An Overview of Autophagy: Morphology, Mechanism, and Regulation

Dissecting the localization and function of Atg18, Atg21 and Ygr223c

(2014) Roswitha Krick et al.   Autophagy

Structure of the autophagic E2 enzyme Atg10

(2012) Seung Beom Hong et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A role for Atg8–PE deconjugation in autophagosome biogenesis

(2012) Usha Nair et al.   Autophagy

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

The role of ALFY in selective autophagy

(2012) P Isakson et al.   CELL DEATH AND DIFFERENTIATION

The Intriguing Life of Autophagosomes

(2012) Dalibor Mijaljica et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biogenesis and Cargo Selectivity of Autophagosomes

(2011) Hilla Weidberg et al.   Annual Review of Biochemistry

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

SNARE Proteins Are Required for Macroautophagy

(2011) Usha Nair et al.   CELL

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

(2011) Trond Lamark et al.   CELL CYCLE

Autophagy: for better or for worse

(2011) Ellen Wirawan et al.   CELL RESEARCH

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

(2011) Cathrin Meissner et al.   JOURNAL OF NEUROCHEMISTRY

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural Basis of Atg8 Activation by a Homodimeric E1, Atg7

(2011) Nobuo N. Noda et al.   MOLECULAR CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8

(2011) Seung Beom Hong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

(2011) L. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

The Tor and cAMP-dependent protein kinase signaling pathways coordinately control autophagy inSaccharomyces cerevisiae

(2010) Joseph S. Stephan et al.   Autophagy

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

Plasma membrane helps autophagosomes grow

(2010) Brinda Ravikumar et al.   Autophagy

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

(2010) Hannah E.J. Polson et al.   Autophagy

Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

(2010) Yoshinori Takahashi et al.   Autophagy

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Chaperone-mediated autophagy in protein quality control

(2010) Esperanza Arias et al.   CURRENT OPINION IN CELL BIOLOGY

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

Regulation of autophagy by phosphatidylinositol 3-phosphate

(2010) Chloe Burman et al.   FEBS LETTERS

Regulation of the autophagy protein LC3 by phosphorylation

(2010) Salvatore J. Cherra et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis

(2010) Muriel Mari et al.   JOURNAL OF CELL BIOLOGY

The regulation of autophagy - unanswered questions

(2010) Y. Chen et al.   JOURNAL OF CELL SCIENCE

Combinational Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins VAMP8 and Vti1b Mediate Fusion of Antimicrobial and Canonical Autophagosomes with Lysosomes

(2010) Nobumichi Furuta et al.   MOLECULAR BIOLOGY OF THE CELL

cAMP-Dependent Activation of Mammalian Target of Rapamycin (mTOR) in Thyroid Cells. Implication in Mitogenesis and Activation of CDK4

(2010) Sara Blancquaert et al.   MOLECULAR ENDOCRINOLOGY

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Association of AMPK with ULK1 Regulates Autophagy

(2010) Jong Woo Lee et al.   PLoS One

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

(2010) S. Miller et al.   SCIENCE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Chaperone-mediated autophagy: Molecular mechanisms and physiological relevance

(2010) Samantha J. Orenstein et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

NBR1 co-operates with p62 in selective autophagy of ubiquitinated targets

(2009) Vladimir Kirkin et al.   Autophagy

A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy

(2009) Carol A. Mercer et al.   Autophagy

3D tomography reveals connections between the phagophore and endoplasmic reticulum

(2009) Päivi Ylä-Anttila et al.   Autophagy

Atg101, a novel mammalian autophagy protein interacting with Atg13

(2009) Nao Hosokawa et al.   Autophagy

TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways

(2009) Claudio Marcelo Fader et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Multiple roles of the cytoskeleton in autophagy

(2009) Iryna Monastyrska et al.   BIOLOGICAL REVIEWS

Bif-1/Endophilin B1: a candidate for crescent driving force in autophagy

(2009) Y Takahashi et al.   CELL DEATH AND DIFFERENTIATION

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP

(2009) Jemma L Webber et al.   EMBO JOURNAL

PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis

(2009) Nabil Djouder et al.   EMBO JOURNAL

The structure of Atg4B–LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy

(2009) Kenji Satoo et al.   EMBO JOURNAL

Degradation of excess peroxisomes in mammalian liver cells by autophagy and other mechanisms

(2009) Sadaki Yokota et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Regulation of Autophagy by the p300 Acetyltransferase

(2009) In Hye Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway

(2009) Y. T. Zheng et al.   JOURNAL OF IMMUNOLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

(2009) M. Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxisome Dynamics in Cultured Mammalian Cells

(2009) Sofie J. Huybrechts et al.   TRAFFIC

hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells

(2008) Ying Yan et al.   BIOCHEMICAL JOURNAL

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

(2008) M. Kundu et al.   BLOOD

The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Jiefei Geng et al.   EMBO REPORTS

The peroxin Pex14p is involved in LC3-dependent degradation of mammalian peroxisomes

(2008) Sayuri Hara-Kuge et al.   EXPERIMENTAL CELL RESEARCH

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Self-Interaction Is Critical for Atg9 Transport and Function at the Phagophore Assembly Site during Autophagy

(2008) Congcong He et al.   MOLECULAR BIOLOGY OF THE CELL

Golgi-resident Small GTPase Rab33B Interacts with Atg16L and Modulates Autophagosome Formation

(2008) Takashi Itoh et al.   MOLECULAR BIOLOGY OF THE CELL

Atg8 Controls Phagophore Expansion during Autophagosome Formation

(2008) Zhiping Xie et al.   MOLECULAR BIOLOGY OF THE CELL

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

(2008) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE