Modification of Proteins by Metabolites in Immunity

Krebs Cycle Reborn in Macrophage Immunometabolism

(2020) Dylan G. Ryan et al.   Annual Review of Immunology

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

(2020) Ming He et al.   Cell Metabolism

Immunometabolism: From basic mechanisms to translation

(2020) Liza Makowski et al.   IMMUNOLOGICAL REVIEWS

The DNA sensor cGAS is decorated by acetylation and phosphorylation modifications in the context of immune signaling

(2020) Bokai Song et al.   MOLECULAR & CELLULAR PROTEOMICS

Chemoproteomic Profiling of Itaconation by Bioorthogonal Probes in Inflammatory Macrophages

(2020) Wei Qin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons

(2019) Brian P. Daniels et al.   IMMUNITY

Malonylation of GAPDH is an inflammatory signal in macrophages

(2019) Silvia Galván-Peña et al.   Nature Communications

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

(2019) Zhenke Wen et al.   NATURE IMMUNOLOGY

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

(2019) Jiang Dai et al.   CELL

Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours

(2019) Han Yao et al.   Nature Biomedical Engineering

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

(2019) Daniel J. Puleston et al.   Cell Metabolism

Acetate Promotes T Cell Effector Function during Glucose Restriction

(2019) Jing Qiu et al.   Cell Reports

Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy

(2019) Heng-Huan Lee et al.   CANCER CELL

S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate

(2019) Wei Qin et al.   Nature Chemical Biology

Palmitoylation is required for TNF-R1 signaling

(2019) Philipp Zingler et al.   Cell Communication and Signaling

Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation

(2019) Young-Chan Kim et al.   Nature Chemical Biology

Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization

(2019) Alanna E. McCarthy et al.   CELL

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

(2019) Stefano Angiari et al.   Cell Metabolism

Epigenetic regulation of macrophages: from homeostasis maintenance to host defense

(2019) Siyuan Chen et al.   Cellular & Molecular Immunology

Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis

(2019) Zhen Xiong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

(2019) Hanlin Zhang et al.   MOLECULAR CELL

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Palmitoylation of NOD1 and NOD2 is required for bacterial sensing

(2019) Yan Lu et al.   SCIENCE

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

(2019) Shan-Ting Liao et al.   Nature Communications

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

(2019) Valentina Pucino et al.   Cell Metabolism

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

(2019) Mario A. Lauterbach et al.   IMMUNITY

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

(2018) Ulrike Bruning et al.   Cell Metabolism

Hypusine, a polyamine-derived amino acid critical for eukaryotic translation

(2018) Myung Hee Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

(2017) Angela Bononi et al.   NATURE

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development

(2017) Benyu Liu et al.   Nature Communications

SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice

(2017) Fang Wang et al.   Cell Reports

SIRT1/Adenosine Monophosphate-Activated Protein Kinase α Signaling Enhances Macrophage Polarization to an Anti-inflammatory Phenotype in Rheumatoid Arthritis

(2017) So Youn Park et al.   Frontiers in Immunology

Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer

(2016) Shima Nakanishi et al.   AMINO ACIDS

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

(2016) Maria L. Balmer et al.   IMMUNITY

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

(2016) Pengyan Xia et al.   NATURE IMMUNOLOGY

Fatty acylation of proteins: The long and the short of it

(2016) Marilyn D. Resh   PROGRESS IN LIPID RESEARCH

Activation of STING requires palmitoylation at the Golgi

(2016) Kojiro Mukai et al.   Nature Communications

Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth

(2016) Ye Xiangyun et al.   Oncotarget

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

(2016) Jan Naujoks et al.   PLoS Pathogens

Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases

(2015) Christopher P. Garnham et al.   CELL

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Immunometabolism: Cellular Metabolism Turns Immune Regulator

(2015) Róisín M. Loftus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation

(2015) Francesca Rampoldi et al.   JOURNAL OF IMMUNOLOGY

Association of NMT2 with the acyl-CoA carrier ACBD6 protects theN-myristoyltransferase reaction from palmitoyl-CoA

(2015) Eric Soupene et al.   JOURNAL OF LIPID RESEARCH

Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation

(2015) Gozde Colak et al.   MOLECULAR & CELLULAR PROTEOMICS

ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization

(2015) David Tse Shen Lin et al.   eLife

Chemoproteomics reveals Toll-like receptor fatty acylation

(2014) Nicholas M Chesarino et al.   BMC BIOLOGY

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

Glucose-dependentde NovoLipogenesis in B Lymphocytes

(2014) Fay J. Dufort et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

Protein post-translational modifications and regulation of pluripotency in human stem cells

(2013) Yu-Chieh Wang et al.   CELL RESEARCH

Expanding the clinical phenotype of hereditaryBAP1cancer predisposition syndrome, reporting three new cases

(2013) Robert Pilarski et al.   GENES CHROMOSOMES & CANCER

Deoxyhypusine Synthase Promotes Differentiation and Proliferation of T Helper Type 1 (Th1) Cells in Autoimmune Diabetes

(2013) Stephanie C. Colvin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability

(2013) G. J. W. van der Windt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The chemical complexity of cellular microtubules: Tubulin post-translational modification enzymes and their roles in tuning microtubule functions

(2012) Christopher P. Garnham et al.   Cytoskeleton

Mechanisms of triglyceride accumulation in activated macrophages

(2012) Kenneth R. Feingold et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lysine Succinylation and Lysine Malonylation in Histones

(2012) Zhongyu Xie et al.   MOLECULAR & CELLULAR PROTEOMICS

Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis

(2011) B. Zhou et al.   CARDIOVASCULAR RESEARCH

Human DHHC proteins: A spotlight on the hidden player of palmitoylation

(2011) Justyna Korycka et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

(2011) Chao Peng et al.   MOLECULAR & CELLULAR PROTEOMICS

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration

(2010) Krzysztof Rogowski et al.   CELL

Identification of lysine succinylation as a new post-translational modification

(2010) Zhihong Zhang et al.   Nature Chemical Biology

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

 -Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

(2010) J. S. Oakhill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA