Autophagy inhibitor facilitates gefitinib sensitivity in vitro and in vivo by activating mitochondrial apoptosis in triple negative breast cancer

Concurrent Autophagy Inhibition Overcomes the Resistance of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Human Bladder Cancer Cells

(2017) Minyong Kang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phaleria macrocarpa (Boerl.) fruit induce G 0 /G 1 and G 2 /M cell cycle arrest and apoptosis through mitochondria-mediated pathway in MDA-MB-231 human breast cancer cell

(2017) Nowroji Kavitha et al.   JOURNAL OF ETHNOPHARMACOLOGY

Enhanced autophagy reveals vulnerability of P-gp mediated epirubicin resistance in triple negative breast cancer cells

(2016) Li-han Zhang et al.   APOPTOSIS

Small Molecule TH-39 Potentially Targets Hec1/Nek2 Interaction and Exhibits Antitumor Efficacy in K562 Cells via G0/G1 Cell Cycle Arrest and Apoptosis Induction

(2016) Yongxia Zhu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Autophagy as a Survival Mechanism for Squamous Cell Carcinoma Cells in Endonuclease G-Mediated Apoptosis

(2016) Atsushi Masui et al.   PLoS One

The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance

(2016) E. Allen Sickmier et al.   PLoS One

EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells

(2015) Shohei Sugita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Co-targeting EGFR and Autophagy Impairs Ovarian Cancer Cell Survival during Detachment from the ECM

(2015) Zongyuan Yang et al.   CURRENT CANCER DRUG TARGETS

Modifiable Lifestyle Factors and Triple-negative Breast Cancer Survival

(2015) Ping-Ping Bao et al.   EPIDEMIOLOGY

DNA Repair—A Double-Edged Sword in the Genomic Stability of Cancer Cells—The Case of Chronic Myeloid Leukemia

(2015) Elzbieta Pawlowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link

(2015) Paola Tricarico et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis

(2015) Seok-Jo Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089

(2015) Khushboo Sharma et al.   Autophagy

Chloroquine Enhances Gefitinib Cytotoxicity in Gefitinib-Resistant Nonsmall Cell Lung Cancer Cells

(2015) Mei-Chuan Tang et al.   PLoS One

Molecular Features of Triple Negative Breast Cancer: Microarray Evidence and Further Integrated Analysis

(2015) Jinsong He et al.   PLoS One

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment

(2015) Sílvia Cufí et al.   Oncotarget

Simvastatin, an HMG-CoA reductase inhibitor, exhibits anti-metastatic and anti-tumorigenic effects in endometrial cancer

(2014) Monica N. Schointuch et al.   GYNECOLOGIC ONCOLOGY

B Cell Lymphoma-2 (BCL-2) Homology Domain 3 (BH3) Mimetics Demonstrate Differential Activities Dependent upon the Functional Repertoire of Pro- and Anti-apoptotic BCL-2 Family Proteins

(2014) Thibaud T. Renault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Fatty Acid Esters of Phloridzin Induce Apoptosis of Human Liver Cancer Cells through Altered Gene Expression

(2014) Sandhya V. G. Nair et al.   PLoS One

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Autophagy-Mediated Tumor Promotion

(2013) Jessie Yanxiang Guo et al.   CELL

Autophagy facilitates the EGFR-TKI acquired resistance of non-small-cell lung cancer cells

(2013) Donglei Liu et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Enhanced autophagy is required for survival in EGFR-independent EGFR-mutant lung adenocarcinoma cells

(2013) Yuji Sakuma et al.   LABORATORY INVESTIGATION

Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer

(2013) Yuan-yuan Li et al.   LUNG CANCER

Induction of Autophagy Is an Early Response to Gefitinib and a Potential Therapeutic Target in Breast Cancer

(2013) Wieslawa H. Dragowska et al.   PLoS One

NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells

(2013) Arya Sobhakumari et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells

(2012) Shi-Wei Huang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Combinatorial Effects of Lapatinib and Rapamycin in Triple-Negative Breast Cancer Cells

(2011) T. Liu et al.   MOLECULAR CANCER THERAPEUTICS

EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells

(2011) Weidong Han et al.   PLoS One

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY