Development of Sesamol Carbamate-L-Phenylalanine Prodrug Targeting L-Type Amino Acid Transporter1 (LAT1) as a Potential Antiproliferative Agent against Melanoma

Route of intracellular uptake and cytotoxicity of sesamol, sesamin, and sesamolin in human melanoma SK-MEL-2 cells

(2021) Tarapong Srisongkram et al.   BIOMEDICINE & PHARMACOTHERAPY

Toward a better understanding of metabolic and pharmacokinetic characteristics of low-solubility, low-permeability natural medicines

(2020) Jie Yang et al.   DRUG METABOLISM REVIEWS

Tyrosine–Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7

(2020) Piman Pocasap et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

L-Type amino acid transporter 1 as a target for drug delivery

(2020) Elena Puris et al.   PHARMACEUTICAL RESEARCH

Delivery of Sesamol Using Polyethylene-Glycol-Functionalized Selenium Nanoparticles in Human Liver Cells in Culture

(2019) Fuguo Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Synthesis of CdS-modified chitosan quantum dots for the drug delivery of Sesamol

(2019) Hani Nasser Abdelhamid et al.   CARBOHYDRATE POLYMERS

Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action

(2019) Amin F. Majdalawieh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Validation of Cell-Based Assay for Quantification of Sesamol Uptake and Its Application for Measuring Target Exposure

(2019) Srisongkram et al.   MOLECULES

Identification Of Novel Sesamol Dimers With Unusual Methylenedioxy Ring-Opening Skeleton And Evaluation Of Their Antioxidant And Cytotoxic Activities

(2019) Sudtha Murthy et al.   CURRENT ORGANIC SYNTHESIS

Role of L-Type Amino Acid Transporter 1 (LAT1) for the Selective Cytotoxicity of Sesamol in Human Melanoma Cells

(2019) Tarapong Srisongkram et al.   MOLECULES

l-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia

(2019) Johanna Huttunen et al.   Scientific Reports

Secondary Carbamate Linker Can Facilitate the Sustained Release of Dopamine from Brain-Targeted Prodrug

(2018) Nikki A. Thiele et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sesamol Inhibited Melanogenesis by Regulating Melanin-Related Signal Transduction in B16F10 Cells

(2018) Po-Yuan Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural properties for selective and efficient l -type amino acid transporter 1 (LAT1) mediated cellular uptake

(2018) Jussi Kärkkäinen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Role of l-Type Amino Acid Transporter 1 at the Inner Blood-Retinal Barrier in the Blood-to-Retina Transport of Gabapentin

(2018) Shin-ichi Akanuma et al.   MOLECULAR PHARMACEUTICS

The expanding role of prodrugs in contemporary drug design and development

(2018) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health

(2018) Mariafrancesca Scalise et al.   Frontiers in Chemistry

Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1)

(2018) Huan-Chieh Chien et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line

(2018) Yu Takahashi et al.   PHARMACEUTICAL RESEARCH

Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing Mitochondrial Function and Suppressing Autophagy

(2017) Zhigang Liu et al.   Scientific Reports

Sesamol induced apoptotic effect in lung adenocarcinoma cells through both intrinsic and extrinsic pathways

(2016) Boondaree Siriwarin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Sesamol induces mitochondrial apoptosis pathway in HCT116 human colon cancer cells via pro-oxidant effect

(2016) Munthipha Khamphio et al.   LIFE SCIENCES

Organic Carbamates in Drug Design and Medicinal Chemistry

(2015) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prognostic significance of L-type amino acid transporter 1 (LAT1) expression in cutaneous melanoma

(2015) Akira Shimizu et al.   MELANOMA RESEARCH

The Prodrug Approach: A Successful Tool for Improving Drug Solubility

(2015) Daniela Jornada et al.   MOLECULES

Biopharmaceutical profiling of sesamol: physiochemical characterization, gastrointestinal permeability and pharmacokinetic evaluation

(2015) T. Geetha et al.   RSC Advances

Targeting glutamine transport to suppress melanoma cell growth

(2014) Qian Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Sesamol-loaded solid lipid nanoparticles for treatment of skin cancer

(2014) T. Geetha et al.   JOURNAL OF DRUG TARGETING

Application of FTIR microspectroscopy for characterization of biomolecular changes in human melanoma cells treated by sesamol and kojic acid

(2013) Montra Srisayam et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Establishment of Stable Cell Lines With High Expression of Heterodimers of Human 4F2hc and Human Amino Acid Transporter LAT1 or LAT2 and Delineation of Their Differential Interaction With ^|^alpha;-Alkyl Moieties

(2012) Narakorn Khunweeraphong et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker

(2011) Kátia C. Carvalho et al.   Clinics

Qualitative structure-metabolism relationships in the hydrolysis of carbamates

(2010) Federica Vacondio et al.   DRUG METABOLISM REVIEWS