Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer

Autophagy as a regulator of cardiovascular redox homeostasis

(2017) Ye Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors

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Natural Compounds from Herbs that can Potentially Execute as Autophagy Inducers for Cancer Therapy

(2017) Shian-Ren Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Accumulation of autophagosomes confers cytotoxicity

(2017) Robert W. Button et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice

(2017) Pan Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line

(2017) Laura Masuelli et al.   Oncotarget

A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition

(2016) Ju-Xian Song et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Research progress of hydroxychloroquine and autophagy inhibitors on cancer

(2016) Ting-Ting Shi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Resistance mechanisms after tyrosine kinase inhibitors afatinib and crizotinib in non-small cell lung cancer, a review of the literature

(2016) A.J. van der -->Wekken et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Identification of resveratrol derivative 3,3′,4,4′,5,5′-hexamethoxy- trans-stilbene as a novel pro-angiogenic small-molecule compound

(2016) ZhiQiang Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Magnetic ferroferric oxide nanoparticles induce vascular endothelial cell dysfunction and inflammation by disturbing autophagy

(2016) Lu Zhang et al.   JOURNAL OF HAZARDOUS MATERIALS

Inhibition of autophagic flux by ROS promotes apoptosis during DTT-induced ER/oxidative stress in HeLa cells

(2016) XI-YAN XIANG et al.   ONCOLOGY REPORTS

Pharmacological inhibitors of autophagy as novel cancer therapeutic agents

(2016) Cheng Wang et al.   PHARMACOLOGICAL RESEARCH

The reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux

(2016) Zhou Long et al.   Oncotarget

Dynamin II is required for 17β-estradiol signaling and autophagy-based ERα degradation

(2016) Pierangela Totta et al.   Scientific Reports

Multiple Roles of the Small GTPase Rab7

(2016) Flora Guerra et al.   Cells

Curcumin Suppresses Proliferation and Migration of MDA-MB-231 Breast Cancer Cells through Autophagy-Dependent Akt Degradation

(2016) Feng Guan et al.   PLoS One

Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells

(2015) Xuejiao Zhao et al.   Autophagy

A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission

(2015) Jing Zhou et al.   Autophagy

Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells

(2015) Lu Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent

(2014) Michael J Morgan et al.   Autophagy

The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation

(2014) Yuanzhi Lao et al.   Autophagy

A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors

(2014) Debra Akin et al.   Autophagy

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

Autophagy and human disease: emerging themes

(2014) Jaime L Schneider et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells

(2014) C De Mei et al.   ONCOGENE

B19, a Novel Monocarbonyl Analogue of Curcumin, Induces Human Ovarian Cancer Cell Apoptosis via Activation of Endoplasmic Reticulum Stress and the Autophagy Signaling Pathway

(2013) Wanglei Qu et al.   International Journal of Biological Sciences

Vorinostat and bortezomib as third-line therapy in patients with advanced non-small cell lung cancer: a Wisconsin Oncology Network Phase II study

(2013) Tien Hoang et al.   INVESTIGATIONAL NEW DRUGS

Combination of D942 With Curcumin Protects Cardiomyocytes From Ischemic Damage Through Promoting Autophagy

(2013) Keping Yang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Curcumin Induces Autophagy via Activating the AMPK Signaling Pathway in Lung Adenocarcinoma Cells

(2013) Kui Xiao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Alkylphosphocholines and curcumin induce programmed cell death in cutaneous T-cell lymphoma cell lines

(2013) Deyan Y. Yosifov et al.   LEUKEMIA RESEARCH

Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage

(2012) Jing Han et al.   Autophagy

Cathepsin-mediated regulation of autophagy in saposin C deficiency

(2012) Massimo Tatti et al.   Autophagy

The Intriguing Life of Autophagosomes

(2012) Dalibor Mijaljica et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active autophagy in the tumor microenvironment: A novel mechanism for cancer metastasis

(2012) YINGHUA XU et al.   Oncology Letters

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

Lysosomal membrane permeabilization is involved in curcumin-induced apoptosis of A549 lung carcinoma cells

(2011) Qing-Yong Chen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

Cancer cell killing via ROS: To increase or decrease, that is the question

(2010) Jie Wang et al.   CANCER BIOLOGY & THERAPY

Lucanthone Is a Novel Inhibitor of Autophagy That Induces Cathepsin D-mediated Apoptosis

(2010) Jennifer S. Carew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple roles of the cytoskeleton in autophagy

(2009) Iryna Monastyrska et al.   BIOLOGICAL REVIEWS

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY