Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation

Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma

(2020) Erik Ladomersky et al.   CLINICAL CANCER RESEARCH

Indoleamine Dioxygenase Inhibitors: Clinical Rationale and Current Development

(2019) Mayanne M. T. Zhu et al.   Current Oncology Reports

PD-1 aborts the activation trajectory of autoreactive CD8+ T cells to prohibit their acquisition of effector functions

(2019) Hikari Okamura et al.   JOURNAL OF AUTOIMMUNITY

TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma

(2019) Xiaochen Wang et al.   JOURNAL OF HEPATOLOGY

Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors

(2019) Florence Schramme et al.   Cancer Immunology Research

Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations

(2018) Xia-Di He et al.   Cell Metabolism

Expression of PD-L1, indoleamine 2,3-dioxygenase and the immune microenvironment in gastric adenocarcinoma

(2018) Pallavi A Patil et al.   HISTOPATHOLOGY

Correction to: miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy

(2018) Qian Huang et al.   Journal of Hematology & Oncology

Predictive test for chemotherapy response in resectable gastric cancer: a multi-cohort, retrospective analysis

(2018) Jae-Ho Cheong et al.   LANCET ONCOLOGY

Elevated Level of CD4+ T Cell Immune Activation in Acutely HIV-1-Infected Stage Associates With Increased IL-2 Production and Cycling Expression, and Subsequent CD4+ T Cell Preservation

(2018) Huan Xia et al.   Frontiers in Immunology

Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy

(2018) Aurélie Durgeau et al.   Frontiers in Immunology

Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?

(2018) Andrea Botticelli et al.   Journal of Translational Medicine

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

(2016) David H. Munn et al.   TRENDS IN IMMUNOLOGY

SnapShot: Mammalian Sirtuins

(2014) Kristin A. Anderson et al.   CELL

The role of indoleamine 2,3-dioxygenase (IDO) in immune tolerance: Focus on macrophage polarization of THP-1 cells

(2014) Xian-Feng Wang et al.   CELLULAR IMMUNOLOGY

NFATc1 Regulates PD-1 Expression upon T Cell Activation

(2014) K. J. Oestreich et al.   JOURNAL OF IMMUNOLOGY

The Kynurenine Pathway of Tryptophan Degradation is Activated During Osteoblastogenesis

(2014) Christopher Vidal et al.   STEM CELLS

Trial watch: IDO inhibitors in cancer therapy

(2014) Erika Vacchelli et al.   OncoImmunology

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

(2013) Rikke B. Holmgaard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unique Features of Naive CD8+ T Cell Activation by IL-2

(2013) J.-H. Cho et al.   JOURNAL OF IMMUNOLOGY

Up-regulated expression of indoleamine 2,3-dioxygenase 1 in non-Hodgkin lymphoma correlates with increased regulatory T-cell infiltration

(2013) Xiao-Qian Liu et al.   LEUKEMIA & LYMPHOMA

Functional Lysine Modification by an Intrinsically Reactive Primary Glycolytic Metabolite

(2013) R. E. Moellering et al.   SCIENCE

Role of LAT in the Granule-Mediated Cytotoxicity of CD8 T Cells

(2012) C.-w. Ou-Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan

(2012) Richard Metz et al.   OncoImmunology

Decreased IDO Activity and Increased TTS Expression Break Immune Tolerance in Patients with Immune Thrombocytopenia

(2011) Chun-yan Wang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Indoleamine 2,3-Dioxygenase

(2010) Hatem Soliman et al.   CANCER JOURNAL

The Prognostic Significance of Tryptophanyl-tRNA Synthetase in Colorectal Cancer

(2009) A. Ghanipour et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism

(2008) Stefan Löb et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Aminoacyl tRNA synthetases and their connections to disease

(2008) S. G. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA