Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

(2022) Shogo Kumagai et al.   CANCER CELL

Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression

(2022) De Huang et al.   NATURE CELL BIOLOGY

Targeting Tryptophan Catabolism in Cancer Immunotherapy Era: Challenges and Perspectives

(2022) Florent Peyraud et al.   Frontiers in Immunology

Telaglenastat Plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 ENTRATA Trial

(2022) Chung-Han Lee et al.   CLINICAL CANCER RESEARCH

Simultaneous glutamine metabolism and PD-L1 inhibition to enhance suppression of triple-negative breast cancer

(2022) Yuxia Tang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Hepatocellular carcinoma‐infiltrating γδ T cells are functionally defected and allogenic Vδ2 + γδ T cell can be a promising complement

(2022) Wenjing He et al.   Clinical and Translational Medicine

Metabolic reprogramming by ex vivo glutamine inhibition endows CAR-T cells with less-differentiated phenotype and persistent antitumor activity

(2022) Luyan Shen et al.   CANCER LETTERS

Development of Sesamol Carbamate-L-Phenylalanine Prodrug Targeting L-Type Amino Acid Transporter1 (LAT1) as a Potential Antiproliferative Agent against Melanoma

(2022) Tarapong Srisongkram et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Kynurenine Is the Main Metabolite of Tryptophan Degradation by Tryptophan 2,3-Dioxygenase in HepG2 Tumor Cells

(2022) Hani Oweira et al.   Journal of Clinical Medicine

Engineering amino acid uptake or catabolism promotes CAR-T cell adaption to the tumour environment

(2022) Silvia Panetti et al.   Blood Advances

Targeting Indoleamine 2,3-Dioxygenase in Cancer Models Using the Novel Small Molecule Inhibitor NTRC 3883-0

(2021) Yvonne Grobben et al.   Frontiers in Immunology

Investigating the Role of Indoleamine 2,3-Dioxygenase in Acute Myeloid Leukemia: A Systematic Review

(2021) Georgia Wells et al.   Frontiers in Immunology

CAR-T cell therapy: current limitations and potential strategies

(2021) Robert C. Sterner et al.   Blood Cancer Journal

IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation

(2021) Adaobi Amobi-McCloud et al.   Frontiers in Immunology

Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor Microenvironment

(2021) Marianna Nachef et al.   Frontiers in Immunology

Polyamine: A metabolic compass for T helper cell fate direction

(2021) Hao Shi et al.   CELL

Therapeutic induction of tolerogenic dendritic cells via aryl hydrocarbon receptor signaling

(2021) Andreia Barroso et al.   CURRENT OPINION IN IMMUNOLOGY

EMT-Derived Alterations in Glutamine Metabolism Sensitize Mesenchymal Breast Cells to mTOR Inhibition

(2021) Sigurdur Trausti Karvelsson et al.   MOLECULAR CANCER RESEARCH

Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics

(2021) Yoshikatsu Kanai   PHARMACOLOGY & THERAPEUTICS

Amino Acid Depletion Therapies: Starving Cancer Cells to Death

(2021) Miriam Butler et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

(2021) Cristina C. Clement et al.   Nature Communications

Cellular and metabolic mechanisms of nutrient actions in immune function

(2021) Philip Newsholme   Nutrition & Diabetes

Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma

(2021) Huimei Huang et al.   Frontiers in Immunology

Phase II trial of the IDO pathway inhibitor indoximod plus pembrolizumab for the treatment of patients with advanced melanoma

(2021) Yousef Zakharia et al.   Journal for ImmunoTherapy of Cancer

Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation

(2021) Rui Qin et al.   Journal for ImmunoTherapy of Cancer

Hallmarks of response, resistance, and toxicity to immune checkpoint blockade

(2021) Golnaz Morad et al.   CELL

The foundations of immune checkpoint blockade and the ipilimumab approval decennial

(2021) Alan J. Korman et al.   NATURE REVIEWS DRUG DISCOVERY

Amino acid deprivation induces AKT activation by inducing GCN2/ATF4/REDD1 axis

(2021) Hyeon-Ok Jin et al.   Cell Death & Disease

Arginine and Arginases Modulate Metabolism, Tumor Microenvironment and Prostate Cancer Progression

(2021) Andreia Matos et al.   Nutrients

Fueling T-cell Antitumor Immunity: Amino Acid Metabolism Revisited

(2021) Chenfeng Han et al.   Cancer Immunology Research

T cell fat catabolism: A novel target for kynurenine?

(2021) Paolo Puccetti et al.   EBioMedicine

Metabolic Reprogramming in the Tumor Microenvironment With Immunocytes and Immune Checkpoints

(2021) Yaolin Xu et al.   Frontiers in Oncology

CAR T cells: continuation in a revolution of immunotherapy

(2020) Anurag K Singh et al.   LANCET ONCOLOGY

Metabolism of pancreatic cancer: paving the way to better anticancer strategies

(2020) Cheng Qin et al.   Molecular Cancer

Tumor Microenvironment, Metabolism, and Immunotherapy

(2020) Ralph J. DeBerardinis   NEW ENGLAND JOURNAL OF MEDICINE

First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors

(2020) Naohiro Okano et al.   INVESTIGATIONAL NEW DRUGS

Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

(2020) Tobias Baumann et al.   NATURE IMMUNOLOGY

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

Myeloid Cell-Derived Arginase in Cancer Immune Response

(2020) Tomasz M. Grzywa et al.   Frontiers in Immunology

Amino Acid Oncometabolism and Immunomodulation of the Tumor Microenvironment in Lung Cancer

(2020) Johannes F. Fahrmann et al.   Frontiers in Oncology

PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala

(2020) Yu Wang et al.   BIOCHEMICAL PHARMACOLOGY

Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity

(2020) Livingstone Fultang et al.   BLOOD

Discovery of indoximod prodrugs and characterization of clinical candidate NLG802

(2020) Sanjeev Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Serine restriction alters sphingolipid diversity to constrain tumour growth

(2020) Thangaselvam Muthusamy et al.   NATURE

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

(2020) Luis Felipe Campesato et al.   Nature Communications

A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity

(2020) Katharina Koch et al.   Cell Death Discovery

Side-effect management of chimeric antigen receptor (CAR) T-cell therapy.

(2020) M.-L. Schubert et al.   ANNALS OF ONCOLOGY

Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy

(2020) Weimin Wang et al.   MOLECULAR CELL

Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor

(2020) Hiroki Okanishi et al.   CANCER SCIENCE

Modification of Proteins by Metabolites in Immunity

(2020) C. Diskin et al.   IMMUNITY

Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer

(2020) Deanna N. Edwards et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity programmed by prenatal dexamethasone and postnatal high-fat diet leads to distinct alterations in nutrition sensory signals and circadian-clock genes in visceral adipose tissue

(2019) Ching-Chou Tsai et al.   Lipids in Health and Disease

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

(2019) Michael Platten et al.   NATURE REVIEWS DRUG DISCOVERY

Enhanced metabolic activities for ATP production and elevated metabolic flux via pentose phosphate pathway contribute for better CIK cells expansion

(2019) Weiwei Zhang et al.   CELL PROLIFERATION

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

(2019) Laura Hinze et al.   CANCER CELL

Targeting Glutamine Metabolism and Redox State for Leukemia Therapy

(2019) Mark A. Gregory et al.   CLINICAL CANCER RESEARCH

Amino acid metabolism in hematologic malignancies and the era of targeted therapy

(2019) Yoko Tabe et al.   BLOOD

Glutaminolysis‐related genes determine sensitivity to xCT‐targeted therapy in head and neck squamous cell carcinoma

(2019) Shogo Okazaki et al.   CANCER SCIENCE

Mechanisms and Implications of Metabolic Heterogeneity in Cancer

(2019) Jiyeon Kim et al.   Cell Metabolism

Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study

(2019) Georgina V Long et al.   LANCET ONCOLOGY

Glutamine antagonism attenuates physical and cognitive deficits in a model of MS

(2019) Kristen R. Hollinger et al.   Neurology-Neuroimmunology & Neuroinflammation

N-Benzyl/Aryl Substituted Tryptanthrin as Dual Inhibitors of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase

(2019) Dan Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cancer cells’ loss is T cells’ gain

(2019) M. Teresa Villanueva   NATURE REVIEWS DRUG DISCOVERY

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

ENERGIZE: a Phase III study of neoadjuvant chemotherapy alone or with nivolumab with/without linrodostat mesylate for muscle-invasive bladder cancer

(2019) Guru Sonpavde et al.   Future Oncology

Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb

(2019) Hao Shi et al.   IMMUNITY

Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response

(2019) Shamir Cassim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phase III randomized study of second line ADI-PEG 20 plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma

(2018) G K Abou-Alfa et al.   ANNALS OF ONCOLOGY

Tumor-Repopulating Cells Induce PD-1 Expression in CD8 + T Cells by Transferring Kynurenine and AhR Activation

(2018) Yuying Liu et al.   CANCER CELL

IDO1 in cancer: a Gemini of immune checkpoints

(2018) Lijie Zhai et al.   Cellular & Molecular Immunology

Tryptophan Metabolism Contributes to Radiation-Induced Immune Checkpoint Reactivation in Glioblastoma

(2018) Pravin Kesarwani et al.   CLINICAL CANCER RESEARCH

A patent review of IDO1 inhibitors for cancer

(2018) Jae Eun Cheong et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Reversal of indoleamine 2,3-dioxygenase–mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme

(2018) Todd A Triplett et al.   NATURE BIOTECHNOLOGY

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

(2018) Michael L Schulte et al.   NATURE MEDICINE

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting the IDO1/TDO2–KYN–AhR Pathway for Cancer Immunotherapy – Challenges and Opportunities

(2018) Jae Eun Cheong et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

ATF4 Regulates CD4 + T Cell Immune Responses through Metabolic Reprogramming

(2018) Xi Yang et al.   Cell Reports

Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors

(2018) Asha Nayak-Kapoor et al.   Journal for ImmunoTherapy of Cancer

Impact of l-Arginine Metabolism on Immune Response and Anticancer Immunotherapy

(2018) Sun-Hee Kim et al.   Frontiers in Oncology

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

(2018) Sung Min Son et al.   Cell Metabolism

Hypusine, a polyamine-derived amino acid critical for eukaryotic translation

(2018) Myung Hee Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonnutritive Effects of Glutamine

(2018) Erich Roth   JOURNAL OF NUTRITION

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response

(2018) Akito Nakamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amino acid transporters revisited: New views in health and disease

(2018) Palanivel Kandasamy et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

(2018) Gaojian Lian et al.   eLife

ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer

(2018) Franklin C. Harwood et al.   Science Advances

Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis

(2018) Brian W. Labadie et al.   CLINICAL CANCER RESEARCH

Cancer immunoediting and resistance to T cell-based immunotherapy

(2018) Jake S. O’Donnell et al.   Nature Reviews Clinical Oncology

Altered cancer metabolism in mechanisms of immunotherapy resistance

(2018) Rishab Ramapriyan et al.   PHARMACOLOGY & THERAPEUTICS

Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer

(2018) Francesca Ferrandino et al.   Frontiers in Immunology

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

(2017) Madhav Kishore et al.   IMMUNITY

Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1)

(2017) Pornparn Kongpracha et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Monitoring immune-checkpoint blockade: response evaluation and biomarker development

(2017) Mizuki Nishino et al.   Nature Reviews Clinical Oncology

Metabolic reprogramming in clear cell renal cell carcinoma

(2017) Hiromi I. Wettersten et al.   Nature Reviews Nephrology

Posttranslational Modification as a Critical Determinant of Cytoplasmic Innate Immune Recognition

(2017) Paul J. Baker et al.   PHYSIOLOGICAL REVIEWS

Metabolic Interactions in the Tumor Microenvironment

(2017) Costas A. Lyssiotis et al.   TRENDS IN CELL BIOLOGY

Paracrossidius radekcervenkai (Coleoptera: Scarabaeidae: Aphodiinae), a new species from China

(2017) RADEK ČERVENKA et al.   ZOOTAXA

Amino-acid transporters in T-cell activation and differentiation

(2017) Wenkai Ren et al.   Cell Death & Disease

Metabolism in cancer metastasis: bioenergetics, biosynthesis, and beyond

(2017) Shao Thing Teoh et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

(2017) Douglas E. Biancur et al.   Nature Communications

Amino Acid Sensing via General Control Nonderepressible-2 Kinase and Immunological Programming

(2017) Srikanth Battu et al.   Frontiers in Immunology

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

(2017) Susanne M. Steggerda et al.   Journal for ImmunoTherapy of Cancer

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer

(2016) V Coothankandaswamy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy of systemlamino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma

(2016) Yasuhiro Ohshima et al.   CANCER SCIENCE

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

(2016) Aaron M. Hosios et al.   DEVELOPMENTAL CELL

Restricting Glutamine or Glutamine-Dependent Purine and Pyrimidine Syntheses Promotes Human T Cells with High FOXP3 Expression and Regulatory Properties

(2016) Barbara Metzler et al.   JOURNAL OF IMMUNOLOGY

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

(2016) Min Pan et al.   NATURE CELL BIOLOGY

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

(2016) Michael E Pacold et al.   Nature Chemical Biology

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

(2016) Mahima Swamy et al.   NATURE IMMUNOLOGY

PD-1–PD-L1 immune-checkpoint blockade in B-cell lymphomas

(2016) Aaron Goodman et al.   Nature Reviews Clinical Oncology

The mTOR signalling cascade: paving new roads to cure neurological disease

(2016) Peter B. Crino   Nature Reviews Neurology

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

(2016) Edouard Mullarky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nutrient sensing, signal transduction and immune responses

(2016) Jessica Walls et al.   SEMINARS IN IMMUNOLOGY

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

(2016) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs

(2015) Soranobu Ninomiya et al.   BLOOD

Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth

(2015) Lingtao Jin et al.   CANCER CELL

Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs

(2015) Y. D. Bhutia et al.   CANCER RESEARCH

Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression

(2015) Zhaoyong Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

(2015) G. C. Preston et al.   EMBO JOURNAL

Metabolic Reprogramming of Immune Cells in Cancer Progression

(2015) Subhra K. Biswas   IMMUNITY

Antitumor activity of an anti-CD98 antibody

(2015) Gregory M. Hayes et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer

(2015) Mohamed Hassanein et al.   INTERNATIONAL JOURNAL OF CANCER

Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways

(2015) Delphine Rispal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

(2015) Kristen N. Pollizzi et al.   JOURNAL OF CLINICAL INVESTIGATION

Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment

(2015) Kazuhiro Tanaka et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development

(2015) Qian Wang et al.   JOURNAL OF PATHOLOGY

Molecular Architecture of 4E-BP Translational Inhibitors Bound to eIF4E

(2015) Daniel Peter et al.   MOLECULAR CELL

Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer

(2015) Hossein Borghaei et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

(2015) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes

(2015) Tim Willinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Tumoral Immune Resistance Mediated by Enzymes That Degrade Tryptophan

(2015) N. van Baren et al.   Cancer Immunology Research

Myeloid derived suppressor cells—An overview of combat strategies to increase immunotherapy efficacy

(2015) Oana Draghiciu et al.   OncoImmunology

Amino Acid Deprivation Promotes Tumor Angiogenesis through the GCN2/ATF4 Pathway

(2015) Yugang Wang et al.   NEOPLASIA

L-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells

(2014) M. Fletcher et al.   CANCER RESEARCH

Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation

(2014) T. Eleftheriadis et al.   INTERNATIONAL IMMUNOLOGY

Targeting glutamine transport to suppress melanoma cell growth

(2014) Qian Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Impaired T cell function in argininosuccinate synthetase deficiency

(2014) Tatyana N. Tarasenko et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

Brachytherapy versus radical hysterectomy after external beam chemoradiation with gemcitabine plus cisplatin: a randomized, phase III study in IB2-IIB cervical cancer patients

(2013) L. Cetina et al.   ANNALS OF ONCOLOGY

Deoxyhypusine Synthase Promotes Differentiation and Proliferation of T Helper Type 1 (Th1) Cells in Autoimmune Diabetes

(2013) Stephanie C. Colvin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

(2013) Rikke B. Holmgaard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The ABCs of membrane transporters in health and disease (SLC series): Introduction

(2013) Matthias A. Hediger et al.   MOLECULAR ASPECTS OF MEDICINE

Control of glutamine metabolism by the tumor suppressor Rb

(2013) M R Reynolds et al.   ONCOGENE

Activation of the Transcriptional Function of the NF- B Protein c-Rel by O-GlcNAc Glycosylation

(2013) P. Ramakrishnan et al.   Science Signaling

CD14+S100A9+Monocytic Myeloid-derived Suppressor Cells and Their Clinical Relevance in Non–Small Cell Lung Cancer

(2012) Po-Hao Feng et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Indoleamine 2,3-Dioxygenase and Metabolites Protect Murine Lung Allografts and Impair the Calcium Mobilization of T Cells

(2012) Khadija Iken et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion

(2012) M. Platten et al.   CANCER RESEARCH

Arginine deficiency leads to impaired cofilin dephosphorylation in activated human T lymphocytes

(2012) Nadja Feldmeyer et al.   INTERNATIONAL IMMUNOLOGY

Amino Acid Metabolism Related to Immune Tolerance by MDSCs

(2012) Baohong Yang et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

Kynurenines in the CNS: recent advances and new questions

(2012) László Vécsei et al.   NATURE REVIEWS DRUG DISCOVERY

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

(2012) David H. Munn et al.   TRENDS IN IMMUNOLOGY

An expanding range of targets for kynurenine metabolites of tryptophan

(2012) Trevor W. Stone et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido

(2011) Vinod P Balachandran et al.   NATURE MEDICINE

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

Glutamine Synthetase Is a Genetic Determinant of Cell Type–Specific Glutamine Independence in Breast Epithelia

(2011) Hsiu-Ni Kung et al.   PLoS Genetics

Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity

(2010) X. Liu et al.   BLOOD

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

(2010) K. E. Wellen et al.   GENES & DEVELOPMENT

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

Amino acids: metabolism, functions, and nutrition

(2009) Guoyao Wu   AMINO ACIDS

Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

(2009) Feng Qian et al.   CANCER RESEARCH

Reduced Cytotoxic Function of Effector CD8+ T Cells Is Responsible for Indoleamine 2,3-Dioxygenase-Dependent Immune Suppression

(2009) H. Liu et al.   JOURNAL OF IMMUNOLOGY

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

The aryl hydrocarbon receptor in immunity

(2009) Charlotte Esser et al.   TRENDS IN IMMUNOLOGY

Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives

(2008) Paulo C. Rodríguez et al.   IMMUNOLOGICAL REVIEWS

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

(2008) Marc Veldhoen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NO scavenging by 3-hydroxyanthranilic acid and 3-hydroxykynurenine: N-nitrosation leads via oxadiazoles to o-quinone diazides

(2008) Claudia Backhaus et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY