Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor Microenvironment

NK cells for cancer immunotherapy

(2020) Noriko Shimasaki et al.   NATURE REVIEWS DRUG DISCOVERY

Role of the HIF oxygen sensing pathway in cell defense and proliferation through the control of amino acid metabolism

(2020) Antonio Bouthelier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity

(2020) Jing Ni et al.   IMMUNITY

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

(2020) Yan Gao et al.   SCIENCE

Nutritional Exchanges Within Tumor Microenvironment: Impact for Cancer Aggressiveness

(2020) Giuseppina Comito et al.   Frontiers in Oncology

Distribution of ACE2, CD147, CD26 and other SARS‐CoV‐2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID‐19 risk factors

(2020) U. Radzikowska et al.   ALLERGY

A guide to plasma membrane solute carrier proteins

(2020) Mattia D. Pizzagalli et al.   FEBS Journal

Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer

(2020) Deanna N. Edwards et al.   JOURNAL OF CLINICAL INVESTIGATION

Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells

(2019) Angelika Bröer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-18 up-regulates amino acid transporters and facilitates amino acid–induced mTORC1 activation in natural killer cells

(2019) Saeedah Musaed Almutairi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer

(2019) Yasuhiro Saito et al.   NATURE

A Metabolism Toolbox for CAR T Therapy

(2019) Xuequn Xu et al.   Frontiers in Oncology

ASCT2: a potential cancer drug target

(2019) Kanu Wahi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Systemic silencing of Phd2 causes reversible immune regulatory dysfunction

(2019) Atsushi Yamamoto et al.   JOURNAL OF CLINICAL INVESTIGATION

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

(2019) Jessica Vetters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer

(2019) Matteo Morotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Competition for nutrients and its role in controlling immune responses

(2019) Nidhi Kedia-Mehta et al.   Nature Communications

The RNA-Binding Protein YBX3 Controls Amino Acid Levels by Regulating SLC mRNA Abundance

(2019) Amy Cooke et al.   Cell Reports

The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation

(2019) Heng Lin et al.   Frontiers in Immunology

NK Cell Metabolism and Tumor Microenvironment

(2019) Iñigo Terrén et al.   Frontiers in Immunology

Targeting L-type amino acid transporter 1 in innate and adaptive T cells efficiently controls skin inflammation

(2019) Danay Cibrian et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ubiquitylation and endocytosis of the human LAT1/SLC7A5 amino acid transporter

(2019) Céline Barthelemy et al.   Scientific Reports

ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the progression of head and neck squamous cell carcinoma

(2019) Ze Zhang et al.   BRITISH JOURNAL OF CANCER

Enhanced glutamine uptake influences composition of immune cell infiltrates in breast cancer

(2019) Rokaya El Ansari et al.   BRITISH JOURNAL OF CANCER

A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells

(2019) Hee Chan Yoo et al.   Cell Metabolism

NK Cell Metabolism and TGFβ – Implications for Immunotherapy

(2019) Karen Slattery et al.   Frontiers in Immunology

Targeting the microenvironment in solid tumors

(2018) Carmen Belli et al.   CANCER TREATMENT REVIEWS

Targeted Suppression and Knockout of ASCT2 or LAT1 in Epithelial and Mesenchymal Human Liver Cancer Cells Fail to Inhibit Growth

(2018) Paige Bothwell et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

(2018) Michael L Schulte et al.   NATURE MEDICINE

Single cell analysis of kynurenine and System L amino acid transport in T cells

(2018) Linda V. Sinclair et al.   Nature Communications

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

(2018) Róisín M. Loftus et al.   Nature Communications

Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets

(2018) Angelika Bröer et al.   Frontiers in Pharmacology

A Landscape of Metabolic Variation across Tumor Types

(2018) Ed Reznik et al.   Cell Systems

The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health

(2018) Mariafrancesca Scalise et al.   Frontiers in Chemistry

The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model

(2018) Pascal Häfliger et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy

(2018) Thibault Le Bourgeois et al.   Frontiers in Oncology

IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

(2018) Minkyung Song et al.   NATURE

A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis

(2017) Pin Liu et al.   HEPATOLOGY

Cutting Edge: IL-2–Induced Expression of the Amino Acid Transporters SLC1A5 and CD98 Is a Prerequisite for NKG2D-Mediated Activation of Human NK Cells

(2017) Helle Jensen et al.   JOURNAL OF IMMUNOLOGY

Control of amino acid transport coordinates metabolic reprogramming in T-cell malignancy

(2017) K M Grzes et al.   LEUKEMIA

Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity

(2017) E Liu et al.   LEUKEMIA

Amino-acid transporters in T-cell activation and differentiation

(2017) Wenkai Ren et al.   Cell Death & Disease

Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis

(2017) Ming Yue et al.   Cell Reports

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

(2017) Yeonwoo Park et al.   Cell Reports

Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation

(2017) Lindsey Araujo et al.   eLife

2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport

(2016) Michael L. Schulte et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth

(2016) Y. Cormerais et al.   CANCER RESEARCH

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche

(2016) David Clever et al.   CELL

MARCH1 E3 Ubiquitin Ligase Dampens the Innate Inflammatory Response by Modulating Monocyte Functions in Mice

(2016) Tristan Galbas et al.   JOURNAL OF IMMUNOLOGY

Metabolic Reprogramming Supports IFN-γ Production by CD56brightNK Cells

(2016) Sinéad E. Keating et al.   JOURNAL OF IMMUNOLOGY

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

(2016) Katherine C. Verbist et al.   NATURE

Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma

(2015) Yun-Yong Park et al.   HEPATOLOGY

LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter

(2015) Lara Napolitano et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Antitumor activity of an anti-CD98 antibody

(2015) Gregory M. Hayes et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer

(2015) Mohamed Hassanein et al.   INTERNATIONAL JOURNAL OF CANCER

Ubiquitylation of CD98 limits cell proliferation and clonal expansion

(2015) J. N. G. Ablack et al.   JOURNAL OF CELL SCIENCE

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction

(2015) Ende Zhao et al.   NATURE IMMUNOLOGY

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

(2015) R. A. Saxton et al.   SCIENCE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

IL-15–PI3K–AKT–mTOR: A Critical Pathway in the Life Journey of Natural Killer Cells

(2015) Alaa Kassim Ali et al.   Frontiers in Immunology

Hypoxia-inducible factors enhance glutamate signaling in cancer cells

(2015) Hongxia Hu et al.   Oncotarget

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells

(2014) Antoine Marçais et al.   NATURE IMMUNOLOGY

The Critical Role of IL-15–PI3K–mTOR Pathway in Natural Killer Cell Effector Functions

(2014) Neethi Nandagopal et al.   Frontiers in Immunology

AMPKα1: A glucose sensor that controls CD8 T-cell memory

(2013) Julia Rolf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Membrane-associated RING-CH (MARCH) 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor

(2013) H. Fujita et al.   JOURNAL OF CELL SCIENCE

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

(2013) Andrew L Doedens et al.   NATURE IMMUNOLOGY

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Nutrient transporters: the Achilles’ heel of anabolism

(2013) Alison N. McCracken et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

CD98 at the crossroads of adaptive immunity and cancer

(2012) J. M. Cantor et al.   JOURNAL OF CELL SCIENCE

HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5

(2012) Ainara Elorza et al.   MOLECULAR CELL

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

(2012) Alejo Efeyan et al.   NATURE

The role of amino acid transporters in inherited and acquired diseases

(2011) Stefan Bröer et al.   BIOCHEMICAL JOURNAL

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Loss of T Cell CD98 H Chain Specifically Ablates T Cell Clonal Expansion and Protects from Autoimmunity

(2011) J. Cantor et al.   JOURNAL OF IMMUNOLOGY

MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation

(2011) Craig A. Eyster et al.   MOLECULAR BIOLOGY OF THE CELL

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL