TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis

SGK1 inhibition-induced autophagy impairs prostate cancer metastasis by reversing EMT

(2018) Weiwei Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Ibrutinib, a Bruton’s tyrosine kinase inhibitor, exhibits antitumoral activity and induces autophagy in glioblastoma

(2017) Jin Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells’ invasion

(2017) Chao Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pleckstrin homology-like domain family A, member 3 (PHLDA3) deficiency improves islets engraftment through the suppression of hypoxic damage

(2017) Naoaki Sakata et al.   PLoS One

Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells

(2017) Min-Chieh Hsin et al.   Cell Death & Disease

GFRA1 promotes cisplatin-induced chemoresistance in osteosarcoma by inducing autophagy

(2016) Mihwa Kim et al.   Autophagy

The expression of TSSC3 and its prognostic value in patients with osteosarcoma

(2016) Xing Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Downregulation of tumor suppressing STF cDNA 3 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by the Wnt/GSK-3β/β-catenin/Snail signaling pathway

(2016) Yang-fan Lv et al.   CANCER LETTERS

Downregulation of the PHLDA1 gene in IMR-32 neuroblastoma cells increases levels of Aurora A, TRKB and affects proteins involved in apoptosis and autophagy pathways

(2016) MałGorzata Durbas et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Epithelial-to-mesenchymal plasticity of cancer stem cells: therapeutic targets in hepatocellular carcinoma

(2016) Aparna Jayachandran et al.   Journal of Hematology & Oncology

p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA

(2016) L-Z Xu et al.   ONCOGENE

RanBP9/TSSC3 complex cooperates to suppress anoikis resistance and metastasis via inhibiting Src-mediated Akt signaling in osteosarcoma

(2016) Huanzi Dai et al.   Cell Death & Disease

Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3

(2016) Marina N. Sharifi et al.   Cell Reports

Therapeutic Targeting of Autophagy

(2016) Christina G. Towers et al.   EBioMedicine

Expression of autophagy-related proteins ATG5 and FIP200 predicts favorable disease-free survival in patients with breast cancer

(2015) Lei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts

(2015) M N Washington et al.   Cell Death & Disease

Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation

(2015) G Grassi et al.   Cell Death & Disease

Enhancer of zeste homolog 2 silencing inhibits tumor growth and lung metastasis in osteosarcoma

(2015) Yang-Fan Lv et al.   Scientific Reports

Protective role of autophagy and autophagy-related protein 5 in early tumorigenesis

(2014) He Liu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Regulation of cell proliferation and migration by p62 through stabilization of Twist1

(2014) L. Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic silencing of methyl-CpG-binding protein 2 gene affects proliferation, invasion, migration, and apoptosis of human osteosarcoma cells

(2014) Gang Meng et al.   TUMOR BIOLOGY

Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells

(2013) Yuan-Fei Peng et al.   Autophagy

Epigenetic regulation of the pro-apoptosis gene TSSC3 in human osteosarcoma cells

(2013) Yi Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Knockdown of autophagy-related protein 5, ATG5, decreases oxidative stress and has an opposing effect on camptothecin-induced cytotoxicity in osteosarcoma cells

(2013) Mario G Hollomon et al.   BMC CANCER

Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy

(2013) Jae Myung Park et al.   CANCER BIOLOGY & THERAPY

Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway

(2013) Dhruv Kumar et al.   CANCER LETTERS

Rapamycin Induces Apoptosis When Autophagy is Inhibited in T-47D Mammary Cells and Both Processes are Regulated by Phlda1

(2013) Ahmed Ismail Hassan Moad et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

(2013) Katy J Petherick et al.   EMBO JOURNAL

IBP-mediated suppression of autophagy promotes growth and metastasis of breast cancer cells via activating mTORC2/Akt/FOXO3a signaling pathway

(2013) S Chen et al.   Cell Death & Disease

TSSC3 overexpression reduces stemness and induces apoptosis of osteosarcoma tumor-initiating cells

(2012) Yusheng Huang et al.   APOPTOSIS

Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer

(2012) Liang Ying et al.   Molecular BioSystems

TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma

(2011) Huanzi Dai et al.   CARCINOGENESIS

HIV-1 Inhibits Autophagy in Bystander Macrophage/Monocytic Cells through Src-Akt and STAT3

(2010) Jennifer Van Grol et al.   PLoS One

Targeting the osteosarcoma cancer stem cell

(2010) Valerie A Siclari et al.   Journal of Orthopaedic Surgery and Research

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

Autophagy and metastasis: another double-edged sword

(2009) Candia M Kenific et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagy-A double-edged sword in oncology

(2009) Anja Apel et al.   INTERNATIONAL JOURNAL OF CANCER

Changes in genomic imprinting and gene expression associated with transformation in a model of human osteosarcoma

(2008) Yi Li et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Regulation of macroautophagy by mTOR and Beclin 1 complexes

(2007) Sophie Pattingre et al.   BIOCHIMIE