Application and interpretation of current autophagy inhibitors and activators

Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment

(2015) Alberto M. Martelli et al.   Oncotarget

Does bafilomycin A1block the fusion of autophagosomes with lysosomes?

(2014) Daniel J. Klionsky et al.   Autophagy

Raman microspectroscopy of live cells under autophagy-inducing conditions

(2012) Stanislav O. Konorov et al.   ANALYST

The regulatory mechanism of 4-phenylbutyric acid against ER stress-induced autophagy in human gingival fibroblasts

(2012) Do-Sung Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila

(2012) Balázs Érdi et al.   Autophagy

The role of autophagy in endoplasmic reticulum stress-induced pancreatic β cell death

(2012) Jia-Jing Yin et al.   Autophagy

Lys05

(2012) Ravi K. Amaravadi et al.   Autophagy

Autophagy is a protective response to ethanol neurotoxicity

(2012) Gang Chen et al.   Autophagy

A novel image-based cytometry method for autophagy detection in living cells

(2012) Leo Li-Ying Chan et al.   Autophagy

Deconvoluting mTOR biology

(2012) Jason D. Weber et al.   CELL CYCLE

GDC-0941, a Novel Class I Selective PI3K Inhibitor, Enhances the Efficacy of Docetaxel in Human Breast Cancer Models by Increasing Cell Death In Vitro and In Vivo

(2012) J. J. Wallin et al.   CLINICAL CANCER RESEARCH

Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells

(2012) Y Yu et al.   LEUKEMIA

Identification of Autophagosome-associated Proteins and Regulators by Quantitative Proteomic Analysis and Genetic Screens

(2012) Jörn Dengjel et al.   MOLECULAR & CELLULAR PROTEOMICS

Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion

(2012) Kohei Shimada et al.   NEUROBIOLOGY OF DISEASE

p53 Mediates autophagy activation and mitochondria dysfunction in kainic acid-induced excitotoxicity in primary striatal neurons

(2012) X.X. Dong et al.   NEUROSCIENCE

Chloroquine-Mediated Lysosomal Dysfunction Enhances the Anticancer Effect of Nutrient Deprivation

(2012) Ljubica Harhaji-Trajkovic et al.   PHARMACEUTICAL RESEARCH

Inhibitors of Phosphatidylinositol 3′-Kinases Promote Mitotic Cell Death in HeLa Cells

(2012) Heli Hou et al.   PLoS One

Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition

(2012) Kevin Bray et al.   PLoS One

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temsirolimus in the treatment of relapsed and/or refractory mantle cell lymphoma

(2012) Sara Galimberti   Cancer Management and Research

Rapamycin Causes Upregulation of Autophagy and Impairs Islets Function Both In Vitro and In Vivo

(2011) M. Tanemura et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Resveratrol in cardiovascular health and disease

(2011) Goran Petrovski et al.   Annals of the New York Academy of Sciences

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Ins(1,4,5)P3receptor-mediated Ca2+signaling and autophagy induction are interrelated

(2011) Jean-Paul Decuypere et al.   Autophagy

Beclin 1-independent autophagy contributes to apoptosis in cortical neurons

(2011) Yulia Grishchuk et al.   Autophagy

Dissecting the dynamic turnover of GFP-LC3 in the autolysosome

(2011) Hong-Min Ni et al.   Autophagy

Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799

(2011) Jun Ohwada et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

microRNA-101 is a potent inhibitor of autophagy

(2011) Lisa B Frankel et al.   EMBO JOURNAL

A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway

(2011) Yuan Tian et al.   FASEB JOURNAL

Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics

(2011) Chun-yang Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagosomes and human diseases

(2011) Isabelle Beau et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The autophagy-inducing drug carbamazepine is a radiation protector and mitigator

(2011) Hyun Kim et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

HDAC6 regulates aggresome-autophagy degradation pathway of α-synuclein in response to MPP+-induced stress

(2011) Min Su et al.   JOURNAL OF NEUROCHEMISTRY

GDC-0980 Is a Novel Class I PI3K/mTOR Kinase Inhibitor with Robust Activity in Cancer Models Driven by the PI3K Pathway

