IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo

Synthesis and biological evaluation of curcumin inspired imidazo[1,2- a ]pyridine analogues as tubulin polymerization inhibitors

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Synthesis of C 5 -tethered indolyl-3-glyoxylamide derivatives as tubulin polymerization inhibitors

(2017) Sravanthi Devi Guggilapu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1,3,5-Triazines: A promising scaffold for anticancer drugs development

(2017) Stella Cascioferro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice

(2017) Sho Endo et al.   GASTROENTEROLOGY

Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors

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Erratum to: Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents

(2017) G. Jagadeesh Kumar et al.   MEDICINAL CHEMISTRY RESEARCH

Identification of Novel Vacuolin-1 Analogues as Autophagy Inhibitors by Virtual Drug Screening and Chemical Synthesis

(2017) Chang Chen et al.   MOLECULES

Inhibition of autophagy by chloroquine induces apoptosis in primary effusion lymphoma in vitro and in vivo through induction of endoplasmic reticulum stress

(2016) Md. Masud Alam et al.   APOPTOSIS

The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair

(2016) Diana H. Liang et al.   CANCER LETTERS

Autophagy in cancer metastasis

(2016) E E Mowers et al.   ONCOGENE

Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells

(2015) Xuejiao Zhao et al.   Autophagy

Anticancer effect of celastrol on human triple negative breast cancer: Possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways

(2015) Shweta Shrivastava et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents

(2015) G. Jagadeesh Kumar et al.   MEDICINAL CHEMISTRY RESEARCH

The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics

(2015) A. N. Hata et al.   Cancer Discovery

Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells

(2014) Shweta Shrivastava et al.   APOPTOSIS

Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A

(2014) Yingying Lu et al.   Autophagy

Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers

(2014) Sylvain Lefort et al.   Autophagy

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(2014) Myrna R Rosenfeld et al.   Autophagy

Role of Autophagy in Cisplatin Resistance in Ovarian Cancer Cells

(2014) Juan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering

(2014) Dan Fu et al.   Nature Chemistry

Autophagy as a modulator and target in prostate cancer

(2014) Jason M. Farrow et al.   Nature Reviews Urology

Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors

(2013) Mark E. Welker et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and anticancer activity of some new s-triazine derivatives

(2013) G. Jagadeesh Kumar et al.   MEDICINAL CHEMISTRY RESEARCH

Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms

(2013) Dhruv Kumar et al.   Molecular Cancer

Multiple Functions of BCL-2 Family Proteins

(2013) J. M. Hardwick et al.   Cold Spring Harbor Perspectives in Biology

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of triazine-benzimidazoles as selective inhibitors of mTOR

(2011) Emily A. Peterson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

(2011) R. K. Amaravadi et al.   CLINICAL CANCER RESEARCH

Hydroxychloroquine: From Malaria to Autoimmunity

(2011) Ilan Ben-Zvi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

(2011) E. L. Kim et al.   NEURO-ONCOLOGY

Triple-Negative Breast Cancer: An Unmet Medical Need

(2011) C. A. Hudis et al.   ONCOLOGIST

Autophagy is a therapeutic target in anticancer drug resistance

(2010) Suning Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Lysosomal–mitochondrial cross-talk during cell death

(2010) Urška Repnik et al.   MITOCHONDRION

A high content screening assay for identifying lysosomotropic compounds

(2010) Sashi Nadanaciva et al.   TOXICOLOGY IN VITRO

Lysosomal involvement in cell death and cancer

(2008) Thomas Kirkegaard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH