Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

Punctate LC3B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation, Metastasis, and Poor Outcome

(2011) R. Lazova et al.   CLINICAL CANCER RESEARCH

Measurements of Tumor Cell Autophagy Predict Invasiveness, Resistance to Chemotherapy, and Survival in Melanoma

(2011) X.-H. Ma et al.   CLINICAL CANCER RESEARCH

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

(2011) R. K. Amaravadi et al.   CLINICAL CANCER RESEARCH

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Design and synthesis of chloroquine analogs with anti-breast cancer property

(2010) V.R. Solomon et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Unconventional secretion ofPichia pastorisAcb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation

(2010) Ravi Manjithaya et al.   JOURNAL OF CELL BIOLOGY

Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma

(2010) Q.-W. Fan et al.   Science Signaling

Novel Classes of Dimer Antitumour Drug Candidates

(2009) Larry Chow et al.   CURRENT PHARMACEUTICAL DESIGN

Designer Peptides: Learning from Nature

(2009) A. Shrivastava et al.   CURRENT PHARMACEUTICAL DESIGN

A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells

(2009) Changkun Hu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Polyvalency: A promising strategy for drug design

(2008) David Vance et al.   BIOTECHNOLOGY AND BIOENGINEERING

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE