Role of the Crosstalk between Autophagy and Apoptosis in Cancer

Molecular basis of the regulation of Beclin 1-dependent autophagy by the γ-herpesvirus 68 Bcl-2 homolog M11

(2014) Sangita C. Sinha et al.   Autophagy

Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells

(2014) Ugur Akar et al.   Autophagy

An insight into the mechanistic role of Beclin 1 and its inhibition by prosurvival Bcl-2 family proteins

(2014) Bonsu Ku et al.   Autophagy

Dual Role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation

(2014) Yongjie Wei et al.   Autophagy

The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes

(2012) Shannon M. Ruppert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process

(2012) M. Rahmani et al.   BLOOD

p53/HMGB1 Complexes Regulate Autophagy and Apoptosis

(2012) K. M. Livesey et al.   CANCER RESEARCH

Mcl-1 Phosphorylation Defines ABT-737 Resistance That Can Be Overcome by Increased NOXA Expression in Leukemic B cells

(2012) S. Mazumder et al.   CANCER RESEARCH

Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein

(2012) Weijiao Huang et al.   CELL RESEARCH

Autophagy and cancer - issues we need to digest

(2012) E. Y. Liu et al.   JOURNAL OF CELL SCIENCE

Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules

(2012) Shouqing Luo et al.   MOLECULAR CELL

Expressional and mutational analyses of ATG5 gene in prostate cancers

(2011) MIN SUNG KIM et al.   APMIS

Conversation between apoptosis and autophagy: “Is it your turn or mine?”

(2011) Vincenzo Giansanti et al.   APOPTOSIS

Cleaving Beclin 1 to suppress autophagy in chemotherapy-induced apoptosis

(2011) Hua Li et al.   Autophagy

A critical role for UVRAG in apoptosis

(2011) Xiaocheng Yin et al.   Autophagy

p53 signaling and autophagy in cancer: A revolutionary strategy could be developed for cancer treatment

(2011) Xinbing Sui et al.   Autophagy

Mitochondrial ROS generation for regulation of autophagic pathways in cancer

(2011) Zi-yue Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Contribution of autophagic cell death to p53-dependent cell death in human glioblastoma cell line SF126

(2011) Yasuhiro Sakamoto et al.   CANCER SCIENCE

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family Members to Promote Mitochondrial Apoptosis

(2011) Assaf D. Rubinstein et al.   MOLECULAR CELL

CALPAIN activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss

(2011) Ira J. Smith et al.   MUSCLE & NERVE

Mutational and expressional analyses of ATG5, an autophagy-related gene, in gastrointestinal cancers

(2011) Chang Hyeok An et al.   PATHOLOGY RESEARCH AND PRACTICE

UVRAGmutations associated with microsatellite unstable colon cancer do not affect autophagy

(2010) Helene Knævelsrud et al.   Autophagy

Over-expression of the Beclin1 gene upregulates chemosensitivity to anti-cancer drugs by enhancing therapy-induced apoptosis in cervix squamous carcinoma CaSki cells

(2010) Yang Sun et al.   CANCER LETTERS

ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death

(2010) Lilliana Radoshevich et al.   CELL

The Beclin 1 interactome

(2010) Congcong He et al.   CURRENT OPINION IN CELL BIOLOGY

Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

(2010) Troy T. Rohn et al.   NEUROBIOLOGY OF DISEASE

p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation

(2010) R. Scherz-Shouval et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1

(2010) Marc Kvansakul et al.   PLoS Pathogens

Atg14 and UVRAG: Mutually exclusive subunits of mammalian Beclin 1-PI3K complexes

(2009) Eisuke Itakura et al.   Autophagy

Playing the DISC: Turning on TRAIL death receptor-mediated apoptosis in cancer

(2009) Bodvaël Pennarun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Life and death partners: apoptosis, autophagy and the cross-talk between them

(2009) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

The autophagy effector Beclin 1: a novel BH3-only protein

(2009) S Sinha et al.   ONCOGENE

Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer

(2009) S Kulkarni et al.   ONCOGENE

p53 Regulation of the IGF-1/AKT/mTOR Pathways and the Endosomal Compartment

(2009) Z. Feng   Cold Spring Harbor Perspectives in Biology

Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells

(2008) Simone Reuter et al.   BIOCHEMICAL PHARMACOLOGY

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Mcl-1 is a potential therapeutic target in multiple types of cancer

(2008) C. Akgul   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting the extrinsic apoptosis pathway in cancer

(2008) Avi Ashkenazi   CYTOKINE & GROWTH FACTOR REVIEWS

Synergistic Tumor-Killing Effect of Radiation and Berberine Combined Treatment in Lung Cancer: The Contribution of Autophagic Cell Death

(2008) Pei-ling Peng et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Bcl-xLand UVRAG Cause a Monomer-Dimer Switch in Beclin1

(2008) Christian G. Noble et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model

(2008) Carolyn Waugh Kinkade et al.   JOURNAL OF CLINICAL INVESTIGATION

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

(2008) Jer-Yen Yang et al.   NATURE CELL BIOLOGY

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Colorectal cancer cells with the BRAFV600E mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM

(2008) J A Wickenden et al.   ONCOGENE

FOXOs, cancer and regulation of apoptosis

(2008) Z Fu et al.   ONCOGENE

Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68

(2008) Bonsu Ku et al.   PLoS Pathogens

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY