Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors
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Title
Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors
Authors
Keywords
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Journal
Cell Death & Disease
Volume 6, Issue 5, Pages e1757-e1757
Publisher
Springer Nature
Online
2015-05-07
DOI
10.1038/cddis.2015.124
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Note: Only part of the references are listed.- Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2
- (2015) H. P. Soares et al. MOLECULAR CANCER THERAPEUTICS
- Inhibition of REV3 Expression Induces Persistent DNA Damage and Growth Arrest in Cancer Cells
- (2015) Philip A. Knobel et al. NEOPLASIA
- GDC-0980-induced apoptosis is enhanced by autophagy inhibition in human pancreatic cancer cells
- (2014) Jian-ying Tang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Tumor Vessel Normalization by Chloroquine Independent of Autophagy
- (2014) Hannelore Maes et al. CANCER CELL
- Whole-Exome Sequencing Reveals Frequent Genetic Alterations in BAP1, NF2, CDKN2A, and CUL1 in Malignant Pleural Mesothelioma
- (2014) G. Guo et al. CANCER RESEARCH
- Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
- (2014) L Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- PI3K/mTOR Signaling in Mesothelioma Patients Treated with Induction Chemotherapy Followed by Extrapleural Pneumonectomy
- (2014) Byron K.Y. Bitanihirwe et al. Journal of Thoracic Oncology
- MET and PI3K/mTOR as a Potential Combinatorial Therapeutic Target in Malignant Pleural Mesothelioma
- (2014) Rajani Kanteti et al. PLoS One
- XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation
- (2014) Monica Yabal et al. Cell Reports
- Autophagy-Mediated Tumor Promotion
- (2013) Jessie Yanxiang Guo et al. CELL
- Tsc1-Tp53 loss induces mesothelioma in mice and evidence for this mechanism in human mesothelioma
- (2013) Y Guo et al. ONCOGENE
- Down-Regulation of Autophagy-Related Protein 5 (ATG5) Contributes to the Pathogenesis of Early-Stage Cutaneous Melanoma
- (2013) H. Liu et al. Science Translational Medicine
- Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer
- (2013) B Liu et al. Cell Death & Disease
- What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway
- (2013) S. J. Klempner et al. Cancer Discovery
- Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin
- (2012) Yandong Shi et al. BMC CANCER
- JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer
- (2012) Adrian Britschgi et al. CANCER CELL
- Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells
- (2012) Taru Muranen et al. CANCER CELL
- The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches
- (2012) Antonella De Luca et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosisviamitochondrial-lysosomal cross-talk
- (2012) Christian Seitz et al. INTERNATIONAL JOURNAL OF CANCER
- Exploratory analysis of activation of PTEN–PI3K pathway and downstream proteins in malignant pleural mesothelioma (MPM)
- (2012) S. Cedrés et al. LUNG CANCER
- Inhibition of phosphoinositide-3 kinase pathway down regulates ABCG2 function and sensitizes malignant pleural mesothelioma to chemotherapy
- (2012) Bruno Fischer et al. LUNG CANCER
- A grading system combining architectural features and mitotic count predicts recurrence in stage I lung adenocarcinoma
- (2012) Kyuichi Kadota et al. MODERN PATHOLOGY
- Targeting the PI3K/mTOR Axis, Alone and in Combination with Autophagy Blockade, for the Treatment of Malignant Peripheral Nerve Sheath Tumors
- (2012) M. P. Ghadimi et al. MOLECULAR CANCER THERAPEUTICS
- Attacking a Nexus of the Oncogenic Circuitry by Reversing Aberrant eIF4F-Mediated Translation
- (2012) P. B. Bitterman et al. MOLECULAR CANCER THERAPEUTICS
- Systematic identification of genomic markers of drug sensitivity in cancer cells
- (2012) Mathew J. Garnett et al. NATURE
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition
- (2012) Kevin Bray et al. PLoS One
- Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagy
- (2011) Cheng-Xiong Xu et al. CANCER BIOLOGY & THERAPY
- Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K—mTOR pathway in pancreatic adenocarcinoma
- (2011) Olga K. Mirzoeva et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- GDC-0980 Is a Novel Class I PI3K/mTOR Kinase Inhibitor with Robust Activity in Cancer Models Driven by the PI3K Pathway
- (2011) J. J. Wallin et al. MOLECULAR CANCER THERAPEUTICS
- The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma
- (2011) Matthew Bott et al. NATURE GENETICS
- The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance
- (2011) D Barbone et al. Cell Death & Disease
- The PI3 kinase/mTOR blocker NVP-BEZ235 overrides resistance against irreversible ErbB inhibitors in breast cancer cells
- (2010) Caroline Brünner-Kubath et al. BREAST CANCER RESEARCH AND TREATMENT
- Activity of the Novel Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 against T-Cell Acute Lymphoblastic Leukemia
- (2010) F. Chiarini et al. CANCER RESEARCH
- NVP-BEZ235 as a New Therapeutic Option for Sarcomas
- (2010) M. C. Manara et al. CLINICAL CANCER RESEARCH
- Distinct 5′ UTRs regulate XIAP expression under normal growth conditions and during cellular stress
- (2010) Alura Riley et al. NUCLEIC ACIDS RESEARCH
- Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma
- (2010) Q.-W. Fan et al. Science Signaling
- Malignant pleural mesothelioma cells resist anoikis as quiescent pluricellular aggregates
- (2009) J Daubriac et al. CELL DEATH AND DIFFERENTIATION
- Loss of the Tumor Suppressor Gene NF2, Encoding Merlin, Constitutively Activates Integrin-Dependent mTORC1 Signaling
- (2009) M. A. Lopez-Lago et al. MOLECULAR AND CELLULAR BIOLOGY
- NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas
- (2009) T.-J. Liu et al. MOLECULAR CANCER THERAPEUTICS
- Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates
- (2009) Viktor I. Korolchuk et al. MOLECULAR CELL
- Spheroid-based drug screen: considerations and practical approach
- (2009) Juergen Friedrich et al. Nature Protocols
- Dynamics and diversity in autophagy mechanisms: lessons from yeast
- (2009) Hitoshi Nakatogawa et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells
- (2009) Saskia M. Brachmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations
- (2008) V. Serra et al. CANCER RESEARCH
- Mammalian Target of Rapamycin Contributes to the Acquired Apoptotic Resistance of Human Mesothelioma Multicellular Spheroids
- (2008) Dario Barbone et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Functional inactivation of NF2/merlin in human mesothelioma
- (2008) Claudio Thurneysen et al. LUNG CANCER
- Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
- (2008) S.-M. Maira et al. MOLECULAR CANCER THERAPEUTICS
- Identification of RIP1 kinase as a specific cellular target of necrostatins
- (2008) Alexei Degterev et al. Nature Chemical Biology
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