(2011) J. J. Wallin et al.   MOLECULAR CANCER THERAPEUTICS

DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy

(2011) Yongchao Zhao et al.   MOLECULAR CELL

Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest

(2011) Ian G. Ganley et al.   MOLECULAR CELL

Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines

(2011) J. Fu et al.   NEURO-ONCOLOGY

Autophagic degradation of tau in primary neurons and its enhancement by trehalose

(2011) Ulrike Krüger et al.   NEUROBIOLOGY OF AGING

Potential autophagy enhancers attenuate rotenone-induced toxicity in SH-SY5Y

(2011) N. Xiong et al.   NEUROSCIENCE

A Mechanism for Synergy with Combined mTOR and PI3 Kinase Inhibitors

(2011) Shujie Yang et al.   PLoS One

Cardioprotection by Endoplasmic Reticulum Stress–Induced Autophagy

(2010) Goran Petrovski et al.   ANTIOXIDANTS & REDOX SIGNALING

Quality control autophagy: A joint effort of ubiquitin, protein deacetylase and actin cytoskeleton

(2010) Joo-Yong Lee et al.   Autophagy

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

p38 Mitogen-Activated Protein Kinase is Involved in Endoplasmic Reticulum Stress-Induced Cell Death and Autophagy in Human Gingival Fibroblasts

(2010) Do-Sung Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways

(2010) Frank Christian et al.   CELLULAR SIGNALLING

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylated α-Synuclein at Ser-129 Is Targeted to the Proteasome Pathway in a Ubiquitin-independent Manner

(2010) Youhei Machiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway

(2010) Bi-Yin Cao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Autophagy basics

(2010) Isei Tanida   MICROBIOLOGY AND IMMUNOLOGY

Autophagy Induction with RAD001 Enhances Chemosensitivity and Radiosensitivity through Met Inhibition in Papillary Thyroid Cancer

(2010) C.-I. Lin et al.   MOLECULAR CANCER RESEARCH

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

(2010) S. Miller et al.   SCIENCE

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

Inhibition of PI3k Class III–Dependent Autophagy Prevents Apoptosis and Necrosis by Oxidative Stress in Dopaminergic Neuroblastoma Cells

(2010) Roberta Castino et al.   TOXICOLOGICAL SCIENCES

Autophagosome Formation Depends on the Small GTPase Rab1 and Functional ER Exit Sites

(2010) Felipe Carlos Martín Zoppino et al.   TRAFFIC

RAD001 (Everolimus) induces autophagy in acute lymphoblastic leukemia

(2009) Roman Crazzolara et al.   Autophagy

Autophagy induction by trehalose counter-acts cellular prion-infection

(2009) Yasmine Aguib et al.   Autophagy

Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells

(2009) Ya Chun Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion

(2009) Zully Pedrozo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3

(2009) Fiona M. Menzies et al.   BRAIN

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

(2009) J M Vicencio et al.   CELL DEATH AND DIFFERENTIATION

Autophagy: Regulation and role in disease

(2009) Alfred J. Meijer et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Autophagy-A double-edged sword in oncology

(2009) Anja Apel et al.   INTERNATIONAL JOURNAL OF CANCER

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydroxychloroquine Modulates Metabolic Activity and Proliferation and Induces Autophagic Cell Death of Human Dermal Fibroblasts

(2009) Bettina Ramser et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hydroxychloroquine Induces Autophagic Cell Death of Human Dermal Fibroblasts: Implications for Treating Fibrotic Skin Diseases

(2009) Aarne Oikarinen   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Discovery of Atg5/Atg7-independent alternative macroautophagy

(2009) Yuya Nishida et al.   NATURE

Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells

(2009) T. Kawakami et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

MPP+ impairs autophagic clearance of alpha-synuclein by impairing the activity of dynein

(2009) Zeng-Lin Cai et al.   NEUROREPORT

Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901

(2008) Chungen Xing et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

mTOR—What Does It Do?

(2008) M.N. Hall   TRANSPLANTATION PROCEEDINGS