Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation
Authors
Keywords
-
Journal
eLife
Volume 7, Issue -, Pages -
Publisher
eLife Sciences Publications, Ltd
Online
2018-09-10
DOI
10.7554/elife.36158
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity
- (2018) Josephin N. Rashida Gnanaprakasam et al. Frontiers in Immunology
- Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming
- (2017) Ramon I. Klein Geltink et al. IMMUNITY
- Glutathione Primes T Cell Metabolism for Inflammation
- (2017) Tak W. Mak et al. IMMUNITY
- The role of glutathione reductase and related enzymes on cellular redox homoeostasis network
- (2016) Narciso Couto et al. FREE RADICAL BIOLOGY AND MEDICINE
- NADPH Oxidase–Derived Superoxide Provides a Third Signal for CD4 T Cell Effector Responses
- (2016) Lindsey E. Padgett et al. JOURNAL OF IMMUNOLOGY
- Metabolite concentrations, fluxes and free energies imply efficient enzyme usage
- (2016) Junyoung O Park et al. Nature Chemical Biology
- Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications
- (2016) Xin Gen Lei et al. PHYSIOLOGICAL REVIEWS
- Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2
- (2016) Ulf Schulze-Topphoff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells
- (2016) Megan M. Blewett et al. Science Signaling
- Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells
- (2016) Megan M. Blewett et al. Science Signaling
- Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
- (2015) Ping-Chih Ho et al. CELL
- Mitochondria in the Regulation of Innate and Adaptive Immunity
- (2015) Samuel E. Weinberg et al. IMMUNITY
- Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK Pathway
- (2015) Qin Wang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
- (2015) Dorota Klysz et al. Science Signaling
- Fumarate induces redox-dependent senescence by modifying glutathione metabolism
- (2015) Liang Zheng et al. Nature Communications
- Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
- (2015) Dorota Klysz et al. Science Signaling
- Fumaderm®in daily practice for psoriasis: dosing, efficacy and quality of life
- (2014) F. Walker et al. BRITISH JOURNAL OF DERMATOLOGY
- ROS Function in Redox Signaling and Oxidative Stress
- (2014) Michael Schieber et al. CURRENT BIOLOGY
- Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
- (2014) Valerie A. Gerriets et al. JOURNAL OF CLINICAL INVESTIGATION
- Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE
- (2014) Hui Chen et al. JOURNAL OF CLINICAL INVESTIGATION
- Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways
- (2014) S. R. Jacobs et al. JOURNAL OF IMMUNOLOGY
- Role of Nrf2 in Oxidative Stress and Toxicity
- (2013) Qiang Ma Annual Review of Pharmacology and Toxicology
- Mitochondria as Oxidative Signaling Organelles in T-cell Activation: Physiological Role and Pathological Implications
- (2013) Marcin M. Kamiński et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- Dimethyl Fumarate Modulation of Immune and Antioxidant Responses: Application to HIV Therapy
- (2013) Alexander J. Gill et al. CRITICAL REVIEWS IN IMMUNOLOGY
- Dimethyl Fumarate for Treatment of Multiple Sclerosis: Mechanism of Action, Effectiveness, and Side Effects
- (2013) Ralf A. Linker et al. Current Neurology and Neuroscience Reports
- Dimethyl fumarate: a Janus-faced substance?
- (2013) Frieder Kees EXPERT OPINION ON PHARMACOTHERAPY
- The thioredoxin antioxidant system
- (2013) Jun Lu et al. FREE RADICAL BIOLOGY AND MEDICINE
- The emerging role of the Nrf2-Keap1 signaling pathway in cancer
- (2013) M. C. Jaramillo et al. GENES & DEVELOPMENT
- Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling
- (2013) Laura A. Sena et al. IMMUNITY
- Mitochondrial ROS Fire Up T Cell Activation
- (2013) Michael P. Murphy et al. IMMUNITY
- Metabolic Pathways in Immune Cell Activation and Quiescence
- (2013) Erika L. Pearce et al. IMMUNITY
- Glutamine and cancer: cell biology, physiology, and clinical opportunities
- (2013) Christopher T. Hensley et al. JOURNAL OF CLINICAL INVESTIGATION
- The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
- (2013) Lucas B. Sullivan et al. MOLECULAR CELL
- Modulation of oxidative stress as an anticancer strategy
- (2013) Chiara Gorrini et al. NATURE REVIEWS DRUG DISCOVERY
- Fueling Immunity: Insights into Metabolism and Lymphocyte Function
- (2013) E. L. Pearce et al. SCIENCE
- Correcting for the effects of natural abundance in stable isotope resolved metabolomics experiments involving ultra-high resolution mass spectrometry
- (2012) Hunter NB Moseley BMC BIOINFORMATICS
- Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
- (2012) Anne Le et al. Cell Metabolism
- Glutathione and Glutaredoxin Act as a Backup of Human Thioredoxin Reductase 1 to Reduce Thioredoxin 1 Preventing Cell Death by Aurothioglucose
- (2012) Yatao Du et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling
- (2012) Haiyan Peng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells
- (2012) David K. Finlay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Glutathione Reductase Facilitates Host Defense by Sustaining Phagocytic Oxidative Burst and Promoting the Development of Neutrophil Extracellular Traps
- (2012) J. Yan et al. JOURNAL OF IMMUNOLOGY
- Metabolic checkpoints in activated T cells
- (2012) Ruoning Wang et al. NATURE IMMUNOLOGY
- Placebo-Controlled Trial of Oral Laquinimod for Multiple Sclerosis
- (2012) Giancarlo Comi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Placebo-Controlled Phase 3 Study of Oral BG-12 or Glatiramer in Multiple Sclerosis
- (2012) Robert J. Fox et al. NEW ENGLAND JOURNAL OF MEDICINE
- Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis
- (2012) Ralf Gold et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inhibition of glutathione synthesis eliminates the adaptive response of ascitic hepatoma 22 cells to nedaplatin that targets thioredoxin reductase
- (2012) Yijun Wang et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Metabolic pathways in T cell fate and function
- (2012) Valerie A. Gerriets et al. TRENDS IN IMMUNOLOGY
- T cell Activation Is Driven by an ADP-Dependent Glucokinase Linking Enhanced Glycolysis with Mitochondrial Reactive Oxygen Species Generation
- (2012) Marcin M. Kamiński et al. Cell Reports
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
- (2011) Eric V. Dang et al. CELL
- Measuring EGSH and H2O2 with roGFP2-based redox probes
- (2011) Bruce Morgan et al. FREE RADICAL BIOLOGY AND MEDICINE
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
- (2011) Ruoning Wang et al. IMMUNITY
- HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells
- (2011) Lewis Z. Shi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
- (2011) R. D. Michalek et al. JOURNAL OF IMMUNOLOGY
- Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation
- (2010) Jian-Bin Wang et al. CANCER CELL
- Loss of Thioredoxin Reductase 1 Renders Tumors Highly Susceptible to Pharmacologic Glutathione Deprivation
- (2010) P. K. Mandal et al. CANCER RESEARCH
- Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis
- (2010) Zizhen Kang et al. IMMUNITY
- The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism
- (2010) Jonathan D. Powell et al. IMMUNITY
- The metabolic life and times of a T-cell
- (2010) Ryan D. Michalek et al. IMMUNOLOGICAL REVIEWS
- Both Thioredoxin 2 and Glutaredoxin 2 Contribute to the Reduction of the Mitochondrial 2-Cys Peroxiredoxin Prx3
- (2010) Eva-Maria Hanschmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NADPH Oxidase Deficiency Regulates Th Lineage Commitment and Modulates Autoimmunity
- (2010) H. M. Tse et al. JOURNAL OF IMMUNOLOGY
- The Thioredoxin-Thioredoxin Reductase System Can Functionin Vivoas an Alternative System to Reduce Oxidized Glutathione in Saccharomyces cerevisiae
- (2009) Shi-Xiong Tan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis
- (2009) Divya Purushothaman et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Mechanism of Scavenging Action ofN-Acetylcysteine for the OH Radical: A Quantum Computational Study
- (2009) Neha Agnihotri et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Enhancing CD8 T-cell memory by modulating fatty acid metabolism
- (2009) Erika L. Pearce et al. NATURE
- Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli
- (2009) Bryson D Bennett et al. Nature Chemical Biology
- Simultaneous analysis of reactive oxygen species and reduced glutathione content in living cells by polychromatic flow cytometry
- (2009) Andrea Cossarizza et al. Nature Protocols
- PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification
- (2009) Athanasia Spandidos et al. NUCLEIC ACIDS RESEARCH
- How mitochondria produce reactive oxygen species
- (2008) Michael P. Murphy BIOCHEMICAL JOURNAL
- Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcysteine (NAC)
- (2008) Burhan Ates et al. FREE RADICAL RESEARCH
- Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase
- (2008) Christopher C. Franklin et al. MOLECULAR ASPECTS OF MEDICINE
- Regulation of glutathione synthesis
- (2008) Shelly C. Lu MOLECULAR ASPECTS OF MEDICINE
- Integration of metabolism and inflammation by lipid-activated nuclear receptors
- (2008) Steven J. Bensinger et al. NATURE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started