A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B
Authors
Keywords
-
Journal
Scientific Reports
Volume 8, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-07-30
DOI
10.1038/s41598-018-29900-x
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- ATG4B inhibitor FMK-9a induces autophagy independent on its enzyme inhibition
- (2018) Jiaqi Chu et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases
- (2018) Karlina J. Kauffman et al. Autophagy
- Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors
- (2016) Zongxing Qiu et al. ACS Medicinal Chemistry Letters
- Identification of breast cancer cell subtypes sensitive to ATG4B inhibition
- (2016) Svetlana Bortnik et al. Oncotarget
- Identification of New ATG4B Inhibitors Based on a Novel High-Throughput Screening Platform
- (2016) Danqing Xu et al. SLAS Discovery
- SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells
- (2015) Benoit Pasquier Autophagy
- Precision autophagy: Will the next wave of selective autophagy markers and specific autophagy inhibitors feed clinical pipelines?
- (2015) Chandra B Lebovitz et al. Autophagy
- Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis
- (2015) Sandra Cabrera et al. Autophagy
- Development of fluorescent peptide substrates and assays for the key autophagy-initiating cysteine protease enzyme, ATG4B
- (2015) Lubomir Vezenkov et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Pharmacologic agents targeting autophagy
- (2015) Helin Vakifahmetoglu-Norberg et al. JOURNAL OF CLINICAL INVESTIGATION
- Synthesis of Improved Lysomotropic Autophagy Inhibitors
- (2015) Tong Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Systems biology-based discovery of a potential Atg4B agonist (Flubendazole) that induces autophagy in breast cancer
- (2015) Lan Zhang et al. Molecular BioSystems
- Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates
- (2015) Daniel F. Egan et al. MOLECULAR CELL
- The promise and peril of chemical probes
- (2015) Cheryl H Arrowsmith et al. Nature Chemical Biology
- Emerging strategies to effectively target autophagy in cancer
- (2015) V W Rebecca et al. ONCOGENE
- Chemical tools for modulating autophagy
- (2015) Gemma Triola TETRAHEDRON
- SLC27A4 regulate ATG4B activity and control reactions to chemotherapeutics-induced autophagy in human lung cancer cells
- (2015) Shifei Wu et al. TUMOR BIOLOGY
- Development of Fluorescent Substrates and Assays for the Key Autophagy-Related Cysteine Protease Enzyme, ATG4B
- (2014) Thanh G. Nguyen et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors
- (2014) Debra Akin et al. Autophagy
- ATG4B promotes colorectal cancer growth independent of autophagic flux
- (2014) Pei-Feng Liu et al. Autophagy
- The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells
- (2014) K. Rothe et al. BLOOD
- Chemistry: Chemical con artists foil drug discovery
- (2014) Jonathan Baell et al. NATURE
- Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
- (2014) William E. Dowdle et al. NATURE CELL BIOLOGY
- ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis
- (2013) Sandra Cabrera et al. Autophagy
- Context-dependent role of ATG4B as target for autophagy inhibition in prostate cancer therapy
- (2013) Elisa Tran et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Autophagy and human diseases
- (2013) Peidu Jiang et al. CELL RESEARCH
- Autophagy in Human Health and Disease
- (2013) Augustine M.K. Choi et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Carboxyl-Terminal Amino Acids Render Pro-Human LC3B Migration Similar to Lipidated LC3B in SDS-PAGE
- (2013) Wei Wang et al. PLoS One
- Targeting autophagy
- (2012) Sharon M. Gorski et al. Autophagy
- Dual roles of Atg8−PE deconjugation by Atg4 in autophagy
- (2012) Zhong-Qiu Yu et al. Autophagy
- Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis
- (2012) Hitoshi Nakatogawa et al. Autophagy
- Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy
- (2012) Paola Maycotte et al. Autophagy
- Autophagy modulation as a potential therapeutic target for diverse diseases
- (2012) David C. Rubinsztein et al. NATURE REVIEWS DRUG DISCOVERY
- Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency
- (2012) Q. McAfee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Kinetics Comparisons of Mammalian Atg4 Homologues Indicate Selective Preferences toward Diverse Atg8 Substrates
- (2010) Min Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A balancing act for autophagin
- (2010) Andreas Till et al. JOURNAL OF CLINICAL INVESTIGATION
- Autophagy is essential for mouse sense of balance
- (2010) Guillermo Mariño et al. JOURNAL OF CLINICAL INVESTIGATION
- Histopathological and Neurological Features of Atg4b Knockout Mice
- (2010) R. Read et al. VETERINARY PATHOLOGY
- The structure of Atg4B–LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy
- (2009) Kenji Satoo et al. EMBO JOURNAL
- Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis
- (2009) V. M. S. Betin et al. JOURNAL OF CELL SCIENCE
- The autophagy machinery is required to initiate hepatitis C virus replication
- (2009) M. Dreux et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Photochemical properties of amino and nitro derivatives of 2-and 4-styrylquinolines and their hydrochlorides
- (2008) M. F. Budyka et al. HIGH ENERGY CHEMISTRY
- An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure
- (2008) Naonobu Fujita et al. MOLECULAR BIOLOGY OF THE CELL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation