Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor

Expression of L-type amino acid transporter 1 as a molecular target for prognostic and therapeutic indicators in bladder carcinoma

(2020) Maihulan Maimaiti et al.   Scientific Reports

First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors

(2020) Naohiro Okano et al.   INVESTIGATIONAL NEW DRUGS

Targeted alpha therapy using astatine (211At)-labeled phenylalanine: A preclinical study in glioma bearing mice

(2020) Tadashi Watabe et al.   Oncotarget

Investigation of cancer drug resistance mechanisms by phosphoproteomics

(2020) Joelle C. Boulos et al.   PHARMACOLOGICAL RESEARCH

A Code of Mono-phosphorylation Modulates the Function of RB

(2019) Ioannis Sanidas et al.   MOLECULAR CELL

Inhibition of the amino‐acid transporter LAT1 demonstrates anti‐neoplastic activity in medulloblastoma

(2019) Yann Cormerais et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Distribution of LAT1-targeting PET tracer was independent of the tumor blood flow in rat xenograft models of C6 glioma and MIA PaCa-2

(2019) Masanao Aoki et al.   ANNALS OF NUCLEAR MEDICINE

Role of Amino Acid Transporter Expression as a Prognostic Marker in Patients With Surgically Resected Colorectal Cancer

(2019) HIROOMI OGAWA et al.   ANTICANCER RESEARCH

A novel therapeutic approach for anaplastic thyroid cancer through inhibition of LAT1

(2019) Keisuke Enomoto et al.   Scientific Reports

Characterization of the expression of LAT1 as a prognostic indicator and a therapeutic target in renal cell carcinoma

(2019) Kosuke Higuchi et al.   Scientific Reports

Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations

(2018) Xia-Di He et al.   Cell Metabolism

Branched Chain Amino Acids: Beyond Nutrition Metabolism

(2018) Cunxi Nie et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quantitative phosphoproteomic analysis of acquired cancer drug resistance to pazopanib and dasatinib

(2018) Simon Vyse et al.   Journal of Proteomics

Integrated proteomic and phosphoproteomic analyses of cisplatin-sensitive and resistant bladder cancer cells reveal CDK2 network as a key therapeutic target

(2018) Jae Hun Jung et al.   CANCER LETTERS

The Regulation and Function of the L-Type Amino Acid Transporter 1 (LAT1) in Cancer

(2018) Travis Salisbury et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model

(2018) Pascal Häfliger et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Amino acid transporters revisited: New views in health and disease

(2018) Palanivel Kandasamy et al.   TRENDS IN BIOCHEMICAL SCIENCES

Expression of amino acid transporter (LAT1 and 4F2hc) in pulmonary pleomorphic carcinoma

(2018) Kyoichi Kaira et al.   HUMAN PATHOLOGY

Inhibition of l-type amino acid transporter 1 activity as a new therapeutic target for cholangiocarcinoma treatment

(2017) Supak Yothaisong et al.   TUMOR BIOLOGY

Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis

(2017) Ming Yue et al.   Cell Reports

Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth

(2017) Mariafrancesca Scalise et al.   Frontiers in Oncology

Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth

(2016) Y. Cormerais et al.   CANCER RESEARCH

Efficacy of systemlamino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma

(2016) Yasuhiro Ohshima et al.   CANCER SCIENCE

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

(2016) Aaron M. Hosios et al.   DEVELOPMENTAL CELL

18F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with 18F-FDG and 11C-Methionine PET

(2016) Tadashi Watabe et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells

(2016) Keitaro Hayashi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Multiple testing corrections in quantitative proteomics: A useful but blunt tool

(2016) Dana Pascovici et al.   PROTEOMICS

Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling

(2016) Mee-Sup Yoon et al.   Cell Reports

Cyclin dependent kinase (CDK) inhibitors as anticancer drugs

(2015) Concepción Sánchez-Martínez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2

(2015) S. G. Dann et al.   EMBO JOURNAL

Prognostic significance of amino-acid transporter expression (LAT1, ASCT2 and xCT) in surgically resected tongue cancer

(2014) M Toyoda et al.   BRITISH JOURNAL OF CANCER

The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation

(2014) Rui Chen et al.   JOURNAL OF CELL BIOLOGY

JPH203, an L-Type Amino Acid Transporter 1–Selective Compound, Induces Apoptosis of YD-38 Human Oral Cancer Cells

(2014) Dae-Woong Yun et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia

(2014) C Rosilio et al.   LEUKEMIA

Nrf2- and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder Carcinoma Cells to Proteasome Inhibition

(2014) P. Ye et al.   MOLECULAR AND CELLULAR BIOLOGY

Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer

(2013) Kyoichi Kaira et al.   BMC CANCER

Targeting Amino Acid Transport in Metastatic Castration-Resistant Prostate Cancer: Effects on Cell Cycle, Cell Growth, and Tumor Development

(2013) Qian Wang et al.   JNCI-Journal of the National Cancer Institute

Kinase-Substrate Enrichment Analysis Provides Insights into the Heterogeneity of Signaling Pathway Activation in Leukemia Cells

(2013) P. Casado et al.   Science Signaling

Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer

(2012) K Kaira et al.   BRITISH JOURNAL OF CANCER

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis

(2011) Mio Furuya et al.   CANCER SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: Comparison with non-cancerous lesions

(2011) Masaaki Ichinoe et al.   PATHOLOGY INTERNATIONAL

l-Type amino acid transporter 1 inhibitors inhibit tumor cell growth

(2009) Koji Oda et al.   CANCER SCIENCE

ATF4-dependent transcription mediates signaling of amino acid limitation

(2009) Michael S. Kilberg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I–III nonsmall cell lung cancer

(2008) K Kaira et al.   BRITISH JOURNAL OF CANCER

l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms

(2008) Kyoichi Kaira et al.   CANCER SCIENCE

Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways

(2008) Christiane Deval et al.   FEBS Journal

Phase Transfer Surfactant-Aided Trypsin Digestion for Membrane Proteome Analysis

(2008) Takeshi Masuda et al.   JOURNAL OF PROTEOME RESEARCH

L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer

(2008) Takeshi Sakata et al.   PATHOLOGY INTERNATIONAL